Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional study / Kaitlin K. CUMMINGS ; Susan Y. BOOKHEIMER ; Mirella DAPRETTO ; Shulamite A. GREEN in Molecular Autism, 14 (2023)  

Public ISBD [article]  inMolecular Autism > 14 (2023) . - 38 p. Titre : Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional study Type de document : texte imprimé Auteurs : Kaitlin K. CUMMINGS, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite A. GREEN, Auteur Article en page(s) : 38 p. Langues : Anglais (eng) Mots-clés : Adolescent  Child  Humans  *Autistic Disorder/diagnostic imaging  *Autism Spectrum Disorder  Cross-Sectional Studies  Prefrontal Cortex/diagnostic imaging  Cerebellum  Magnetic Resonance Imaging/methods  Autism spectrum disorder  Development  Neural activity  Sensory over-responsivity  Sensory processing  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory over-responsivity (SOR) is an impairing sensory processing challenge in autism spectrum disorder (ASD) which shows heterogenous developmental trajectories and appears to improve into adulthood in some but not all autistic individuals. However, the neural mechanisms underlying interindividual differences in these trajectories are currently unknown. METHODS: Here, we used functional magnetic resonance imaging (fMRI) to investigate the association between age and neural activity linearly and nonlinearly in response to mildly aversive sensory stimulation as well as how SOR severity moderates this association. Participants included 52 ASD (14F) and 41 (13F) typically developing (TD) youth, aged 8.6-18.0 years. RESULTS: We found that in pre-teens, ASD children showed widespread activation differences in sensorimotor, frontal and cerebellar regions compared to TD children, while there were fewer differences between ASD and TD teens. In TD youth, older age was associated with less activation in the prefrontal cortex. In contrast, in ASD youth, older age was associated with more engagement of sensory integration and emotion regulation regions. In particular, orbitofrontal and medial prefrontal cortices showed a nonlinear relationship with age in ASD, with an especially steep increase in sensory-evoked neural activity during the mid-to-late teen years. There was also an interaction between age and SOR severity in ASD youth such that these age-related trends were more apparent in youth with higher SOR. LIMITATIONS: The cross-sectional design limits causal interpretations of the data. Future longitudinal studies will be instrumental in determining how prefrontal engagement and SOR co-develop across adolescence. CONCLUSIONS: Our results suggest that enhanced recruitment of prefrontal regions may underlie age-related decreases in SOR for a subgroup of ASD youth. En ligne : https://dx.doi.org/10.1186/s13229-023-00571-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518 [article] Age-related changes in neural responses to sensory stimulation in autism: a cross-sectional study [texte imprimé] / Kaitlin K. CUMMINGS, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite A. GREEN, Auteur . - 38 p. Langues : Anglais (eng) in Molecular Autism > 14 (2023) . - 38 p. Mots-clés : Adolescent  Child  Humans  *Autistic Disorder/diagnostic imaging  *Autism Spectrum Disorder  Cross-Sectional Studies  Prefrontal Cortex/diagnostic imaging  Cerebellum  Magnetic Resonance Imaging/methods  Autism spectrum disorder  Development  Neural activity  Sensory over-responsivity  Sensory processing  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory over-responsivity (SOR) is an impairing sensory processing challenge in autism spectrum disorder (ASD) which shows heterogenous developmental trajectories and appears to improve into adulthood in some but not all autistic individuals. However, the neural mechanisms underlying interindividual differences in these trajectories are currently unknown. METHODS: Here, we used functional magnetic resonance imaging (fMRI) to investigate the association between age and neural activity linearly and nonlinearly in response to mildly aversive sensory stimulation as well as how SOR severity moderates this association. Participants included 52 ASD (14F) and 41 (13F) typically developing (TD) youth, aged 8.6-18.0 years. RESULTS: We found that in pre-teens, ASD children showed widespread activation differences in sensorimotor, frontal and cerebellar regions compared to TD children, while there were fewer differences between ASD and TD teens. In TD youth, older age was associated with less activation in the prefrontal cortex. In contrast, in ASD youth, older age was associated with more engagement of sensory integration and emotion regulation regions. In particular, orbitofrontal and medial prefrontal cortices showed a nonlinear relationship with age in ASD, with an especially steep increase in sensory-evoked neural activity during the mid-to-late teen years. There was also an interaction between age and SOR severity in ASD youth such that these age-related trends were more apparent in youth with higher SOR. LIMITATIONS: The cross-sectional design limits causal interpretations of the data. Future longitudinal studies will be instrumental in determining how prefrontal engagement and SOR co-develop across adolescence. CONCLUSIONS: Our results suggest that enhanced recruitment of prefrontal regions may underlie age-related decreases in SOR for a subgroup of ASD youth. En ligne : https://dx.doi.org/10.1186/s13229-023-00571-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=518

An Observed Assessment of Sensory Responsivity in Autism Spectrum Disorders: Associations with Diagnosis, Age, and Parent Report / Sapna RAMAPPA in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3860-3872 Titre : An Observed Assessment of Sensory Responsivity in Autism Spectrum Disorders: Associations with Diagnosis, Age, and Parent Report Type de document : texte imprimé Auteurs : Sapna RAMAPPA, Auteur ; Ariana ANDERSON, Auteur ; Jiwon JUNG, Auteur ; Robyn CHU, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Genevieve PATTERSON, Auteur ; Nana J. OKADA, Auteur ; Shulamite A. GREEN, Auteur Article en page(s) : p.3860-3872 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sensory features are common and impairing in autism spectrum disorder (ASD), but there are few observational sensory assessments that are valid across ages. We used the Sensory Processing 3-Dimensional (SP3-D) observed Assessment and parent-reported Inventory to examine sensory responsivity in 41 ASD and 33 typically-developing (TD) youth across 7-17 years. ASD youth had higher and more variable observed and reported sensory responsivity symptoms compared to TD, but the two measures were not correlated. Observed sensory over-responsivity (SOR) and sensory craving (SC) decreased with age in ASD, though SOR remained higher in ASD versus TD through adolescence. Results suggest that in ASD, the SP3-D Assessment can identify SOR through adolescence, and that there is value in integrating multiple sensory measures. En ligne : https://doi.org/10.1007/s10803-022-05653-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] An Observed Assessment of Sensory Responsivity in Autism Spectrum Disorders: Associations with Diagnosis, Age, and Parent Report [texte imprimé] / Sapna RAMAPPA, Auteur ; Ariana ANDERSON, Auteur ; Jiwon JUNG, Auteur ; Robyn CHU, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Genevieve PATTERSON, Auteur ; Nana J. OKADA, Auteur ; Shulamite A. GREEN, Auteur . - p.3860-3872. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3860-3872 Index. décimale : PER Périodiques Résumé : Sensory features are common and impairing in autism spectrum disorder (ASD), but there are few observational sensory assessments that are valid across ages. We used the Sensory Processing 3-Dimensional (SP3-D) observed Assessment and parent-reported Inventory to examine sensory responsivity in 41 ASD and 33 typically-developing (TD) youth across 7-17 years. ASD youth had higher and more variable observed and reported sensory responsivity symptoms compared to TD, but the two measures were not correlated. Observed sensory over-responsivity (SOR) and sensory craving (SC) decreased with age in ASD, though SOR remained higher in ASD versus TD through adolescence. Results suggest that in ASD, the SP3-D Assessment can identify SOR through adolescence, and that there is value in integrating multiple sensory measures. En ligne : https://doi.org/10.1007/s10803-022-05653-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Anxiety and Sensory Over-Responsivity in Toddlers with Autism Spectrum Disorders: Bidirectional Effects Across Time / Shulamite A. GREEN in Journal of Autism and Developmental Disorders, 42-6 (June 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1112-1119 Titre : Anxiety and Sensory Over-Responsivity in Toddlers with Autism Spectrum Disorders: Bidirectional Effects Across Time Type de document : texte imprimé Auteurs : Shulamite A. GREEN, Auteur ; Ayelet BEN-SASSON, Auteur ; Timothy W. SOTO, Auteur ; Alice S. CARTER, Auteur Année de publication : 2012 Article en page(s) : p.1112-1119 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Anxiety  Sensory over-responsivity Index. décimale : PER Périodiques Résumé : This report focuses on the emergence of and bidirectional effects between anxiety and sensory over-responsivity (SOR) in toddlers with autism spectrum disorders (ASD). Participants were 149 toddlers with ASD and their mothers, assessed at 2 annual time points. A cross-lag analysis showed that anxiety symptoms increased over time while SOR remained relatively stable. SOR positively predicted changes in anxiety over and above child age, autism symptom severity, NVDQ, and maternal anxiety, but anxiety did not predict changes in SOR. Results suggest that SOR emerges earlier than anxiety, and predicts later development of anxiety. En ligne : http://dx.doi.org/10.1007/s10803-011-1361-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 [article] Anxiety and Sensory Over-Responsivity in Toddlers with Autism Spectrum Disorders: Bidirectional Effects Across Time [texte imprimé] / Shulamite A. GREEN, Auteur ; Ayelet BEN-SASSON, Auteur ; Timothy W. SOTO, Auteur ; Alice S. CARTER, Auteur . - 2012 . - p.1112-1119. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1112-1119 Mots-clés : Autism spectrum disorders  Anxiety  Sensory over-responsivity Index. décimale : PER Périodiques Résumé : This report focuses on the emergence of and bidirectional effects between anxiety and sensory over-responsivity (SOR) in toddlers with autism spectrum disorders (ASD). Participants were 149 toddlers with ASD and their mothers, assessed at 2 annual time points. A cross-lag analysis showed that anxiety symptoms increased over time while SOR remained relatively stable. SOR positively predicted changes in anxiety over and above child age, autism symptom severity, NVDQ, and maternal anxiety, but anxiety did not predict changes in SOR. Results suggest that SOR emerges earlier than anxiety, and predicts later development of anxiety. En ligne : http://dx.doi.org/10.1007/s10803-011-1361-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156

Anxiety Disorders and Sensory Over-Responsivity in Children with Autism Spectrum Disorders: Is There a Causal Relationship? / Shulamite A. GREEN in Journal of Autism and Developmental Disorders, 40-12 (December 2010)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1495-1504 Titre : Anxiety Disorders and Sensory Over-Responsivity in Children with Autism Spectrum Disorders: Is There a Causal Relationship? Type de document : texte imprimé Auteurs : Shulamite A. GREEN, Auteur ; Ayelet BEN-SASSON, Auteur Année de publication : 2010 Article en page(s) : p.1495-1504 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Anxiety  Sensory over-responsivity  Hyperarousal  Sensory defensiveness Index. décimale : PER Périodiques Résumé : Anxiety disorders and sensory over-responsivity (SOR) are common in children with autism spectrum disorders (ASD), and there is evidence for an association between these two conditions. Currently, it is unclear what causal mechanisms may exist between SOR and anxiety. We propose three possible theories to explain the association between anxiety and SOR: (a) SOR is caused by anxiety; (b) Anxiety is caused by SOR; or (c) SOR and anxiety are causally unrelated but are associated through a common risk factor or diagnostic overlap. In this paper, we examine support for each theory in the existing anxiety, autism, and neuroscience literature, and discuss how each theory informs choice of interventions and implications for future studies. En ligne : http://dx.doi.org/10.1007/s10803-010-1007-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Anxiety Disorders and Sensory Over-Responsivity in Children with Autism Spectrum Disorders: Is There a Causal Relationship? [texte imprimé] / Shulamite A. GREEN, Auteur ; Ayelet BEN-SASSON, Auteur . - 2010 . - p.1495-1504. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 40-12 (December 2010) . - p.1495-1504 Mots-clés : Autism spectrum disorders  Anxiety  Sensory over-responsivity  Hyperarousal  Sensory defensiveness Index. décimale : PER Périodiques Résumé : Anxiety disorders and sensory over-responsivity (SOR) are common in children with autism spectrum disorders (ASD), and there is evidence for an association between these two conditions. Currently, it is unclear what causal mechanisms may exist between SOR and anxiety. We propose three possible theories to explain the association between anxiety and SOR: (a) SOR is caused by anxiety; (b) Anxiety is caused by SOR; or (c) SOR and anxiety are causally unrelated but are associated through a common risk factor or diagnostic overlap. In this paper, we examine support for each theory in the existing anxiety, autism, and neuroscience literature, and discuss how each theory informs choice of interventions and implications for future studies. En ligne : http://dx.doi.org/10.1007/s10803-010-1007-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

Associations between physiological and neural measures of sensory reactivity in youth with autism / Jiwon JUNG in Journal of Child Psychology and Psychiatry, 62-10 (October 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1183-1194 Titre : Associations between physiological and neural measures of sensory reactivity in youth with autism Type de document : texte imprimé Auteurs : Jiwon JUNG, Auteur ; Tomislav D. ZBOZINEK, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Frank H. WILHELM, Auteur ; Mirella DAPRETTO, Auteur ; Michelle G. CRASKE, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Shulamite A. GREEN, Auteur Article en page(s) : p.1183-1194 Langues : Anglais (eng) Mots-clés : Adolescent  Attention  Autism Spectrum Disorder  Autistic Disorder  Brain/diagnostic imaging  Child  Humans  Magnetic Resonance Imaging  Autism spectrum disorders  fMRI  physiology  sensory over-responsivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with Autism Spectrum Disorder (ASD) commonly show sensory over-responsivity (SOR), an impairing condition related to over-reactive brain and behavioral responses to aversive stimuli. While individuals with ASD often show atypically high physiological arousal, it is unclear how this relates to sensory reactivity. We therefore investigated how physiological arousal relates to brain and behavioral indices of SOR, to inform understanding of the biological mechanisms underlying SOR and to determine whether physiological measures are associated with SOR-related brain responses. METHODS: Youth aged 8-18 (49 ASD; 30 age- and performance-IQ-matched typically developing (TD)) experienced mildly aversive tactile and auditory stimuli first during functional magnetic resonance imaging (N = 41 ASD, 26 TD) and then during skin conductance (SCR) (N = 48 ASD, 28 TD) and heart rate (HR) measurements (N = 48 ASD, 30 TD). Parents reported on their children's SOR severity. RESULTS: Autism Spectrum Disorder youth overall displayed greater SCR to aversive sensory stimulation than TD youth and greater baseline HR. Within ASD, higher SOR was associated with higher mean HR across all stimuli after controlling for baseline HR. Furthermore, the ASD group overall, and the ASD-high-SOR group in particular, showed reduced HR deceleration/greater acceleration to sensory stimulation compared to the TD group. Both SCR and HR were associated with brain responses to sensory stimulation in regions previously associated with SOR and sensory regulation. CONCLUSIONS: Autism Spectrum Disorder youth displayed heightened physiological arousal to mildly aversive sensory stimulation, with HR responses in particular showing associations with brain and behavioral measures of SOR. These results have implications for using psychophysiological measures to assess SOR, particularly in individuals with ASD who cannot undergo MRI. En ligne : http://dx.doi.org/10.1111/jcpp.13387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Associations between physiological and neural measures of sensory reactivity in youth with autism [texte imprimé] / Jiwon JUNG, Auteur ; Tomislav D. ZBOZINEK, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Frank H. WILHELM, Auteur ; Mirella DAPRETTO, Auteur ; Michelle G. CRASKE, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Shulamite A. GREEN, Auteur . - p.1183-1194. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1183-1194 Mots-clés : Adolescent  Attention  Autism Spectrum Disorder  Autistic Disorder  Brain/diagnostic imaging  Child  Humans  Magnetic Resonance Imaging  Autism spectrum disorders  fMRI  physiology  sensory over-responsivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with Autism Spectrum Disorder (ASD) commonly show sensory over-responsivity (SOR), an impairing condition related to over-reactive brain and behavioral responses to aversive stimuli. While individuals with ASD often show atypically high physiological arousal, it is unclear how this relates to sensory reactivity. We therefore investigated how physiological arousal relates to brain and behavioral indices of SOR, to inform understanding of the biological mechanisms underlying SOR and to determine whether physiological measures are associated with SOR-related brain responses. METHODS: Youth aged 8-18 (49 ASD; 30 age- and performance-IQ-matched typically developing (TD)) experienced mildly aversive tactile and auditory stimuli first during functional magnetic resonance imaging (N = 41 ASD, 26 TD) and then during skin conductance (SCR) (N = 48 ASD, 28 TD) and heart rate (HR) measurements (N = 48 ASD, 30 TD). Parents reported on their children's SOR severity. RESULTS: Autism Spectrum Disorder youth overall displayed greater SCR to aversive sensory stimulation than TD youth and greater baseline HR. Within ASD, higher SOR was associated with higher mean HR across all stimuli after controlling for baseline HR. Furthermore, the ASD group overall, and the ASD-high-SOR group in particular, showed reduced HR deceleration/greater acceleration to sensory stimulation compared to the TD group. Both SCR and HR were associated with brain responses to sensory stimulation in regions previously associated with SOR and sensory regulation. CONCLUSIONS: Autism Spectrum Disorder youth displayed heightened physiological arousal to mildly aversive sensory stimulation, with HR responses in particular showing associations with brain and behavioral measures of SOR. These results have implications for using psychophysiological measures to assess SOR, particularly in individuals with ASD who cannot undergo MRI. En ligne : http://dx.doi.org/10.1111/jcpp.13387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Atypical cerebellar functional connectivity at 9 months of age predicts delayed socio-communicative profiles in infants at high and low risk for autism / Nana J. OKADA in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

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Atypical early neural responses to native and non-native language in infants at high likelihood for developing autism / Megan BANCHIK ; Tawny TSANG ; Nana J. OKADA ; Rebecca ALTSHULER ; Nicole M. MCDONALD ; Susan Y. BOOKHEIMER ; Shafali S. JESTE ; Shulamite A. GREEN ; Mirella DAPRETTO in Molecular Autism, 16 (2025)  

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Cognitive-Behavioral Therapy for Anxiety Disorders in Youth with ASD: Emotional, Adaptive, and Social Outcomes / Shulamite A. GREEN

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Discrimination of amygdala response predicts future separation anxiety in youth with early deprivation / Shulamite A. GREEN in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

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Effects of sensory distraction and salience priming on emotion identification in autism: an fMRI study / Genevieve PATTERSON in Journal of Neurodevelopmental Disorders, 13 (2021)  

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Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium / Roseann C. SCHAAF ; Karla K. AUSDERAU ; Grace T. BARANEK ; D. Jonah BARRETT ; Carissa J. CASCIO ; Rachel L. DUMONT ; Ekomobong E. EYOH ; Michelle D. FAILLA ; Jacob I. FELDMAN ; Jennifer H. FOSS-FEIG ; Heather L. GREEN ; Shulamite A. GREEN ; Jason L. HE ; Elizabeth A. KAPLAN-KAHN ; Bahar KEÇELI-KAYSILI ; Keren MACLENNAN ; Zoe MAILLOUX ; Elysa J. MARCO ; Lisa E. MASH ; Elizabeth P. MCKERNAN ; Sophie MOLHOLM ; Stewart H. MOSTOFSKY ; Nicolaas A.J. PUTS ; Caroline E. ROBERTSON ; Natalie RUSSO ; Nicole SHEA ; John SIDERIS ; James S. SUTCLIFFE ; Teresa TAVASSOLI ; Mark T. WALLACE ; Ericka L. WODKA ; Tiffany G. WOYNAROSKI in Molecular Autism, 14 (2023)  

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How sex of children with autism spectrum disorders and access to treatment services relates to parental stress / Irina ZAMORA in Autism Research and Treatment, 2014 (2014)  

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Predictors and Course of Daily Living Skills Development in Toddlers with Autism Spectrum Disorders / Shulamite A. GREEN in Journal of Autism and Developmental Disorders, 44-2 (February 2014)  

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Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD / Shulamite A. GREEN in Autism Research, 10-5 (May 2017)  

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Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism / G. PATTERSON ; Kaitlin K. CUMMINGS ; Jiwon JUNG ; M.E. CAKAR ; L. ABBAS ; Susan Y. BOOKHEIMER ; Mirella DAPRETTO ; Shulamite A. GREEN in Autism Research, 17-7 (July 2024)  

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