Pubmed (TSA) du 05/04/26
1. Imbelloni L, Rivoli A, Lemos Neto SV, Santos MV, SantaRosa AA, Modolo NP. Anesthetic Strategy for 30 Radiotherapy Sessions in a Child With Autism Spectrum Disorder (ASD) and Severe Behavioral Dysregulation: A Case Report. Cureus;2026 (Apr);18(4):e106480.
Autism spectrum disorder (ASD) refers to a spectrum of neurodevelopmental conditions characterized by challenges in social interaction and communication, which coexist with repetitive behaviors and narrowly focused interests. Autistic patients, particularly children, often present with heightened sensitivity, which must be considered when anesthesia is necessary. A six-year-old child with ASD was diagnosed with rhabdomyosarcoma of the left lower limb, and after surgical treatment, was indicated for 30 radiotherapy sessions. The routine technique for radiotherapy in children involves inhalation anesthesia with sevoflurane. After the first session, there were undesirable side effects, and it was decided to use sedation with clonidine as pre-anesthesia and ketamine and dexmedetomidine intranasally in the radiotherapy room. The remaining 29 sessions were all performed with this technique, achieving ease during radiotherapy and awakening without aggression in the post-anesthesia care unit (PACU). Clonidine is used as a pre-anesthetic medication in pediatrics due to its sedative and analgesic properties, providing preoperative sedation and preventing postoperative pain and vomiting. Ketodex is a combination of ketamine and dexmedetomidine. The combined use of ketamine and dexmedetomidine offers several clinical advantages, including cardiovascular stability, preservation of spontaneous ventilation, effective postoperative analgesia, and smooth recovery.
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2. Koegel LK, Wehman P, Claude CM, Lam MS, Bruzzese T, Derry M, Brooke A, Ham W, Ponder E, Roane TJ, Rooney B, Anderson J. Using Artificial Intelligence to Support Emotionally Responsive Verbal Communication Among Autistic Workers in a Work Internship Setting. J Autism Dev Disord;2026 (Apr 4)
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3. Lu H, Li S, Peng S, Zhang Y, Li N, Hu Z. Stepped-Care Digital Gaming Intervention Enhanced Emotion Recognition in Autistic Children: A Randomized Controlled Trial. J Autism Dev Disord;2026 (Apr 4)
PURPOSE: This randomized controlled trial (RCT) evaluated the efficacy of a novel stepped-care digital game intervention for improving emotion recognition in autistic children. METHODS: Thirty-six autistic children (aged 3-10 years) were randomly assigned to an experimental group (N = 18) or a control group (N = 18). The intervention, grounded in the Theory of Mind framework, comprised three hierarchically structured games designed to progressively train emotion recognition. Pretest and posttest including questionnaires and emotion recognition tests were administered before and after the intervention. RESULTS: Results indicated that the experimental group showed significant improvements in accuracy on the emotion recognition tests, whereas the control group did not. A significant interaction was found for scores on the autism treatment evaluation checklist (ATEC), suggesting differential change patterns across groups. Parenting stress increased significantly in the control group but remained stable in the experimental group. CONCLUSION: These findings demonstrated that this stepped-care digital game intervention can effectively enhance emotion recognition in autistic children and may bring benefits for their core traits and parenting stress.
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4. The Lancet Diabetes E. World Autism Awareness Day: autism and metabolic health. Lancet Diabetes Endocrinol;2026 (Apr 1)
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5. Wilkinson E, Yu YY, Bal VH, Clarke EB. Examining the Utility of the W-ADL to Assess Daily Living Skills in Non- or Minimally Speaking Autistic Adults. J Autism Dev Disord;2026 (Apr 4)
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6. Xiao R, Liang D, Ren Z, Jia Z, Qi H. Comprehension of Spatial Demonstratives in 4- to 6-Year-Old Chinese-Speaking Children with Autism Spectrum Disorder. J Psycholinguist Res;2026 (Apr 4);55(3)
