A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort / Keely CHESLACK-POSTAVA in Autism Research, 14-11 (November 2021)  

Public ISBD [article]  inAutism Research > 14-11 (November 2021) . - p.2444-2453 Titre : A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort Type de document : texte imprimé Auteurs : Keely CHESLACK-POSTAVA, Auteur ; Andre SOURANDER, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Ian W. MCKEAGUE, Auteur ; Heljä-Marja SURCEL, Auteur ; Alan S. BROWN, Auteur Article en page(s) : p.2444-2453 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Biomarkers  Case-Control Studies  Child  Female  Finland/epidemiology  Humans  Maternal Exposure  Pregnancy  Prenatal Exposure Delayed Effects/epidemiology  Smoking  autism  cotinine  prenatal exposure delayed effects  smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30 days), sex, and place of birth (N = 962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] A biomarker-based study of prenatal smoking exposure and autism in a Finnish national birth cohort [texte imprimé] / Keely CHESLACK-POSTAVA, Auteur ; Andre SOURANDER, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Ian W. MCKEAGUE, Auteur ; Heljä-Marja SURCEL, Auteur ; Alan S. BROWN, Auteur . - p.2444-2453. Langues : Anglais (eng) in Autism Research > 14-11 (November 2021) . - p.2444-2453 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Biomarkers  Case-Control Studies  Child  Female  Finland/epidemiology  Humans  Maternal Exposure  Pregnancy  Prenatal Exposure Delayed Effects/epidemiology  Smoking  autism  cotinine  prenatal exposure delayed effects  smoking Index. décimale : PER Périodiques Résumé : Maternal exposure to tobacco smoke during pregnancy is a common and persistent exposure linked to adverse neurodevelopmental outcomes in the offspring. However, previous studies provide mixed evidence regarding the relationship between prenatal smoking and offspring autism. This study used cotinine level, a biomarker for nicotine, to investigate the relationship between prenatal smoking and autism. The authors conducted a population-based case-control study nested in a national cohort of all births in Finland from 1987 to 2005. Cases diagnosed with childhood autism (ICD-10/9 code F84.0/299.0) through 2007 were identified using data from linked national registers. Each case was matched with a control on date of birth (±30 days), sex, and place of birth (N = 962 pairs). Maternal serum cotinine levels were prospectively measured in first- to early second-trimester serum samples archived in a national biobank using a quantitative immunoassay. Data were analyzed using conditional logistic regression. Prenatal maternal levels of serum cotinine were not associated with the odds of autism, whether cotinine was classified continuously, by deciles, or using previously defined categories corresponding to probable maternal smoking status. After adjusting for maternal age, paternal age, previous births, and any history of parental psychiatric disorder, the odds ratio for categorical high versus low cotinine, using a 3-level exposure variable, was 0.98 (95% CI = 0.76, 1.26; p = 0.88). In conclusion, this national birth cohort-based study does not provide evidence for an association between maternal cotinine, a biomarker of maternal smoking, and risk of autism. LAY SUMMARY: This study explored whether prenatal exposure to tobacco smoke in mothers is related to the diagnosis of autism in their children, by measuring the levels of cotinine, a biomarker for tobacco exposure, in stored serum samples drawn from mothers during pregnancy. The levels of cotinine in the mothers of children diagnosed with autism were similar to those in the mothers of control children of similar age and gender distribution. En ligne : http://dx.doi.org/10.1002/aur.2608 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design / Katja M. LAMPI in Journal of Autism and Developmental Disorders, 41-8 (August 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1090-1096 Titre : Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design Type de document : texte imprimé Auteurs : Katja M. LAMPI, Auteur ; P. Nina BANERJEE, Auteur ; Mika GISSLER, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Jukka HUTTUNEN, Auteur ; Ulla KULMALA, Auteur ; Jarna LINDROOS, Auteur ; Solja NIEMELA, Auteur ; Maria RIHKO, Auteur ; Terja RISTKARI, Auteur ; Kristiina SAANAKORPI, Auteur ; Tanja SARLIN, Auteur ; Lauri SILLANMAKI, Auteur ; Ian W. MCKEAGUE, Auteur ; Heljä-Marja SURCEL, Auteur ; Hans HELENIUS, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur Année de publication : 2011 Article en page(s) : p.1090-1096 Langues : Anglais (eng) Mots-clés : Autism  Register study  Prenatal risk factors  Epidemiology  Methodology Index. décimale : PER Périodiques Résumé : This article presents an overview of the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), a new study designed to examine the relationship between prenatal serologic factors, mediating and moderating developmental antecedents, and risk of autism spectrum disorders (ASD). The FIPS-A is based on register linkages between births from 1987 to 2005 ascertained from the Finnish Medical Birth Register (FMBR) and other national registers on treatment for this group of disorders. All subjects were members of the Finnish Maternity Cohort (FMC), which consists of virtually all births in Finland from 1983 to the present, and which includes archived maternal serum samples. This study also capitalizes on other registry information, such as systematically collected data on pregnancy, prenatal and neonatal complications and manual data collection from well-child clinics providing developmental data from birth to the age of 7 years. In this paper, we describe the methods used in the FIPS-A study, including a description of the national registers, available data and case ascertainment procedures. Finally, we discuss implications of the data for future work on uncovering putative aetiologies of ASD and key strengths and limitations of the design. En ligne : http://dx.doi.org/10.1007/s10803-010-1132-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132 [article] Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A): Overview and Design [texte imprimé] / Katja M. LAMPI, Auteur ; P. Nina BANERJEE, Auteur ; Mika GISSLER, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Jukka HUTTUNEN, Auteur ; Ulla KULMALA, Auteur ; Jarna LINDROOS, Auteur ; Solja NIEMELA, Auteur ; Maria RIHKO, Auteur ; Terja RISTKARI, Auteur ; Kristiina SAANAKORPI, Auteur ; Tanja SARLIN, Auteur ; Lauri SILLANMAKI, Auteur ; Ian W. MCKEAGUE, Auteur ; Heljä-Marja SURCEL, Auteur ; Hans HELENIUS, Auteur ; Alan S. BROWN, Auteur ; Andre SOURANDER, Auteur . - 2011 . - p.1090-1096. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-8 (August 2011) . - p.1090-1096 Mots-clés : Autism  Register study  Prenatal risk factors  Epidemiology  Methodology Index. décimale : PER Périodiques Résumé : This article presents an overview of the Finnish Prenatal Study of Autism and Autism Spectrum Disorders (FIPS-A), a new study designed to examine the relationship between prenatal serologic factors, mediating and moderating developmental antecedents, and risk of autism spectrum disorders (ASD). The FIPS-A is based on register linkages between births from 1987 to 2005 ascertained from the Finnish Medical Birth Register (FMBR) and other national registers on treatment for this group of disorders. All subjects were members of the Finnish Maternity Cohort (FMC), which consists of virtually all births in Finland from 1983 to the present, and which includes archived maternal serum samples. This study also capitalizes on other registry information, such as systematically collected data on pregnancy, prenatal and neonatal complications and manual data collection from well-child clinics providing developmental data from birth to the age of 7 years. In this paper, we describe the methods used in the FIPS-A study, including a description of the national registers, available data and case ascertainment procedures. Finally, we discuss implications of the data for future work on uncovering putative aetiologies of ASD and key strengths and limitations of the design. En ligne : http://dx.doi.org/10.1007/s10803-010-1132-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=132

Prenatal toxoplasmosis antibody and childhood autism / Marisa N. SPANN in Autism Research, 10-5 (May 2017)  

Public ISBD [article]  inAutism Research > 10-5 (May 2017) . - p.769-777 Titre : Prenatal toxoplasmosis antibody and childhood autism Type de document : texte imprimé Auteurs : Marisa N. SPANN, Auteur ; Andre SOURANDER, Auteur ; Heljä-Marja SURCEL, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Alan S. BROWN, Auteur Article en page(s) : p.769-777 Langues : Anglais (eng) Mots-clés : toxoplasmosis  autism  antibody  childhood Index. décimale : PER Périodiques Résumé : There is evidence that some maternal infections during the prenatal period are associated with neurodevelopmental disorders, such as childhood autism. However, the association between autism and Toxoplasma gondii (T. gondii), an intracellular parasite, remains unclear. The authors examined whether serologically confirmed maternal antibodies to T. gondii are associated with odds of childhood autism in offspring. The study is based on a nested case-control design of a large national birth cohort (N = 1.2 million) and the national psychiatric registries in Finland. There were 874 cases of childhood autism and controls matched 1:1 on date of birth, sex, birthplace and residence in Finland. Maternal sera were prospectively assayed from a national biobank for T. gondii IgM and IgG antibodies; IgG avidity analyses were also performed. High maternal T. gondii IgM antibody was associated with a significantly decreased odds of childhood autism. Low maternal T. gondii IgG antibody was associated with increased offspring odds of autism. In women with high T. gondii IgM antibodies, the IgG avidity was high for both cases and controls, with the exception of three controls. The findings suggest that the relationship between maternal T. gondii antibodies and odds of childhood autism may be related to the immune response to this pathogen or the overall activation of the immune system. En ligne : http://dx.doi.org/10.1002/aur.1722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 [article] Prenatal toxoplasmosis antibody and childhood autism [texte imprimé] / Marisa N. SPANN, Auteur ; Andre SOURANDER, Auteur ; Heljä-Marja SURCEL, Auteur ; Susanna HINKKA-YLI-SALOMAKI, Auteur ; Alan S. BROWN, Auteur . - p.769-777. Langues : Anglais (eng) in Autism Research > 10-5 (May 2017) . - p.769-777 Mots-clés : toxoplasmosis  autism  antibody  childhood Index. décimale : PER Périodiques Résumé : There is evidence that some maternal infections during the prenatal period are associated with neurodevelopmental disorders, such as childhood autism. However, the association between autism and Toxoplasma gondii (T. gondii), an intracellular parasite, remains unclear. The authors examined whether serologically confirmed maternal antibodies to T. gondii are associated with odds of childhood autism in offspring. The study is based on a nested case-control design of a large national birth cohort (N = 1.2 million) and the national psychiatric registries in Finland. There were 874 cases of childhood autism and controls matched 1:1 on date of birth, sex, birthplace and residence in Finland. Maternal sera were prospectively assayed from a national biobank for T. gondii IgM and IgG antibodies; IgG avidity analyses were also performed. High maternal T. gondii IgM antibody was associated with a significantly decreased odds of childhood autism. Low maternal T. gondii IgG antibody was associated with increased offspring odds of autism. In women with high T. gondii IgM antibodies, the IgG avidity was high for both cases and controls, with the exception of three controls. The findings suggest that the relationship between maternal T. gondii antibodies and odds of childhood autism may be related to the immune response to this pathogen or the overall activation of the immune system. En ligne : http://dx.doi.org/10.1002/aur.1722 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307

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