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Auteur Robert L. HENDREN
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Documents disponibles écrits par cet auteur (15)
Faire une suggestion Affiner la rechercheAutomated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability / Abigail BANGERTER in Molecular Autism, 11 (2020)
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[article]
Titre : Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability Type de document : texte imprimé Auteurs : Abigail BANGERTER, Auteur ; Meenakshi CHATTERJEE, Auteur ; Joseph MANFREDONIA, Auteur ; Nikolay V. MANYAKOV, Auteur ; Seth NESS, Auteur ; Matthew A. BOICE, Auteur ; Andrew SKALKIN, Auteur ; Matthew GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert L. HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : 31 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Emotional regulation Emotions Facial expression Impulsive behavior LLC, and may hold company equity. AS was an employee of Janssen Research & Development at the time of the study. MSG has received research and consulting funding from Janssen Research & Development. GD is on the Scientific Advisory Boards of Janssen Research & Development Akili, Inc. LabCorp, Inc. and Roche Pharmaceutical Company is a consultant for Apple, Inc Gerson Lehrman Group Guidepoint, Inc. and Axial Ventures has received grant funding from Janssen Research & Development and is the CEO of DASIO, LLC. GD receives royalties from Guilford Press, Springer, and Oxford University Press. RH received reimbursement for consultation from Janssen Research & Development. BL has received research grant funding from the NIH is a consultant to Janssen Research & Development, the Illinois Children’s Healthcare Foundation and is a board member of the Brain Research Foundation. FS is on the Scientific Advisory Board, is a consultant to and received grant funding from Janssen Research & Development, and has also received grant funding from Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent of this discrepancy is limited and inconsistent. Use of automated facial expression detection technology enables accurate and efficient tracking of facial expressions that has potential to identify individual response differences. METHODS: Children and adults with ASD (N = 124) and typically developing (TD, N = 41) were shown short clips of "funny videos." Using automated facial analysis software, we investigated differences between ASD and TD groups and within the ASD group in evidence of facial action unit (AU) activation related to the expression of positive facial expression, in particular, a smile. RESULTS: Individuals with ASD on average showed less evidence of facial AUs (AU12, AU6) relating to positive facial expression, compared to the TD group (p < .05, r = - 0.17). Using Gaussian mixture model for clustering, we identified two distinct distributions within the ASD group, which were then compared to the TD group. One subgroup (n = 35), termed "over-responsive," expressed more intense positive facial expressions in response to the videos than the TD group (p < .001, r = 0.31). The second subgroup (n = 89), ("under-responsive"), displayed fewer, less intense positive facial expressions in response to videos than the TD group (p < .001; r = - 0.36). The over-responsive subgroup differed from the under-responsive subgroup in age and caregiver-reported impulsivity (p < .05, r = 0.21). Reduced expression in the under-responsive, but not the over-responsive group, was related to caregiver-reported social withdrawal (p < .01, r = - 0.3). LIMITATIONS: This exploratory study does not account for multiple comparisons, and future work will have to ascertain the strength and reproducibility of all results. Reduced displays of positive facial expressions do not mean individuals with ASD do not experience positive emotions. CONCLUSIONS: Individuals with ASD differed from the TD group in their facial expressions of positive emotion in response to "funny videos." Identification of subgroups based on response may help in parsing heterogeneity in ASD and enable targeting of treatment based on subtypes. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02299700. Registration date: November 24, 2014. En ligne : http://dx.doi.org/10.1186/s13229-020-00327-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427
in Molecular Autism > 11 (2020) . - 31 p.[article] Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability [texte imprimé] / Abigail BANGERTER, Auteur ; Meenakshi CHATTERJEE, Auteur ; Joseph MANFREDONIA, Auteur ; Nikolay V. MANYAKOV, Auteur ; Seth NESS, Auteur ; Matthew A. BOICE, Auteur ; Andrew SKALKIN, Auteur ; Matthew GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert L. HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur . - 31 p.
Langues : Anglais (eng)
in Molecular Autism > 11 (2020) . - 31 p.
Mots-clés : Autism spectrum disorder Emotional regulation Emotions Facial expression Impulsive behavior LLC, and may hold company equity. AS was an employee of Janssen Research & Development at the time of the study. MSG has received research and consulting funding from Janssen Research & Development. GD is on the Scientific Advisory Boards of Janssen Research & Development Akili, Inc. LabCorp, Inc. and Roche Pharmaceutical Company is a consultant for Apple, Inc Gerson Lehrman Group Guidepoint, Inc. and Axial Ventures has received grant funding from Janssen Research & Development and is the CEO of DASIO, LLC. GD receives royalties from Guilford Press, Springer, and Oxford University Press. RH received reimbursement for consultation from Janssen Research & Development. BL has received research grant funding from the NIH is a consultant to Janssen Research & Development, the Illinois Children’s Healthcare Foundation and is a board member of the Brain Research Foundation. FS is on the Scientific Advisory Board, is a consultant to and received grant funding from Janssen Research & Development, and has also received grant funding from Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent of this discrepancy is limited and inconsistent. Use of automated facial expression detection technology enables accurate and efficient tracking of facial expressions that has potential to identify individual response differences. METHODS: Children and adults with ASD (N = 124) and typically developing (TD, N = 41) were shown short clips of "funny videos." Using automated facial analysis software, we investigated differences between ASD and TD groups and within the ASD group in evidence of facial action unit (AU) activation related to the expression of positive facial expression, in particular, a smile. RESULTS: Individuals with ASD on average showed less evidence of facial AUs (AU12, AU6) relating to positive facial expression, compared to the TD group (p < .05, r = - 0.17). Using Gaussian mixture model for clustering, we identified two distinct distributions within the ASD group, which were then compared to the TD group. One subgroup (n = 35), termed "over-responsive," expressed more intense positive facial expressions in response to the videos than the TD group (p < .001, r = 0.31). The second subgroup (n = 89), ("under-responsive"), displayed fewer, less intense positive facial expressions in response to videos than the TD group (p < .001; r = - 0.36). The over-responsive subgroup differed from the under-responsive subgroup in age and caregiver-reported impulsivity (p < .05, r = 0.21). Reduced expression in the under-responsive, but not the over-responsive group, was related to caregiver-reported social withdrawal (p < .01, r = - 0.3). LIMITATIONS: This exploratory study does not account for multiple comparisons, and future work will have to ascertain the strength and reproducibility of all results. Reduced displays of positive facial expressions do not mean individuals with ASD do not experience positive emotions. CONCLUSIONS: Individuals with ASD differed from the TD group in their facial expressions of positive emotion in response to "funny videos." Identification of subgroups based on response may help in parsing heterogeneity in ASD and enable targeting of treatment based on subtypes. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02299700. Registration date: November 24, 2014. En ligne : http://dx.doi.org/10.1186/s13229-020-00327-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder / Joseph MANFREDONIA in Journal of Autism and Developmental Disorders, 49-1 (January 2019)
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Titre : Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Joseph MANFREDONIA, Auteur ; Abigail BANGERTER, Auteur ; Nikolay V. MANYAKOV, Auteur ; Seth NESS, Auteur ; David LEWIN, Auteur ; Andrew SKALKIN, Auteur ; Matthew A. BOICE, Auteur ; Matthew GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert L. HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : p.279-293 Langues : Anglais (eng) Mots-clés : Asd Automated Emotion Expression Facet Facial Index. décimale : PER Périodiques Résumé : Facial expression is impaired in autism spectrum disorder (ASD), but rarely systematically studied. We focus on the ability of individuals with ASD to produce facial expressions of emotions in response to a verbal prompt. We used the Janssen Autism Knowledge Engine (JAKE((R))), including automated facial expression analysis software (FACET) to measure facial expressions in individuals with ASD (n = 144) and a typically developing (TD) comparison group (n = 41). Differences in ability to produce facial expressions were observed between ASD and TD groups, demonstrated by activation of facial action units (happy, scared, surprised, disgusted, but not angry or sad). Activation of facial action units correlated with parent-reported social communication skills. This approach has potential for diagnostic and response to intervention measures.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-018-3757-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377
in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.279-293[article] Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder [texte imprimé] / Joseph MANFREDONIA, Auteur ; Abigail BANGERTER, Auteur ; Nikolay V. MANYAKOV, Auteur ; Seth NESS, Auteur ; David LEWIN, Auteur ; Andrew SKALKIN, Auteur ; Matthew A. BOICE, Auteur ; Matthew GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert L. HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur . - p.279-293.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.279-293
Mots-clés : Asd Automated Emotion Expression Facet Facial Index. décimale : PER Périodiques Résumé : Facial expression is impaired in autism spectrum disorder (ASD), but rarely systematically studied. We focus on the ability of individuals with ASD to produce facial expressions of emotions in response to a verbal prompt. We used the Janssen Autism Knowledge Engine (JAKE((R))), including automated facial expression analysis software (FACET) to measure facial expressions in individuals with ASD (n = 144) and a typically developing (TD) comparison group (n = 41). Differences in ability to produce facial expressions were observed between ASD and TD groups, demonstrated by activation of facial action units (happy, scared, surprised, disgusted, but not angry or sad). Activation of facial action units correlated with parent-reported social communication skills. This approach has potential for diagnostic and response to intervention measures.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-018-3757-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 Brief report: Game day: A novel method of assessing change in social competence in students with autism spectrum disorder (ASD) / Stephen BENT in Research in Autism Spectrum Disorders, 84 (June 2021)
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Titre : Brief report: Game day: A novel method of assessing change in social competence in students with autism spectrum disorder (ASD) Type de document : texte imprimé Auteurs : Stephen BENT, Auteur ; Michael G. MCDONALD, Auteur ; Yingtong CHEN, Auteur ; Felicia WIDJAJA, Auteur ; Jessica WAHLBERG, Auteur ; Bushra HOSSAIN, Auteur ; Robert L. HENDREN, Auteur Article en page(s) : 101766 Langues : Anglais (eng) Mots-clés : Autism Social skills Outcome measure Index. décimale : PER Périodiques Résumé : Background Group social skills programs for autism spectrum disorder (ASD) have been shown to improve social skills knowledge and parent and teacher survey ratings, but have been limited by a lack of directly observed measures of social skills in unstructured settings. Methods The goal of this study was to examine the feasibility of using a novel, directly observed measure (“game day”) to monitor changes in social skills in students with ASD participating in a 16-week, school-based social skills program (Program for the Education and Enrichment of Relational Skills - PEERS). Game day occurred once a month and consisted of the instructor placing a set of board games in the room and then leaving. Videos of the game day sessions were rated by three reviewers (blinded to the video sequence) using a modified version of the Contextual Assessment of Social Skills (CASS). Results Six students (age range 13–22, 5 male) enrolled and completed all PEERS instruction and 5 monthly game day sessions. Reviewers were able to complete ratings for all scale items except frequency of initiations and responses. The remaining nine CASS items were used to generate a summary score for each child; the mean score improved from 38.5 to 43.6 (p = 0.011). Validated surveys also showed statistically significant improvements in social skills knowledge, problem behaviors, and ASD behaviors. Conclusions This study provides initial evidence that a directly observed measure detects changes in social competence in ASD and may provide a broader assessment of social ability. En ligne : https://doi.org/10.1016/j.rasd.2021.101766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446
in Research in Autism Spectrum Disorders > 84 (June 2021) . - 101766[article] Brief report: Game day: A novel method of assessing change in social competence in students with autism spectrum disorder (ASD) [texte imprimé] / Stephen BENT, Auteur ; Michael G. MCDONALD, Auteur ; Yingtong CHEN, Auteur ; Felicia WIDJAJA, Auteur ; Jessica WAHLBERG, Auteur ; Bushra HOSSAIN, Auteur ; Robert L. HENDREN, Auteur . - 101766.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 84 (June 2021) . - 101766
Mots-clés : Autism Social skills Outcome measure Index. décimale : PER Périodiques Résumé : Background Group social skills programs for autism spectrum disorder (ASD) have been shown to improve social skills knowledge and parent and teacher survey ratings, but have been limited by a lack of directly observed measures of social skills in unstructured settings. Methods The goal of this study was to examine the feasibility of using a novel, directly observed measure (“game day”) to monitor changes in social skills in students with ASD participating in a 16-week, school-based social skills program (Program for the Education and Enrichment of Relational Skills - PEERS). Game day occurred once a month and consisted of the instructor placing a set of board games in the room and then leaving. Videos of the game day sessions were rated by three reviewers (blinded to the video sequence) using a modified version of the Contextual Assessment of Social Skills (CASS). Results Six students (age range 13–22, 5 male) enrolled and completed all PEERS instruction and 5 monthly game day sessions. Reviewers were able to complete ratings for all scale items except frequency of initiations and responses. The remaining nine CASS items were used to generate a summary score for each child; the mean score improved from 38.5 to 43.6 (p = 0.011). Validated surveys also showed statistically significant improvements in social skills knowledge, problem behaviors, and ASD behaviors. Conclusions This study provides initial evidence that a directly observed measure detects changes in social competence in ASD and may provide a broader assessment of social ability. En ligne : https://doi.org/10.1016/j.rasd.2021.101766 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=446 Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial / Stephen BENT in Journal of Autism and Developmental Disorders, 42-6 (June 2012)
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Titre : Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial Type de document : texte imprimé Auteurs : Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Paul ASHWOOD, Auteur ; Edward NEMETH, Auteur ; Robert L. HENDREN, Auteur Année de publication : 2012 Article en page(s) : p.1127-1132 Langues : Anglais (eng) Mots-clés : Autism Clinical trial Alternative therapy Index. décimale : PER Périodiques Résumé : We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes. En ligne : http://dx.doi.org/10.1007/s10803-011-1337-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1127-1132[article] Brief Report: Hyperbaric Oxygen Therapy (HBOT) in Children with Autism Spectrum Disorder: A Clinical Trial [texte imprimé] / Stephen BENT, Auteur ; Kiah BERTOGLIO, Auteur ; Paul ASHWOOD, Auteur ; Edward NEMETH, Auteur ; Robert L. HENDREN, Auteur . - 2012 . - p.1127-1132.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1127-1132
Mots-clés : Autism Clinical trial Alternative therapy Index. décimale : PER Périodiques Résumé : We sought to determine whether HBOT leads to parental reported behavioral changes and alterations in cytokines in children with ASD. Ten children completed 80 sessions of HBOT and all improved by 2 points on the clinician-rated CGI-I scale (much improved) as well as several parent-completed measures of behavior. The lack of a control group limits the ability to determine if improvements were related to HBOT. Enrolled children did not exhibit abnormal cytokine levels at baseline and no significant changes in mean cytokine levels were observed. Although this study was limited by the small sample size and by the variable nature of cytokines, we found no evidence that HBOT affects cytokine levels or that cytokine levels were associated with behavioral changes. En ligne : http://dx.doi.org/10.1007/s10803-011-1337-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder / Abigail BANGERTER in Journal of Autism and Developmental Disorders, 50-6 (June 2020)
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Considerations from the 2017 IMFAR Preconference on Measuring Meaningful Outcomes from School-Age to Adulthood / Vanessa H. BAL in Autism Research, 11-11 (November 2018)
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PermalinkEfficacy and safety of memantine in children with autism spectrum disorder: Results from three phase 2 multicenter studies / Antonio Y. HARDAN in Autism, 23-8 (November 2019)
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PermalinkIdentification of urinary metabolites that correlate with clinical improvements in children with autism treated with sulforaphane from broccoli / Stephen BENT in Molecular Autism, 9 (2018)
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PermalinkOmega-3 Fatty Acids for Autistic Spectrum Disorder: A Systematic Review / Stephen BENT in Journal of Autism and Developmental Disorders, 39-8 (August 2009)
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PermalinkA Pilot Randomized Controlled Trial of Omega-3 Fatty Acids for Autism Spectrum Disorder / Stephen BENT in Journal of Autism and Developmental Disorders, 41-5 (May 2011)
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PermalinkA Review of Complementary and Alternative Treatments for Autism Spectrum Disorders / Nicholas LOFTHOUSE in Autism Research and Treatment, (September 2012)
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PermalinkSocial attention to activities in children and adults with autism spectrum disorder: effects of context and age / Dzmitry A. KALIUKHOVICH in Molecular Autism, 11 (2020)
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PermalinkThe SOFIA Study: Negative Multi-center Study of Low Dose Fluoxetine on Repetitive Behaviors in Children and Adolescents with Autistic Disorder / Paul HERSCU in Journal of Autism and Developmental Disorders, 50-9 (September 2020)
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PermalinkVisual Exploration in Autism Spectrum Disorder: Exploring Age Differences and Dynamic Features Using Recurrence Quantification Analysis / Nikolay V. MANYAKOV in Autism Research, 11-11 (November 2018)
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PermalinkVisual Preference for Biological Motion in Children and Adults with Autism Spectrum Disorder: An Eye-Tracking Study / Dzmitry A. KALIUKHOVICH in Journal of Autism and Developmental Disorders, 51-7 (July 2021)
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