Alpha oscillatory activity during attentional control in children with Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), and ASD+ADHD / Roser CAÑIGUERAL in Journal of Child Psychology and Psychiatry, 63-7 (July 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.745-761 Titre : Alpha oscillatory activity during attentional control in children with Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), and ASD+ADHD Type de document : texte imprimé Auteurs : Roser CAÑIGUERAL, Auteur ; Jason PALMER, Auteur ; Karen L. ASHWOOD, Auteur ; Bahare AZADI, Auteur ; Philip ASHERSON, Auteur ; Patrick BOLTON, Auteur ; Gráinne MCLOUGHLIN, Auteur ; Charlotte TYE, Auteur Article en page(s) : p.745-761 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/diagnosis  Autism Spectrum Disorder/diagnosis  Child  Executive Function/physiology  Humans  Reaction Time/physiology  Adhd  Autism Spectrum Disorder  attention  comorbidity Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) share impairments in top-down and bottom-up modulation of attention. However, it is not yet well understood if co-occurrence of ASD and ADHD reflects a distinct or additive profile of attention deficits. We aimed to characterise alpha oscillatory activity (stimulus-locked alpha desynchronisation and prestimulus alpha) as an index of integration of top-down and bottom-up attentional processes in ASD and ADHD. METHODS: Children with ASD, ADHD, comorbid ASD+ADHD, and typically-developing children completed a fixed-choice reaction-time task ('Fast task') while neurophysiological activity was recorded. Outcome measures were derived from source-decomposed neurophysiological data. Main measures of interest were prestimulus alpha power and alpha desynchronisation (difference between poststimulus and prestimulus alpha). Poststimulus activity linked to attention allocation (P1, P3), attentional control (N2), and cognitive control (theta synchronisation, 100-600 ms) was also examined. ANOVA was used to test differences across diagnostics groups on these measures. Spearman's correlations were used to investigate the relationship between attentional control processes (alpha oscillations), central executive functions (theta synchronisation), early visual processing (P1), and behavioural performance. RESULTS: Children with ADHD (ADHD and ASD+ADHD) showed attenuated alpha desynchronisation, indicating poor integration of top-down and bottom-up attentional processes. Children with ADHD showed reduced N2 and P3 amplitudes, while children with ASD (ASD and ASD+ADHD) showed greater N2 amplitude, indicating atypical attentional control and attention allocation across ASD and ADHD. In the ASD group, prestimulus alpha and theta synchronisation were negatively correlated, and alpha desynchronisation and theta synchronisation were positively correlated, suggesting an atypical association between attentional control processes and executive functions. CONCLUSIONS: ASD and ADHD are associated with disorder-specific impairments, while children with ASD+ADHD overall presented an additive profile with attentional deficits of both disorders. Importantly, these findings may inform the improvement of transdiagnostic procedures and optimisation of personalised intervention approaches. En ligne : http://dx.doi.org/10.1111/jcpp.13514 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Alpha oscillatory activity during attentional control in children with Autism Spectrum Disorder (ASD), Attention-Deficit/Hyperactivity Disorder (ADHD), and ASD+ADHD [texte imprimé] / Roser CAÑIGUERAL, Auteur ; Jason PALMER, Auteur ; Karen L. ASHWOOD, Auteur ; Bahare AZADI, Auteur ; Philip ASHERSON, Auteur ; Patrick BOLTON, Auteur ; Gráinne MCLOUGHLIN, Auteur ; Charlotte TYE, Auteur . - p.745-761. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-7 (July 2022) . - p.745-761 Mots-clés : Attention Deficit Disorder with Hyperactivity/diagnosis  Autism Spectrum Disorder/diagnosis  Child  Executive Function/physiology  Humans  Reaction Time/physiology  Adhd  Autism Spectrum Disorder  attention  comorbidity Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) share impairments in top-down and bottom-up modulation of attention. However, it is not yet well understood if co-occurrence of ASD and ADHD reflects a distinct or additive profile of attention deficits. We aimed to characterise alpha oscillatory activity (stimulus-locked alpha desynchronisation and prestimulus alpha) as an index of integration of top-down and bottom-up attentional processes in ASD and ADHD. METHODS: Children with ASD, ADHD, comorbid ASD+ADHD, and typically-developing children completed a fixed-choice reaction-time task ('Fast task') while neurophysiological activity was recorded. Outcome measures were derived from source-decomposed neurophysiological data. Main measures of interest were prestimulus alpha power and alpha desynchronisation (difference between poststimulus and prestimulus alpha). Poststimulus activity linked to attention allocation (P1, P3), attentional control (N2), and cognitive control (theta synchronisation, 100-600 ms) was also examined. ANOVA was used to test differences across diagnostics groups on these measures. Spearman's correlations were used to investigate the relationship between attentional control processes (alpha oscillations), central executive functions (theta synchronisation), early visual processing (P1), and behavioural performance. RESULTS: Children with ADHD (ADHD and ASD+ADHD) showed attenuated alpha desynchronisation, indicating poor integration of top-down and bottom-up attentional processes. Children with ADHD showed reduced N2 and P3 amplitudes, while children with ASD (ASD and ASD+ADHD) showed greater N2 amplitude, indicating atypical attentional control and attention allocation across ASD and ADHD. In the ASD group, prestimulus alpha and theta synchronisation were negatively correlated, and alpha desynchronisation and theta synchronisation were positively correlated, suggesting an atypical association between attentional control processes and executive functions. CONCLUSIONS: ASD and ADHD are associated with disorder-specific impairments, while children with ASD+ADHD overall presented an additive profile with attentional deficits of both disorders. Importantly, these findings may inform the improvement of transdiagnostic procedures and optimisation of personalised intervention approaches. En ligne : http://dx.doi.org/10.1111/jcpp.13514 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex / Charlotte TYE in Journal of Neurodevelopmental Disorders, 7-1 (December 2015)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.33 Titre : Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex Type de document : texte imprimé Auteurs : Charlotte TYE, Auteur ; Teresa FARRONI, Auteur ; Ágnes VOLEIN, Auteur ; Evelyne MERCURE, Auteur ; Leslie TUCKER, Auteur ; Mark Henry JOHNSON, Auteur ; Patrick BOLTON, Auteur Article en page(s) : p.33 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Erp  Face  Gaze  Tuberous sclerosis complex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a common and highly heritable neurodevelopmental disorder that is likely to be the outcome of complex aetiological mechanisms. One strategy to provide insight is to study ASD within tuberous sclerosis complex (TSC), a rare disorder with a high incidence of ASD, but for which the genetic cause is determined. Individuals with ASD consistently demonstrate face processing impairments, but these have not been examined in adults with TSC using event-related potentials (ERPs) that are able to capture distinct temporal stages of processing. METHODS: For adults with TSC (n = 14), 6 of which had a diagnosis of ASD, and control adults (n = 13) passively viewed upright and inverted human faces with direct or averted gaze, with concurrent EEG recording. Amplitude and latency of the P1 and N170 ERPs were measured. RESULTS: Individuals with TSC + ASD exhibited longer N170 latencies to faces compared to typical adults. Typical adults and adults with TSC-only exhibited longer N170 latency to inverted versus upright faces, whereas individuals with TSC + ASD did not show latency differences according to face orientation. In addition, individuals with TSC + ASD showed increased N170 latency to averted compared to direct gaze, which was not demonstrated in typical adults. A reduced lateralization was shown for the TSC + ASD groups on P1 and N170 amplitude. CONCLUSIONS: The findings suggest that individuals with TSC + ASD may have similar electrophysiological abnormalities to idiopathic ASD and are suggestive of developmental delay. Identifying brain-based markers of ASD that are similar in TSC and idiopathic cases is likely to help elucidate the risk pathways to ASD. En ligne : http://dx.doi.org/10.1186/s11689-015-9129-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348 [article] Autism diagnosis differentiates neurophysiological responses to faces in adults with tuberous sclerosis complex [texte imprimé] / Charlotte TYE, Auteur ; Teresa FARRONI, Auteur ; Ágnes VOLEIN, Auteur ; Evelyne MERCURE, Auteur ; Leslie TUCKER, Auteur ; Mark Henry JOHNSON, Auteur ; Patrick BOLTON, Auteur . - p.33. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 7-1 (December 2015) . - p.33 Mots-clés : Autism spectrum disorder  Erp  Face  Gaze  Tuberous sclerosis complex Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is a common and highly heritable neurodevelopmental disorder that is likely to be the outcome of complex aetiological mechanisms. One strategy to provide insight is to study ASD within tuberous sclerosis complex (TSC), a rare disorder with a high incidence of ASD, but for which the genetic cause is determined. Individuals with ASD consistently demonstrate face processing impairments, but these have not been examined in adults with TSC using event-related potentials (ERPs) that are able to capture distinct temporal stages of processing. METHODS: For adults with TSC (n = 14), 6 of which had a diagnosis of ASD, and control adults (n = 13) passively viewed upright and inverted human faces with direct or averted gaze, with concurrent EEG recording. Amplitude and latency of the P1 and N170 ERPs were measured. RESULTS: Individuals with TSC + ASD exhibited longer N170 latencies to faces compared to typical adults. Typical adults and adults with TSC-only exhibited longer N170 latency to inverted versus upright faces, whereas individuals with TSC + ASD did not show latency differences according to face orientation. In addition, individuals with TSC + ASD showed increased N170 latency to averted compared to direct gaze, which was not demonstrated in typical adults. A reduced lateralization was shown for the TSC + ASD groups on P1 and N170 amplitude. CONCLUSIONS: The findings suggest that individuals with TSC + ASD may have similar electrophysiological abnormalities to idiopathic ASD and are suggestive of developmental delay. Identifying brain-based markers of ASD that are similar in TSC and idiopathic cases is likely to help elucidate the risk pathways to ASD. En ligne : http://dx.doi.org/10.1186/s11689-015-9129-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=348

Brief Report: Adaptive Functioning in Children with ASD, ADHD and ASD + ADHD / Karen L. ASHWOOD in Journal of Autism and Developmental Disorders, 45-7 (July 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2235-2242 Titre : Brief Report: Adaptive Functioning in Children with ASD, ADHD and ASD + ADHD Type de document : texte imprimé Auteurs : Karen L. ASHWOOD, Auteur ; Charlotte TYE, Auteur ; Bahare AZADI, Auteur ; Sally CARTWRIGHT, Auteur ; Philip ASHERSON, Auteur ; Patrick BOLTON, Auteur Année de publication : 2015 Article en page(s) : p.2235-2242 Langues : Anglais (eng) Mots-clés : Adaptive behaviour  Vineland  Autism  ADHD  Comorbidity Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often co-occur. Children with ASD and ADHD demonstrate deficits in adaptive functioning, yet pure and comorbid groups have not been directly compared. Vineland Adaptive Behaviour Scales (VABS-II) data were examined in boys with ASD (n = 17), ADHD (n = 31) and ASD + ADHD (n = 38). Results demonstrated lower socialisation and composite scores and greater discrepancy between cognitive and adaptive abilities in the ASD + ADHD group compared to the ADHD-only group. Significant associations were shown between reduced adaptive functioning and autism symptoms, but not ADHD symptoms. Children with ASD + ADHD present with exacerbated impairments in adaptive functioning relative to children with ADHD, associated with ASD symptoms. Disentangling variation in adaptive skills may aid the assessment of complex cases. En ligne : http://dx.doi.org/10.1007/s10803-014-2352-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261 [article] Brief Report: Adaptive Functioning in Children with ASD, ADHD and ASD + ADHD [texte imprimé] / Karen L. ASHWOOD, Auteur ; Charlotte TYE, Auteur ; Bahare AZADI, Auteur ; Sally CARTWRIGHT, Auteur ; Philip ASHERSON, Auteur ; Patrick BOLTON, Auteur . - 2015 . - p.2235-2242. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-7 (July 2015) . - p.2235-2242 Mots-clés : Adaptive behaviour  Vineland  Autism  ADHD  Comorbidity Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often co-occur. Children with ASD and ADHD demonstrate deficits in adaptive functioning, yet pure and comorbid groups have not been directly compared. Vineland Adaptive Behaviour Scales (VABS-II) data were examined in boys with ASD (n = 17), ADHD (n = 31) and ASD + ADHD (n = 38). Results demonstrated lower socialisation and composite scores and greater discrepancy between cognitive and adaptive abilities in the ASD + ADHD group compared to the ADHD-only group. Significant associations were shown between reduced adaptive functioning and autism symptoms, but not ADHD symptoms. Children with ASD + ADHD present with exacerbated impairments in adaptive functioning relative to children with ADHD, associated with ASD symptoms. Disentangling variation in adaptive skills may aid the assessment of complex cases. En ligne : http://dx.doi.org/10.1007/s10803-014-2352-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=261

Face processing in infants at elevated likelihood for autism: A systematic review and meta-analysis / Kloe FICO in Research in Autism, 133 (May 2026)  

Public ISBD [article]  inResearch in Autism > 133 (May 2026) . - p.202874 Titre : Face processing in infants at elevated likelihood for autism: A systematic review and meta-analysis Type de document : texte imprimé Auteurs : Kloe FICO, Auteur ; Manon A. KROL, Auteur ; Giorgia BUSSU, Auteur ; Corentin J. GOSLING, Auteur ; Charlotte TYE, Auteur ; Sabine HUNNIUS, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : p.202874 Langues : Anglais (eng) Mots-clés : Autism spectrum condition (ASC)  Infant face processing  EEG  N290 latency  P400 amplitude  Early brain development  Meta-analysis Index. décimale : PER Périodiques Résumé : Face processing has been reported to be atypical in Autism Spectrum Condition (ASC). The latency of the N170 event-related potential component in response to faces has been reported to be slower in children and adults with ASC compared to age-matched controls. To explore whether atypical face processing is evident earlier in development, we focused on the developmental precursor of the N170: the N290/P400 complex. We conducted a systematic review and meta-analysis of studies examining infants aged 6–24 months at elevated likelihood (EL) versus average likelihood (AL) for ASC. Using a random-effects multi-level model, we investigated differences in N290, P400 and Nc latency and amplitude in response to face stimuli between EL and AL infants, and whether these differences were associated with ASC outcomes at age 3. Fourteen studies (405 EL, 323 AL) met the inclusion criteria. EL infants showed no significant differences in N290, P400 and Nc latency or amplitude compared to AL infants. However, EL infants who later received an ASC diagnosis showed slightly longer N290 latency (g=0.13, 95% CI [0.00, 0.26]) and smaller P400 amplitudes (g=-0.23, 95% CI [-0.28,-0.19]). These findings show that subtle differences in face processing may already be present in EL infants who will develop ASC later in life, providing evidence of early atypical face processing in this group. En ligne : https://doi.org/10.1016/j.reia.2026.202874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585 [article] Face processing in infants at elevated likelihood for autism: A systematic review and meta-analysis [texte imprimé] / Kloe FICO, Auteur ; Manon A. KROL, Auteur ; Giorgia BUSSU, Auteur ; Corentin J. GOSLING, Auteur ; Charlotte TYE, Auteur ; Sabine HUNNIUS, Auteur ; Jan K. BUITELAAR, Auteur . - p.202874. Langues : Anglais (eng) in Research in Autism > 133 (May 2026) . - p.202874 Mots-clés : Autism spectrum condition (ASC)  Infant face processing  EEG  N290 latency  P400 amplitude  Early brain development  Meta-analysis Index. décimale : PER Périodiques Résumé : Face processing has been reported to be atypical in Autism Spectrum Condition (ASC). The latency of the N170 event-related potential component in response to faces has been reported to be slower in children and adults with ASC compared to age-matched controls. To explore whether atypical face processing is evident earlier in development, we focused on the developmental precursor of the N170: the N290/P400 complex. We conducted a systematic review and meta-analysis of studies examining infants aged 6–24 months at elevated likelihood (EL) versus average likelihood (AL) for ASC. Using a random-effects multi-level model, we investigated differences in N290, P400 and Nc latency and amplitude in response to face stimuli between EL and AL infants, and whether these differences were associated with ASC outcomes at age 3. Fourteen studies (405 EL, 323 AL) met the inclusion criteria. EL infants showed no significant differences in N290, P400 and Nc latency or amplitude compared to AL infants. However, EL infants who later received an ASC diagnosis showed slightly longer N290 latency (g=0.13, 95% CI [0.00, 0.26]) and smaller P400 amplitudes (g=-0.23, 95% CI [-0.28,-0.19]). These findings show that subtle differences in face processing may already be present in EL infants who will develop ASC later in life, providing evidence of early atypical face processing in this group. En ligne : https://doi.org/10.1016/j.reia.2026.202874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=585

Is quality of life related to high autistic traits, high ADHD traits and their Interaction? Evidence from a Young-Adult Community-Based twin sample / Simone J. CAPP in Journal of Autism and Developmental Disorders, 53-9 (September 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3493-3508 Titre : Is quality of life related to high autistic traits, high ADHD traits and their Interaction? Evidence from a Young-Adult Community-Based twin sample Type de document : texte imprimé Auteurs : Simone J. CAPP, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Alex LAU-ZHU, Auteur ; Emma COLVERT, Auteur ; Charlotte TYE, Auteur ; Ümit AYDIN, Auteur ; Alexandra LAUTARESCU, Auteur ; Claire ELLIS, Auteur ; Tyler SAUNDERS, Auteur ; Lucy O'BRIEN, Auteur ; Angelica RONALD, Auteur ; Francesca HAPPE, Auteur ; Gráinne MCLOUGHLIN, Auteur Article en page(s) : p.3493-3508 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study explored whether high autistic traits, high attention deficit hyperactivity disorder (ADHD) traits and their interaction were associated with quality of life (QoL) in a sample of 556 of young-adult twins (Mean age 22 years 5 months, 52% Female). Four participant groups were created: high autistic traits, high ADHD traits, high autistic/ADHD traits, and low ADHD/autistic traits. High autistic traits were associated with lower QoL across domains (physical, psychological, social, and environmental). High ADHD traits associated with lower physical, psychological, and environmental QoL. The interaction of autistic and ADHD traits was not significant in any domain. While mental health difficulties were associated with lower QoL, after accounting for mental health, most relationships between autistic traits, ADHD traits and QoL remained. En ligne : https://doi.org/10.1007/s10803-022-05640-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Is quality of life related to high autistic traits, high ADHD traits and their Interaction? Evidence from a Young-Adult Community-Based twin sample [texte imprimé] / Simone J. CAPP, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Alex LAU-ZHU, Auteur ; Emma COLVERT, Auteur ; Charlotte TYE, Auteur ; Ümit AYDIN, Auteur ; Alexandra LAUTARESCU, Auteur ; Claire ELLIS, Auteur ; Tyler SAUNDERS, Auteur ; Lucy O'BRIEN, Auteur ; Angelica RONALD, Auteur ; Francesca HAPPE, Auteur ; Gráinne MCLOUGHLIN, Auteur . - p.3493-3508. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3493-3508 Index. décimale : PER Périodiques Résumé : This study explored whether high autistic traits, high attention deficit hyperactivity disorder (ADHD) traits and their interaction were associated with quality of life (QoL) in a sample of 556 of young-adult twins (Mean age 22 years 5 months, 52% Female). Four participant groups were created: high autistic traits, high ADHD traits, high autistic/ADHD traits, and low ADHD/autistic traits. High autistic traits were associated with lower QoL across domains (physical, psychological, social, and environmental). High ADHD traits associated with lower physical, psychological, and environmental QoL. The interaction of autistic and ADHD traits was not significant in any domain. While mental health difficulties were associated with lower QoL, after accounting for mental health, most relationships between autistic traits, ADHD traits and QoL remained. En ligne : https://doi.org/10.1007/s10803-022-05640-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Response time variability under slow and fast-incentive conditions in children with ASD, ADHD and ASD+ADHD / Charlotte TYE in Journal of Child Psychology and Psychiatry, 57-12 (December 2016)  

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Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD / Elizabeth SHEPHARD in Journal of Autism and Developmental Disorders, 48-1 (January 2018)  

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Shared genetic influences on ADHD symptoms and very low-frequency EEG activity: a twin study / Charlotte TYE in Journal of Child Psychology and Psychiatry, 53-6 (June 2012)  

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