Pubmed (TDAH) du 14/01/26
1. Kauppinen I, Miettunen J, Nordström T, Halt AH, Hurtig T. Do ADHD symptoms in adolescence predict psychiatric disorders later in life? A longitudinal study of the Northern Finland birth cohort 1986. Soc Psychiatry Psychiatr Epidemiol;2026 (Jan 13)
PURPOSE: Attention Deficit Hyperactivity Disorder (ADHD) and concurrent psychiatric comorbidities have been thoroughly investigated but less is known on how ADHD symptoms predict subsequent psychiatric disorders. The aim of this study is to examine whether ADHD symptoms in adolescence predict adult psychiatric disorders in a longitudinal unselected population-based cohort. METHODS: The study is based on the Northern Finland Birth Cohort 1986 (N = 9432), in which ADHD symptoms had been measured with the parent-filled Strengths and Weaknesses of ADHD Symptoms and Normal Behaviours (SWAN) questionnaire at the age of 16 years. Adult psychiatric disorders were retrieved from the nationwide registers up to age 35 years. The population was divided into tertiles based on ADHD symptoms and the correlations between middle and highest tertiles and certain later psychiatric disorders were examined with logistic regression analyses, taking family type, parents’ education and adolescent-reported psychiatric symptoms as covariates. RESULTS: Among females, ADHD symptoms in adolescence predicted later anxiety and depressive disorders in both the crude and adjusted models for the middle and highest tertiles and substance use disorders in the highest tertile. The highest risk was associated with substance use disorders. In males, only anxiety disorders could be predicted for the middle and highest tertiles in all the analyses. CONCLUSIONS: ADHD symptoms in adolescence predict multiple psychiatric disorders among females and anxiety disorders among males. ADHD symptoms should be addressed as soon as they appear even if they do not fulfil the diagnostic criteria for ADHD. More research needs to be done into this question.
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2. Sarah BSN, Sandra SS, Mari-Carmen M, Otmane B, Tania B, Abbas A, Laurent G, Paul B, Nóra K, Ana-Maria SP, Walid H, Marc L. Animal models of attention-deficit/hyperactivity disorder: Diversity and validity. Pharmacol Rev;2025 (Dec 1);78(1):100108.
Attention-deficit/hyperactivity disorder (ADHD) is one of the most widespread neurodevelopmental disorders globally, marked by chronic symptoms of inattention and/or hyperactivity-impulsivity. Its multifactorial origin and phenotypic heterogeneity make it a complex condition, and despite substantial research, the precise causes of ADHD remain poorly understood. A significant challenge in advancing ADHD research is the lack of a unified resource that consolidates animal models across different species and considers the diversity of ADHD subtypes and associated coexisting conditions. This lack of standardization of the models delays progress in developing a deeper understanding of the neuronal and molecular mechanisms behind the disorder, which is essential to advance its treatment. This review aims to bridge this gap by offering a comprehensive compilation of available animal models used in ADHD research, accompanied by an evaluation of their validity. It is essential for researchers to have access to a range of models, each selected based on the specific scientific objectives and hypotheses of their studies. The review highlights that an extensive approach to studying ADHD, including its various dimensions and associated conditions, requires the use of multiple animal models. Moreover, it emphasizes the importance of assessing the mechanisms and broader effects of current pharmacological treatments while also exploring novel therapeutic possibilities. By providing a clearer and more structured resource, this work pursues to assist researchers in selecting the most appropriate models for their investigations. Additionally, it aims to contribute to the broader understanding of ADHD neurobiology, offering new perspectives for new models and the potential for more targeted therapeutic strategies. SIGNIFICANT STATEMENT: Attention-deficit/hyperactivity disorder (ADHD), one of the most prevalent neurodevelopmental disorders globally, is marked by inattention and/or hyperactivity-impulsivity. This review evaluates animal models for ADHD and its coexisting conditions, emphasizing the need for diverse models to reflect its complexity. It underscores the importance of selecting appropriate models to address specific research goals and investigates current and potential pharmacological treatments, providing a vital resource for advancing ADHD research and improving therapeutic approaches.
