Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children / Annelies A. DE BILDT in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2076-2091 Titre : Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children Type de document : Texte imprimé et/ou numérique Auteurs : Annelies A. DE BILDT, Auteur ; Sjoerd SYTEMA, Auteur ; Eric ZANDER, Auteur ; Sven BÖLTE, Auteur ; Harald STURM, Auteur ; Nurit YIRMIYA, Auteur ; Maya YAARI, Auteur ; Tony CHARMAN, Auteur ; Erica SALOMONE, Auteur ; Ann LECOUTEUR, Auteur ; Jonathan GREEN, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Emma VAN DAALEN, Auteur ; Maretha V. DE JONGE, Auteur ; Emilía GUÐMUNDSDÓTTIR, Auteur ; Sigurrós JÓHANNSDÓTTIR, Auteur ; Marija RALEVA, Auteur ; Meri BOSKOVSKA, Auteur ; Bernadette ROGE, Auteur ; Sophie BADUEL, Auteur ; Irma MOILANEN, Auteur ; Anneli YLIHERVA, Auteur ; Jan K. BUITELAAR, Auteur ; IrisJ OOSTERLING, Auteur Année de publication : 2015 Article en page(s) : p.2076-2091 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Early diagnosis  Assessment Index. décimale : PER Périodiques Résumé : The current study aimed to investigate the Autism Diagnostic Interview-Revised (ADI-R) algorithms for toddlers and young preschoolers (Kim and Lord, J Autism Dev Disord 42(1):82–93, 2012) in a non-US sample from ten sites in nine countries (n = 1,104). The construct validity indicated a good fit of the algorithms. The diagnostic validity was lower, with satisfactorily high specificities but moderate sensitivities. Young children with clinical ASD and lower language ability were largely in the mild-to-moderate or moderate-to-severe concern ranges of the ADI-R, nearly half of the older and phrase speech ASD-group fell into the little-to-no concern range. Although broadly the findings support the toddler algorithms, further work is required to understand why they might have different properties in different samples to further inform research and clinical use. En ligne : http://dx.doi.org/10.1007/s10803-015-2372-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers: Application in a Non-US Sample of 1,104 Children [Texte imprimé et/ou numérique] / Annelies A. DE BILDT, Auteur ; Sjoerd SYTEMA, Auteur ; Eric ZANDER, Auteur ; Sven BÖLTE, Auteur ; Harald STURM, Auteur ; Nurit YIRMIYA, Auteur ; Maya YAARI, Auteur ; Tony CHARMAN, Auteur ; Erica SALOMONE, Auteur ; Ann LECOUTEUR, Auteur ; Jonathan GREEN, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Patricia GARCÍA PRIMO, Auteur ; Emma VAN DAALEN, Auteur ; Maretha V. DE JONGE, Auteur ; Emilía GUÐMUNDSDÓTTIR, Auteur ; Sigurrós JÓHANNSDÓTTIR, Auteur ; Marija RALEVA, Auteur ; Meri BOSKOVSKA, Auteur ; Bernadette ROGE, Auteur ; Sophie BADUEL, Auteur ; Irma MOILANEN, Auteur ; Anneli YLIHERVA, Auteur ; Jan K. BUITELAAR, Auteur ; IrisJ OOSTERLING, Auteur . - 2015 . - p.2076-2091. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2076-2091 Mots-clés : Autism spectrum disorders  Early diagnosis  Assessment Index. décimale : PER Périodiques Résumé : The current study aimed to investigate the Autism Diagnostic Interview-Revised (ADI-R) algorithms for toddlers and young preschoolers (Kim and Lord, J Autism Dev Disord 42(1):82–93, 2012) in a non-US sample from ten sites in nine countries (n = 1,104). The construct validity indicated a good fit of the algorithms. The diagnostic validity was lower, with satisfactorily high specificities but moderate sensitivities. Young children with clinical ASD and lower language ability were largely in the mild-to-moderate or moderate-to-severe concern ranges of the ADI-R, nearly half of the older and phrase speech ASD-group fell into the little-to-no concern range. Although broadly the findings support the toddler algorithms, further work is required to understand why they might have different properties in different samples to further inform research and clinical use. En ligne : http://dx.doi.org/10.1007/s10803-015-2372-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Autistic adults' subjective experiences of hoarding and self-injurious behaviors / Yael GOLDFARB in Autism, 25-5 (July 2021)  

Public ISBD [article]  inAutism > 25-5 (July 2021) . - p.1457-1468 Titre : Autistic adults' subjective experiences of hoarding and self-injurious behaviors Type de document : Texte imprimé et/ou numérique Auteurs : Yael GOLDFARB, Auteur ; Osnat ZAFRANI, Auteur ; Darren HEDLEY, Auteur ; Maya YAARI, Auteur ; Eynat GAL, Auteur Article en page(s) : p.1457-1468 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Cognition  Hoarding  Humans  Self-Injurious Behavior  Repetitive and Restrictive Behaviors and Interests  adults  self-injurious behaviors  conflicts of interest with respect to the research, authorship, and/or  publication of this article. Index. décimale : PER Périodiques Résumé : Hoarding and self-injurious behaviors are relatively common in autism, but knowledge about their expressions in adulthood is scarce. Through interviews collecting subjective experiences of autistic adults, these behaviors were explored, and categorized to their underlying purposes. Findings portray the occurrence of these behaviors in the lives of autistic adults, their self-regulatory purposes, and their relationship to other behaviors in the domain of Restrictive and Repetitive Behaviors and Interests. En ligne : http://dx.doi.org/10.1177/1362361321992640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Autistic adults' subjective experiences of hoarding and self-injurious behaviors [Texte imprimé et/ou numérique] / Yael GOLDFARB, Auteur ; Osnat ZAFRANI, Auteur ; Darren HEDLEY, Auteur ; Maya YAARI, Auteur ; Eynat GAL, Auteur . - p.1457-1468. Langues : Anglais (eng) in Autism > 25-5 (July 2021) . - p.1457-1468 Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Cognition  Hoarding  Humans  Self-Injurious Behavior  Repetitive and Restrictive Behaviors and Interests  adults  self-injurious behaviors  conflicts of interest with respect to the research, authorship, and/or  publication of this article. Index. décimale : PER Périodiques Résumé : Hoarding and self-injurious behaviors are relatively common in autism, but knowledge about their expressions in adulthood is scarce. Through interviews collecting subjective experiences of autistic adults, these behaviors were explored, and categorized to their underlying purposes. Findings portray the occurrence of these behaviors in the lives of autistic adults, their self-regulatory purposes, and their relationship to other behaviors in the domain of Restrictive and Repetitive Behaviors and Interests. En ligne : http://dx.doi.org/10.1177/1362361321992640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Autistic adults' subjective experiences of hoarding and self-injurious behaviors / Yael GOLDFARB in Autism, 26-5 (July 2022)  

Public ISBD [article]  inAutism > 26-5 (July 2022) . - p.1457-1468 Titre : Autistic adults' subjective experiences of hoarding and self-injurious behaviors Type de document : Texte imprimé et/ou numérique Auteurs : Yael GOLDFARB, Auteur ; Osnat ZAFRANI, Auteur ; Darren HEDLEY, Auteur ; Maya YAARI, Auteur ; Eynat GAL, Auteur Article en page(s) : p.1457-1468 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Cognition  Hoarding  Humans  Self-Injurious Behavior  Repetitive and Restrictive Behaviors and Interests  adults  autism spectrum disorder  hoarding  self-injurious behaviors  conflicts of interest with respect to the research, authorship, and/or  publication of this article. Index. décimale : PER Périodiques Résumé : Hoarding and self-injurious behaviors are relatively common in autism, but knowledge about their expressions in adulthood is scarce. Through interviews collecting subjective experiences of autistic adults, these behaviors were explored, and categorized to their underlying purposes. Findings portray the occurrence of these behaviors in the lives of autistic adults, their self-regulatory purposes, and their relationship to other behaviors in the domain of Restrictive and Repetitive Behaviors and Interests. En ligne : http://dx.doi.org/10.1177/1362361321992640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Autistic adults' subjective experiences of hoarding and self-injurious behaviors [Texte imprimé et/ou numérique] / Yael GOLDFARB, Auteur ; Osnat ZAFRANI, Auteur ; Darren HEDLEY, Auteur ; Maya YAARI, Auteur ; Eynat GAL, Auteur . - p.1457-1468. Langues : Anglais (eng) in Autism > 26-5 (July 2022) . - p.1457-1468 Mots-clés : Adult  Autism Spectrum Disorder  Autistic Disorder  Cognition  Hoarding  Humans  Self-Injurious Behavior  Repetitive and Restrictive Behaviors and Interests  adults  autism spectrum disorder  hoarding  self-injurious behaviors  conflicts of interest with respect to the research, authorship, and/or  publication of this article. Index. décimale : PER Périodiques Résumé : Hoarding and self-injurious behaviors are relatively common in autism, but knowledge about their expressions in adulthood is scarce. Through interviews collecting subjective experiences of autistic adults, these behaviors were explored, and categorized to their underlying purposes. Findings portray the occurrence of these behaviors in the lives of autistic adults, their self-regulatory purposes, and their relationship to other behaviors in the domain of Restrictive and Repetitive Behaviors and Interests. En ligne : http://dx.doi.org/10.1177/1362361321992640 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study / Elad LERER in Autism Research, 3-6 (December 2010)  

Public ISBD [article]  inAutism Research > 3-6 (December 2010) . - p.293-302 Titre : Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study Type de document : Texte imprimé et/ou numérique Auteurs : Elad LERER, Auteur ; Shlomit LEVI, Auteur ; Salomon ISRAEL, Auteur ; Maya YAARI, Auteur ; Lubov NEMANOV, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur ; Richard P. EBSTEIN, Auteur Année de publication : 2010 Article en page(s) : p.293-302 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD)  CD38;polymorphism  gene expression  real time PCR  haplotype Index. décimale : PER Périodiques Résumé : Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 “unaffected” parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their “unaffected” parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to “unaffected” parents, strengthening the connection between oxytocin and ASD. En ligne : http://dx.doi.org/10.1002/aur.156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Low CD38 expression in lymphoblastoid cells and haplotypes are both associated with autism in a family-based study [Texte imprimé et/ou numérique] / Elad LERER, Auteur ; Shlomit LEVI, Auteur ; Salomon ISRAEL, Auteur ; Maya YAARI, Auteur ; Lubov NEMANOV, Auteur ; David MANKUTA, Auteur ; Nurit YIRMIYA, Auteur ; Richard P. EBSTEIN, Auteur . - 2010 . - p.293-302. Langues : Anglais (eng) in Autism Research > 3-6 (December 2010) . - p.293-302 Mots-clés : autism spectrum disorder (ASD)  CD38;polymorphism  gene expression  real time PCR  haplotype Index. décimale : PER Périodiques Résumé : Background: Impairments in social processes characterize one of the core deficits in autism spectrum disorders (ASD) and accumulating evidence suggests that oxytocin neurotransmission is implicated in mediating social adaptation in ASD. Using a mouse model, CD38, a transmembrane protein expressed in immune cells but also in brain, was found to be critical for social behavior via regulation of oxytocin secretion. This prompted us to both examine CD38 expression in human lymphoblastoid cell lines (LBC) as well as to test association between SNPs across the CD38 gene and ASD. Methods: LBC's were derived from 44 ASD lines and 40 “unaffected” parents. Family-based association (UNPHASED) was examined by genotyping 11 tagging SNPs spanning the CD38 gene identified using HapMap data in 170 trios. An additional SNP (rs3796863) associated in a study by Munesue et al. with ASD was also genotyped. Results: A highly significant reduction in CD38 expression was observed in immortalized lymphocytes derived from ASD subjects compared to their “unaffected” parents (F = 17.2, P = 0.00024, df = 1). Haplotype analysis showed significant association (permutation corrected) between three and seven locus haplotypes and DSM IV ASD in low functioning (IQ<70) subjects. Conclusions: The current report supports a role for CD38 in conferring risk for ASD. Notably, our study shows that this gene is not only associated with low functioning ASD but that CD38 expression is markedly reduced in LBC derived from ASD subjects compared to “unaffected” parents, strengthening the connection between oxytocin and ASD. En ligne : http://dx.doi.org/10.1002/aur.156 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Parent resolution of diagnosis and intervention fidelity in a parent-delivered intervention for pre-school children with autism: A mixed methods study / Paula GROGAN in Research in Autism Spectrum Disorders, 101 (March 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 101 (March 2023) . - 102102 Titre : Parent resolution of diagnosis and intervention fidelity in a parent-delivered intervention for pre-school children with autism: A mixed methods study Type de document : Texte imprimé et/ou numérique Auteurs : Paula GROGAN, Auteur ; Maya YAARI, Auteur ; Rachel JELLETT, Auteur ; Katy UNWIN, Auteur ; Cheryl DISSANAYAKE, Auteur Article en page(s) : 102102 Langues : Anglais (eng) Mots-clés : Autism  ASD  Early intervention  Intervention fidelity  Resolution of diagnosis Index. décimale : PER Périodiques Résumé : Background There is growing interest in parent-delivered interventions (PDI) for children with autism. Treatment fidelity has been associated with child outcomes in PDI but little is known about what impacts fidelity. One factor not previously examined is parents’ resolution to the autism diagnosis which involves adjusting expectations about the child and sensitively responding to their cues, strengths and needs. Relatively little is known about resolution in the context of autism but there is evidence of an association between resolution and parent wellbeing. Method The study adopted a mixed methods approach to examine whether there is an association between PDI fidelity and parent resolution to diagnosis, and whether resolution is associated with parent wellbeing. Parents of 31 preschool children diagnosed with autism who attended up to 12 Parent-delivered Early Start Denver Model (P-ESDM) coaching sessions participated in the study. A thematic analysis of parent interviews was also undertaken to identify themes raised by resolved and unresolved parents in interviews. Results There was no difference in overall mean fidelity scores between resolved and unresolved parents. Those classified as resolved had lower depression scores and parenting stress scores than parents classified as unresolved. The qualitative analysis revealed that parents’ perceptions of their child’s progress and their hopes for the future appeared to distinguish resolved and unresolved parents. Conclusions Findings suggest that parent wellbeing and child progress may predict resolution which was not related to parent treatment fidelity in this study. Parent wellbeing and resolution status should be assessed at entry to PDI. En ligne : https://doi.org/10.1016/j.rasd.2023.102102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Parent resolution of diagnosis and intervention fidelity in a parent-delivered intervention for pre-school children with autism: A mixed methods study [Texte imprimé et/ou numérique] / Paula GROGAN, Auteur ; Maya YAARI, Auteur ; Rachel JELLETT, Auteur ; Katy UNWIN, Auteur ; Cheryl DISSANAYAKE, Auteur . - 102102. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 101 (March 2023) . - 102102 Mots-clés : Autism  ASD  Early intervention  Intervention fidelity  Resolution of diagnosis Index. décimale : PER Périodiques Résumé : Background There is growing interest in parent-delivered interventions (PDI) for children with autism. Treatment fidelity has been associated with child outcomes in PDI but little is known about what impacts fidelity. One factor not previously examined is parents’ resolution to the autism diagnosis which involves adjusting expectations about the child and sensitively responding to their cues, strengths and needs. Relatively little is known about resolution in the context of autism but there is evidence of an association between resolution and parent wellbeing. Method The study adopted a mixed methods approach to examine whether there is an association between PDI fidelity and parent resolution to diagnosis, and whether resolution is associated with parent wellbeing. Parents of 31 preschool children diagnosed with autism who attended up to 12 Parent-delivered Early Start Denver Model (P-ESDM) coaching sessions participated in the study. A thematic analysis of parent interviews was also undertaken to identify themes raised by resolved and unresolved parents in interviews. Results There was no difference in overall mean fidelity scores between resolved and unresolved parents. Those classified as resolved had lower depression scores and parenting stress scores than parents classified as unresolved. The qualitative analysis revealed that parents’ perceptions of their child’s progress and their hopes for the future appeared to distinguish resolved and unresolved parents. Conclusions Findings suggest that parent wellbeing and child progress may predict resolution which was not related to parent treatment fidelity in this study. Parent wellbeing and resolution status should be assessed at entry to PDI. En ligne : https://doi.org/10.1016/j.rasd.2023.102102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Risk for ASD in Preterm Infants: A Three-Year Follow-Up Study / Ayelet HAREL-GADASSI in Autism Research and Treatment, 2018 (2018)  

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Stability of early risk assessment for autism spectrum disorder in preterm infants / Maya YAARI in Autism, 20-7 (October 2016)  

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