Annual Research Review: Does late-onset attention-deficit/hyperactivity disorder exist? / Philip ASHERSON in Journal of Child Psychology and Psychiatry, 60-4 (April 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-4 (April 2019) . - p.333-352 Titre : Annual Research Review: Does late-onset attention-deficit/hyperactivity disorder exist? Type de document : Texte imprimé et/ou numérique Auteurs : Philip ASHERSON, Auteur ; Jessica AGNEW-BLAIS, Auteur Article en page(s) : p.333-352 Langues : Anglais (eng) Mots-clés : Adhd  developmental epidemiology  developmental psychopathology  longitudinal studies Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) is conceptualized as an early onset childhood neurodevelopmental disorder. Prevalence in adults is around two-thirds that in childhood, yet longitudinal outcome studies of children with ADHD found a minority continue to meet full criteria in adulthood. This suggests that not all adult cases meet ADHD criteria as children, a conclusion supported by earlier studies relying on retrospective recall in adolescent and adult samples. More recently prospective follow-up of population and control samples suggest that adolescent and young adult ADHD is not always a continuation of childhood ADHD. Here, we review the literature on age of onset, to explore whether late-onset ADHD exists, and if so, examine the evidence for whether this should be considered the same or a different disorder as childhood onset ADHD. We conclude that current evidence supports the view that a significant proportion of young adults meeting criteria for ADHD would not have met full diagnostic criteria for ADHD as children. However, many in the late-onset group show some ADHD symptoms in childhood, or an externalizing disorder such as oppositional defiant disorder. Furthermore, the current studies suggest that most (but not all) cases of late-onset ADHD develop the disorder between the ages of 12-16 and can therefore be considered adolescent or early adult onset ADHD. There is a relative lack of data spanning young to older adulthood to address the question of adult-onset. Currently, there is insufficient data to clarify the extent to which early and late onset ADHD reflect a different balance of genetic and environmental risks or share the same underlying neural mechanisms. Clinicians should be aware that significantly impairing forms of ADHD can emerge beyond the age of 12 years, although perhaps rarely in the context of a complete absence of precursors. The current evidence on treatment responses is limited. En ligne : https://dx.doi.org/10.1111/jcpp.13020 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Annual Research Review: Does late-onset attention-deficit/hyperactivity disorder exist? [Texte imprimé et/ou numérique] / Philip ASHERSON, Auteur ; Jessica AGNEW-BLAIS, Auteur . - p.333-352. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-4 (April 2019) . - p.333-352 Mots-clés : Adhd  developmental epidemiology  developmental psychopathology  longitudinal studies Index. décimale : PER Périodiques Résumé : Attention-deficit/hyperactivity disorder (ADHD) is conceptualized as an early onset childhood neurodevelopmental disorder. Prevalence in adults is around two-thirds that in childhood, yet longitudinal outcome studies of children with ADHD found a minority continue to meet full criteria in adulthood. This suggests that not all adult cases meet ADHD criteria as children, a conclusion supported by earlier studies relying on retrospective recall in adolescent and adult samples. More recently prospective follow-up of population and control samples suggest that adolescent and young adult ADHD is not always a continuation of childhood ADHD. Here, we review the literature on age of onset, to explore whether late-onset ADHD exists, and if so, examine the evidence for whether this should be considered the same or a different disorder as childhood onset ADHD. We conclude that current evidence supports the view that a significant proportion of young adults meeting criteria for ADHD would not have met full diagnostic criteria for ADHD as children. However, many in the late-onset group show some ADHD symptoms in childhood, or an externalizing disorder such as oppositional defiant disorder. Furthermore, the current studies suggest that most (but not all) cases of late-onset ADHD develop the disorder between the ages of 12-16 and can therefore be considered adolescent or early adult onset ADHD. There is a relative lack of data spanning young to older adulthood to address the question of adult-onset. Currently, there is insufficient data to clarify the extent to which early and late onset ADHD reflect a different balance of genetic and environmental risks or share the same underlying neural mechanisms. Clinicians should be aware that significantly impairing forms of ADHD can emerge beyond the age of 12 years, although perhaps rarely in the context of a complete absence of precursors. The current evidence on treatment responses is limited. En ligne : https://dx.doi.org/10.1111/jcpp.13020 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Associations between ADHD and emotional problems from childhood to young adulthood: a longitudinal genetically sensitive study / Adi STERN in Journal of Child Psychology and Psychiatry, 61-11 (November 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1234-1242 Titre : Associations between ADHD and emotional problems from childhood to young adulthood: a longitudinal genetically sensitive study Type de document : Texte imprimé et/ou numérique Auteurs : Adi STERN, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Andrea DANESE, Auteur ; Helen L. FISHER, Auteur ; Timothy MATTHEWS, Auteur ; Guilherme V. POLANCZYK, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur Article en page(s) : p.1234-1242 Langues : Anglais (eng) Mots-clés : Attention deficit/hyperactivity disorder  anxiety  depression  development  genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is associated with emotional problems, and their co-occurrence often leads to worse outcomes. We investigated the developmental associations between ADHD and emotional problems from childhood to early adolescence and examined the genetic and environmental contributions to their developmental link. We further tested whether this developmental association remained across the transition to young adulthood. METHODS: We used data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a cohort of 2,232 British twins. In childhood, ADHD and emotional problems were assessed at ages 5, 7, 10 and 12 with mothers' and teachers' reports. At age 18, we used self-reported symptoms according to DSM-5 criteria for ADHD, and DSM-IV for anxiety and depression. RESULTS: Longitudinal analyses showed that earlier ADHD was associated with later emotional problems consistently across childhood. However, earlier emotional problems were not associated with later ADHD symptoms. The developmental association between ADHD and later emotional problems in childhood was entirely explained by common genetic factors. Consistent with results in childhood, earlier symptoms of ADHD were associated with later emotional problems during the transition to young adulthood. CONCLUSIONS: Our findings demonstrate that ADHD symptoms are predictors of the development of emotional problems, from childhood up to young adulthood, through shared genetic influences. Interventions targeting ADHD symptoms might prevent the development of emotional problems. Clinicians treating youth with ADHD must be aware of their risk for developing emotional problems and ought to assess, monitor and treat emotional problems alongside ADHD symptoms from childhood to adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Associations between ADHD and emotional problems from childhood to young adulthood: a longitudinal genetically sensitive study [Texte imprimé et/ou numérique] / Adi STERN, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Andrea DANESE, Auteur ; Helen L. FISHER, Auteur ; Timothy MATTHEWS, Auteur ; Guilherme V. POLANCZYK, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur . - p.1234-1242. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-11 (November 2020) . - p.1234-1242 Mots-clés : Attention deficit/hyperactivity disorder  anxiety  depression  development  genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention deficit/hyperactivity disorder (ADHD) is associated with emotional problems, and their co-occurrence often leads to worse outcomes. We investigated the developmental associations between ADHD and emotional problems from childhood to early adolescence and examined the genetic and environmental contributions to their developmental link. We further tested whether this developmental association remained across the transition to young adulthood. METHODS: We used data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a cohort of 2,232 British twins. In childhood, ADHD and emotional problems were assessed at ages 5, 7, 10 and 12 with mothers' and teachers' reports. At age 18, we used self-reported symptoms according to DSM-5 criteria for ADHD, and DSM-IV for anxiety and depression. RESULTS: Longitudinal analyses showed that earlier ADHD was associated with later emotional problems consistently across childhood. However, earlier emotional problems were not associated with later ADHD symptoms. The developmental association between ADHD and later emotional problems in childhood was entirely explained by common genetic factors. Consistent with results in childhood, earlier symptoms of ADHD were associated with later emotional problems during the transition to young adulthood. CONCLUSIONS: Our findings demonstrate that ADHD symptoms are predictors of the development of emotional problems, from childhood up to young adulthood, through shared genetic influences. Interventions targeting ADHD symptoms might prevent the development of emotional problems. Clinicians treating youth with ADHD must be aware of their risk for developing emotional problems and ought to assess, monitor and treat emotional problems alongside ADHD symptoms from childhood to adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Is quality of life related to high autistic traits, high ADHD traits and their Interaction? Evidence from a Young-Adult Community-Based twin sample / Simone J. CAPP in Journal of Autism and Developmental Disorders, 53-9 (September 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3493-3508 Titre : Is quality of life related to high autistic traits, high ADHD traits and their Interaction? Evidence from a Young-Adult Community-Based twin sample Type de document : Texte imprimé et/ou numérique Auteurs : Simone J. CAPP, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Alex LAU-ZHU, Auteur ; Emma COLVERT, Auteur ; Charlotte TYE, Auteur ; Ümit AYDIN, Auteur ; Alexandra LAUTARESCU, Auteur ; Claire ELLIS, Auteur ; Tyler SAUNDERS, Auteur ; Lucy O?BRIEN, Auteur ; Angelica RONALD, Auteur ; Francesca HAPPE, Auteur ; Gráinne MCLOUGHLIN, Auteur Article en page(s) : p.3493-3508 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study explored whether high autistic traits, high attention deficit hyperactivity disorder (ADHD) traits and their interaction were associated with quality of life (QoL) in a sample of 556 of young-adult twins (Mean age 22 years 5 months, 52% Female). Four participant groups were created: high autistic traits, high ADHD traits, high autistic/ADHD traits, and low ADHD/autistic traits. High autistic traits were associated with lower QoL across domains (physical, psychological, social, and environmental). High ADHD traits associated with lower physical, psychological, and environmental QoL. The interaction of autistic and ADHD traits was not significant in any domain. While mental health difficulties were associated with lower QoL, after accounting for mental health, most relationships between autistic traits, ADHD traits and QoL remained. En ligne : https://doi.org/10.1007/s10803-022-05640-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Is quality of life related to high autistic traits, high ADHD traits and their Interaction? Evidence from a Young-Adult Community-Based twin sample [Texte imprimé et/ou numérique] / Simone J. CAPP, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Alex LAU-ZHU, Auteur ; Emma COLVERT, Auteur ; Charlotte TYE, Auteur ; Ümit AYDIN, Auteur ; Alexandra LAUTARESCU, Auteur ; Claire ELLIS, Auteur ; Tyler SAUNDERS, Auteur ; Lucy O?BRIEN, Auteur ; Angelica RONALD, Auteur ; Francesca HAPPE, Auteur ; Gráinne MCLOUGHLIN, Auteur . - p.3493-3508. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3493-3508 Index. décimale : PER Périodiques Résumé : This study explored whether high autistic traits, high attention deficit hyperactivity disorder (ADHD) traits and their interaction were associated with quality of life (QoL) in a sample of 556 of young-adult twins (Mean age 22 years 5 months, 52% Female). Four participant groups were created: high autistic traits, high ADHD traits, high autistic/ADHD traits, and low ADHD/autistic traits. High autistic traits were associated with lower QoL across domains (physical, psychological, social, and environmental). High ADHD traits associated with lower physical, psychological, and environmental QoL. The interaction of autistic and ADHD traits was not significant in any domain. While mental health difficulties were associated with lower QoL, after accounting for mental health, most relationships between autistic traits, ADHD traits and QoL remained. En ligne : https://doi.org/10.1007/s10803-022-05640-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study / Jessica AGNEW-BLAIS in Journal of Child Psychology and Psychiatry, 63-10 (October 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1153-1163 Titre : Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study Type de document : Texte imprimé et/ou numérique Auteurs : Jessica AGNEW-BLAIS, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Andrea DANESE, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Guilherme V. POLANCZYK, Auteur ; Karen SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Terrie E. MOFFITT, Auteur Année de publication : 2022 Article en page(s) : p.1153-1163 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Child  Female  Gene-Environment Interaction  Humans  Mothers  Parents  Risk Factors  Adhd  early life experience  family factors  genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Chaotic home environments may contribute to children's attention-deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. METHODS: Participants were mothers and children from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self-report at age 12. Genome-wide ADHD polygenic risk scores (PRS) were calculated for mothers (n=880) and twins (n=1,999); of these, n=871 mothers and n=1,925 children had information on children's ADHD and household chaos. RESULTS: Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene-environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene-environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. CONCLUSIONS: Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures. En ligne : http://dx.doi.org/10.1111/jcpp.13659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Mother's and children's ADHD genetic risk, household chaos and children's ADHD symptoms: A gene-environment correlation study [Texte imprimé et/ou numérique] / Jessica AGNEW-BLAIS, Auteur ; Jasmin WERTZ, Auteur ; Louise ARSENEAULT, Auteur ; Daniel W. BELSKY, Auteur ; Andrea DANESE, Auteur ; Jean-Baptiste PINGAULT, Auteur ; Guilherme V. POLANCZYK, Auteur ; Karen SUGDEN, Auteur ; Benjamin S. WILLIAMS, Auteur ; Terrie E. MOFFITT, Auteur . - 2022 . - p.1153-1163. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-10 (October 2022) . - p.1153-1163 Mots-clés : Attention Deficit Disorder with Hyperactivity/epidemiology/genetics  Child  Female  Gene-Environment Interaction  Humans  Mothers  Parents  Risk Factors  Adhd  early life experience  family factors  genetics  longitudinal studies Index. décimale : PER Périodiques Résumé : BACKGROUND: Chaotic home environments may contribute to children's attention-deficit hyperactivity disorder (ADHD) symptoms. However, ADHD genetic risk may also influence household chaos. This study investigated whether children in chaotic households had more ADHD symptoms, if mothers and children with higher ADHD genetic risk lived in more chaotic households, and the joint association of genetic risk and household chaos on the longitudinal course of ADHD symptoms across childhood. METHODS: Participants were mothers and children from the Environmental Risk (E-Risk) Longitudinal Twin Study, a UK population-representative birth cohort of 2,232 twins. Children's ADHD symptoms were assessed at ages 5, 7, 10 and 12years. Household chaos was rated by research workers at ages 7, 10 and 12, and by mother's and twin's self-report at age 12. Genome-wide ADHD polygenic risk scores (PRS) were calculated for mothers (n=880) and twins (n=1,999); of these, n=871 mothers and n=1,925 children had information on children's ADHD and household chaos. RESULTS: Children in more chaotic households had higher ADHD symptoms. Mothers and children with higher ADHD PRS lived in more chaotic households. Children's ADHD PRS was associated with household chaos over and above mother's PRS, suggesting evocative gene-environment correlation. Children in more chaotic households had higher baseline ADHD symptoms and a slower rate of decline in symptoms. However, sensitivity analyses estimated that gene-environment correlation accounted for a large proportion of the association of household chaos on ADHD symptoms. CONCLUSIONS: Children's ADHD genetic risk was independently associated with higher levels of household chaos, emphasising the active role of children in shaping their home environment. Our findings suggest that household chaos partly reflects children's genetic risk for ADHD, calling into question whether household chaos directly influences children's core ADHD symptoms. Our findings highlight the importance of considering parent and child genetic risk in relation to apparent environmental exposures. En ligne : http://dx.doi.org/10.1111/jcpp.13659 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Parental monitoring and knowledge: Testing bidirectional associations with youths’ antisocial behavior / Jasmin WERTZ in Development and Psychopathology, 28-3 (August 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-3 (August 2016) . - p.623-638 Titre : Parental monitoring and knowledge: Testing bidirectional associations with youths’ antisocial behavior Type de document : Texte imprimé et/ou numérique Auteurs : Jasmin WERTZ, Auteur ; Kate NOTTINGHAM, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Timothy MATTHEWS, Auteur ; Carmine M. PARIANTE, Auteur ; Terrie E. MOFFITT, Auteur ; Louise ARSENEAULT, Auteur Article en page(s) : p.623-638 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In the present study, we used separate measures of parental monitoring and parental knowledge and compared their associations with youths’ antisocial behavior during preadolescence, between the ages of 10 and 12. Parental monitoring and knowledge were reported by mothers, fathers, and youths taking part in the Environmental Risk (E-Risk) Longitudinal Twin Study that follows 1,116 families with twins. Information on youths’ antisocial behavior was obtained from mothers as well as teachers. We report two main findings. First, longitudinal cross-lagged models revealed that greater parental monitoring did not predict less antisocial behavior later, once family characteristics were taken into account. Second, greater youth antisocial behavior predicted less parental knowledge later. This effect of youths’ behavior on parents’ knowledge was consistent across mothers’, fathers’, youths’, and teachers’ reports, and robust to controls for family confounders. The association was partially genetically mediated according to a Cholesky decomposition twin model; youths’ genetically influenced antisocial behavior led to a decrease in parents’ knowledge of youths’ activities. These two findings question the assumption that greater parental monitoring can reduce preadolescents’ antisocial behavior. They also indicate that parents’ knowledge of their children's activities is influenced by youths’ behavior. En ligne : http://dx.doi.org/10.1017/S0954579416000213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291 [article] Parental monitoring and knowledge: Testing bidirectional associations with youths’ antisocial behavior [Texte imprimé et/ou numérique] / Jasmin WERTZ, Auteur ; Kate NOTTINGHAM, Auteur ; Jessica AGNEW-BLAIS, Auteur ; Timothy MATTHEWS, Auteur ; Carmine M. PARIANTE, Auteur ; Terrie E. MOFFITT, Auteur ; Louise ARSENEAULT, Auteur . - p.623-638. Langues : Anglais (eng) in Development and Psychopathology > 28-3 (August 2016) . - p.623-638 Index. décimale : PER Périodiques Résumé : In the present study, we used separate measures of parental monitoring and parental knowledge and compared their associations with youths’ antisocial behavior during preadolescence, between the ages of 10 and 12. Parental monitoring and knowledge were reported by mothers, fathers, and youths taking part in the Environmental Risk (E-Risk) Longitudinal Twin Study that follows 1,116 families with twins. Information on youths’ antisocial behavior was obtained from mothers as well as teachers. We report two main findings. First, longitudinal cross-lagged models revealed that greater parental monitoring did not predict less antisocial behavior later, once family characteristics were taken into account. Second, greater youth antisocial behavior predicted less parental knowledge later. This effect of youths’ behavior on parents’ knowledge was consistent across mothers’, fathers’, youths’, and teachers’ reports, and robust to controls for family confounders. The association was partially genetically mediated according to a Cholesky decomposition twin model; youths’ genetically influenced antisocial behavior led to a decrease in parents’ knowledge of youths’ activities. These two findings question the assumption that greater parental monitoring can reduce preadolescents’ antisocial behavior. They also indicate that parents’ knowledge of their children's activities is influenced by youths’ behavior. En ligne : http://dx.doi.org/10.1017/S0954579416000213 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=291

Taking stock of the present and looking to the future of ADHD research: a commentary on Sonuga-Barke et al. (2023) / Jessica AGNEW-BLAIS in Journal of Child Psychology and Psychiatry, 64-4 (April 2023)  

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