Pubmed (TDAH) du 18/01/26
1. Netzer Turgeman R, Pollak Y. What Are You Waiting For?! Roles of Motivation, Goal Orientation, and Emotion Regulation in Explaining the Link Between ADHD and Procrastination. J Atten Disord;2026 (Jan 18):10870547251408120.
OBJECTIVE: This study aims to investigate the complex relation between adult ADHD symptoms, procrastination, and mediating factors, in light of leading procrastination theories: the Temporal Motivation Theory (TMT), emotion regulation, and a General Architecture for Modeling the Dynamics of Goal-Directed Motivation and Decision-Making – the GOAL architecture. METHOD: The study was preregistered. A survey was conducted with 640 adults recruited online to examine the associations between ADHD symptoms, procrastination, and seven mediating factors. Participants completed measures assessing ADHD symptoms, procrastination tendencies, emotion regulation, motivation, and goal-related behaviors. Structural equation modeling (SEM) was used to test the direct and indirect pathways among the variables. RESULTS: A positive association was revealed between ADHD inattention symptoms and procrastination tendencies. The mediating factors that significantly contributed to this relations were sensitivity to delay, perceived low value of the task, and flexible goal adjustment. While ADHD inattention symptoms was associated with all seven variables, three variables directly contributed to increased procrastination behavior, thus explaining the link between inattention symptoms and procrastination. CONCLUSIONS: The study highlights the relations between procrastination and adult ADHD symptoms and underscores the need to address mediating factors in intervention strategies. Understanding these mechanisms is essential for developing targeted interventions to improve functional outcomes for individuals with ADHD.
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2. Nishimura Y, Mustika D, Ueno S, Tominaga S, Shindo M, Tajiri N, Jung CG, Hida H. The intake of monosodium aspartate attenuates aggression induced by post-weaning social isolation in an ADHD rat model. J Physiol Sci;2026 (Jan 9);76(1):100056.
We investigated whether monosodium aspartate (MSA), an umami compound structurally analogous to monosodium glutamate (MSG), influences aggressive behavior in a rat model of attention-deficit/hyperactivity disorder. Spontaneously hypertensive rats (SHR/Izm) were subjected to post-weaning social isolation and assessed using the resident-intruder paradigm. MSA ingestion significantly reduced aggression, particularly the frequency and duration of attacks, while the open field test showed no differences in anxiety-like behavior. c-Fos immunohistochemistry revealed increased neuronal activation in the intermediate nucleus of the solitary tract (iNTS) and decreased activation in the central amygdala (CeA) following MSA ingestion. This effect, along with the reduction in aggression, was abolished by vagotomy, suggesting gut-brain involvement. These findings indicate that MSA, like MSG, can reduce aggression via the gut-brain axis, implicating the vagus nerve, iNTS and CeA as key mediators. This highlights that the modulation of aggression by ingested amino acids is a broader effect acting through shared mechanisms.
