Associations between birth weight and attention-deficit/hyperactivity disorder symptom severity: indirect effects via primary neuropsychological functions / Burt HATCH in Journal of Child Psychology and Psychiatry, 55-4 (April 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.384-392 Titre : Associations between birth weight and attention-deficit/hyperactivity disorder symptom severity: indirect effects via primary neuropsychological functions Type de document : texte imprimé Auteurs : Burt HATCH, Auteur ; Dione M. HEALEY, Auteur ; Jeffrey M. HALPERIN, Auteur Article en page(s) : p.384-392 Mots-clés : ADHD  neuropsychology  birth weight Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) has a range of aetiological origins which are associated with a number of disruptions in neuropsychological functioning. This study aimed to examine how low birth weight, a proxy measure for a range of environmental complications during gestation, predicted ADHD symptom severity in preschool-aged children indirectly via neuropsychological functioning. Methods A total of 197 preschool-aged children were recruited as part of a larger longitudinal study. Two neuropsychological factors were derived from NEPSY domain scores. One, referred to as ‘Primary Neuropsychological Function,’ was loaded highly with Sensorimotor and Visuospatial scores. The other, termed ‘Higher-Order Function’ was loaded highly with Language and Memory domain scores. Executive functioning split evenly across the two. Analyses examined whether these neuropsychological factors allowed for an indirect association between birth weight and ADHD symptom severity. Results As both factors were associated with symptom severity, only the Primary Neuropsychological Factor was associated with birth weight. Furthermore, birth weight was indirectly associated to symptom severity via this factor. Conclusions These data indicate that birth weight is indirectly associated with ADHD severity via disruption of neuropsychological functions that are more primary in function as opposed to functions that play a higher-order role in utilising and integrating the primary functions. En ligne : http://dx.doi.org/10.1111/jcpp.12168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 [article] Associations between birth weight and attention-deficit/hyperactivity disorder symptom severity: indirect effects via primary neuropsychological functions [texte imprimé] / Burt HATCH, Auteur ; Dione M. HEALEY, Auteur ; Jeffrey M. HALPERIN, Auteur . - p.384-392. in Journal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.384-392 Mots-clés : ADHD  neuropsychology  birth weight Index. décimale : PER Périodiques Résumé : Background Attention-deficit/hyperactivity disorder (ADHD) has a range of aetiological origins which are associated with a number of disruptions in neuropsychological functioning. This study aimed to examine how low birth weight, a proxy measure for a range of environmental complications during gestation, predicted ADHD symptom severity in preschool-aged children indirectly via neuropsychological functioning. Methods A total of 197 preschool-aged children were recruited as part of a larger longitudinal study. Two neuropsychological factors were derived from NEPSY domain scores. One, referred to as ‘Primary Neuropsychological Function,’ was loaded highly with Sensorimotor and Visuospatial scores. The other, termed ‘Higher-Order Function’ was loaded highly with Language and Memory domain scores. Executive functioning split evenly across the two. Analyses examined whether these neuropsychological factors allowed for an indirect association between birth weight and ADHD symptom severity. Results As both factors were associated with symptom severity, only the Primary Neuropsychological Factor was associated with birth weight. Furthermore, birth weight was indirectly associated to symptom severity via this factor. Conclusions These data indicate that birth weight is indirectly associated with ADHD severity via disruption of neuropsychological functions that are more primary in function as opposed to functions that play a higher-order role in utilising and integrating the primary functions. En ligne : http://dx.doi.org/10.1111/jcpp.12168 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230

Correction to: Longitudinal Differences in Response to Name Among Infants Developing ASD and Risk for ADHD / Burt HATCH in Journal of Autism and Developmental Disorders, 51-3 (March 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.837-838 Titre : Correction to: Longitudinal Differences in Response to Name Among Infants Developing ASD and Risk for ADHD Type de document : texte imprimé Auteurs : Burt HATCH, Auteur ; Ana-Maria IOSIF, Auteur ; Annie CHUANG, Auteur ; Leiana DE LA PAZ, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur Article en page(s) : p.837-838 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04590-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Correction to: Longitudinal Differences in Response to Name Among Infants Developing ASD and Risk for ADHD [texte imprimé] / Burt HATCH, Auteur ; Ana-Maria IOSIF, Auteur ; Annie CHUANG, Auteur ; Leiana DE LA PAZ, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur . - p.837-838. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.837-838 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-020-04590-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children / Burt HATCH in Autism, 29-11 (November 2025)  

Public ISBD [article]  inAutism > 29-11 (November 2025) . - p.2885-2897 Titre : Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children Type de document : texte imprimé Auteurs : Burt HATCH, Auteur ; Derek S. ANDREWS, Auteur ; Brett D. DUFOUR, Auteur ; Shayan M ALAVYNEJAD, Auteur ; Joshua K LEE, Auteur ; Sally ROGERS, Auteur ; Marjorie SOLOMON, Auteur ; Meghan MILLER, Auteur ; Christine WU NORDAHL, Auteur Article en page(s) : p.2885-2897 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  externalizing  hypothalamus  internalizing  MRI  sleep Index. décimale : PER Périodiques Résumé : Difficulty initiating or maintaining sleep is common among autistic individuals and co-occurs with internalizing and externalizing symptoms. This study tested associations between subcortical regions implicated in sleep processes and measures of dysregulated sleep initiation/maintenance in autistic and non-autistic 2- to 4-year-olds. The role of co-occurring externalizing and internalizing symptoms in these associations was also evaluated. Participants included 203 autistic (131 males, 72 females) and 92 non-autistic (49 males, 43 females) 2- to 4-year-olds who completed magnetic resonance imaging. A subscale of items from the Children’s Sleep Habits Questionnaire, previously shown to be reliable across both autistic and non-autistic children, was used to measure dysregulated sleep initiation/maintenance. Externalizing and internalizing symptoms were evaluated using the Child Behavior Checklist–Preschool. Associations between volumes for nine subcortical structures known to be implicated in sleep were separately modeled. Mediation analyses explored whether such associations could be accounted for by externalizing or internalizing symptoms. Smaller right hypothalamus volume was associated with dysregulated sleep initiation/maintenance in both autistic and non-autistic children. Externalizing (but not internalizing) problems partially mediated this association. Findings implicate the right hypothalamus in sleep initiation and maintenance issues for both autistic and non-autistic young children, supporting prior evidence of its central role in sleep regulation.Lay Abstract Difficulty initiating or maintaining sleep is common among autistic individuals and often goes alongside difficulties regulating emotions and behavior during the day. Although there is a body of research suggesting that subcortical brain regions, including a brain region known as the hypothalamus, play important roles regulating sleep, few studies have examined whether this extends to young autistic children. Using data from a sample of 203 autistic (131 males, 72 females) and 92 non-autistic (49 males, 43 females) 2- to 4-year-olds, we examined whether size of subcortical brain regions implicated in sleep processes is associated with difficulties initiating and/or maintaining sleep. In addition, we examined whether daytime behaviors and emotions were also implicated in these associations. We found that smaller right hypothalamus volume was associated with dysregulated sleep initiation/maintenance in both autistic and non-autistic children. This relationship remained evident even after accounting for externalizing behaviors and emotions like anger that were also associated with both the hypothalamus and dysregulated sleep initiation/maintenance. The strength of association between right hypothalamus volumes and dysregulated sleep initiation/maintenance was similar for autistic and non-autistic children. These findings suggest that for both young autistic and non-autistic children, the hypothalamus plays unique roles in regulating both sleep and externalizing behaviors. For managing sleep initiation and maintenance difficulties in clinical practice, the findings underscore the importance of considering environmental (e.g. not having a regular bedtime routine) and neurobiological factors, for both autistic and non-autistic young children. En ligne : https://dx.doi.org/10.1177/13623613251352249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570 [article] Hypothalamic volume is associated with dysregulated sleep in autistic and non-autistic young children [texte imprimé] / Burt HATCH, Auteur ; Derek S. ANDREWS, Auteur ; Brett D. DUFOUR, Auteur ; Shayan M ALAVYNEJAD, Auteur ; Joshua K LEE, Auteur ; Sally ROGERS, Auteur ; Marjorie SOLOMON, Auteur ; Meghan MILLER, Auteur ; Christine WU NORDAHL, Auteur . - p.2885-2897. Langues : Anglais (eng) in Autism > 29-11 (November 2025) . - p.2885-2897 Mots-clés : autism spectrum disorder  externalizing  hypothalamus  internalizing  MRI  sleep Index. décimale : PER Périodiques Résumé : Difficulty initiating or maintaining sleep is common among autistic individuals and co-occurs with internalizing and externalizing symptoms. This study tested associations between subcortical regions implicated in sleep processes and measures of dysregulated sleep initiation/maintenance in autistic and non-autistic 2- to 4-year-olds. The role of co-occurring externalizing and internalizing symptoms in these associations was also evaluated. Participants included 203 autistic (131 males, 72 females) and 92 non-autistic (49 males, 43 females) 2- to 4-year-olds who completed magnetic resonance imaging. A subscale of items from the Children’s Sleep Habits Questionnaire, previously shown to be reliable across both autistic and non-autistic children, was used to measure dysregulated sleep initiation/maintenance. Externalizing and internalizing symptoms were evaluated using the Child Behavior Checklist–Preschool. Associations between volumes for nine subcortical structures known to be implicated in sleep were separately modeled. Mediation analyses explored whether such associations could be accounted for by externalizing or internalizing symptoms. Smaller right hypothalamus volume was associated with dysregulated sleep initiation/maintenance in both autistic and non-autistic children. Externalizing (but not internalizing) problems partially mediated this association. Findings implicate the right hypothalamus in sleep initiation and maintenance issues for both autistic and non-autistic young children, supporting prior evidence of its central role in sleep regulation.Lay Abstract Difficulty initiating or maintaining sleep is common among autistic individuals and often goes alongside difficulties regulating emotions and behavior during the day. Although there is a body of research suggesting that subcortical brain regions, including a brain region known as the hypothalamus, play important roles regulating sleep, few studies have examined whether this extends to young autistic children. Using data from a sample of 203 autistic (131 males, 72 females) and 92 non-autistic (49 males, 43 females) 2- to 4-year-olds, we examined whether size of subcortical brain regions implicated in sleep processes is associated with difficulties initiating and/or maintaining sleep. In addition, we examined whether daytime behaviors and emotions were also implicated in these associations. We found that smaller right hypothalamus volume was associated with dysregulated sleep initiation/maintenance in both autistic and non-autistic children. This relationship remained evident even after accounting for externalizing behaviors and emotions like anger that were also associated with both the hypothalamus and dysregulated sleep initiation/maintenance. The strength of association between right hypothalamus volumes and dysregulated sleep initiation/maintenance was similar for autistic and non-autistic children. These findings suggest that for both young autistic and non-autistic children, the hypothalamus plays unique roles in regulating both sleep and externalizing behaviors. For managing sleep initiation and maintenance difficulties in clinical practice, the findings underscore the importance of considering environmental (e.g. not having a regular bedtime routine) and neurobiological factors, for both autistic and non-autistic young children. En ligne : https://dx.doi.org/10.1177/13623613251352249 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=570

Longitudinal Differences in Response to Name Among Infants Developing ASD and Risk for ADHD / Burt HATCH in Journal of Autism and Developmental Disorders, 51-3 (March 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.827-836 Titre : Longitudinal Differences in Response to Name Among Infants Developing ASD and Risk for ADHD Type de document : texte imprimé Auteurs : Burt HATCH, Auteur ; Ana-Maria IOSIF, Auteur ; Annie CHUANG, Auteur ; Leiana DE LA PAZ, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur Article en page(s) : p.827-836 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  Autism spectrum disorder  Early detection  Infancy  Social communication Index. décimale : PER Périodiques Résumé : Diminished response to name, a potential early marker of autism spectrum disorder (ASD), may also indicate risk for other disorders characterized by attention problems, including attention-deficit/hyperactivity disorder (ADHD). Using a familial risk design, we examined whether response to name ability at 6, 12, 18, 24, and 36 months of age differed between three 36-month outcome groups: ASD, ADHD Concerns, or a Comparison group. Persistent differences between the ASD and Comparison groups were evident beginning at 12 months; differences between the ADHD Concerns and Comparison groups were evident between 12 and 18 months only. Results suggest that response to name may be a general marker for ASD and ADHD risk in infancy but a specific indicator of ASD by 24-months. En ligne : http://dx.doi.org/10.1007/s10803-020-04369-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Longitudinal Differences in Response to Name Among Infants Developing ASD and Risk for ADHD [texte imprimé] / Burt HATCH, Auteur ; Ana-Maria IOSIF, Auteur ; Annie CHUANG, Auteur ; Leiana DE LA PAZ, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur . - p.827-836. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.827-836 Mots-clés : Attention-deficit/hyperactivity disorder  Autism spectrum disorder  Early detection  Infancy  Social communication Index. décimale : PER Périodiques Résumé : Diminished response to name, a potential early marker of autism spectrum disorder (ASD), may also indicate risk for other disorders characterized by attention problems, including attention-deficit/hyperactivity disorder (ADHD). Using a familial risk design, we examined whether response to name ability at 6, 12, 18, 24, and 36 months of age differed between three 36-month outcome groups: ASD, ADHD Concerns, or a Comparison group. Persistent differences between the ASD and Comparison groups were evident beginning at 12 months; differences between the ADHD Concerns and Comparison groups were evident between 12 and 18 months only. Results suggest that response to name may be a general marker for ASD and ADHD risk in infancy but a specific indicator of ASD by 24-months. En ligne : http://dx.doi.org/10.1007/s10803-020-04369-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

Patterns of objectively measured motor activity among infants developing ASD and concerns for ADHD / Rachel REETZKE in Journal of Child Psychology and Psychiatry, 63-6 (June 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-6 (June 2022) . - p.663-673 Titre : Patterns of objectively measured motor activity among infants developing ASD and concerns for ADHD Type de document : texte imprimé Auteurs : Rachel REETZKE, Auteur ; Ana-Maria IOSIF, Auteur ; Burt HATCH, Auteur ; Leiana DE LA PAZ, Auteur ; Annie CHUANG, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur Article en page(s) : p.663-673 Langues : Anglais (eng) Mots-clés : Activity level  attention-deficit/hyperactivity disorder  autism spectrum disorder  infancy Index. décimale : PER Périodiques Résumé : BACKGROUND: Heightened motor activity is a hallmark of attention-deficit/hyperactivity disorder (ADHD), yet high activity levels are also often reported in young children with autism spectrum disorder (ASD). It is currently unclear whether increased motor activity represents a distinct versus shared early predictor of ASD and ADHD; no prior studies have directly examined this prospectively. We investigated differences in longitudinal patterns of objectively measured motor activity during early development. METHODS: Participants included 113 infants at high and low risk for ASD or ADHD. Continuous motion-based activity was recorded using tri-axial accelerometers at 12, 18, 24, and 36 months of age. At 36 months, participants were categorized into one of three outcome groups: ASD (n=19), ADHD Concerns (n=17), and Typically Developing (TD; n=77). Group differences in trajectories of motor activity were examined in structured and semistructured contexts. Associations with behaviors relevant to ASD, ADHD, and general development were also examined. RESULTS: In both structured and semistructured contexts, both the ASD and ADHD Concerns groups exhibited heightened activity relative to the TD group by 18 months; the ASD group exhibited higher activity than the ADHD Concerns group at 24-36 months in the structured context only. Attention/behavior regulation, nonverbal, and verbal development-but not social engagement-were differentially associated with objectively measured activity by outcome group across contexts. CONCLUSIONS: Overactivity may be a shared, rather than distinct, precursor of atypical development in infants/toddlers developing ASD and concerns for ADHD, emerging as early as 18 months. Group differences in overactivity may be context-specific and associated with different underlying mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.13504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Patterns of objectively measured motor activity among infants developing ASD and concerns for ADHD [texte imprimé] / Rachel REETZKE, Auteur ; Ana-Maria IOSIF, Auteur ; Burt HATCH, Auteur ; Leiana DE LA PAZ, Auteur ; Annie CHUANG, Auteur ; Sally OZONOFF, Auteur ; Meghan MILLER, Auteur . - p.663-673. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-6 (June 2022) . - p.663-673 Mots-clés : Activity level  attention-deficit/hyperactivity disorder  autism spectrum disorder  infancy Index. décimale : PER Périodiques Résumé : BACKGROUND: Heightened motor activity is a hallmark of attention-deficit/hyperactivity disorder (ADHD), yet high activity levels are also often reported in young children with autism spectrum disorder (ASD). It is currently unclear whether increased motor activity represents a distinct versus shared early predictor of ASD and ADHD; no prior studies have directly examined this prospectively. We investigated differences in longitudinal patterns of objectively measured motor activity during early development. METHODS: Participants included 113 infants at high and low risk for ASD or ADHD. Continuous motion-based activity was recorded using tri-axial accelerometers at 12, 18, 24, and 36 months of age. At 36 months, participants were categorized into one of three outcome groups: ASD (n=19), ADHD Concerns (n=17), and Typically Developing (TD; n=77). Group differences in trajectories of motor activity were examined in structured and semistructured contexts. Associations with behaviors relevant to ASD, ADHD, and general development were also examined. RESULTS: In both structured and semistructured contexts, both the ASD and ADHD Concerns groups exhibited heightened activity relative to the TD group by 18 months; the ASD group exhibited higher activity than the ADHD Concerns group at 24-36 months in the structured context only. Attention/behavior regulation, nonverbal, and verbal development-but not social engagement-were differentially associated with objectively measured activity by outcome group across contexts. CONCLUSIONS: Overactivity may be a shared, rather than distinct, precursor of atypical development in infants/toddlers developing ASD and concerns for ADHD, emerging as early as 18 months. Group differences in overactivity may be context-specific and associated with different underlying mechanisms. En ligne : http://dx.doi.org/10.1111/jcpp.13504 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Shared and distinct developmental pathways to ASD and ADHD phenotypes among infants at familial risk / Meghan MILLER in Development and Psychopathology, 32-4 (October 2020)  

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