Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2076-2091 Titre : Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children Type de document : texte imprimé Auteurs : Annelies A. DE BILDT, Auteur ; Sjoerd SYTEMA, Auteur ; Eric ZANDER, Auteur ; Sven BÖLTE, Auteur ; Harald STURM, Auteur ; Nurit YIRMIYA, Auteur ; Maya YAARI, Auteur ; Tony CHARMAN, Auteur ; Erica SALOMONE, Auteur ; Ann LECOUTEUR, Auteur ; Jonathan GREEN, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Emma VAN DAALEN, Auteur ; Maretha V. DE JONGE, Auteur ; Emilía GUÐMUNDSDÓTTIR, Auteur ; Sigurrós JÓHANNSDÓTTIR, Auteur ; Marija RALEVA, Auteur ; Meri BOSKOVSKA, Auteur ; Bernadette ROGE, Auteur ; Sophie BADUEL, Auteur ; Irma MOILANEN, Auteur ; Anneli YLIHERVA, Auteur ; Jan K. BUITELAAR, Auteur ; Iris J. OOSTERLING, Auteur Année de publication : 2015 Article en page(s) : p.2076-2091 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Early diagnosis  Assessment Index. décimale : PER Périodiques Résumé : The current study aimed to investigate the Autism Diagnostic Interview-Revised (ADI-R) algorithms for toddlers and young preschoolers (Kim and Lord, J Autism Dev Disord 42(1):82–93, 2012) in a non-US sample from ten sites in nine countries (n = 1,104). The construct validity indicated a good fit of the algorithms. The diagnostic validity was lower, with satisfactorily high specificities but moderate sensitivities. Young children with clinical ASD and lower language ability were largely in the mild-to-moderate or moderate-to-severe concern ranges of the ADI-R, nearly half of the older and phrase speech ASD-group fell into the little-to-no concern range. Although broadly the findings support the toddler algorithms, further work is required to understand why they might have different properties in different samples to further inform research and clinical use. En ligne : http://dx.doi.org/10.1007/s10803-015-2372-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children [texte imprimé] / Annelies A. DE BILDT, Auteur ; Sjoerd SYTEMA, Auteur ; Eric ZANDER, Auteur ; Sven BÖLTE, Auteur ; Harald STURM, Auteur ; Nurit YIRMIYA, Auteur ; Maya YAARI, Auteur ; Tony CHARMAN, Auteur ; Erica SALOMONE, Auteur ; Ann LECOUTEUR, Auteur ; Jonathan GREEN, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Emma VAN DAALEN, Auteur ; Maretha V. DE JONGE, Auteur ; Emilía GUÐMUNDSDÓTTIR, Auteur ; Sigurrós JÓHANNSDÓTTIR, Auteur ; Marija RALEVA, Auteur ; Meri BOSKOVSKA, Auteur ; Bernadette ROGE, Auteur ; Sophie BADUEL, Auteur ; Irma MOILANEN, Auteur ; Anneli YLIHERVA, Auteur ; Jan K. BUITELAAR, Auteur ; Iris J. OOSTERLING, Auteur . - 2015 . - p.2076-2091. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2076-2091 Mots-clés : Autism spectrum disorders  Early diagnosis  Assessment Index. décimale : PER Périodiques Résumé : The current study aimed to investigate the Autism Diagnostic Interview-Revised (ADI-R) algorithms for toddlers and young preschoolers (Kim and Lord, J Autism Dev Disord 42(1):82–93, 2012) in a non-US sample from ten sites in nine countries (n = 1,104). The construct validity indicated a good fit of the algorithms. The diagnostic validity was lower, with satisfactorily high specificities but moderate sensitivities. Young children with clinical ASD and lower language ability were largely in the mild-to-moderate or moderate-to-severe concern ranges of the ADI-R, nearly half of the older and phrase speech ASD-group fell into the little-to-no concern range. Although broadly the findings support the toddler algorithms, further work is required to understand why they might have different properties in different samples to further inform research and clinical use. En ligne : http://dx.doi.org/10.1007/s10803-015-2372-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Autistic adults' subjective experiences of hoarding and self-injurious behaviors / Yael GOLDFARB in Autism, 25-5 (July 2021)  

Public ISBD [article]  inAutism > 25-5 (July 2021) . - p.1457-1468 Titre : Autistic adults' subjective experiences of hoarding and self-injurious behaviors Type de document : texte imprimé Auteurs : Yael GOLDFARB, Auteur ; Osnat ZAFRANI, Auteur ; Darren HEDLEY, Auteur ; Maya YAARI, Auteur ; Eynat GAL, Auteur Article en page(s) : p.1457-1468 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Cognition  Hoarding  Humans  Self-Injurious Behavior  Repetitive and Restrictive Behaviors and Interests  adults  self-injurious behaviors  conflicts of interest with respect to the research, authorship, and/or  publication of this article. Index. décimale : PER Périodiques Résumé : Hoarding and self-injurious behaviors are relatively common in autism, but knowledge about their expressions in adulthood is scarce. Through interviews collecting subjective experiences of autistic adults, these behaviors were explored, and categorized to their underlying purposes. Findings portray the occurrence of these behaviors in the lives of autistic adults, their self-regulatory purposes, and their relationship to other behaviors in the domain of Restrictive and Repetitive Behaviors and Interests. En ligne : http://dx.doi.org/10.1177/1362361321992640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Autistic adults' subjective experiences of hoarding and self-injurious behaviors [texte imprimé] / Yael GOLDFARB, Auteur ; Osnat ZAFRANI, Auteur ; Darren HEDLEY, Auteur ; Maya YAARI, Auteur ; Eynat GAL, Auteur . - p.1457-1468. Langues : Anglais (eng) in Autism > 25-5 (July 2021) . - p.1457-1468 Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Cognition  Hoarding  Humans  Self-Injurious Behavior  Repetitive and Restrictive Behaviors and Interests  adults  self-injurious behaviors  conflicts of interest with respect to the research, authorship, and/or  publication of this article. Index. décimale : PER Périodiques Résumé : Hoarding and self-injurious behaviors are relatively common in autism, but knowledge about their expressions in adulthood is scarce. Through interviews collecting subjective experiences of autistic adults, these behaviors were explored, and categorized to their underlying purposes. Findings portray the occurrence of these behaviors in the lives of autistic adults, their self-regulatory purposes, and their relationship to other behaviors in the domain of Restrictive and Repetitive Behaviors and Interests. En ligne : http://dx.doi.org/10.1177/1362361321992640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Autistic adults' subjective experiences of hoarding and self-injurious behaviors / Yael GOLDFARB in Autism, 26-5 (July 2022)  

Public ISBD [article]  inAutism > 26-5 (July 2022) . - p.1457-1468 Titre : Autistic adults' subjective experiences of hoarding and self-injurious behaviors Type de document : texte imprimé Auteurs : Yael GOLDFARB, Auteur ; Osnat ZAFRANI, Auteur ; Darren HEDLEY, Auteur ; Maya YAARI, Auteur ; Eynat GAL, Auteur Article en page(s) : p.1457-1468 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Cognition  Hoarding  Humans  Self-Injurious Behavior  Repetitive and Restrictive Behaviors and Interests  adults  autism spectrum disorder  hoarding  self-injurious behaviors  conflicts of interest with respect to the research, authorship, and/or  publication of this article. Index. décimale : PER Périodiques Résumé : Hoarding and self-injurious behaviors are relatively common in autism, but knowledge about their expressions in adulthood is scarce. Through interviews collecting subjective experiences of autistic adults, these behaviors were explored, and categorized to their underlying purposes. Findings portray the occurrence of these behaviors in the lives of autistic adults, their self-regulatory purposes, and their relationship to other behaviors in the domain of Restrictive and Repetitive Behaviors and Interests. En ligne : http://dx.doi.org/10.1177/1362361321992640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Autistic adults' subjective experiences of hoarding and self-injurious behaviors [texte imprimé] / Yael GOLDFARB, Auteur ; Osnat ZAFRANI, Auteur ; Darren HEDLEY, Auteur ; Maya YAARI, Auteur ; Eynat GAL, Auteur . - p.1457-1468. Langues : Anglais (eng) in Autism > 26-5 (July 2022) . - p.1457-1468 Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Cognition  Hoarding  Humans  Self-Injurious Behavior  Repetitive and Restrictive Behaviors and Interests  adults  autism spectrum disorder  hoarding  self-injurious behaviors  conflicts of interest with respect to the research, authorship, and/or  publication of this article. Index. décimale : PER Périodiques Résumé : Hoarding and self-injurious behaviors are relatively common in autism, but knowledge about their expressions in adulthood is scarce. Through interviews collecting subjective experiences of autistic adults, these behaviors were explored, and categorized to their underlying purposes. Findings portray the occurrence of these behaviors in the lives of autistic adults, their self-regulatory purposes, and their relationship to other behaviors in the domain of Restrictive and Repetitive Behaviors and Interests. En ligne : http://dx.doi.org/10.1177/1362361321992640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development / Edwa FRIEDLANDER in Autism Research, 12-7 (July 2019)  

Public ISBD [article]  inAutism Research > 12-7 (July 2019) . - p.1087-1100 Titre : Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development Type de document : texte imprimé Auteurs : Edwa FRIEDLANDER, Auteur ; Nurit YIRMIYA, Auteur ; Efrat LAIBA, Auteur ; Ayelet HAREL-GADASSI, Auteur ; Maya YAARI, Auteur ; Ohad FELDSTEIN, Auteur ; David MANKUTA, Auteur ; Salomon ISRAEL, Auteur Année de publication : 2019 Article en page(s) : p.1087-1100 Langues : Anglais (eng) Mots-clés : Oxtr  autism spectrum disorder  gene-environment interaction  oxytocin  oxytocin receptor antagonist  oxytocin receptor gene Index. décimale : PER Périodiques Résumé : Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene-environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty-three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk-allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk-allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087-1100. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD-related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development. En ligne : http://dx.doi.org/10.1002/aur.2111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Cumulative Risk of the Oxytocin Receptor Gene Interacts with Prenatal Exposure to Oxytocin Receptor Antagonist to Predict Children's Social Communication Development [texte imprimé] / Edwa FRIEDLANDER, Auteur ; Nurit YIRMIYA, Auteur ; Efrat LAIBA, Auteur ; Ayelet HAREL-GADASSI, Auteur ; Maya YAARI, Auteur ; Ohad FELDSTEIN, Auteur ; David MANKUTA, Auteur ; Salomon ISRAEL, Auteur . - 2019 . - p.1087-1100. Langues : Anglais (eng) in Autism Research > 12-7 (July 2019) . - p.1087-1100 Mots-clés : Oxtr  autism spectrum disorder  gene-environment interaction  oxytocin  oxytocin receptor antagonist  oxytocin receptor gene Index. décimale : PER Périodiques Résumé : Compelling evidence for the far-reaching role of oxytocin (OT) in social cognition and affiliative behaviors set the basis for examining the association between genetic variation in the OT receptor (OXTR) gene and risk for autism spectrum disorder (ASD). In the current study, gene-environment interaction between OXTR and prenatal exposure to either OT or OXTR antagonist (OXTRA) in predicting early social communication development was examined. One hundred and fifty-three children (age: M = 4.32, SD = 1.07) were assigned to four groups based on prenatal history: children whose mothers prenatally received OXTRA and Nifedipine to delay preterm labor (n = 27); children whose mothers received Nifedipine only to delay preterm labor (n = 35); children whose mothers received OT for labor augmentation (n = 56), and a no intervention group (n = 35). Participants completed a developmental assessment of intelligence quotient (IQ), adaptive behavior, and social communication abilities. DNA was extracted via buccal swab. A genetic risk score was calculated based on four OXTR single nucleotide polymorphisms (rs53576, rs237887, rs1042778, and rs2254298) previously reported to be associated with ASD symptomatology. OXTRrisk-allele dosage was associated with more severe autism diagnostics observation schedule (ADOS) scores only in the OXTRA group. In contrast, in the Nifedipine, OT, and no intervention groups, OXTRrisk-allele dosage was not associated with children's ADOS scores. These findings highlight the importance of both genetic and environmental pathways of OT in signaling early social development and raise the need for further research in this field. Autism Res 2019, 12: 1087-1100. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In the current study, we examined if the association between prenatal exposure to an oxytocin receptor antagonist (OXTRA) and autism spectrum disorder (ASD) related impairments are dependent on an individual's genetic background for the oxytocin receptor gene (OXTR). Children who carried a greater number of risk alleles for the OXTR gene and whose mothers received OXTRA to delay preterm labor showed more ASD-related impairments. The results highlight the importance of both genetic and environmental pathways of oxytocin in shaping early social development. En ligne : http://dx.doi.org/10.1002/aur.2111 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study / Elad LERER in Autism Research, 3-6 (December 2010)  

Public ISBD [article]  inAutism Research > 3-6 (December 2010) . - p.293-302 Titre : Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study Type de document : texte imprimé Auteurs : Elad LERER, Auteur ; Shlomit LEVI, Auteur ; Salomon ISRAEL, Auteur ; Maya YAARI, Auteur ; Lubov NEMANOV, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2010 Article en page(s) : p.293-302 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD)  CD38;polymorphism  gene expression  real time PCR  haplotype Index. décimale : PER Périodiques Résumé : Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 “unaffected” parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their “unaffected” parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to “unaffected” parents, strengthening the connection between oxytocin and ASD. En ligne : http://dx.doi.org/10.1002/aur.156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study [texte imprimé] / Elad LERER, Auteur ; Shlomit LEVI, Auteur ; Salomon ISRAEL, Auteur ; Maya YAARI, Auteur ; Lubov NEMANOV, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur ; Richard P. EBSTEIN, Auteur . - 2010 . - p.293-302. Langues : Anglais (eng) in Autism Research > 3-6 (December 2010) . - p.293-302 Mots-clés : autism spectrum disorder (ASD)  CD38;polymorphism  gene expression  real time PCR  haplotype Index. décimale : PER Périodiques Résumé : Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 “unaffected” parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their “unaffected” parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to “unaffected” parents, strengthening the connection between oxytocin and ASD. En ligne : http://dx.doi.org/10.1002/aur.156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Parent resolution of diagnosis and intervention fidelity in a parent-delivered intervention for pre-school children with autism: A mixed methods study / Paula GROGAN in Research in Autism Spectrum Disorders, 101 (March 2023)  

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Risk for ASD in Preterm Infants: A Three-Year Follow-Up Study / Ayelet HAREL-GADASSI in Autism Research and Treatment, 2018 (2018)  

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Stability of early risk assessment for autism spectrum disorder in preterm infants / Maya YAARI in Autism, 20-7 (October 2016)  

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