Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder / Soichiro KITAMURA in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1886-1895 Titre : Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder Type de document : texte imprimé Auteurs : Soichiro KITAMURA, Auteur ; Manabu MAKINODAN, Auteur ; Kiwamu MATSUOKA, Auteur ; Masato TAKAHASHI, Auteur ; Hiroaki YOSHIKAWA, Auteur ; Rie ISHIDA, Auteur ; Naoko KISHIMOTO, Auteur ; Fumihiko YASUNO, Auteur ; Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Toshiteru MIYASAKA, Auteur ; Kimihiko KICHIKAWA, Auteur ; Naoko KISHIMOTO, Auteur Article en page(s) : p.1886-1895 Langues : Anglais (eng) Mots-clés : Adult  Adverse Childhood Experiences  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Parietal Lobe/diagnostic imaging  autism spectrum disorder  gray matter  parietal lobe  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder [texte imprimé] / Soichiro KITAMURA, Auteur ; Manabu MAKINODAN, Auteur ; Kiwamu MATSUOKA, Auteur ; Masato TAKAHASHI, Auteur ; Hiroaki YOSHIKAWA, Auteur ; Rie ISHIDA, Auteur ; Naoko KISHIMOTO, Auteur ; Fumihiko YASUNO, Auteur ; Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Toshiteru MIYASAKA, Auteur ; Kimihiko KICHIKAWA, Auteur ; Naoko KISHIMOTO, Auteur . - p.1886-1895. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1886-1895 Mots-clés : Adult  Adverse Childhood Experiences  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Gray Matter/diagnostic imaging  Humans  Magnetic Resonance Imaging  Parietal Lobe/diagnostic imaging  autism spectrum disorder  gray matter  parietal lobe  post-traumatic stress disorder Index. décimale : PER Périodiques Résumé : Compared to typically developing (TD) children, people with autism spectrum disorder (ASD) have an increased risk of adverse childhood experiences (ACEs). Exposure to ACEs is associated with adult ASD psychological comorbidities, such as posttraumatic stress disorder (PTSD). Occurrence of intrusive event reexperiencing, characteristic of PTSD, often causes social dysfunction in adults with ASD, but its pathological basis is unclear. This study examined brain regions related to the severity of intrusive reexperiencing and explored whether ACE severity was associated with that of intrusive reexperiencing and/or extracted regional gray matter volume. Forty-six individuals with ASD and 41 TD subjects underwent T1-weighted magnetic resonance imaging and evaluation of ACEs and intrusive reexperiencing. Brain regions related to the severity of intrusive reexperiencing in both groups were identified by voxel-based whole brain analyses. Associations among the severity of intrusive reexperiencing, that of ACEs, and gray matter volume were examined in both groups. The severities of intrusive reexperiencing and ACEs were significantly associated with reduced gray matter volume in the right precuneus in individuals with ASD but not in TD subjects. Although the right precuneus gray matter volume was smaller in individuals with ASD and severe ACEs than in those with mild ACEs or TD subjects, it was similar in the latter two groups. However, ACE-dependent gray matter volume reduction in the right precuneus led to intrusive reexperiencing in individuals with ASD. This suggests that exposure to ACEs is associated with right precuneus gray matter reduction, which is critical for intrusive reexperiencing in adults with ASD. LAY SUMMARY: Individuals with autism spectrum disorder (ASD) are at increased risk of adverse childhood experiences (ACEs) and of subsequent manifestation of intrusive reexperiencing of stressful life events. The present study found that reduced gray matter volume in the right precuneus of the brain was associated with more severe intrusive reexperiencing of ACEs by individuals with ASD. These results suggest that ACEs affect neural development in the precuneus, which is the pathological basis of intrusive event reexperiencing in ASD. En ligne : http://dx.doi.org/10.1002/aur.2558 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder / Yuka YASUDA in Molecular Autism, (May 2011)  

Public ISBD [article]  inMolecular Autism > (May 2011) . - 8 p. Titre : Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder Type de document : texte imprimé Auteurs : Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Hidenaga YAMAMORI, Auteur ; Kazutaka OHI, Auteur ; Motoyuki FUKUMOTO, Auteur ; Satomi UMEDA-YANO, Auteur ; Ikuko MOHRI, Auteur ; Akira ITO, Auteur ; Masako TANIIKE, Auteur ; Masatoshi TAKEDA, Auteur Année de publication : 2011 Article en page(s) : 8 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background The autism spectrum disorders (ASDs) are complex neurodevelopmental disorders that result in severe and pervasive impairment in the development of reciprocal social interaction and verbal and nonverbal communication skills. In addition, individuals with ASD have stereotypical behavior, interests and activities. Rare mutations of some genes, such as neuroligin (NLGN) 3/4, neurexin (NRXN) 1, SHANK3, MeCP2 and NHE9, have been reported to be associated with ASD. In the present study, we investigated whether alterations in mRNA expression levels of these genes could be found in lymphoblastoid cell lines derived from patients with ASD. Methods We measured mRNA expression levels of NLGN3/4, NRXN1, SHANK3, MeCP2, NHE9 and AKT1 in lymphoblastoid cells from 35 patients with ASD and 35 healthy controls, as well as from 45 patients with schizophrenia and 45 healthy controls, using real-time quantitative reverse transcriptase polymerase chain reaction assays. Results The mRNA expression levels of NLGN3 and SHANK3 normalized by β-actin or TBP were significantly decreased in the individuals with ASD compared to controls, whereas no difference was found in the mRNA expression level of MeCP2, NHE9 or AKT1. However, normalized NLGN3 and SHANK3 gene expression levels were not altered in patients with schizophrenia, and expression levels of NLGN4 and NRXN1 mRNA were not quantitatively measurable in lymphoblastoid cells. Conclusions Our results provide evidence that the NLGN3 and SHANK3 genes may be differentially expressed in lymphoblastoid cell lines from individuals with ASD compared to those from controls. These findings suggest the possibility that decreased mRNA expression levels of these genes might be involved in the pathophysiology of ASD in a substantial population of ASD patients. En ligne : http://dx.doi.org/10.1186/2040-2392-2-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=131 [article] Gene expression analysis in lymphoblasts derived from patients with autism spectrum disorder [texte imprimé] / Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Hidenaga YAMAMORI, Auteur ; Kazutaka OHI, Auteur ; Motoyuki FUKUMOTO, Auteur ; Satomi UMEDA-YANO, Auteur ; Ikuko MOHRI, Auteur ; Akira ITO, Auteur ; Masako TANIIKE, Auteur ; Masatoshi TAKEDA, Auteur . - 2011 . - 8 p. Langues : Anglais (eng) in Molecular Autism > (May 2011) . - 8 p. Index. décimale : PER Périodiques Résumé : Background The autism spectrum disorders (ASDs) are complex neurodevelopmental disorders that result in severe and pervasive impairment in the development of reciprocal social interaction and verbal and nonverbal communication skills. In addition, individuals with ASD have stereotypical behavior, interests and activities. Rare mutations of some genes, such as neuroligin (NLGN) 3/4, neurexin (NRXN) 1, SHANK3, MeCP2 and NHE9, have been reported to be associated with ASD. In the present study, we investigated whether alterations in mRNA expression levels of these genes could be found in lymphoblastoid cell lines derived from patients with ASD. Methods We measured mRNA expression levels of NLGN3/4, NRXN1, SHANK3, MeCP2, NHE9 and AKT1 in lymphoblastoid cells from 35 patients with ASD and 35 healthy controls, as well as from 45 patients with schizophrenia and 45 healthy controls, using real-time quantitative reverse transcriptase polymerase chain reaction assays. Results The mRNA expression levels of NLGN3 and SHANK3 normalized by β-actin or TBP were significantly decreased in the individuals with ASD compared to controls, whereas no difference was found in the mRNA expression level of MeCP2, NHE9 or AKT1. However, normalized NLGN3 and SHANK3 gene expression levels were not altered in patients with schizophrenia, and expression levels of NLGN4 and NRXN1 mRNA were not quantitatively measurable in lymphoblastoid cells. Conclusions Our results provide evidence that the NLGN3 and SHANK3 genes may be differentially expressed in lymphoblastoid cell lines from individuals with ASD compared to those from controls. These findings suggest the possibility that decreased mRNA expression levels of these genes might be involved in the pathophysiology of ASD in a substantial population of ASD patients. En ligne : http://dx.doi.org/10.1186/2040-2392-2-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=131

The Self-Construal Scale: A Potential Tool for Predicting Subjective Well-Being of Individuals With Autism Spectrum Disorder / Sachie KANEKO in Autism Research, 13-6 (June 2020)  

Public ISBD [article]  inAutism Research > 13-6 (June 2020) . - p.947-958 Titre : The Self-Construal Scale: A Potential Tool for Predicting Subjective Well-Being of Individuals With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Sachie KANEKO, Auteur ; Takahiro A. KATO, Auteur ; Manabu MAKINODAN, Auteur ; Takashi KOMORI, Auteur ; Rio ISHIDA, Auteur ; Naoko KISHIMOTO, Auteur ; Masato TAKAHASHI, Auteur ; Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Hidemi IWASAKA, Auteur ; Ayumi TANAKA, Auteur ; Yukiko UCHIDA, Auteur ; Shigenobu KANBA, Auteur ; Toshifumi KISHIMOTO, Auteur Article en page(s) : p.947-958 Langues : Anglais (eng) Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  heterogeneity  self-construal scale  well-being Index. décimale : PER Périodiques Résumé : Despite accumulating evidence that culture shapes the symptoms of autism spectrum disorder (ASD), no studies have yet applied the Self-Construal Scale to individuals with ASD. We compared the self-construals (measured using the Self-Construal Scale) of 31 high-functioning Japanese individuals with ASD with those of 60 typically developing (TD) individuals. We also examined how the self-construals of individuals with ASD related to their intelligence quotient, adverse childhood experiences, attention deficit hyperactivity disorder, ASD symptoms during adulthood and preschool years, and subjective well-being. Individuals with ASD were more likely to display independent self-construals than were TD individuals; unexpectedly, however, a substantial proportion of individuals with ASD (43.8%) displayed relatively interdependent self-construals. Among individuals with ASD, self-construals were significantly associated with ASD symptoms during preschool years, and with satisfaction of the need for autonomy and frustration of the need for relatedness. Evaluating self-construals can help predict the subjective well-being of high-functioning individuals with ASD. Moreover, the Self-Construal Scale may be useful for understanding the heterogeneous phenotypes of ASD, based on its association with autistic symptoms during preschool years, suggesting that the scale is a potential tool to develop efficient interventions for high-functioning individuals with ASD. Autism Res 2020, 13: 947-958. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Autism Spectrum Disorders (ASD) are a group of disorders presenting a variety of symptoms and biological origins that can complicate choosing an intervention best suited for improving well-being. Results indicate that a self-construal scale could help understand individuals with high-functioning ASD by independent and interdependent self-construals that are associated with ASD symptoms during preschool years and adult subjective well-being. Our findings suggest that this scale can help understand ASD and select appropriate interventions. En ligne : http://dx.doi.org/10.1002/aur.2242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] The Self-Construal Scale: A Potential Tool for Predicting Subjective Well-Being of Individuals With Autism Spectrum Disorder [texte imprimé] / Sachie KANEKO, Auteur ; Takahiro A. KATO, Auteur ; Manabu MAKINODAN, Auteur ; Takashi KOMORI, Auteur ; Rio ISHIDA, Auteur ; Naoko KISHIMOTO, Auteur ; Masato TAKAHASHI, Auteur ; Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Hidemi IWASAKA, Auteur ; Ayumi TANAKA, Auteur ; Yukiko UCHIDA, Auteur ; Shigenobu KANBA, Auteur ; Toshifumi KISHIMOTO, Auteur . - p.947-958. Langues : Anglais (eng) in Autism Research > 13-6 (June 2020) . - p.947-958 Mots-clés : attention deficit/hyperactivity disorder  autism spectrum disorder  heterogeneity  self-construal scale  well-being Index. décimale : PER Périodiques Résumé : Despite accumulating evidence that culture shapes the symptoms of autism spectrum disorder (ASD), no studies have yet applied the Self-Construal Scale to individuals with ASD. We compared the self-construals (measured using the Self-Construal Scale) of 31 high-functioning Japanese individuals with ASD with those of 60 typically developing (TD) individuals. We also examined how the self-construals of individuals with ASD related to their intelligence quotient, adverse childhood experiences, attention deficit hyperactivity disorder, ASD symptoms during adulthood and preschool years, and subjective well-being. Individuals with ASD were more likely to display independent self-construals than were TD individuals; unexpectedly, however, a substantial proportion of individuals with ASD (43.8%) displayed relatively interdependent self-construals. Among individuals with ASD, self-construals were significantly associated with ASD symptoms during preschool years, and with satisfaction of the need for autonomy and frustration of the need for relatedness. Evaluating self-construals can help predict the subjective well-being of high-functioning individuals with ASD. Moreover, the Self-Construal Scale may be useful for understanding the heterogeneous phenotypes of ASD, based on its association with autistic symptoms during preschool years, suggesting that the scale is a potential tool to develop efficient interventions for high-functioning individuals with ASD. Autism Res 2020, 13: 947-958. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Autism Spectrum Disorders (ASD) are a group of disorders presenting a variety of symptoms and biological origins that can complicate choosing an intervention best suited for improving well-being. Results indicate that a self-construal scale could help understand individuals with high-functioning ASD by independent and interdependent self-construals that are associated with ASD symptoms during preschool years and adult subjective well-being. Our findings suggest that this scale can help understand ASD and select appropriate interventions. En ligne : http://dx.doi.org/10.1002/aur.2242 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Tumor necrosis factor-α expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder / Takahira YAMAUCHI in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2330-2341 Titre : Tumor necrosis factor-α expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder Type de document : texte imprimé Auteurs : Takahira YAMAUCHI, Auteur ; Manabu MAKINODAN, Auteur ; Michihiro TORITSUKA, Auteur ; Kazuki OKUMURA, Auteur ; Yoshinori KAYASHIMA, Auteur ; Rie ISHIDA, Auteur ; Naoko KISHIMOTO, Auteur ; Masato TAKAHASHI, Auteur ; Takashi KOMORI, Auteur ; Yasunari YAMAGUCHI, Auteur ; Ryohei TAKADA, Auteur ; Kazuhiko YAMAMURO, Auteur ; Sohei KIMOTO, Auteur ; Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Naoko KISHIMOTO, Auteur Article en page(s) : p.2330-2341 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Cytokines  Humans  Macrophages  Monocytes  Tumor Necrosis Factor-alpha  Tnf-?  diagnosis  inflammation  macrophage  monocyte Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is characterized by enhanced inflammatory activities; however, the precise pathobiology and underlying causes of ASD remain unclear. This study was performed to identify inflammatory indicators useful for diagnosing ASD. The mRNA expression of cytokines, including tumor necrosis factor-α (TNF-α), was measured in cultured M1 and M2 macrophages from patients with ASD (n = 29) and typically developed (TD) individuals (n = 30). Additionally, TNF-α expression in the monocytes of patients with ASD (n = 7), showing aberrations in TNF-α expression in M1/M2 macrophages and TD individuals (n = 6), was measured. TNF-α expression in M1 macrophages and the TNF-α expression ratio in M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals; however, this increase was not observed in M2 macrophages (M1: sensitivity = 34.5%, specificity = 96.7%, area under the curve = 0.74, positive likelihood ratio = 10.34; ratio of M1/M2: sensitivity = 55.2%, specificity = 96.7%, area under the curve = 0.79, positive likelihood ratio = 16.55). Additionally, TNF-α expression in monocytes did not significantly differ between patients with ASD and TD individuals. In conclusion, further studies on TNF-α expression in cultured macrophages may improve the understanding of ASD pathobiology. LAY SUMMARY: TNF-α expression in differentiated M1 macrophages and TNF-α expression ratio in differentiated M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals, while no difference in TNF-α expression was found in pre-differentiation cells such as monocytes. These measurements allow elucidation of the novel pathobiology of ASD and can contribute to biomarker implementation for the diagnosis of adult high-functioning ASD. En ligne : http://dx.doi.org/10.1002/aur.2585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Tumor necrosis factor-α expression aberration of M1/M2 macrophages in adult high-functioning autism spectrum disorder [texte imprimé] / Takahira YAMAUCHI, Auteur ; Manabu MAKINODAN, Auteur ; Michihiro TORITSUKA, Auteur ; Kazuki OKUMURA, Auteur ; Yoshinori KAYASHIMA, Auteur ; Rie ISHIDA, Auteur ; Naoko KISHIMOTO, Auteur ; Masato TAKAHASHI, Auteur ; Takashi KOMORI, Auteur ; Yasunari YAMAGUCHI, Auteur ; Ryohei TAKADA, Auteur ; Kazuhiko YAMAMURO, Auteur ; Sohei KIMOTO, Auteur ; Yuka YASUDA, Auteur ; Ryota HASHIMOTO, Auteur ; Naoko KISHIMOTO, Auteur . - p.2330-2341. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2330-2341 Mots-clés : Adult  Autism Spectrum Disorder  Cytokines  Humans  Macrophages  Monocytes  Tumor Necrosis Factor-alpha  Tnf-?  diagnosis  inflammation  macrophage  monocyte Index. décimale : PER Périodiques Résumé : The etiology of autism spectrum disorder (ASD) is complex, and its pathobiology is characterized by enhanced inflammatory activities; however, the precise pathobiology and underlying causes of ASD remain unclear. This study was performed to identify inflammatory indicators useful for diagnosing ASD. The mRNA expression of cytokines, including tumor necrosis factor-α (TNF-α), was measured in cultured M1 and M2 macrophages from patients with ASD (n = 29) and typically developed (TD) individuals (n = 30). Additionally, TNF-α expression in the monocytes of patients with ASD (n = 7), showing aberrations in TNF-α expression in M1/M2 macrophages and TD individuals (n = 6), was measured. TNF-α expression in M1 macrophages and the TNF-α expression ratio in M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals; however, this increase was not observed in M2 macrophages (M1: sensitivity = 34.5%, specificity = 96.7%, area under the curve = 0.74, positive likelihood ratio = 10.34; ratio of M1/M2: sensitivity = 55.2%, specificity = 96.7%, area under the curve = 0.79, positive likelihood ratio = 16.55). Additionally, TNF-α expression in monocytes did not significantly differ between patients with ASD and TD individuals. In conclusion, further studies on TNF-α expression in cultured macrophages may improve the understanding of ASD pathobiology. LAY SUMMARY: TNF-α expression in differentiated M1 macrophages and TNF-α expression ratio in differentiated M1/M2 macrophages were markedly higher in patients with ASD than in TD individuals, while no difference in TNF-α expression was found in pre-differentiation cells such as monocytes. These measurements allow elucidation of the novel pathobiology of ASD and can contribute to biomarker implementation for the diagnosis of adult high-functioning ASD. En ligne : http://dx.doi.org/10.1002/aur.2585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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