Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders / Hannah M. BROWN in Journal of Child Psychology and Psychiatry, 54-6 (June 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.678-685 Titre : Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders Type de document : Texte imprimé et/ou numérique Auteurs : Hannah M. BROWN, Auteur ; Tom A. MCADAMS, Auteur ; Kathryn J. LESTER, Auteur ; Robert GOODMAN, Auteur ; David M. CLARK, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.678-685 Langues : Anglais (eng) Mots-clés : Anxiety  attention  children  familial risk Index. décimale : PER Périodiques Résumé : Background: Twin studies in children reveal that familial aggregation of anxiety disorders is due to both genetic and environmental factors. Cognitive biases for threat information are considered a robust characteristic of childhood anxiety. However, little is known regarding the underlying aetiology of such biases and their role in anxiety disorders. Method: A face version of the dot-probe task measuring attentional biases for negative (anger, fear, sad, disgust) and positive (happy) facial expressions was completed by 600, 8-year-old twins; the largest study of its kind. Twin correlations for attentional bias scores were compared to estimate genetic and environmental effects. Parent-report diagnostic interviews identified children with an anxiety disorder. Indices of inferred genetic and familial risk for anxiety disorders were created for each child. Data were analysed using a series of logistic regressions. Results: Anxious children showed greater attentional avoidance of negative faces than nonanxious children; t (548) = 2.55, p .05. Attentional avoidance was not under genetic or shared environmental influence. Risk for anxiety disorders was predicted by familial factors. Both attentional avoidance and inferred familial risk were significant but independent predictors of anxiety disorders (ORs = .65 and 3.64, respectively). Conclusions: Anxiety-related attentional biases and familial risk play important but independent roles in childhood anxiety disorders. If replicated, these findings indicate that links between genetic risk and anxiety disorders lie outside the domain of attentional processes. En ligne : http://dx.doi.org/10.1111/jcpp.12024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=200 [article] Attentional threat avoidance and familial risk are independently associated with childhood anxiety disorders [Texte imprimé et/ou numérique] / Hannah M. BROWN, Auteur ; Tom A. MCADAMS, Auteur ; Kathryn J. LESTER, Auteur ; Robert GOODMAN, Auteur ; David M. CLARK, Auteur ; Thalia C. ELEY, Auteur . - p.678-685. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-6 (June 2013) . - p.678-685 Mots-clés : Anxiety  attention  children  familial risk Index. décimale : PER Périodiques Résumé : Background: Twin studies in children reveal that familial aggregation of anxiety disorders is due to both genetic and environmental factors. Cognitive biases for threat information are considered a robust characteristic of childhood anxiety. However, little is known regarding the underlying aetiology of such biases and their role in anxiety disorders. Method: A face version of the dot-probe task measuring attentional biases for negative (anger, fear, sad, disgust) and positive (happy) facial expressions was completed by 600, 8-year-old twins; the largest study of its kind. Twin correlations for attentional bias scores were compared to estimate genetic and environmental effects. Parent-report diagnostic interviews identified children with an anxiety disorder. Indices of inferred genetic and familial risk for anxiety disorders were created for each child. Data were analysed using a series of logistic regressions. Results: Anxious children showed greater attentional avoidance of negative faces than nonanxious children; t (548) = 2.55, p .05. Attentional avoidance was not under genetic or shared environmental influence. Risk for anxiety disorders was predicted by familial factors. Both attentional avoidance and inferred familial risk were significant but independent predictors of anxiety disorders (ORs = .65 and 3.64, respectively). Conclusions: Anxiety-related attentional biases and familial risk play important but independent roles in childhood anxiety disorders. If replicated, these findings indicate that links between genetic risk and anxiety disorders lie outside the domain of attentional processes. En ligne : http://dx.doi.org/10.1111/jcpp.12024 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=200

Experimental Modification of Interpretation Bias about Animal Fear in Young Children: Effects on Cognition, Avoidance Behavior, Anxiety Vulnerability, and Physiological Responding / Kathryn J. LESTER in Journal of Clinical Child & Adolescent Psychology, 40-6 (November-December 2011)  

Public ISBD [article]  inJournal of Clinical Child & Adolescent Psychology > 40-6 (November-December 2011) . - p.864-877 Titre : Experimental Modification of Interpretation Bias about Animal Fear in Young Children: Effects on Cognition, Avoidance Behavior, Anxiety Vulnerability, and Physiological Responding Type de document : Texte imprimé et/ou numérique Auteurs : Kathryn J. LESTER, Auteur ; Andy P. FIELD, Auteur ; Peter MURIS, Auteur Année de publication : 2011 Article en page(s) : p.864-877 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated the effects of experimentally modifying interpretation biases for children's cognitions, avoidance behavior, anxiety vulnerability, and physiological responding. Sixty-seven children (6–11 years) were randomly assigned to receive a positive or negative interpretation bias modification procedure to induce interpretation biases toward or away from threat about ambiguous situations involving Australian marsupials. Children rapidly learned to select outcomes of ambiguous situations, which were congruent with their assigned condition. Furthermore, following positive modification, children's threat biases about novel ambiguous situations significantly decreased, whereas threat biases significantly increased after negative modification. In response to a stress-evoking behavioral avoidance test, positive modification attenuated behavioral avoidance compared to negative modification. However, no significant effects of bias modification on anxiety vulnerability or physiological responses to this stress-evoking Behavioral Avoidance Task were observed. En ligne : http://dx.doi.org/10.1080/15374416.2011.618449 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Experimental Modification of Interpretation Bias about Animal Fear in Young Children: Effects on Cognition, Avoidance Behavior, Anxiety Vulnerability, and Physiological Responding [Texte imprimé et/ou numérique] / Kathryn J. LESTER, Auteur ; Andy P. FIELD, Auteur ; Peter MURIS, Auteur . - 2011 . - p.864-877. Langues : Anglais (eng) in Journal of Clinical Child & Adolescent Psychology > 40-6 (November-December 2011) . - p.864-877 Index. décimale : PER Périodiques Résumé : This study investigated the effects of experimentally modifying interpretation biases for children's cognitions, avoidance behavior, anxiety vulnerability, and physiological responding. Sixty-seven children (6–11 years) were randomly assigned to receive a positive or negative interpretation bias modification procedure to induce interpretation biases toward or away from threat about ambiguous situations involving Australian marsupials. Children rapidly learned to select outcomes of ambiguous situations, which were congruent with their assigned condition. Furthermore, following positive modification, children's threat biases about novel ambiguous situations significantly decreased, whereas threat biases significantly increased after negative modification. In response to a stress-evoking behavioral avoidance test, positive modification attenuated behavioral avoidance compared to negative modification. However, no significant effects of bias modification on anxiety vulnerability or physiological responses to this stress-evoking Behavioral Avoidance Task were observed. En ligne : http://dx.doi.org/10.1080/15374416.2011.618449 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

Patterns of sub-optimal change following CBT for childhood anxiety / Lizél-Antoinette BERTIE in Journal of Child Psychology and Psychiatry, 65-12 (December 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-12 (December 2024) . - p.1612-1623 Titre : Patterns of sub-optimal change following CBT for childhood anxiety Type de document : Texte imprimé et/ou numérique Auteurs : Lizél-Antoinette BERTIE, Auteur ; Kristian ARENDT, Auteur ; Jonathan R. I. COLEMAN, Auteur ; Peter COOPER, Auteur ; Cathy CRESWELL, Auteur ; Thalia C. ELEY, Auteur ; Catharina HARTMAN, Auteur ; Einar R. HEIERVANG, Auteur ; Tina IN-ALBON, Auteur ; Karen KRAUSE, Auteur ; Kathryn J. LESTER, Auteur ; Carla E. MARIN, Auteur ; Maaike NAUTA, Auteur ; Ronald M. RAPEE, Auteur ; Silvia SCHNEIDER, Auteur ; Carolyn SCHNIERING, Auteur ; Wendy K. SILVERMAN, Auteur ; Mikael THASTUM, Auteur ; Kerstin THIRLWALL, Auteur ; Polly WAITE, Auteur ; Gro Janne WERGELAND, Auteur ; Jennifer L. HUDSON, Auteur Article en page(s) : p.1612-1623 Langues : Anglais (eng) Mots-clés : Anxiety  childhood  cognitive behavioural therapy  sub-optimal response  response patterns Index. décimale : PER Périodiques Résumé : Background Children and adolescents demonstrate diverse patterns of symptom change and disorder remission following cognitive behavioural therapy (CBT) for anxiety disorders. To better understand children who respond sub-optimally to CBT, this study investigated youths (N?=?1,483) who continued to meet criteria for one or more clinical anxiety diagnosis immediately following treatment or at any point during the 12?months following treatment. Methods Data were collected from 10 clinical sites with assessments at pre-and post-treatment and at least once more at 3, 6 or 12-month follow-up. Participants were assigned to one of three groups based on diagnostic status for youths who: (a) retained an anxiety diagnosis from post to end point (minimal responders); (b) remitted anxiety diagnoses at post but relapsed by end point (relapsed responders); and (c) retained a diagnosis at post but remitted to be diagnosis free at end point (delayed responders). Growth curve models assessed patterns of change over time for the three groups and examined predictors associated with these patterns including demographic, clinical and parental factors, as well as treatment factors. Results Higher primary disorder severity, being older, having a greater number of anxiety disorders, having social anxiety disorder, as well as higher maternal psychopathology differentiated the minimal responders from the delayed and relapsed responders at the baseline. Results from the growth curve models showed that severity of the primary disorder and treatment modality differentiated patterns of linear change only. Higher severity was associated with significantly less improvement over time for the minimal and relapsed response groups, as was receiving group CBT, when compared to the delayed response group. Conclusions Sub-optimal response patterns can be partially differentiated using variables assessed at pre-treatment. Increased understanding of different patterns of change following treatment may provide direction for clinical decision-making and for tailoring treatments to specific groups of clinically anxious youth. Future research may benefit from assessing progress during treatment to detect emerging response patterns earlier. En ligne : https://doi.org/10.1111/jcpp.14009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542 [article] Patterns of sub-optimal change following CBT for childhood anxiety [Texte imprimé et/ou numérique] / Lizél-Antoinette BERTIE, Auteur ; Kristian ARENDT, Auteur ; Jonathan R. I. COLEMAN, Auteur ; Peter COOPER, Auteur ; Cathy CRESWELL, Auteur ; Thalia C. ELEY, Auteur ; Catharina HARTMAN, Auteur ; Einar R. HEIERVANG, Auteur ; Tina IN-ALBON, Auteur ; Karen KRAUSE, Auteur ; Kathryn J. LESTER, Auteur ; Carla E. MARIN, Auteur ; Maaike NAUTA, Auteur ; Ronald M. RAPEE, Auteur ; Silvia SCHNEIDER, Auteur ; Carolyn SCHNIERING, Auteur ; Wendy K. SILVERMAN, Auteur ; Mikael THASTUM, Auteur ; Kerstin THIRLWALL, Auteur ; Polly WAITE, Auteur ; Gro Janne WERGELAND, Auteur ; Jennifer L. HUDSON, Auteur . - p.1612-1623. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-12 (December 2024) . - p.1612-1623 Mots-clés : Anxiety  childhood  cognitive behavioural therapy  sub-optimal response  response patterns Index. décimale : PER Périodiques Résumé : Background Children and adolescents demonstrate diverse patterns of symptom change and disorder remission following cognitive behavioural therapy (CBT) for anxiety disorders. To better understand children who respond sub-optimally to CBT, this study investigated youths (N?=?1,483) who continued to meet criteria for one or more clinical anxiety diagnosis immediately following treatment or at any point during the 12?months following treatment. Methods Data were collected from 10 clinical sites with assessments at pre-and post-treatment and at least once more at 3, 6 or 12-month follow-up. Participants were assigned to one of three groups based on diagnostic status for youths who: (a) retained an anxiety diagnosis from post to end point (minimal responders); (b) remitted anxiety diagnoses at post but relapsed by end point (relapsed responders); and (c) retained a diagnosis at post but remitted to be diagnosis free at end point (delayed responders). Growth curve models assessed patterns of change over time for the three groups and examined predictors associated with these patterns including demographic, clinical and parental factors, as well as treatment factors. Results Higher primary disorder severity, being older, having a greater number of anxiety disorders, having social anxiety disorder, as well as higher maternal psychopathology differentiated the minimal responders from the delayed and relapsed responders at the baseline. Results from the growth curve models showed that severity of the primary disorder and treatment modality differentiated patterns of linear change only. Higher severity was associated with significantly less improvement over time for the minimal and relapsed response groups, as was receiving group CBT, when compared to the delayed response group. Conclusions Sub-optimal response patterns can be partially differentiated using variables assessed at pre-treatment. Increased understanding of different patterns of change following treatment may provide direction for clinical decision-making and for tailoring treatments to specific groups of clinically anxious youth. Future research may benefit from assessing progress during treatment to detect emerging response patterns earlier. En ligne : https://doi.org/10.1111/jcpp.14009 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=542

Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information / Jennifer L. HUDSON in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1086-1094 Titre : Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer L. HUDSON, Auteur ; Kathryn J. LESTER, Auteur ; Cathryn M. LEWIS, Auteur ; Maria TROPEANO, Auteur ; Cathy CRESWELL, Auteur ; David A. COLLIER, Auteur ; Peter J. COOPER, Auteur ; Heidi J. LYNEHAM, Auteur ; Talia MORRIS, Auteur ; Ronald M. RAPEE, Auteur ; Susanna ROBERTS, Auteur ; Jennifer A. DONALD, Auteur ; Thalia C. ELEY, Auteur Article en page(s) : p.1086-1094 Langues : Anglais (eng) Mots-clés : CBT  G × E  anxiety disorders  child anxiety disorders Index. décimale : PER Périodiques Résumé : Background Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. The aim of this study was to explore one potential means of extending the translational reach of G × E data in a way that may be clinically informative. We describe a ‘risk-index’ approach combining genetic, demographic and clinical data and test its ability to predict diagnostic outcome following CBT in anxious children. Method DNA and clinical data were collected from 384 children with a primary anxiety disorder undergoing CBT. We tested our risk model in five cross-validation training sets. Results In predicting treatment outcome, six variables had a minimum mean beta value of 0.5:5HTTLPR, NGF rs6330, gender, primary anxiety severity, comorbid mood disorder and comorbid externalising disorder. A risk index (range 0–8) constructed from these variables had moderate a predictive ability (AUC = .62–.69) in this study. Children scoring high on this index (5–8) were approximately three times as likely to retain their primary anxiety disorder at follow-up as compared with those children scoring 2 or less. Conclusion Significant genetic, demographic and clinical predictors of outcome following CBT for anxiety-disordered children were identified. Combining these predictors within a risk index could be used to identify which children are less likely to be diagnosis-free following CBT alone and require longer or enhanced treatment. The ‘risk-index’ approach represents one means of harnessing the translational potential of G × E data. En ligne : http://dx.doi.org/10.1111/jcpp.12092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information [Texte imprimé et/ou numérique] / Jennifer L. HUDSON, Auteur ; Kathryn J. LESTER, Auteur ; Cathryn M. LEWIS, Auteur ; Maria TROPEANO, Auteur ; Cathy CRESWELL, Auteur ; David A. COLLIER, Auteur ; Peter J. COOPER, Auteur ; Heidi J. LYNEHAM, Auteur ; Talia MORRIS, Auteur ; Ronald M. RAPEE, Auteur ; Susanna ROBERTS, Auteur ; Jennifer A. DONALD, Auteur ; Thalia C. ELEY, Auteur . - p.1086-1094. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1086-1094 Mots-clés : CBT  G × E  anxiety disorders  child anxiety disorders Index. décimale : PER Périodiques Résumé : Background Within a therapeutic gene by environment (G × E) framework, we recently demonstrated that variation in the Serotonin Transporter Promoter Polymorphism; 5HTTLPR and marker rs6330 in Nerve Growth Factor gene; NGF is associated with poorer outcomes following cognitive behaviour therapy (CBT) for child anxiety disorders. The aim of this study was to explore one potential means of extending the translational reach of G × E data in a way that may be clinically informative. We describe a ‘risk-index’ approach combining genetic, demographic and clinical data and test its ability to predict diagnostic outcome following CBT in anxious children. Method DNA and clinical data were collected from 384 children with a primary anxiety disorder undergoing CBT. We tested our risk model in five cross-validation training sets. Results In predicting treatment outcome, six variables had a minimum mean beta value of 0.5:5HTTLPR, NGF rs6330, gender, primary anxiety severity, comorbid mood disorder and comorbid externalising disorder. A risk index (range 0–8) constructed from these variables had moderate a predictive ability (AUC = .62–.69) in this study. Children scoring high on this index (5–8) were approximately three times as likely to retain their primary anxiety disorder at follow-up as compared with those children scoring 2 or less. Conclusion Significant genetic, demographic and clinical predictors of outcome following CBT for anxiety-disordered children were identified. Combining these predictors within a risk index could be used to identify which children are less likely to be diagnosis-free following CBT alone and require longer or enhanced treatment. The ‘risk-index’ approach represents one means of harnessing the translational potential of G × E data. En ligne : http://dx.doi.org/10.1111/jcpp.12092 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

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