Dépouillements

Editorial: From risk prediction to action: leveraging electronic health records to improve pediatric population mental health / Scott H KOLLINS in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.113-115 Titre : Editorial: From risk prediction to action: leveraging electronic health records to improve pediatric population mental health Type de document : Texte imprimé et/ou numérique Auteurs : Scott H KOLLINS, Auteur Article en page(s) : p.113-115 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The identification of child, family, and other environmental factors that confer risk for poor developmental outcomes has long been a major theme in child and adolescent psychopathology research. Over the past 6 decades, the Journal of Child Psychology & Psychiatry has seen an exponential increase in articles that have included the search term 'risk prediction', with 17 such works appearing in the 1960s and 930 occurring in the 2010s. Indeed, the current issue of JCPP continues this trend with a number of high-quality studies that in some capacity seek to predict poor child and adolescent outcomes on the basis of variables that can be measured earlier in development. En ligne : http://dx.doi.org/10.1111/jcpp.13199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Editorial: From risk prediction to action: leveraging electronic health records to improve pediatric population mental health [Texte imprimé et/ou numérique] / Scott H KOLLINS, Auteur . - p.113-115. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.113-115 Index. décimale : PER Périodiques Résumé : The identification of child, family, and other environmental factors that confer risk for poor developmental outcomes has long been a major theme in child and adolescent psychopathology research. Over the past 6 decades, the Journal of Child Psychology & Psychiatry has seen an exponential increase in articles that have included the search term 'risk prediction', with 17 such works appearing in the 1960s and 930 occurring in the 2010s. Indeed, the current issue of JCPP continues this trend with a number of high-quality studies that in some capacity seek to predict poor child and adolescent outcomes on the basis of variables that can be measured earlier in development. En ligne : http://dx.doi.org/10.1111/jcpp.13199 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Practitioner Review: Twenty years of research with adverse childhood experience scores - Advantages, disadvantages and applications to practice / Rebecca E. LACEY in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.116-130 Titre : Practitioner Review: Twenty years of research with adverse childhood experience scores - Advantages, disadvantages and applications to practice Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca E. LACEY, Auteur ; Helen MINNIS, Auteur Article en page(s) : p.116-130 Langues : Anglais (eng) Mots-clés : Adversity  child abuse  early life experience  social psychiatry  social work Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse childhood experience (ACE) scores have become a common approach for considering childhood adversities and are highly influential in public policy and clinical practice. Their use is also controversial. Other ways of measuring adversity - examining single adversities, or using theoretically or empirically driven methods - might have advantages over ACE scores. METHODS: In this narrative review we critique the conceptualisation and measurement of ACEs in research, clinical practice, public health and public discourse. RESULTS: The ACE score approach has the advantages - and limitations - of simplicity: its simplicity facilitates wide-ranging applications in public policy, public health and clinical settings but risks over-simplistic communication of risk/causality, determinism and stigma. The other common approach - focussing on single adversities - is also limited because adversities tend to co-occur. Researchers are using rapidly accruing datasets on ACEs to facilitate new theoretical and empirical approaches but this work is at an early stage, e.g. weighting ACEs and including severity, frequency, duration and timing. More research is needed to establish what should be included as an ACE, how individual ACEs should be weighted, how ACEs cluster, and the implications of these findings for clinical work and policy. New ways of conceptualising and measuring ACEs that incorporate this new knowledge, while maintaining some of the simplicity of the current ACE questionnaire, could be helpful for clinicians, practitioners, patients and the public. CONCLUSIONS: Although we welcome the current focus on ACEs, a more critical view of their conceptualisation, measurement, and application to practice settings is urgently needed. En ligne : http://dx.doi.org/10.1111/jcpp.13135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Practitioner Review: Twenty years of research with adverse childhood experience scores - Advantages, disadvantages and applications to practice [Texte imprimé et/ou numérique] / Rebecca E. LACEY, Auteur ; Helen MINNIS, Auteur . - p.116-130. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.116-130 Mots-clés : Adversity  child abuse  early life experience  social psychiatry  social work Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse childhood experience (ACE) scores have become a common approach for considering childhood adversities and are highly influential in public policy and clinical practice. Their use is also controversial. Other ways of measuring adversity - examining single adversities, or using theoretically or empirically driven methods - might have advantages over ACE scores. METHODS: In this narrative review we critique the conceptualisation and measurement of ACEs in research, clinical practice, public health and public discourse. RESULTS: The ACE score approach has the advantages - and limitations - of simplicity: its simplicity facilitates wide-ranging applications in public policy, public health and clinical settings but risks over-simplistic communication of risk/causality, determinism and stigma. The other common approach - focussing on single adversities - is also limited because adversities tend to co-occur. Researchers are using rapidly accruing datasets on ACEs to facilitate new theoretical and empirical approaches but this work is at an early stage, e.g. weighting ACEs and including severity, frequency, duration and timing. More research is needed to establish what should be included as an ACE, how individual ACEs should be weighted, how ACEs cluster, and the implications of these findings for clinical work and policy. New ways of conceptualising and measuring ACEs that incorporate this new knowledge, while maintaining some of the simplicity of the current ACE questionnaire, could be helpful for clinicians, practitioners, patients and the public. CONCLUSIONS: Although we welcome the current focus on ACEs, a more critical view of their conceptualisation, measurement, and application to practice settings is urgently needed. En ligne : http://dx.doi.org/10.1111/jcpp.13135 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Association between preeclampsia and autism spectrum disorder: a population-based study / Gillian M. MAHER in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.131-139 Titre : Association between preeclampsia and autism spectrum disorder: a population-based study Type de document : Texte imprimé et/ou numérique Auteurs : Gillian M. MAHER, Auteur ; Gerard W. O'KEEFFE, Auteur ; Christina DALMAN, Auteur ; Patricia M. KEARNEY, Auteur ; Fergus P. MCCARTHY, Auteur ; Louise C. KENNY, Auteur ; Ali S. KHASHAN, Auteur Article en page(s) : p.131-139 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  epidemiology  preeclampsia Index. décimale : PER Périodiques Résumé : BACKGROUND: The environmental contribution of autism spectrum disorder (ASD) is approximately 17%-50%, highlighting the importance of investigating factors potentially contributing to the likelihood of its development, and of gaining a greater understanding of the pathogenesis surrounding ASD. The objective of this study was to examine the association between preeclampsia and ASD using a population-based cohort study. METHODS: All singleton live births in Sweden from 1982 to 2010 were included, using data from Swedish National Registers. Exposures of interest included: (a) preeclampsia (classified according to ICD-8, ICD-9 and ICD-10) and (b) preeclampsia and small for gestational age (SGA) combined, used as a proxy for preeclampsia with placental dysfunction. ASD status was based on ICD-9 and ICD-10. The cohort consisted of 2,842,230 children, with 54,071 cases of ASD. Follow-up began from the child's first birthday, and data were censored at first diagnosis of ASD, death, migration or end of study period (31st December 2016). We conducted multivariate Cox proportional hazards regression analysis, adjusting for several perinatal and sociodemographic factors, selected a priori. We further controlled for shared genetic and familial confounding using sibling-matched analysis. RESULTS: In the adjusted Cox proportional hazards regression analysis, preeclampsia was associated with a 25% increase in the likelihood of ASD (Hazard Ratio (HR): 1.25, 95% CI:1.19, 1.30) compared with those unexposed to preeclampsia, while in the sibling-matched analysis the HR was 1.17 (95% CI: 1.06, 1.28). The HR for preeclampsia and SGA combined was 1.66 (95% CI: 1.49, 1.85) in the adjusted Cox model and 1.95 (95% CI: 1.53, 2.48) in the sibling-matched analysis. CONCLUSIONS: Exposure to preeclampsia or preeclampsia/SGA (i.e. SGA baby exposed to preeclampsia) was associated with ASD. The stronger association with preeclampsia/SGA than preeclampsia alone suggests that placental pathology may be a mechanism for the increased likelihood of ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13127 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Association between preeclampsia and autism spectrum disorder: a population-based study [Texte imprimé et/ou numérique] / Gillian M. MAHER, Auteur ; Gerard W. O'KEEFFE, Auteur ; Christina DALMAN, Auteur ; Patricia M. KEARNEY, Auteur ; Fergus P. MCCARTHY, Auteur ; Louise C. KENNY, Auteur ; Ali S. KHASHAN, Auteur . - p.131-139. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.131-139 Mots-clés : Autism spectrum disorder  epidemiology  preeclampsia Index. décimale : PER Périodiques Résumé : BACKGROUND: The environmental contribution of autism spectrum disorder (ASD) is approximately 17%-50%, highlighting the importance of investigating factors potentially contributing to the likelihood of its development, and of gaining a greater understanding of the pathogenesis surrounding ASD. The objective of this study was to examine the association between preeclampsia and ASD using a population-based cohort study. METHODS: All singleton live births in Sweden from 1982 to 2010 were included, using data from Swedish National Registers. Exposures of interest included: (a) preeclampsia (classified according to ICD-8, ICD-9 and ICD-10) and (b) preeclampsia and small for gestational age (SGA) combined, used as a proxy for preeclampsia with placental dysfunction. ASD status was based on ICD-9 and ICD-10. The cohort consisted of 2,842,230 children, with 54,071 cases of ASD. Follow-up began from the child's first birthday, and data were censored at first diagnosis of ASD, death, migration or end of study period (31st December 2016). We conducted multivariate Cox proportional hazards regression analysis, adjusting for several perinatal and sociodemographic factors, selected a priori. We further controlled for shared genetic and familial confounding using sibling-matched analysis. RESULTS: In the adjusted Cox proportional hazards regression analysis, preeclampsia was associated with a 25% increase in the likelihood of ASD (Hazard Ratio (HR): 1.25, 95% CI:1.19, 1.30) compared with those unexposed to preeclampsia, while in the sibling-matched analysis the HR was 1.17 (95% CI: 1.06, 1.28). The HR for preeclampsia and SGA combined was 1.66 (95% CI: 1.49, 1.85) in the adjusted Cox model and 1.95 (95% CI: 1.53, 2.48) in the sibling-matched analysis. CONCLUSIONS: Exposure to preeclampsia or preeclampsia/SGA (i.e. SGA baby exposed to preeclampsia) was associated with ASD. The stronger association with preeclampsia/SGA than preeclampsia alone suggests that placental pathology may be a mechanism for the increased likelihood of ASD. En ligne : http://dx.doi.org/10.1111/jcpp.13127 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Use of medication for attention-deficit/hyperactivity disorder and risk of unintentional injuries in children and adolescents with co-occurring neurodevelopmental disorders / Laura GHIRARDI in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.140-147 Titre : Use of medication for attention-deficit/hyperactivity disorder and risk of unintentional injuries in children and adolescents with co-occurring neurodevelopmental disorders Type de document : Texte imprimé et/ou numérique Auteurs : Laura GHIRARDI, Auteur ; Qi CHEN, Auteur ; Zheng CHANG, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Charlotte SKOGLUND, Auteur ; Patrick D. QUINN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik LARSSON, Auteur Article en page(s) : p.140-147 Langues : Anglais (eng) Mots-clés : ADHD medication  injuries  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is often associated with other neurodevelopmental disorders (NDs) and with risky behaviors and adverse health outcomes, including injuries. Treatment with ADHD medication has been associated with reduced risk of injuries. However, it is unknown whether the association is present in individuals with co-occurring NDs. The aim of the present study was to estimate the association between ADHD medication use and unintentional injuries in Sweden in children and adolescents with ADHD, including those with co-occurring NDs. METHODS: Using a linkage of several national registers via the unique personal identification number, we identified individuals with a diagnosis of ADHD and of other NDs, including autism spectrum disorder, intellectual disability, communication disorders, learning disorders and motor disorders. The primary outcome was unintentional injuries. Secondary outcome was traumatic brain injury (TBI). Individuals were followed from January 1st 2006 or their 5th birthday or the date of the first unintentional injury, whichever came last, to December 31st 2013 or their 18th birthday or death, whichever came first. We compared the rate of injuries during periods on-treatment with the rate of injuries during periods off-treatment within the same individual using stratified Cox regression to calculate hazard ratio (HR) with 95% confidence intervals (CIs). RESULTS: For children and adolescents with ADHD (N = 9,421) the rate of any unintentional injuries (HR = 0.85; 95% CI = 0.78-0.92) and TBIs (HR = 0.27; 95% CIs = 0.20-0.38) during medicated periods was lower than during non-medicated periods. Similar results were found among individuals with co-occurring NDs (N = 2,986), for unintentional injuries (HR = 0.88; 95% CI = 0.77-1.01) and for TBIs (HR = 0.27; 95% CI = 0.16-0.44). CONCLUSIONS: Beneficial effects of ADHD medication may extend beyond reduction of ADHD core symptoms to prevention of unintentional injuries in children and adolescents, including individuals with co-occurring NDs. En ligne : http://dx.doi.org/10.1111/jcpp.13136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Use of medication for attention-deficit/hyperactivity disorder and risk of unintentional injuries in children and adolescents with co-occurring neurodevelopmental disorders [Texte imprimé et/ou numérique] / Laura GHIRARDI, Auteur ; Qi CHEN, Auteur ; Zheng CHANG, Auteur ; Ralf KUJA-HALKOLA, Auteur ; Charlotte SKOGLUND, Auteur ; Patrick D. QUINN, Auteur ; Brian M. D'ONOFRIO, Auteur ; Henrik LARSSON, Auteur . - p.140-147. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.140-147 Mots-clés : ADHD medication  injuries  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is often associated with other neurodevelopmental disorders (NDs) and with risky behaviors and adverse health outcomes, including injuries. Treatment with ADHD medication has been associated with reduced risk of injuries. However, it is unknown whether the association is present in individuals with co-occurring NDs. The aim of the present study was to estimate the association between ADHD medication use and unintentional injuries in Sweden in children and adolescents with ADHD, including those with co-occurring NDs. METHODS: Using a linkage of several national registers via the unique personal identification number, we identified individuals with a diagnosis of ADHD and of other NDs, including autism spectrum disorder, intellectual disability, communication disorders, learning disorders and motor disorders. The primary outcome was unintentional injuries. Secondary outcome was traumatic brain injury (TBI). Individuals were followed from January 1st 2006 or their 5th birthday or the date of the first unintentional injury, whichever came last, to December 31st 2013 or their 18th birthday or death, whichever came first. We compared the rate of injuries during periods on-treatment with the rate of injuries during periods off-treatment within the same individual using stratified Cox regression to calculate hazard ratio (HR) with 95% confidence intervals (CIs). RESULTS: For children and adolescents with ADHD (N = 9,421) the rate of any unintentional injuries (HR = 0.85; 95% CI = 0.78-0.92) and TBIs (HR = 0.27; 95% CIs = 0.20-0.38) during medicated periods was lower than during non-medicated periods. Similar results were found among individuals with co-occurring NDs (N = 2,986), for unintentional injuries (HR = 0.88; 95% CI = 0.77-1.01) and for TBIs (HR = 0.27; 95% CI = 0.16-0.44). CONCLUSIONS: Beneficial effects of ADHD medication may extend beyond reduction of ADHD core symptoms to prevention of unintentional injuries in children and adolescents, including individuals with co-occurring NDs. En ligne : http://dx.doi.org/10.1111/jcpp.13136 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Oral contraceptive use in adolescence predicts lasting vulnerability to depression in adulthood / Christine ANDERL in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.148-156 Titre : Oral contraceptive use in adolescence predicts lasting vulnerability to depression in adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Christine ANDERL, Auteur ; Gu LI, Auteur ; Frances S. CHEN, Auteur Article en page(s) : p.148-156 Langues : Anglais (eng) Mots-clés : Nhanes  Oral contraceptive use  adolescence  depression  sensitive period Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous evidence suggests that use of oral contraceptives (OCs), especially during adolescence, may increase women's vulnerability to depression in the short term. Here, we investigate whether women who had first used OC in adolescence show an increased prevalence of depression in the long term. METHODS: We examined 1,236 women in the United States National Health and Nutrition Examination Survey for whom information on depression and age at first OC use was publicly available. We compared women who reported first use of OCs in adolescence to women who had never used OCs and women who had first used OCs in adulthood on 1-year prevalence of major depressive disorder (MDD) assessed by trained interviewers. RESULTS: Compared with women who had used OCs during adolescence, women who had never used OCs were less likely to meet the criteria for MDD within the past year in adulthood [odds ratio (OR) = 0.31, 95% CI = 0.16-0.60], and so were women who only started using OCs in adulthood (OR = 0.54, 95% CI = 0.30-0.95). Third factors that have previously been proposed to explain the relationship between OC use and depression risk such as age at sexual debut, and, importantly, current OC use, did not account for the results in propensity score analyses. CONCLUSIONS: We show a long-term association between adolescent OC use and depression risk in adulthood regardless of current OC use. Our findings suggest that adolescence may be a sensitive period during which OC use could increase women's risk for depression, years after first exposure. En ligne : http://dx.doi.org/10.1111/jcpp.13115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Oral contraceptive use in adolescence predicts lasting vulnerability to depression in adulthood [Texte imprimé et/ou numérique] / Christine ANDERL, Auteur ; Gu LI, Auteur ; Frances S. CHEN, Auteur . - p.148-156. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.148-156 Mots-clés : Nhanes  Oral contraceptive use  adolescence  depression  sensitive period Index. décimale : PER Périodiques Résumé : BACKGROUND: Previous evidence suggests that use of oral contraceptives (OCs), especially during adolescence, may increase women's vulnerability to depression in the short term. Here, we investigate whether women who had first used OC in adolescence show an increased prevalence of depression in the long term. METHODS: We examined 1,236 women in the United States National Health and Nutrition Examination Survey for whom information on depression and age at first OC use was publicly available. We compared women who reported first use of OCs in adolescence to women who had never used OCs and women who had first used OCs in adulthood on 1-year prevalence of major depressive disorder (MDD) assessed by trained interviewers. RESULTS: Compared with women who had used OCs during adolescence, women who had never used OCs were less likely to meet the criteria for MDD within the past year in adulthood [odds ratio (OR) = 0.31, 95% CI = 0.16-0.60], and so were women who only started using OCs in adulthood (OR = 0.54, 95% CI = 0.30-0.95). Third factors that have previously been proposed to explain the relationship between OC use and depression risk such as age at sexual debut, and, importantly, current OC use, did not account for the results in propensity score analyses. CONCLUSIONS: We show a long-term association between adolescent OC use and depression risk in adulthood regardless of current OC use. Our findings suggest that adolescence may be a sensitive period during which OC use could increase women's risk for depression, years after first exposure. En ligne : http://dx.doi.org/10.1111/jcpp.13115 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5-years / Rachel E. LEAN in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.157-166 Titre : Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5-years Type de document : Texte imprimé et/ou numérique Auteurs : Rachel E. LEAN, Auteur ; Christina N. LESSOV-SHLAGGAR, Auteur ; Emily D. GERSTEIN, Auteur ; Tara A. SMYSER, Auteur ; Rachel A. PAUL, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur Article en page(s) : p.157-166 Langues : Anglais (eng) Mots-clés : Prematurity  latent profile analysis  neurodevelopment  psychiatric impairments Index. décimale : PER Périodiques Résumé : BACKGROUND: Very preterm (VPT; <30 weeks gestation) children are a heterogeneous group, yet the co-occurrence of psychiatric and neurodevelopmental impairments remains unclear. Moreover, the clinical and socio-environmental factors that promote resilient developmental outcomes among VPT children are poorly understood. METHODS: One hundred and twenty five children (85 VPT and 40 full-term) underwent neurodevelopmental evaluation at age 5-years. Parents and teachers completed measures of internalizing, externalizing, attention-deficit/hyperactivity (ADHD), and autism symptoms. Psychiatric and neurodevelopmental measures were analyzed using Latent Profile Analysis. Multinomial regression examined the extent that infant, sociodemographic, and family factors, collected prospectively from birth to follow-up, independently differentiated resilient and impaired children. RESULTS: Four latent profiles were identified, including a Typically Developing Group which represented 27.1% of the VPT group and 65.0% of the full-term group, an At-Risk Group with mild psychiatric and neurodevelopmental problems (VPT 44.7%, full-term 22.5%), a Psychiatric Group with moderate-to-severe psychiatric ratings (VPT 12.9%, full-term 10.0%), and a school-based Inattentive/Hyperactive Group (VPT 15.3%, full-term 2.5%). Clinical diagnoses were highest among the Psychiatric Group (80%). Factors that differentiated resilient and impaired subgroups of VPT children included prolonged exposure to maternal psychosocial distress (p En ligne : http://dx.doi.org/10.1111/jcpp.13116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5-years [Texte imprimé et/ou numérique] / Rachel E. LEAN, Auteur ; Christina N. LESSOV-SHLAGGAR, Auteur ; Emily D. GERSTEIN, Auteur ; Tara A. SMYSER, Auteur ; Rachel A. PAUL, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur . - p.157-166. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.157-166 Mots-clés : Prematurity  latent profile analysis  neurodevelopment  psychiatric impairments Index. décimale : PER Périodiques Résumé : BACKGROUND: Very preterm (VPT; <30 weeks gestation) children are a heterogeneous group, yet the co-occurrence of psychiatric and neurodevelopmental impairments remains unclear. Moreover, the clinical and socio-environmental factors that promote resilient developmental outcomes among VPT children are poorly understood. METHODS: One hundred and twenty five children (85 VPT and 40 full-term) underwent neurodevelopmental evaluation at age 5-years. Parents and teachers completed measures of internalizing, externalizing, attention-deficit/hyperactivity (ADHD), and autism symptoms. Psychiatric and neurodevelopmental measures were analyzed using Latent Profile Analysis. Multinomial regression examined the extent that infant, sociodemographic, and family factors, collected prospectively from birth to follow-up, independently differentiated resilient and impaired children. RESULTS: Four latent profiles were identified, including a Typically Developing Group which represented 27.1% of the VPT group and 65.0% of the full-term group, an At-Risk Group with mild psychiatric and neurodevelopmental problems (VPT 44.7%, full-term 22.5%), a Psychiatric Group with moderate-to-severe psychiatric ratings (VPT 12.9%, full-term 10.0%), and a school-based Inattentive/Hyperactive Group (VPT 15.3%, full-term 2.5%). Clinical diagnoses were highest among the Psychiatric Group (80%). Factors that differentiated resilient and impaired subgroups of VPT children included prolonged exposure to maternal psychosocial distress (p En ligne : http://dx.doi.org/10.1111/jcpp.13116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Life stress moderates the effects of preschool behavioral inhibition on anxiety in early adolescence / Emma E. MUMPER in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.167-174 Titre : Life stress moderates the effects of preschool behavioral inhibition on anxiety in early adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Emma E. MUMPER, Auteur ; Margaret W. DYSON, Auteur ; Megan C. FINSAAS, Auteur ; Thomas M. OLINO, Auteur ; Daniel N. KLEIN, Auteur Article en page(s) : p.167-174 Langues : Anglais (eng) Mots-clés : Temperament  adolescence  anxiety  behavioral inhibition  natural disaster  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Although a robust body of literature implicates temperamental behavioral inhibition (BI) as a prominent risk factor for anxiety disorders, many children with heightened BI do not develop anxiety. The current study examines the role of two forms of life stress (life events and natural disaster exposure) in moderating the relationship between BI in preschoolers and anxiety in early adolescence. METHOD: A community sample of 392 3-year-old children was administered a laboratory observational assessment of temperament. When children were a mean age 10, the region was struck by a devastating hurricane and exposure to disaster-related stress was assessed. In early adolescence, youth and a parent were administered the UCLA Life Stress Interview (LSI) to assess behaviorally independent and dependent negative life events during the prior year and youth completed the Screen for Child Anxiety Related Emotional Disorders (SCARED). RESULTS: The association between early childhood BI and anxiety symptoms in early adolescence was moderated by both independent life events and disaster-related stress. Children high in BI at age 3 reported greater anxiety symptoms at age 12 after exposure to higher levels of both forms of stress. CONCLUSIONS: Stress moderated the association between early BI and later anxiety. Importantly, this was evident for two different kinds of stressors that were independent of the child's behavior that increases confidence in the causal role of stress in the development of anxiety in high BI children. En ligne : http://dx.doi.org/10.1111/jcpp.13121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Life stress moderates the effects of preschool behavioral inhibition on anxiety in early adolescence [Texte imprimé et/ou numérique] / Emma E. MUMPER, Auteur ; Margaret W. DYSON, Auteur ; Megan C. FINSAAS, Auteur ; Thomas M. OLINO, Auteur ; Daniel N. KLEIN, Auteur . - p.167-174. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.167-174 Mots-clés : Temperament  adolescence  anxiety  behavioral inhibition  natural disaster  stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Although a robust body of literature implicates temperamental behavioral inhibition (BI) as a prominent risk factor for anxiety disorders, many children with heightened BI do not develop anxiety. The current study examines the role of two forms of life stress (life events and natural disaster exposure) in moderating the relationship between BI in preschoolers and anxiety in early adolescence. METHOD: A community sample of 392 3-year-old children was administered a laboratory observational assessment of temperament. When children were a mean age 10, the region was struck by a devastating hurricane and exposure to disaster-related stress was assessed. In early adolescence, youth and a parent were administered the UCLA Life Stress Interview (LSI) to assess behaviorally independent and dependent negative life events during the prior year and youth completed the Screen for Child Anxiety Related Emotional Disorders (SCARED). RESULTS: The association between early childhood BI and anxiety symptoms in early adolescence was moderated by both independent life events and disaster-related stress. Children high in BI at age 3 reported greater anxiety symptoms at age 12 after exposure to higher levels of both forms of stress. CONCLUSIONS: Stress moderated the association between early BI and later anxiety. Importantly, this was evident for two different kinds of stressors that were independent of the child's behavior that increases confidence in the causal role of stress in the development of anxiety in high BI children. En ligne : http://dx.doi.org/10.1111/jcpp.13121 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Development of bipolar disorder and other comorbidity among youth with attention-deficit/hyperactivity disorder / L. Eugene ARNOLD in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.175-181 Titre : Development of bipolar disorder and other comorbidity among youth with attention-deficit/hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : L. Eugene ARNOLD, Auteur ; Anna R. VAN METER, Auteur ; Mary A. FRISTAD, Auteur ; Eric A. YOUNGSTROM, Auteur ; Boris BIRMAHER, Auteur ; Robert L. FINDLING, Auteur ; Sarah HORWITZ, Auteur ; Sarah R. BLACK, Auteur Article en page(s) : p.175-181 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  bipolar disorder  comorbidity Index. décimale : PER Périodiques Résumé : OBJECTIVE: To examine development of bipolar spectrum disorders (BPSD) and other disorders in prospectively followed children with attention-deficit/hyperactivity disorder (ADHD). METHOD: In the Longitudinal Assessment of Manic Symptoms (LAMS) study, 531 of 685 children age 6-12 (most selected for scores > 12 on General Behavior Inventory 10-item Mania scale) had ADHD, 112 with BPSD, and 419 without. With annual assessments for 8 years, retention averaged 6.2 years. Chi-square analyses compared rate of new BPSD and other comorbidity between those with versus without baseline ADHD and between retained versus resolved ADHD diagnosis. Cox regression tested factors influencing speed of BPSD onset. RESULTS: Of 419 with baseline ADHD but not BPSD, 52 (12.4%) developed BPSD, compared with 16 of 110 (14.5%) without either baseline diagnosis. Those who developed BPSD had more nonmood comorbidity over the follow-up than those who did not develop BPSD (p = .0001). Of 170 who still had ADHD at eight-year follow-up (and not baseline BPSD), 26 (15.3%) had developed BPSD, compared with 16 of 186 (8.6%) who had ADHD without BPSD at baseline but lost the ADHD diagnosis (chi(2) = 3.82, p = .051). There was no statistical difference in whether ADHD persisted or not across new BPSD subtypes (chi(2) = 1.62, p = .446). Of those who developed BPSD, speed of onset was not significantly related to baseline ADHD (p = .566), baseline anxiety (p = .121), baseline depression (p = .185), baseline disruptive behavior disorder (p = .184), age (B = -.11 p = .092), maternal mania (p = .389), or paternal mania (B = .73, p = .056). Those who started with both diagnoses had more severe symptoms/impairment than those with later developed BPSD and reported having ADHD first. CONCLUSIONS: In a cohort selected for symptoms of mania at age 6-12, baseline ADHD was not a significant prospective risk factor for developing BPSD. However, persistence of ADHD may marginally mediate risk of BPSD, and early comorbidity of both diagnoses increases severity/impairment. En ligne : http://dx.doi.org/10.1111/jcpp.13122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Development of bipolar disorder and other comorbidity among youth with attention-deficit/hyperactivity disorder [Texte imprimé et/ou numérique] / L. Eugene ARNOLD, Auteur ; Anna R. VAN METER, Auteur ; Mary A. FRISTAD, Auteur ; Eric A. YOUNGSTROM, Auteur ; Boris BIRMAHER, Auteur ; Robert L. FINDLING, Auteur ; Sarah HORWITZ, Auteur ; Sarah R. BLACK, Auteur . - p.175-181. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.175-181 Mots-clés : Attention-deficit/hyperactivity disorder  bipolar disorder  comorbidity Index. décimale : PER Périodiques Résumé : OBJECTIVE: To examine development of bipolar spectrum disorders (BPSD) and other disorders in prospectively followed children with attention-deficit/hyperactivity disorder (ADHD). METHOD: In the Longitudinal Assessment of Manic Symptoms (LAMS) study, 531 of 685 children age 6-12 (most selected for scores > 12 on General Behavior Inventory 10-item Mania scale) had ADHD, 112 with BPSD, and 419 without. With annual assessments for 8 years, retention averaged 6.2 years. Chi-square analyses compared rate of new BPSD and other comorbidity between those with versus without baseline ADHD and between retained versus resolved ADHD diagnosis. Cox regression tested factors influencing speed of BPSD onset. RESULTS: Of 419 with baseline ADHD but not BPSD, 52 (12.4%) developed BPSD, compared with 16 of 110 (14.5%) without either baseline diagnosis. Those who developed BPSD had more nonmood comorbidity over the follow-up than those who did not develop BPSD (p = .0001). Of 170 who still had ADHD at eight-year follow-up (and not baseline BPSD), 26 (15.3%) had developed BPSD, compared with 16 of 186 (8.6%) who had ADHD without BPSD at baseline but lost the ADHD diagnosis (chi(2) = 3.82, p = .051). There was no statistical difference in whether ADHD persisted or not across new BPSD subtypes (chi(2) = 1.62, p = .446). Of those who developed BPSD, speed of onset was not significantly related to baseline ADHD (p = .566), baseline anxiety (p = .121), baseline depression (p = .185), baseline disruptive behavior disorder (p = .184), age (B = -.11 p = .092), maternal mania (p = .389), or paternal mania (B = .73, p = .056). Those who started with both diagnoses had more severe symptoms/impairment than those with later developed BPSD and reported having ADHD first. CONCLUSIONS: In a cohort selected for symptoms of mania at age 6-12, baseline ADHD was not a significant prospective risk factor for developing BPSD. However, persistence of ADHD may marginally mediate risk of BPSD, and early comorbidity of both diagnoses increases severity/impairment. En ligne : http://dx.doi.org/10.1111/jcpp.13122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Associations between infant and toddler regulatory problems, childhood co-developing internalising and externalising trajectories, and adolescent depression, psychotic and borderline personality disorder symptoms / Catherine WINSPER in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.182-194 Titre : Associations between infant and toddler regulatory problems, childhood co-developing internalising and externalising trajectories, and adolescent depression, psychotic and borderline personality disorder symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Catherine WINSPER, Auteur ; Ayten BILGIN, Auteur ; Dieter WOLKE, Auteur Article en page(s) : p.182-194 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  Regulatory problems  internalising and externalising symptoms  parallel process latent class growth analysis Index. décimale : PER Périodiques Résumé : BACKGROUND: Early regulatory problems (RPs) are associated with childhood internalising and externalising symptoms. Internalising and externalising symptoms, in turn, are associated with adolescent psychopathology (e.g. personality disorders, depression). We examined whether RPs are directly associated with adolescent psychopathology, or whether associations are indirect via childhood internalising and externalising symptoms. METHODS: We used data from the Avon Longitudinal Study of Parents and Children. Mothers reported on their child's RPs at 6, 15-18 and 24-30 months, and internalising and externalising symptoms at 4, 7, 8 and 9.5 years. Adolescent psychotic, depression and BPD symptoms were assessed at 11-12 years. Children were grouped by their patterns of co-developing internalising and externalising symptoms using parallel process latent class growth analysis (PP-LCGA). Path analysis was used to examine direct and indirect associations from RPs to the three adolescent outcomes. RESULTS: There were four groups of children with distinct patterns of co-developing internalising and externalising (INT/EXT) symptoms. Most children (53%) demonstrated low-moderate and stable levels of INT/EXT symptoms. A small proportion (7.7%) evidenced moderate and increasing INT and high stable EXT symptoms: this pattern was strongly predictive of adolescent psychopathology (e.g. depression at 11 years: unadjusted odds ratio = 5.62; 95% confidence intervals = 3.82, 8.27). The other two groups were differentially associated with adolescent outcomes (i.e. moderate-high increasing INT/moderate decreasing EXT predicted mother-reported depression at 12, while low stable INT/moderate-high stable EXT predicted child-reported depression at 11). In path analysis, RPs at each time-point were significantly indirectly associated with symptoms of BPD and child- and mother-reported depression symptoms via the most severe class of INT/EXT symptoms. CONCLUSIONS: Consistent with a cascade model of development, RPs are predictive of higher levels of co-developing INT/EXT symptoms, which in turn increase risk of adolescent psychopathology. Clinicians should be aware of, and treat, early RPs to prevent chronic psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13125 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Associations between infant and toddler regulatory problems, childhood co-developing internalising and externalising trajectories, and adolescent depression, psychotic and borderline personality disorder symptoms [Texte imprimé et/ou numérique] / Catherine WINSPER, Auteur ; Ayten BILGIN, Auteur ; Dieter WOLKE, Auteur . - p.182-194. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.182-194 Mots-clés : Avon Longitudinal Study of Parents and Children  Regulatory problems  internalising and externalising symptoms  parallel process latent class growth analysis Index. décimale : PER Périodiques Résumé : BACKGROUND: Early regulatory problems (RPs) are associated with childhood internalising and externalising symptoms. Internalising and externalising symptoms, in turn, are associated with adolescent psychopathology (e.g. personality disorders, depression). We examined whether RPs are directly associated with adolescent psychopathology, or whether associations are indirect via childhood internalising and externalising symptoms. METHODS: We used data from the Avon Longitudinal Study of Parents and Children. Mothers reported on their child's RPs at 6, 15-18 and 24-30 months, and internalising and externalising symptoms at 4, 7, 8 and 9.5 years. Adolescent psychotic, depression and BPD symptoms were assessed at 11-12 years. Children were grouped by their patterns of co-developing internalising and externalising symptoms using parallel process latent class growth analysis (PP-LCGA). Path analysis was used to examine direct and indirect associations from RPs to the three adolescent outcomes. RESULTS: There were four groups of children with distinct patterns of co-developing internalising and externalising (INT/EXT) symptoms. Most children (53%) demonstrated low-moderate and stable levels of INT/EXT symptoms. A small proportion (7.7%) evidenced moderate and increasing INT and high stable EXT symptoms: this pattern was strongly predictive of adolescent psychopathology (e.g. depression at 11 years: unadjusted odds ratio = 5.62; 95% confidence intervals = 3.82, 8.27). The other two groups were differentially associated with adolescent outcomes (i.e. moderate-high increasing INT/moderate decreasing EXT predicted mother-reported depression at 12, while low stable INT/moderate-high stable EXT predicted child-reported depression at 11). In path analysis, RPs at each time-point were significantly indirectly associated with symptoms of BPD and child- and mother-reported depression symptoms via the most severe class of INT/EXT symptoms. CONCLUSIONS: Consistent with a cascade model of development, RPs are predictive of higher levels of co-developing INT/EXT symptoms, which in turn increase risk of adolescent psychopathology. Clinicians should be aware of, and treat, early RPs to prevent chronic psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.13125 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Maternal and paternal depressive symptoms and children's emotional problems at the age of 2 and 5 years: a longitudinal study / Johanna T. PIETIKAINEN in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.195-204 Titre : Maternal and paternal depressive symptoms and children's emotional problems at the age of 2 and 5 years: a longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Johanna T. PIETIKAINEN, Auteur ; Olli KIVIRUUSU, Auteur ; Anneli KYLLIAINEN, Auteur ; Pirjo POLKKI, Auteur ; Outi SAARENPAA-HEIKKILA, Auteur ; Tiina PAUNIO, Auteur ; E. Juulia PAAVONEN, Auteur Article en page(s) : p.195-204 Langues : Anglais (eng) Mots-clés : Depression  child development  longitudinal studies  maternal depression  perinatal Index. décimale : PER Périodiques Résumé : BACKGROUND: Maternal and paternal depressive symptoms are related to children's emotional problems, but their combined effect remains unclear. Here, we constructed four parental longitudinal depressive symptom trajectory groups and studied their associations with children's emotional problems at the age of 2 and 5 years. METHODS: We did an assessment of maternal and paternal depressive symptoms (gestational week 32, as well as 3, 8 and 24 months postnatally) and children's emotional problems at ages two (N = 939) and five (N = 700) in the CHILD-SLEEP cohort. Three separate maternal and paternal depressive symptom trajectories based on latent profile analysis were combined to form four parental depressive symptom trajectory groups. We compared groups with a general linear model, with children's emotional (total, internalizing and externalizing) - problem scores serving as the dependent variables. RESULTS: At both ages, combined parental depressive symptom trajectories were associated with children's emotional problems: effect sizes were medium for total and small for other domains. According to post hoc comparisons, children whose mothers or both parents had persistent depressive symptoms had significantly more total, externalizing and internalizing problems than did children who had neither parent nor only the father showing depressive symptoms. A higher (and persistent) level of maternal depressive symptoms was related to a higher level of these children's emotional problems, a pattern not evident with paternal depressive symptoms. In all analyses, the interaction effect was nonsignificant between parental trajectories and child gender. CONCLUSIONS: Findings suggest that an absence of depressive symptoms in their fathers cannot compensate for the adverse effects of maternal depressive symptoms upon their children. Moreover, paternal depressive symptoms alone do not lead to increased risk for emotional problems in these 2- and 5-year-old children. In contrast, even subclinical levels of maternal depressive symptoms in late pregnancy are associated with increased risk for their children's experiencing internalizing and externalizing emotional problems. En ligne : http://dx.doi.org/10.1111/jcpp.13126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Maternal and paternal depressive symptoms and children's emotional problems at the age of 2 and 5 years: a longitudinal study [Texte imprimé et/ou numérique] / Johanna T. PIETIKAINEN, Auteur ; Olli KIVIRUUSU, Auteur ; Anneli KYLLIAINEN, Auteur ; Pirjo POLKKI, Auteur ; Outi SAARENPAA-HEIKKILA, Auteur ; Tiina PAUNIO, Auteur ; E. Juulia PAAVONEN, Auteur . - p.195-204. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.195-204 Mots-clés : Depression  child development  longitudinal studies  maternal depression  perinatal Index. décimale : PER Périodiques Résumé : BACKGROUND: Maternal and paternal depressive symptoms are related to children's emotional problems, but their combined effect remains unclear. Here, we constructed four parental longitudinal depressive symptom trajectory groups and studied their associations with children's emotional problems at the age of 2 and 5 years. METHODS: We did an assessment of maternal and paternal depressive symptoms (gestational week 32, as well as 3, 8 and 24 months postnatally) and children's emotional problems at ages two (N = 939) and five (N = 700) in the CHILD-SLEEP cohort. Three separate maternal and paternal depressive symptom trajectories based on latent profile analysis were combined to form four parental depressive symptom trajectory groups. We compared groups with a general linear model, with children's emotional (total, internalizing and externalizing) - problem scores serving as the dependent variables. RESULTS: At both ages, combined parental depressive symptom trajectories were associated with children's emotional problems: effect sizes were medium for total and small for other domains. According to post hoc comparisons, children whose mothers or both parents had persistent depressive symptoms had significantly more total, externalizing and internalizing problems than did children who had neither parent nor only the father showing depressive symptoms. A higher (and persistent) level of maternal depressive symptoms was related to a higher level of these children's emotional problems, a pattern not evident with paternal depressive symptoms. In all analyses, the interaction effect was nonsignificant between parental trajectories and child gender. CONCLUSIONS: Findings suggest that an absence of depressive symptoms in their fathers cannot compensate for the adverse effects of maternal depressive symptoms upon their children. Moreover, paternal depressive symptoms alone do not lead to increased risk for emotional problems in these 2- and 5-year-old children. In contrast, even subclinical levels of maternal depressive symptoms in late pregnancy are associated with increased risk for their children's experiencing internalizing and externalizing emotional problems. En ligne : http://dx.doi.org/10.1111/jcpp.13126 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD / Joel T. NIGG in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.205-214 Titre : Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Joel T. NIGG, Auteur ; Sarah L. KARALUNAS, Auteur ; Hanna C. GUSTAFSSON, Auteur ; Priya BHATT, Auteur ; Peter RYABININ, Auteur ; Michael A. MOONEY, Auteur ; Stephen V. FARAONE, Auteur ; Damien A. FAIR, Auteur ; Beth WILMOT, Auteur Article en page(s) : p.205-214 Langues : Anglais (eng) Mots-clés : Adhd  irritability  polygenic score  temperament Index. décimale : PER Périodiques Résumé : BACKGROUND: A central nosological problem concerns the etiological relationship of emotional dysregulation with ADHD. Molecular genetic risk scores provide a novel method for informing this question. METHODS: Participants were 514 community-recruited children of Northern European descent age 7-11 defined as ADHD or non-ADHD by detailed research evaluation. Parents-rated ADHD on standardized ratings and child temperament on the Temperament in Middle Childhood Questionnaire (TMCQ) and reported on ADHD and comorbid disorders by semi-structured clinical interview. Categorical and dimensional variables were created for ADHD, emotional dysregulation (implicating disruption of regulation of both anger-irritability and of positive valence surgency-sensation seeking), and irritability alone (anger dysregulation). Genome-wide polygenic risk scores (PRS) were computed for ADHD and depression genetic liability. Structural equation models and computationally derived emotion profiles guided analysis. RESULTS: The ADHD PRS was associated in variable-centered analyses with irritability (beta = .179, 95% CI = 0.087-0.280; DeltaR(2) = .034, p < .0002), but also with surgency/sensation seeking (B = .146, 95%CI = 0.052-0.240, DeltaR(2) =.022, p = .002). In person-centered analysis, the ADHD PRS was elevated in the emotion dysregulation ADHD group versus other ADHD children (OR = 1.44, 95% CI = 1.03-2.20, Nagelkerke DeltaR(2) = .013, p = .033) but did not differentiate irritable from surgent ADHD profiles. All effects were independent of variation in ADHD severity across traits or groups. The depression PRS was related to oppositional defiant disorder but not to ADHD emotion dysregulation. CONCLUSIONS: Irritability-anger and surgency-sensation seeking, as forms of negative and positively valenced dysregulated affect in ADHD populations, both relate principally to ADHD genetic risk and not mood-related genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.13132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD [Texte imprimé et/ou numérique] / Joel T. NIGG, Auteur ; Sarah L. KARALUNAS, Auteur ; Hanna C. GUSTAFSSON, Auteur ; Priya BHATT, Auteur ; Peter RYABININ, Auteur ; Michael A. MOONEY, Auteur ; Stephen V. FARAONE, Auteur ; Damien A. FAIR, Auteur ; Beth WILMOT, Auteur . - p.205-214. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.205-214 Mots-clés : Adhd  irritability  polygenic score  temperament Index. décimale : PER Périodiques Résumé : BACKGROUND: A central nosological problem concerns the etiological relationship of emotional dysregulation with ADHD. Molecular genetic risk scores provide a novel method for informing this question. METHODS: Participants were 514 community-recruited children of Northern European descent age 7-11 defined as ADHD or non-ADHD by detailed research evaluation. Parents-rated ADHD on standardized ratings and child temperament on the Temperament in Middle Childhood Questionnaire (TMCQ) and reported on ADHD and comorbid disorders by semi-structured clinical interview. Categorical and dimensional variables were created for ADHD, emotional dysregulation (implicating disruption of regulation of both anger-irritability and of positive valence surgency-sensation seeking), and irritability alone (anger dysregulation). Genome-wide polygenic risk scores (PRS) were computed for ADHD and depression genetic liability. Structural equation models and computationally derived emotion profiles guided analysis. RESULTS: The ADHD PRS was associated in variable-centered analyses with irritability (beta = .179, 95% CI = 0.087-0.280; DeltaR(2) = .034, p < .0002), but also with surgency/sensation seeking (B = .146, 95%CI = 0.052-0.240, DeltaR(2) =.022, p = .002). In person-centered analysis, the ADHD PRS was elevated in the emotion dysregulation ADHD group versus other ADHD children (OR = 1.44, 95% CI = 1.03-2.20, Nagelkerke DeltaR(2) = .013, p = .033) but did not differentiate irritable from surgent ADHD profiles. All effects were independent of variation in ADHD severity across traits or groups. The depression PRS was related to oppositional defiant disorder but not to ADHD emotion dysregulation. CONCLUSIONS: Irritability-anger and surgency-sensation seeking, as forms of negative and positively valenced dysregulated affect in ADHD populations, both relate principally to ADHD genetic risk and not mood-related genetic risk. En ligne : http://dx.doi.org/10.1111/jcpp.13132 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415