Dépouillements

The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults / Szilárd HOLKA in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70263 Titre : The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults Type de document : texte imprimé Auteurs : Szilárd HOLKA, Auteur ; Dániel SÖRNYEI, Auteur ; Ágota VASS, Auteur ; Levente RÓNAI, Auteur ; Kinga FARKAS, Auteur Article en page(s) : p.e70263 Langues : Anglais (eng) Mots-clés : autism  mentalization  network analysis  psychosocial vulnerability  schizotypy  self-perception Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is characterized by alterations in social understanding and self-related experience that overlap with broader dimensions of psychosocial vulnerability. These domains are tightly interconnected, motivating the use of analytic approaches that can capture their organization as complex associations rather than as isolated dimensions. We applied network analysis to autistic adults (N?=?156) and demographically matched neurotypical controls (N?=?454). Gaussian graphical models were estimated using sum scores of psychosocial constructs, and networks were compared using centrality metrics and the network comparison test. Compared to neurotypical participants, autistic individuals showed higher levels of psychosocial difficulties and lower global network strength. Mentalization emerged as a central node in both groups, while autistic traits were more central in the neurotypical network and trait anxiety showed relatively higher centrality in the ASD network. These findings suggest that psychosocial vulnerability in autism is characterized by a distinct and less integrated network organization, with mentalization playing a central role across groups and anxiety showing a relatively greater centrality in ASD. Network-based approaches may therefore help identify mechanism-relevant targets for intervention and refine dimensional models of social and self-related functioning in autism. En ligne : https://doi.org/10.1002/aur.70263 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] The Network Model of Mentalization, Social Vulnerability, and the Self in Autism: A Comparison With Neurotypical Adults [texte imprimé] / Szilárd HOLKA, Auteur ; Dániel SÖRNYEI, Auteur ; Ágota VASS, Auteur ; Levente RÓNAI, Auteur ; Kinga FARKAS, Auteur . - p.e70263. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70263 Mots-clés : autism  mentalization  network analysis  psychosocial vulnerability  schizotypy  self-perception Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is characterized by alterations in social understanding and self-related experience that overlap with broader dimensions of psychosocial vulnerability. These domains are tightly interconnected, motivating the use of analytic approaches that can capture their organization as complex associations rather than as isolated dimensions. We applied network analysis to autistic adults (N?=?156) and demographically matched neurotypical controls (N?=?454). Gaussian graphical models were estimated using sum scores of psychosocial constructs, and networks were compared using centrality metrics and the network comparison test. Compared to neurotypical participants, autistic individuals showed higher levels of psychosocial difficulties and lower global network strength. Mentalization emerged as a central node in both groups, while autistic traits were more central in the neurotypical network and trait anxiety showed relatively higher centrality in the ASD network. These findings suggest that psychosocial vulnerability in autism is characterized by a distinct and less integrated network organization, with mentalization playing a central role across groups and anxiety showing a relatively greater centrality in ASD. Network-based approaches may therefore help identify mechanism-relevant targets for intervention and refine dimensional models of social and self-related functioning in autism. En ligne : https://doi.org/10.1002/aur.70263 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Conceptualizing Functioning Levels of Theory of Mind Ability and Performance in Preschool to School-Aged Autistic and Neurotypical Children / Shih-Chieh LEE in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70264 Titre : Conceptualizing Functioning Levels of Theory of Mind Ability and Performance in Preschool to School-Aged Autistic and Neurotypical Children Type de document : texte imprimé Auteurs : Shih-Chieh LEE, Auteur ; Chien-Yu HUANG, Auteur ; Tzu-Yun HUANG, Auteur ; Wei-Chun HSU, Auteur ; Cian-Ya LAN, Auteur ; Kuan-Lin CHEN, Auteur Article en page(s) : p.e70264 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  psychometrics  Rasch analysis  theory of mind Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children often show reduced theory of mind (ToM). However, existing ToM measures neither sufficiently distinguish ToM ability from performance nor interpret both scores effectively, limiting their interpretability and clinical utility. To resolve these limitations, we characterized the measurement-based functioning levels and correspondence between ToM ability and performance among preschool to school-aged children. Data from 288 autistic and 168 neurotypical children were analyzed using a multidimensional Rasch model. The functioning levels and correspondence were established using expected responses across statistically distinguishable ToM levels. The results revealed three levels of ToM ability?Early (failure on all items), Basic (success on desire-based emotion), and Advanced (success on all items)?and five levels of ToM performance: Pre-ToM (understanding needs and wants), Emerging (simple emotion recognition), Transition (first-order false belief), Premature (contextual understanding), and Mature (pragmatic understanding). Importantly, while ToM performance tended to improve with ToM ability, only 20% of the items were comparable with neurotypical children. In conclusion, our findings highlight a critical gap in autistic children and provide the first empirically derived functioning framework linking ToM ability and performance. Beyond theoretical contribution, this study offers a practical pathway toward valid assessments and tailored interventions that target children's specific social-cognitive needs. En ligne : https://doi.org/10.1002/aur.70264 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Conceptualizing Functioning Levels of Theory of Mind Ability and Performance in Preschool to School-Aged Autistic and Neurotypical Children [texte imprimé] / Shih-Chieh LEE, Auteur ; Chien-Yu HUANG, Auteur ; Tzu-Yun HUANG, Auteur ; Wei-Chun HSU, Auteur ; Cian-Ya LAN, Auteur ; Kuan-Lin CHEN, Auteur . - p.e70264. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70264 Mots-clés : autism spectrum disorder  psychometrics  Rasch analysis  theory of mind Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children often show reduced theory of mind (ToM). However, existing ToM measures neither sufficiently distinguish ToM ability from performance nor interpret both scores effectively, limiting their interpretability and clinical utility. To resolve these limitations, we characterized the measurement-based functioning levels and correspondence between ToM ability and performance among preschool to school-aged children. Data from 288 autistic and 168 neurotypical children were analyzed using a multidimensional Rasch model. The functioning levels and correspondence were established using expected responses across statistically distinguishable ToM levels. The results revealed three levels of ToM ability?Early (failure on all items), Basic (success on desire-based emotion), and Advanced (success on all items)?and five levels of ToM performance: Pre-ToM (understanding needs and wants), Emerging (simple emotion recognition), Transition (first-order false belief), Premature (contextual understanding), and Mature (pragmatic understanding). Importantly, while ToM performance tended to improve with ToM ability, only 20% of the items were comparable with neurotypical children. In conclusion, our findings highlight a critical gap in autistic children and provide the first empirically derived functioning framework linking ToM ability and performance. Beyond theoretical contribution, this study offers a practical pathway toward valid assessments and tailored interventions that target children's specific social-cognitive needs. En ligne : https://doi.org/10.1002/aur.70264 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Neural Correlates for Anticipating and Observing Goal-Directed Actions in Autism / Manon A. KROL in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70272 Titre : Neural Correlates for Anticipating and Observing Goal-Directed Actions in Autism Type de document : texte imprimé Auteurs : Manon A. KROL, Auteur ; Tereza SKODOVA, Auteur ; Tjeerd JELLEMA, Auteur Article en page(s) : p.e70272 Langues : Anglais (eng) Mots-clés : action observation  anticipation  ASD  lower mu band  mu rhythm  upper mu band Index. décimale : PER Périodiques Résumé : ABSTRACT We investigated possible atypicalities in activation of cortical motor-related circuits in young adults with Autism Spectrum Conditions (ASC) and typical-development (TD) when observing others' actions. Activation of these circuits is reflected by suppression of power in EEG-Mu oscillations (8-13?Hz). Despite strong indications for functional distinctions between the upper (10.5-13?Hz) and lower (8?10.5?Hz) Mu-subbands, their separation remained unchartered territory in ASC research. Recordings were made from central, sensorimotor and occipital areas, while goal-directed actions that varied in the extent of both social interaction and biological motion were presented in video-clips. Anticipatory Mu suppression in response to upcoming actions was found exclusively at the sensorimotor site, in both groups. That is, during the presentation of a color signal embedded in the videos, which indicated whether or not an action would ensue, significantly more Mu-suppression occurred when the signal indicated an upcoming action. No such anticipatory activity occurred at central and occipital sites. During action observation, both groups showed significantly larger Mu suppressions in (i) the lower compared to the upper Mu band, and at (ii) sensorimotor compared to occipital and central sites. Extent of social interaction and biological motion of the actions did not significantly affect responses in either group. The groups did not differ significantly from each other in either band, condition or hemisphere. At the sensorimotor site, there was an overall tendency?though no significant evidence?for less desynchronisation to observed actions, and for more synchronization to no-action events (still image), in ASC compared to TD. En ligne : https://doi.org/10.1002/aur.70272 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Neural Correlates for Anticipating and Observing Goal-Directed Actions in Autism [texte imprimé] / Manon A. KROL, Auteur ; Tereza SKODOVA, Auteur ; Tjeerd JELLEMA, Auteur . - p.e70272. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70272 Mots-clés : action observation  anticipation  ASD  lower mu band  mu rhythm  upper mu band Index. décimale : PER Périodiques Résumé : ABSTRACT We investigated possible atypicalities in activation of cortical motor-related circuits in young adults with Autism Spectrum Conditions (ASC) and typical-development (TD) when observing others' actions. Activation of these circuits is reflected by suppression of power in EEG-Mu oscillations (8-13?Hz). Despite strong indications for functional distinctions between the upper (10.5-13?Hz) and lower (8?10.5?Hz) Mu-subbands, their separation remained unchartered territory in ASC research. Recordings were made from central, sensorimotor and occipital areas, while goal-directed actions that varied in the extent of both social interaction and biological motion were presented in video-clips. Anticipatory Mu suppression in response to upcoming actions was found exclusively at the sensorimotor site, in both groups. That is, during the presentation of a color signal embedded in the videos, which indicated whether or not an action would ensue, significantly more Mu-suppression occurred when the signal indicated an upcoming action. No such anticipatory activity occurred at central and occipital sites. During action observation, both groups showed significantly larger Mu suppressions in (i) the lower compared to the upper Mu band, and at (ii) sensorimotor compared to occipital and central sites. Extent of social interaction and biological motion of the actions did not significantly affect responses in either group. The groups did not differ significantly from each other in either band, condition or hemisphere. At the sensorimotor site, there was an overall tendency?though no significant evidence?for less desynchronisation to observed actions, and for more synchronization to no-action events (still image), in ASC compared to TD. En ligne : https://doi.org/10.1002/aur.70272 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Staged Audiovisual Speech Integration and Altered Early-Stage Audiovisual Processing in Autistic Children: An EEG Investigation / Shuyuan FENG in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70273 Titre : Staged Audiovisual Speech Integration and Altered Early-Stage Audiovisual Processing in Autistic Children: An EEG Investigation Type de document : texte imprimé Auteurs : Shuyuan FENG, Auteur ; Baolin LI, Auteur ; Wei NI, Auteur ; Sio Pan HOI, Auteur ; Xue LI, Auteur ; Juan ZHANG, Auteur ; Qiandong WANG, Auteur ; Lihan CHEN, Auteur ; Li YI, Auteur Article en page(s) : p.e70273 Langues : Anglais (eng) Mots-clés : audiovisual incongruence  audiovisual speech integration  autism  EEG  McGurk effect Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children exhibit difficulties in audiovisual speech integration, which are associated with their social communication challenges. The neural mechanism underlying audiovisual speech integration difficulties in autism remains unclear. We recruited 19 neurotypical (NT) children and 29 autistic children. We recorded their behavioral responses and Electroencephalography (EEG) signals to audiovisual congruent syllables, and incongruent syllables that could evoke audiovisual speech integration (i.e., McGurk effect). For the EEG analysis, we further classified autistic children into the autistic McGurk group and the autistic non-McGurk group based on their strength of audiovisual speech integration. Behaviorally, we found reduced audiovisual speech integration in autistic children. At the neural level, we found that: (1) NT children showed an early stage audiovisual processing (indexed by the N1 amplitude), which was altered in two autistic groups; (2) all three groups exhibited a successful audiovisual incongruence detection (i.e., phonological Mismatch Negativity, pMMN); (3) NT and autistic McGurk groups could successfully resolve the audiovisual incongruence (indexed by the restoration of pMMN), but the autistic non-McGurk group could not (indexed by the sustained negative amplitude). Furthermore, we found a distinct temporal decoding pattern between non-McGurk and congruent trials across groups: both NT and autistic McGurk groups exhibited early EEG decoding, whereas the autistic non-McGurk group demonstrated successful decoding during late processing stages. Audiovisual speech integration entails a three-stage process in NT children: early audiovisual processing, audiovisual incongruence detection, and audiovisual incongruence resolution. The altered early-stage processing was possibly the neural mechanism underlying the reduced audiovisual speech integration in autistic children. En ligne : https://doi.org/10.1002/aur.70273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Staged Audiovisual Speech Integration and Altered Early-Stage Audiovisual Processing in Autistic Children: An EEG Investigation [texte imprimé] / Shuyuan FENG, Auteur ; Baolin LI, Auteur ; Wei NI, Auteur ; Sio Pan HOI, Auteur ; Xue LI, Auteur ; Juan ZHANG, Auteur ; Qiandong WANG, Auteur ; Lihan CHEN, Auteur ; Li YI, Auteur . - p.e70273. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70273 Mots-clés : audiovisual incongruence  audiovisual speech integration  autism  EEG  McGurk effect Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children exhibit difficulties in audiovisual speech integration, which are associated with their social communication challenges. The neural mechanism underlying audiovisual speech integration difficulties in autism remains unclear. We recruited 19 neurotypical (NT) children and 29 autistic children. We recorded their behavioral responses and Electroencephalography (EEG) signals to audiovisual congruent syllables, and incongruent syllables that could evoke audiovisual speech integration (i.e., McGurk effect). For the EEG analysis, we further classified autistic children into the autistic McGurk group and the autistic non-McGurk group based on their strength of audiovisual speech integration. Behaviorally, we found reduced audiovisual speech integration in autistic children. At the neural level, we found that: (1) NT children showed an early stage audiovisual processing (indexed by the N1 amplitude), which was altered in two autistic groups; (2) all three groups exhibited a successful audiovisual incongruence detection (i.e., phonological Mismatch Negativity, pMMN); (3) NT and autistic McGurk groups could successfully resolve the audiovisual incongruence (indexed by the restoration of pMMN), but the autistic non-McGurk group could not (indexed by the sustained negative amplitude). Furthermore, we found a distinct temporal decoding pattern between non-McGurk and congruent trials across groups: both NT and autistic McGurk groups exhibited early EEG decoding, whereas the autistic non-McGurk group demonstrated successful decoding during late processing stages. Audiovisual speech integration entails a three-stage process in NT children: early audiovisual processing, audiovisual incongruence detection, and audiovisual incongruence resolution. The altered early-stage processing was possibly the neural mechanism underlying the reduced audiovisual speech integration in autistic children. En ligne : https://doi.org/10.1002/aur.70273 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses / Sara CACCIATO-SALCEDO in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70275 Titre : Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses Type de document : texte imprimé Auteurs : Sara CACCIATO-SALCEDO, Auteur ; Shreya JAOKAR, Auteur ; Neil J. INGHAM, Auteur ; Manuel S. MALMIERCA, Auteur ; Marija M. PETRINOVIC, Auteur Article en page(s) : p.e70275 Langues : Anglais (eng) Mots-clés : autism spectrum disorder (ASD)  electroencephalography (EEG)  magnetoencephalography (MEG)  mismatch fields (MMF)  mismatch negativity (MMN) Index. décimale : PER Périodiques Résumé : ABSTRACT Auditory mismatch responses?mismatch negativity (MMN) and mismatch fields (MMF)?are well established electrophysiological markers of automatic auditory discrimination supported by short-term sensory memory. These responses, typically elicited using passive oddball paradigms, are increasingly used to investigate sensory and language processing in autism. This systematic review synthesizes findings from 55 studies comparing MMN and MMF responses in autistic and typically developing (TD) individuals across childhood, adolescence, and adulthood. Using the Synthesis Without Meta-analysis (SWiM) framework, we identified consistent evidence for smaller MMN amplitudes and reduced MMF power in autistic children and adolescents relative to TD peers, particularly in response to frequency, duration, and speech-based deviants. Studies also frequently reported longer mismatch latencies in autistic participants and associated these delays with language difficulties and heightened auditory sensitivity. Although some studies reported age-related convergence in MMN and MMF measures between autistic and TD groups in later childhood or adolescence, greater right-hemisphere lateralization in autistic individuals emerged as a consistent finding across both speech and non-speech paradigms, suggesting differences in hemispheric weighting for auditory processing of linguistic and non-linguistic cues. To explain interindividual and developmental variability in mismatch responses, we propose a precision-weighted predictive coding account, in which divergent assignment of confidence to sensory prediction errors may contribute to autism-related differences. While study quality was generally fair, methodological heterogeneity, underrepresentation of females, and limited cross-cultural sampling constrain generalizability. Future research should prioritize longitudinal, sex-stratified, and culturally diverse designs, using standardized protocols and collaborative data practices. MMN and MMF responses hold promise as non-invasive translational biomarkers of early-stage sensory prediction and neurodevelopmental variation in autism. En ligne : https://doi.org/10.1002/aur.70275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Auditory Sensitivity in Autism: A Systematic Review of Mismatch Negativity and Mismatch Field Responses [texte imprimé] / Sara CACCIATO-SALCEDO, Auteur ; Shreya JAOKAR, Auteur ; Neil J. INGHAM, Auteur ; Manuel S. MALMIERCA, Auteur ; Marija M. PETRINOVIC, Auteur . - p.e70275. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70275 Mots-clés : autism spectrum disorder (ASD)  electroencephalography (EEG)  magnetoencephalography (MEG)  mismatch fields (MMF)  mismatch negativity (MMN) Index. décimale : PER Périodiques Résumé : ABSTRACT Auditory mismatch responses?mismatch negativity (MMN) and mismatch fields (MMF)?are well established electrophysiological markers of automatic auditory discrimination supported by short-term sensory memory. These responses, typically elicited using passive oddball paradigms, are increasingly used to investigate sensory and language processing in autism. This systematic review synthesizes findings from 55 studies comparing MMN and MMF responses in autistic and typically developing (TD) individuals across childhood, adolescence, and adulthood. Using the Synthesis Without Meta-analysis (SWiM) framework, we identified consistent evidence for smaller MMN amplitudes and reduced MMF power in autistic children and adolescents relative to TD peers, particularly in response to frequency, duration, and speech-based deviants. Studies also frequently reported longer mismatch latencies in autistic participants and associated these delays with language difficulties and heightened auditory sensitivity. Although some studies reported age-related convergence in MMN and MMF measures between autistic and TD groups in later childhood or adolescence, greater right-hemisphere lateralization in autistic individuals emerged as a consistent finding across both speech and non-speech paradigms, suggesting differences in hemispheric weighting for auditory processing of linguistic and non-linguistic cues. To explain interindividual and developmental variability in mismatch responses, we propose a precision-weighted predictive coding account, in which divergent assignment of confidence to sensory prediction errors may contribute to autism-related differences. While study quality was generally fair, methodological heterogeneity, underrepresentation of females, and limited cross-cultural sampling constrain generalizability. Future research should prioritize longitudinal, sex-stratified, and culturally diverse designs, using standardized protocols and collaborative data practices. MMN and MMF responses hold promise as non-invasive translational biomarkers of early-stage sensory prediction and neurodevelopmental variation in autism. En ligne : https://doi.org/10.1002/aur.70275 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Examining the Validity and Reliability of Evaluation in Ayres Sensory Integration Data Collected With Autistic Children: A Rasch Analysis / Patricia GRADY-DOMINGUEZ in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70276 Titre : Examining the Validity and Reliability of Evaluation in Ayres Sensory Integration Data Collected With Autistic Children: A Rasch Analysis Type de document : texte imprimé Auteurs : Patricia GRADY-DOMINGUEZ, Auteur ; Anita C. BUNDY, Auteur ; Zoe MAILLOUX, Auteur ; Roseann C. SCHAAF, Auteur Article en page(s) : p.e70276 Langues : Anglais (eng) Mots-clés : autism  behavioral measurement  pre-school children  school-age children  sensory integration Index. décimale : PER Périodiques Résumé : ABSTRACT Performance-based assessments of sensory function provide essential insights into sensory integration challenges in autistic children and provide objective, standardized measurement data that can be used to tailor targeted interventions. We sought to evaluate the validity and reliability of data collected using the Evaluation in Ayres Sensory Integration (EASI) for assessing sensory and motor functions in autistic children. We used the Rasch Measurement Model to evaluate data collected with 146 autistic children aged 3?12?years (United States: n?=?24, Australia: n?=?115, Brazil: n?=?7). We analyzed 19 performance-based tests assessing sensory perception, praxis, and motor functions. Rasch analyses examined item fit, unidimensionality, item targeting, and internal reliability. Seventeen of 19 analyzed EASI tests demonstrated strong construct validity, with adequate item-fit and unidimensionality. Fourteen tests met reliability thresholds (person separation reliability ≥?0.70), while five tests exhibited lower person separation reliability. Some tests showed poor item targeting, potentially limiting their precision for children with stronger sensorimotor abilities. Most EASI tests demonstrate strong validity and reliability for assessing sensory integration in autistic children. Clinicians can use tests meeting reliability thresholds with confidence; tests with lower reliability can provide useful information but should be corroborated with other clinical data. Findings for PF should be considered preliminary given limited sample size. In general, this initial validation of EASI advances the evaluation of sensory integration for autistic children. En ligne : https://doi.org/10.1002/aur.70276 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Examining the Validity and Reliability of Evaluation in Ayres Sensory Integration Data Collected With Autistic Children: A Rasch Analysis [texte imprimé] / Patricia GRADY-DOMINGUEZ, Auteur ; Anita C. BUNDY, Auteur ; Zoe MAILLOUX, Auteur ; Roseann C. SCHAAF, Auteur . - p.e70276. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70276 Mots-clés : autism  behavioral measurement  pre-school children  school-age children  sensory integration Index. décimale : PER Périodiques Résumé : ABSTRACT Performance-based assessments of sensory function provide essential insights into sensory integration challenges in autistic children and provide objective, standardized measurement data that can be used to tailor targeted interventions. We sought to evaluate the validity and reliability of data collected using the Evaluation in Ayres Sensory Integration (EASI) for assessing sensory and motor functions in autistic children. We used the Rasch Measurement Model to evaluate data collected with 146 autistic children aged 3?12?years (United States: n?=?24, Australia: n?=?115, Brazil: n?=?7). We analyzed 19 performance-based tests assessing sensory perception, praxis, and motor functions. Rasch analyses examined item fit, unidimensionality, item targeting, and internal reliability. Seventeen of 19 analyzed EASI tests demonstrated strong construct validity, with adequate item-fit and unidimensionality. Fourteen tests met reliability thresholds (person separation reliability ≥?0.70), while five tests exhibited lower person separation reliability. Some tests showed poor item targeting, potentially limiting their precision for children with stronger sensorimotor abilities. Most EASI tests demonstrate strong validity and reliability for assessing sensory integration in autistic children. Clinicians can use tests meeting reliability thresholds with confidence; tests with lower reliability can provide useful information but should be corroborated with other clinical data. Findings for PF should be considered preliminary given limited sample size. In general, this initial validation of EASI advances the evaluation of sensory integration for autistic children. En ligne : https://doi.org/10.1002/aur.70276 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Artificial Intelligence Methods in Early Detection of Autism Spectrum Disorder: A DSM-5 Criterion-Based Systematic Review / Mohamed Ali ZOROMBA in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70279 Titre : Artificial Intelligence Methods in Early Detection of Autism Spectrum Disorder: A DSM-5 Criterion-Based Systematic Review Type de document : texte imprimé Auteurs : Mohamed Ali ZOROMBA, Auteur ; Heba Emad EL-GAZAR, Auteur Article en page(s) : p.e70279 Langues : Anglais (eng) Mots-clés : artificial intelligence  autism Spectrum disorder  children  deep learning  DSM-5 criteria  early detection  machine learning Index. décimale : PER Périodiques Résumé : ABSTRACT Can Artificial Intelligence (AI) revolutionize early detection of Autism Spectrum Disorder (ASD) by offering a more objective alternative to the subjective behavioral assessments? This systematic review evaluates AI-based methods for early ASD detection in children, assessing the distribution, performance, and DSM-5 alignment of AI techniques, and the methodological quality of existing studies. Following PRISMA guidelines, seven databases (PubMed, Web of Science, Scopus, IEEE Xplore, PsycNET, CINAHL, and Cochrane Library) were searched from January 2015 to March 2025; no backward or forward citation tracking was conducted. Studies were included if they focused on pediatric populations (ages 0?18) with clinically diagnosed ASD, employed AI detection/classification methods, utilized observable behavioral data, and reported diagnostic performance metrics. Studies using exclusively neurobiological data, adult populations, non-English publications, or lacking clear diagnostic reference standards were excluded. Two reviewers independently screened 1018 records; 43 met inclusion criteria. Methodological quality was assessed using QUADAS-2, adapted for machine learning considerations. Classical Machine Learning (34%), Deep Learning (34%), and Hybrid approaches (32%) were equally prevalent. Convolutional Neural Networks and Support Vector Machines dominated for unstructured and structured data, respectively. Most studies (74%) targeted both DSM-5 Criteria A and B; 23% focused solely on Criterion A. Direct DSM-5 alignment correlated with higher accuracy (median ~95%); overall accuracy ranged from 68.18% to 100%. Methodological concerns included 57% unclear patient selection and 43% unclear index test risk. AI demonstrates transformative potential for early ASD detection, particularly for social communication deficits. Gaps in Criterion B coverage, geographic skew toward high-income settings, and methodological inconsistencies limit clinical applicability. Future work should prioritize standardized protocols, multimodal integration, and diverse external validation. Trial Registration: PROSPERO registration ID: CRD420250656126 En ligne : https://doi.org/10.1002/aur.70279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Artificial Intelligence Methods in Early Detection of Autism Spectrum Disorder: A DSM-5 Criterion-Based Systematic Review [texte imprimé] / Mohamed Ali ZOROMBA, Auteur ; Heba Emad EL-GAZAR, Auteur . - p.e70279. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70279 Mots-clés : artificial intelligence  autism Spectrum disorder  children  deep learning  DSM-5 criteria  early detection  machine learning Index. décimale : PER Périodiques Résumé : ABSTRACT Can Artificial Intelligence (AI) revolutionize early detection of Autism Spectrum Disorder (ASD) by offering a more objective alternative to the subjective behavioral assessments? This systematic review evaluates AI-based methods for early ASD detection in children, assessing the distribution, performance, and DSM-5 alignment of AI techniques, and the methodological quality of existing studies. Following PRISMA guidelines, seven databases (PubMed, Web of Science, Scopus, IEEE Xplore, PsycNET, CINAHL, and Cochrane Library) were searched from January 2015 to March 2025; no backward or forward citation tracking was conducted. Studies were included if they focused on pediatric populations (ages 0?18) with clinically diagnosed ASD, employed AI detection/classification methods, utilized observable behavioral data, and reported diagnostic performance metrics. Studies using exclusively neurobiological data, adult populations, non-English publications, or lacking clear diagnostic reference standards were excluded. Two reviewers independently screened 1018 records; 43 met inclusion criteria. Methodological quality was assessed using QUADAS-2, adapted for machine learning considerations. Classical Machine Learning (34%), Deep Learning (34%), and Hybrid approaches (32%) were equally prevalent. Convolutional Neural Networks and Support Vector Machines dominated for unstructured and structured data, respectively. Most studies (74%) targeted both DSM-5 Criteria A and B; 23% focused solely on Criterion A. Direct DSM-5 alignment correlated with higher accuracy (median ~95%); overall accuracy ranged from 68.18% to 100%. Methodological concerns included 57% unclear patient selection and 43% unclear index test risk. AI demonstrates transformative potential for early ASD detection, particularly for social communication deficits. Gaps in Criterion B coverage, geographic skew toward high-income settings, and methodological inconsistencies limit clinical applicability. Future work should prioritize standardized protocols, multimodal integration, and diverse external validation. Trial Registration: PROSPERO registration ID: CRD420250656126 En ligne : https://doi.org/10.1002/aur.70279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Limited Discrepancy Between Cognitive Ability and Daily Living Skills in Autism: A Longitudinal Study From Ages 2–25 / Elaine B. CLARKE in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70280 Titre : Limited Discrepancy Between Cognitive Ability and Daily Living Skills in Autism: A Longitudinal Study From Ages 2–25 Type de document : texte imprimé Auteurs : Elaine B. CLARKE, Auteur ; Catherine LORD, Auteur ; Vanessa H. BAL, Auteur Article en page(s) : p.e70280 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental disabilities  intelligence  latent variable modeling  longitudinal studies Index. décimale : PER Périodiques Résumé : ABSTRACT Many autistic individuals with average or higher cognitive abilities (also referred to as intelligence quotient; IQ) exhibit weaker than expected daily living skills (DLS). However, existing evidence is primarily cross-sectional. This study examined: (1) how IQ-DLS discrepancies develop from early childhood through early adulthood, (2) whether childhood factors (e.g., autism features, non-verbal IQ) predict these developmental pathways, and (3) how IQ-DLS discrepancy trajectories relate to adult experiences (e.g., employment, well-being, relationships). Analyses included 92 individuals from the Longitudinal Study of Autism with average or better IQ and repeated assessments of IQ and DLS from ages 2?25?years. Developmental patterns in IQ-DLS discrepancy scores were identified using group-based trajectory modeling. Two trajectory groups were identified: IQ?=?DLS (commensurate cognitive and daily living skills) and IQ?>?DLS (weaker DLS than expected for IQ). Most participants had commensurate IQ and DLS across development. When discrepancies emerged, they did so gradually, becoming apparent by mid-childhood. White participants were more likely to be in the IQ?>?DLS group; participant race was the only early childhood predictor of group membership. IQ-DLS discrepancy trajectories were not significantly associated with adult experiences. In contrast to existing literature, this study suggests autistic individuals with average or higher IQ may not always have persistent deficits in DLS relative to cognitive ability. When discrepancies occurred in this sample, they developed over time rather than being present from early childhood. These findings challenge deterministic assumptions about adaptive function in autism and highlight the importance of sustained opportunities to learn and practice DLS across development. En ligne : https://doi.org/10.1002/aur.70280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Limited Discrepancy Between Cognitive Ability and Daily Living Skills in Autism: A Longitudinal Study From Ages 2–25 [texte imprimé] / Elaine B. CLARKE, Auteur ; Catherine LORD, Auteur ; Vanessa H. BAL, Auteur . - p.e70280. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70280 Mots-clés : autism spectrum disorder  developmental disabilities  intelligence  latent variable modeling  longitudinal studies Index. décimale : PER Périodiques Résumé : ABSTRACT Many autistic individuals with average or higher cognitive abilities (also referred to as intelligence quotient; IQ) exhibit weaker than expected daily living skills (DLS). However, existing evidence is primarily cross-sectional. This study examined: (1) how IQ-DLS discrepancies develop from early childhood through early adulthood, (2) whether childhood factors (e.g., autism features, non-verbal IQ) predict these developmental pathways, and (3) how IQ-DLS discrepancy trajectories relate to adult experiences (e.g., employment, well-being, relationships). Analyses included 92 individuals from the Longitudinal Study of Autism with average or better IQ and repeated assessments of IQ and DLS from ages 2?25?years. Developmental patterns in IQ-DLS discrepancy scores were identified using group-based trajectory modeling. Two trajectory groups were identified: IQ?=?DLS (commensurate cognitive and daily living skills) and IQ?>?DLS (weaker DLS than expected for IQ). Most participants had commensurate IQ and DLS across development. When discrepancies emerged, they did so gradually, becoming apparent by mid-childhood. White participants were more likely to be in the IQ?>?DLS group; participant race was the only early childhood predictor of group membership. IQ-DLS discrepancy trajectories were not significantly associated with adult experiences. In contrast to existing literature, this study suggests autistic individuals with average or higher IQ may not always have persistent deficits in DLS relative to cognitive ability. When discrepancies occurred in this sample, they developed over time rather than being present from early childhood. These findings challenge deterministic assumptions about adaptive function in autism and highlight the importance of sustained opportunities to learn and practice DLS across development. En ligne : https://doi.org/10.1002/aur.70280 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

ShopAutiPlan: Validating a Serious Game for Assessing Executive Planning in Autism / Athmar N. M. SHAMHAN in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70281 Titre : ShopAutiPlan: Validating a Serious Game for Assessing Executive Planning in Autism Type de document : texte imprimé Auteurs : Athmar N. M. SHAMHAN, Auteur ; Marrianna CONSTANTINOU, Auteur ; Howraa HAJAIG, Auteur ; Marwa QARAQE, Auteur ; Dena AL-THANI, Auteur Article en page(s) : p.e70281 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  convergent validity  ecological validity  executive function  serious games Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) frequently experience difficulties in executive functions, particularly planning and goal-directed behavior, yet traditional assessments such as the Tower of London and Zoo Map offer limited ecological validity and do not capture how planning challenges manifest in everyday contexts. This study introduces and validates ShopAutiPlan, a supermarket-based serious game designed to assess planning skills through naturalistic, multistep tasks. A total of 57 children aged 7?10?years (27 ASD and 30 neurotypical), matched on age and IQ, completed both the game and conventional EF assessments, including the BRIEF-2 and two BADS-C subtests (Zoo Map and Key Search). ShopAutiPlan automatically recorded behavioral indicators related to task completion and efficiency. Group comparisons revealed that neurotypical children outperformed those with ASD across all standardized measures, and autistic participants exhibited reduced in-game efficiency?demonstrated by longer completion times, greater distances traveled, and more pauses?despite achieving similar item completion. Significant correlations between game-derived metrics and traditional planning tests provided strong evidence of convergent validity. Overall, findings demonstrate that ShopAutiPlan is a valid, ecologically grounded, and engaging tool for assessing executive planning in children with ASD, complementing and extending conventional neuropsychological approaches. En ligne : https://doi.org/10.1002/aur.70281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] ShopAutiPlan: Validating a Serious Game for Assessing Executive Planning in Autism [texte imprimé] / Athmar N. M. SHAMHAN, Auteur ; Marrianna CONSTANTINOU, Auteur ; Howraa HAJAIG, Auteur ; Marwa QARAQE, Auteur ; Dena AL-THANI, Auteur . - p.e70281. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70281 Mots-clés : autism spectrum disorder  convergent validity  ecological validity  executive function  serious games Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) frequently experience difficulties in executive functions, particularly planning and goal-directed behavior, yet traditional assessments such as the Tower of London and Zoo Map offer limited ecological validity and do not capture how planning challenges manifest in everyday contexts. This study introduces and validates ShopAutiPlan, a supermarket-based serious game designed to assess planning skills through naturalistic, multistep tasks. A total of 57 children aged 7?10?years (27 ASD and 30 neurotypical), matched on age and IQ, completed both the game and conventional EF assessments, including the BRIEF-2 and two BADS-C subtests (Zoo Map and Key Search). ShopAutiPlan automatically recorded behavioral indicators related to task completion and efficiency. Group comparisons revealed that neurotypical children outperformed those with ASD across all standardized measures, and autistic participants exhibited reduced in-game efficiency?demonstrated by longer completion times, greater distances traveled, and more pauses?despite achieving similar item completion. Significant correlations between game-derived metrics and traditional planning tests provided strong evidence of convergent validity. Overall, findings demonstrate that ShopAutiPlan is a valid, ecologically grounded, and engaging tool for assessing executive planning in children with ASD, complementing and extending conventional neuropsychological approaches. En ligne : https://doi.org/10.1002/aur.70281 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

The Effectiveness of Acceptance and Commitment Therapy Group Intervention (Navigator ACT) for Parents of Children With Neurodevelopmental Disabilities: A Randomized Controlled Trial / T. HOLMBERG BERGMAN in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70282 Titre : The Effectiveness of Acceptance and Commitment Therapy Group Intervention (Navigator ACT) for Parents of Children With Neurodevelopmental Disabilities: A Randomized Controlled Trial Type de document : texte imprimé Auteurs : T. HOLMBERG BERGMAN, Auteur ; P. LAPPALAINEN, Auteur ; A. GHADERI, Auteur ; T. HIRVIKOSKI, Auteur Article en page(s) : p.e70282 Langues : Anglais (eng) Mots-clés : acceptance and commitment therapy  ADHD  autism  intellectual disability  neurodevelopmental disabilities  parenting  parenting stress  psychological flexibility Index. décimale : PER Périodiques Résumé : ABSTRACT High levels of parental stress and psychological inflexibility are common among caregivers raising children with neurodevelopmental disabilities. Navigator ACT is a group-based treatment developed to increase psychological flexibility and reduce the impact of stress among parents of children with various disabilities (e.g., autism spectrum disorder, ADHD, intellectual disability, acquired brain injury). This two-arm randomized controlled trial (n?=?137) was conducted in Sweden within outpatient disability services setting, and pre-registered in the clinical trials register. To compare conditions, stressed and distressed parents were randomly assigned to either the ACT group (n?=?70) or treatment-as-usual (TAU, n?=?67). In the ACT group, 83.3% completed the full course of treatment. Mixed-model linear regression analyses indicated that ACT was significantly more effective than TAU in reducing self-reported psychological inflexibility (p? En ligne : https://doi.org/10.1002/aur.70282 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] The Effectiveness of Acceptance and Commitment Therapy Group Intervention (Navigator ACT) for Parents of Children With Neurodevelopmental Disabilities: A Randomized Controlled Trial [texte imprimé] / T. HOLMBERG BERGMAN, Auteur ; P. LAPPALAINEN, Auteur ; A. GHADERI, Auteur ; T. HIRVIKOSKI, Auteur . - p.e70282. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70282 Mots-clés : acceptance and commitment therapy  ADHD  autism  intellectual disability  neurodevelopmental disabilities  parenting  parenting stress  psychological flexibility Index. décimale : PER Périodiques Résumé : ABSTRACT High levels of parental stress and psychological inflexibility are common among caregivers raising children with neurodevelopmental disabilities. Navigator ACT is a group-based treatment developed to increase psychological flexibility and reduce the impact of stress among parents of children with various disabilities (e.g., autism spectrum disorder, ADHD, intellectual disability, acquired brain injury). This two-arm randomized controlled trial (n?=?137) was conducted in Sweden within outpatient disability services setting, and pre-registered in the clinical trials register. To compare conditions, stressed and distressed parents were randomly assigned to either the ACT group (n?=?70) or treatment-as-usual (TAU, n?=?67). In the ACT group, 83.3% completed the full course of treatment. Mixed-model linear regression analyses indicated that ACT was significantly more effective than TAU in reducing self-reported psychological inflexibility (p? En ligne : https://doi.org/10.1002/aur.70282 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Atypical Predictive Processing Is Associated With Sensory Over-Responsivity in Autism / Bar YOSEF in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70283 Titre : Atypical Predictive Processing Is Associated With Sensory Over-Responsivity in Autism Type de document : texte imprimé Auteurs : Bar YOSEF, Auteur ; Valerie BURGESS, Auteur ; Megan BANCHIK, Auteur ; Joshua CEBALLOS, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite GREEN, Auteur Article en page(s) : p.e70283 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  fMRI  neural activity  predictive processing  sensory over-responsivity  sensory processing Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is characterized by sensory processing atypicalities including sensory over-responsivity (SOR), a heightened negative response to sensory stimuli. Although the neural mechanisms underlying SOR are not fully understood, SOR has been associated with sensory-limbic hyper-reactivity during sensory stimulation. Altered predictive processing may play a key role in atypical sensory processing but few studies have directly probed the relationship between SOR and prediction, particularly using aversive stimuli that bother autistic individuals in everyday life. Here, we examined whether visual cues signaling the onset of aversive sensory stimuli would either (a) reduce neural hyper-reactivity in autism by making stimuli less unexpected or (b) show limited effects in autism due to atypical predictive processing hindering the use of the cue to attenuate responses. Fifty-five autistic (ASD; 30 female, mean age 21.01?±?3.49) and 28 typically developing (TD; 16 female, mean age 19.76?±?3.00) adolescents and young adults underwent functional magnetic resonance imaging (fMRI) while they were exposed to mildly aversive auditory and tactile stimulation. Stimulus blocks were either presented with a visual cue representing the upcoming sensory stimulus (Predictable), or no cue (Unpredictable). Results showed sensory cortical hyper-reactivity in ASD compared to TD in the Unpredictable condition, but responses to Predictable stimuli were overall similar between groups. In addition, expected stimuli were associated with increased frontal activity in autism, suggesting that visual cues facilitated regulation of sensory responses. Notably, within the autism group, SOR was associated with increased responses to expected stimuli in relevant sensory cortices, suggesting that reduced expectancy suppression may be specifically related to SOR within ASD rather than being a general autistic trait. En ligne : https://doi.org/10.1002/aur.70283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Atypical Predictive Processing Is Associated With Sensory Over-Responsivity in Autism [texte imprimé] / Bar YOSEF, Auteur ; Valerie BURGESS, Auteur ; Megan BANCHIK, Auteur ; Joshua CEBALLOS, Auteur ; Mirella DAPRETTO, Auteur ; Shulamite GREEN, Auteur . - p.e70283. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70283 Mots-clés : autism spectrum disorder  fMRI  neural activity  predictive processing  sensory over-responsivity  sensory processing Index. décimale : PER Périodiques Résumé : ABSTRACT Autism is characterized by sensory processing atypicalities including sensory over-responsivity (SOR), a heightened negative response to sensory stimuli. Although the neural mechanisms underlying SOR are not fully understood, SOR has been associated with sensory-limbic hyper-reactivity during sensory stimulation. Altered predictive processing may play a key role in atypical sensory processing but few studies have directly probed the relationship between SOR and prediction, particularly using aversive stimuli that bother autistic individuals in everyday life. Here, we examined whether visual cues signaling the onset of aversive sensory stimuli would either (a) reduce neural hyper-reactivity in autism by making stimuli less unexpected or (b) show limited effects in autism due to atypical predictive processing hindering the use of the cue to attenuate responses. Fifty-five autistic (ASD; 30 female, mean age 21.01?±?3.49) and 28 typically developing (TD; 16 female, mean age 19.76?±?3.00) adolescents and young adults underwent functional magnetic resonance imaging (fMRI) while they were exposed to mildly aversive auditory and tactile stimulation. Stimulus blocks were either presented with a visual cue representing the upcoming sensory stimulus (Predictable), or no cue (Unpredictable). Results showed sensory cortical hyper-reactivity in ASD compared to TD in the Unpredictable condition, but responses to Predictable stimuli were overall similar between groups. In addition, expected stimuli were associated with increased frontal activity in autism, suggesting that visual cues facilitated regulation of sensory responses. Notably, within the autism group, SOR was associated with increased responses to expected stimuli in relevant sensory cortices, suggesting that reduced expectancy suppression may be specifically related to SOR within ASD rather than being a general autistic trait. En ligne : https://doi.org/10.1002/aur.70283 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Informational and Normative Influence on Conformity in Autism / Akiko KOBAYASHI in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70284 Titre : Informational and Normative Influence on Conformity in Autism Type de document : texte imprimé Auteurs : Akiko KOBAYASHI, Auteur ; Takuya MAKINO, Auteur ; Yuka MIZUNO, Auteur ; Hirotaka KOSAKA, Auteur ; Keise IZUMA, Auteur Article en page(s) : p.e70284 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  heterogeneity  informational influence  normative influence  social camouflaging  social conformity Index. décimale : PER Périodiques Résumé : ABSTRACT This preregistered study examined whether adults with autism spectrum disorder (ASD) show reduced social conformity and whether any such reduction depends on the type of social influence. Social conformity?the tendency to adjust one's judgments to align with those of others?is typically driven by normative (acceptance-seeking) and informational (accuracy-seeking) motives. Thirty adults with ASD and 30 matched neurotypical (NT) adults completed two tasks: a preference rating task indexing normative influence, and a dot-counting task indexing informational influence with monetary rewards. Contrary to our predictions, adults with ASD conformed as much as NT adults in the preference rating task but showed significantly reduced conformity in the dot-counting task. Exploratory analyses indicated that this reduction was driven by a distinct subgroup of nine adults with ASD who never revised their initial estimates despite informative social cues, resulting in poorer accuracy and lower rewards. When this subgroup was excluded, group differences in conformity were no longer evident. These findings suggest that, overall, adults with ASD are as susceptible as NT adults to normative influence but less responsive to informational influence, highlighting the importance of distinguishing between types of social influence and considering individual differences when characterizing social behavior in ASD. En ligne : https://doi.org/10.1002/aur.70284 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Informational and Normative Influence on Conformity in Autism [texte imprimé] / Akiko KOBAYASHI, Auteur ; Takuya MAKINO, Auteur ; Yuka MIZUNO, Auteur ; Hirotaka KOSAKA, Auteur ; Keise IZUMA, Auteur . - p.e70284. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70284 Mots-clés : autism spectrum disorder  heterogeneity  informational influence  normative influence  social camouflaging  social conformity Index. décimale : PER Périodiques Résumé : ABSTRACT This preregistered study examined whether adults with autism spectrum disorder (ASD) show reduced social conformity and whether any such reduction depends on the type of social influence. Social conformity?the tendency to adjust one's judgments to align with those of others?is typically driven by normative (acceptance-seeking) and informational (accuracy-seeking) motives. Thirty adults with ASD and 30 matched neurotypical (NT) adults completed two tasks: a preference rating task indexing normative influence, and a dot-counting task indexing informational influence with monetary rewards. Contrary to our predictions, adults with ASD conformed as much as NT adults in the preference rating task but showed significantly reduced conformity in the dot-counting task. Exploratory analyses indicated that this reduction was driven by a distinct subgroup of nine adults with ASD who never revised their initial estimates despite informative social cues, resulting in poorer accuracy and lower rewards. When this subgroup was excluded, group differences in conformity were no longer evident. These findings suggest that, overall, adults with ASD are as susceptible as NT adults to normative influence but less responsive to informational influence, highlighting the importance of distinguishing between types of social influence and considering individual differences when characterizing social behavior in ASD. En ligne : https://doi.org/10.1002/aur.70284 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Does Ongoing Task Load Influence Prospective Remembering in Autism Spectrum Disorders? / Daniela NÜRNBERG in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70285 Titre : Does Ongoing Task Load Influence Prospective Remembering in Autism Spectrum Disorders? Type de document : texte imprimé Auteurs : Daniela NÜRNBERG, Auteur ; Mareike ALTGASSEN, Auteur Article en page(s) : p.e70285 Langues : Anglais (eng) Mots-clés : autism  cognitive load  ongoing task  prospective memory Index. décimale : PER Périodiques Résumé : ABSTRACT Prospective memory (PM) refers to the cognitive ability to remember to carry out intended actions in the future. The present study investigated PM performance in autistic and non-autistic adults as well as the impact of the cognitive load of the ongoing task on PM performance. A total of 50 autistic individuals and 51 age- and non-verbal ability-matched non-autistic individuals completed an event-based PM task, which was embedded into an ongoing n-back task. The cognitive load of the n-back task was varied (2- vs. 3-back for low versus high cognitive load). Results showed that autistic participants did not differ from non-autistic participants in their PM performance. The cognitive load of the ongoing task had no impact on event-based PM performance in both groups. This is the first study to investigate the impact of ongoing task load on event-based PM performance in autistic adults. The results support the neurodiversity perspective of ASD as a highly heterogeneous population which is not necessarily characterized by reduced PM performance. En ligne : https://doi.org/10.1002/aur.70285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Does Ongoing Task Load Influence Prospective Remembering in Autism Spectrum Disorders? [texte imprimé] / Daniela NÜRNBERG, Auteur ; Mareike ALTGASSEN, Auteur . - p.e70285. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70285 Mots-clés : autism  cognitive load  ongoing task  prospective memory Index. décimale : PER Périodiques Résumé : ABSTRACT Prospective memory (PM) refers to the cognitive ability to remember to carry out intended actions in the future. The present study investigated PM performance in autistic and non-autistic adults as well as the impact of the cognitive load of the ongoing task on PM performance. A total of 50 autistic individuals and 51 age- and non-verbal ability-matched non-autistic individuals completed an event-based PM task, which was embedded into an ongoing n-back task. The cognitive load of the n-back task was varied (2- vs. 3-back for low versus high cognitive load). Results showed that autistic participants did not differ from non-autistic participants in their PM performance. The cognitive load of the ongoing task had no impact on event-based PM performance in both groups. This is the first study to investigate the impact of ongoing task load on event-based PM performance in autistic adults. The results support the neurodiversity perspective of ASD as a highly heterogeneous population which is not necessarily characterized by reduced PM performance. En ligne : https://doi.org/10.1002/aur.70285 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice / Krisztina SÁFÁR in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70286 Titre : Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice Type de document : texte imprimé Auteurs : Krisztina SÁFÁR, Auteur ; Vivien SZENDI, Auteur ; Paulina HOPPA, Auteur ; Yutong WANG, Auteur ; Fanni Á SERES, Auteur ; Szilvia BARTÓK, Auteur ; Tyler TEADORA, Auteur ; Lei SHI, Auteur ; Árpád DOBOLYI, Auteur ; Gina PUSKA, Auteur ; István ADORJÁN, Auteur Article en page(s) : p.e70286 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  calretinin  CNTNAP2  parvalbumin  social behavior  social novelty preference  striatum Index. décimale : PER Périodiques Résumé : ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown. Interneurons, as key regulators of excitatory?inhibitory balance, represent a candidate source of vulnerability. In this study, we quantified calretinin-positive (CR+) and parvalbumin-positive (PV+) interneuron density in the caudoputamen (CP) and somatosensory cortex (SSC) of Cntnap2 knockout (KO) and wild-type (WT) mice and assessed their relationship with social behavior. Cntnap2 KO mice exhibited significantly lower CR+ interneuron density in both brain regions, whereas no significant difference was observed in the PV+ density. Cntnap2 KO females showed altered behavior in the social novelty preference test compared to WT females. Cntnap2 KO animals also displayed elevated ?moving away? responses, a social withdrawal phenotype. Correlation analyses revealed that within the KO group, higher striatal CR+ density was associated with a greater frequency and duration of ?moving away.? CR+ density in the SSC did not correlate with this behavioral phenotype. The results suggest that striatal CR+ interneurons may modulate the persistence and intensity of social withdrawal behavior. In conclusion, our findings reveal region-specific alterations in CR+ interneuron density in Cntnap2 KO mice and uncover a previously unrecognized link between Cntnap2 function, striatal interneuron organization and social withdrawal behavior. The results highlight CR+ interneurons as potential contributors to altered basal ganglia function in ASD and underscore the need for circuit-level analyses of genetically defined risk models. En ligne : https://doi.org/10.1002/aur.70286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Lower Striatal and Cortical Calretinin Interneuron Density Associated With Altered Social Behavior in Cntnap2 Knockout Mice [texte imprimé] / Krisztina SÁFÁR, Auteur ; Vivien SZENDI, Auteur ; Paulina HOPPA, Auteur ; Yutong WANG, Auteur ; Fanni Á SERES, Auteur ; Szilvia BARTÓK, Auteur ; Tyler TEADORA, Auteur ; Lei SHI, Auteur ; Árpád DOBOLYI, Auteur ; Gina PUSKA, Auteur ; István ADORJÁN, Auteur . - p.e70286. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70286 Mots-clés : autism spectrum disorder  calretinin  CNTNAP2  parvalbumin  social behavior  social novelty preference  striatum Index. décimale : PER Périodiques Résumé : ABSTRACT Variants in the CNTNAP2 gene, encoding the cell adhesion molecule CASPR2, have been identified as genetic risk factors for autism spectrum disorder (ASD). However, the mechanisms through which CNTNAP2 dysfunction alters circuit function remain unknown. Interneurons, as key regulators of excitatory?inhibitory balance, represent a candidate source of vulnerability. In this study, we quantified calretinin-positive (CR+) and parvalbumin-positive (PV+) interneuron density in the caudoputamen (CP) and somatosensory cortex (SSC) of Cntnap2 knockout (KO) and wild-type (WT) mice and assessed their relationship with social behavior. Cntnap2 KO mice exhibited significantly lower CR+ interneuron density in both brain regions, whereas no significant difference was observed in the PV+ density. Cntnap2 KO females showed altered behavior in the social novelty preference test compared to WT females. Cntnap2 KO animals also displayed elevated ?moving away? responses, a social withdrawal phenotype. Correlation analyses revealed that within the KO group, higher striatal CR+ density was associated with a greater frequency and duration of ?moving away.? CR+ density in the SSC did not correlate with this behavioral phenotype. The results suggest that striatal CR+ interneurons may modulate the persistence and intensity of social withdrawal behavior. In conclusion, our findings reveal region-specific alterations in CR+ interneuron density in Cntnap2 KO mice and uncover a previously unrecognized link between Cntnap2 function, striatal interneuron organization and social withdrawal behavior. The results highlight CR+ interneurons as potential contributors to altered basal ganglia function in ASD and underscore the need for circuit-level analyses of genetically defined risk models. En ligne : https://doi.org/10.1002/aur.70286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults / Hsiang-Yuan LIN in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70287 Titre : Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults Type de document : texte imprimé Auteurs : Hsiang-Yuan LIN, Auteur ; Arthur N. WESTOVER, Auteur ; Amy S.F. LUTZ, Auteur ; Manish K. JHA, Auteur Article en page(s) : p.e70287 Langues : Anglais (eng) Mots-clés : autism  autistic adults  challenging behaviors  clinical trials  emotional dysregulation  irritability Index. décimale : PER Périodiques Résumé : ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a vulnerable neurobiology (e.g., sensory sensitivities, intolerance of uncertainty), but may also stem from intrinsic neurobiological dysregulation independent of environmental triggers. The current treatment paradigm for autistic adults, largely extrapolated from pediatric antipsychotic trials, leaves these adults critically underserved due to a lack of evidence-based treatments, clinical trials, or validated tools to measure their internal experience. This viewpoint deconstructs irritability, differentiating its affective nature from aggression, and highlights heterogeneity across the lifespan and support needs. We critique the limitations of current assessment methods and recommend a shift toward a multi-modal strategy integrating self-report (when feasible) with objective, physiologically-informed tools (e.g., wearable biosensors) and nuanced observer reports. We argue that the field is poised for neuroscience-informed treatment innovation?including novel pharmacological agents and adapted psychosocial interventions?but is hampered by a lack of rigorous clinical trials in adults. Finally, we call for mechanistically driven trials to address the large unmet burden of inadequately treated irritability, ultimately improving the quality of life for autistic adults and their families/caregivers. En ligne : https://doi.org/10.1002/aur.70287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults [texte imprimé] / Hsiang-Yuan LIN, Auteur ; Arthur N. WESTOVER, Auteur ; Amy S.F. LUTZ, Auteur ; Manish K. JHA, Auteur . - p.e70287. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70287 Mots-clés : autism  autistic adults  challenging behaviors  clinical trials  emotional dysregulation  irritability Index. décimale : PER Périodiques Résumé : ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a vulnerable neurobiology (e.g., sensory sensitivities, intolerance of uncertainty), but may also stem from intrinsic neurobiological dysregulation independent of environmental triggers. The current treatment paradigm for autistic adults, largely extrapolated from pediatric antipsychotic trials, leaves these adults critically underserved due to a lack of evidence-based treatments, clinical trials, or validated tools to measure their internal experience. This viewpoint deconstructs irritability, differentiating its affective nature from aggression, and highlights heterogeneity across the lifespan and support needs. We critique the limitations of current assessment methods and recommend a shift toward a multi-modal strategy integrating self-report (when feasible) with objective, physiologically-informed tools (e.g., wearable biosensors) and nuanced observer reports. We argue that the field is poised for neuroscience-informed treatment innovation?including novel pharmacological agents and adapted psychosocial interventions?but is hampered by a lack of rigorous clinical trials in adults. Finally, we call for mechanistically driven trials to address the large unmet burden of inadequately treated irritability, ultimately improving the quality of life for autistic adults and their families/caregivers. En ligne : https://doi.org/10.1002/aur.70287 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Linking Brain Morphometry to Psychometric Measures and Energy-Metabolic Biomarkers in Adults With Autism Spectrum Disorder / Eleonora ESPOSTO in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70288 Titre : Linking Brain Morphometry to Psychometric Measures and Energy-Metabolic Biomarkers in Adults With Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Eleonora ESPOSTO, Auteur ; Kathrin NICKEL, Auteur ; Dominique ENDRES, Auteur ; Kimon RUNGE, Auteur ; Katharina DOMSCHKE, Auteur ; Thomas LANGE, Auteur ; Marco REISERT, Auteur ; Anke SCHUMANN, Auteur ; Cinzia NIOLU, Auteur ; Ludger Tebartz VAN ELST, Auteur ; Simon MAIER, Auteur Article en page(s) : p.e70288 Langues : Anglais (eng) Mots-clés : acylcarnitines  autism spectrum disorder  brain morphometry  cortical thickness  magnetic resonance spectroscopy  mitochondrial energy biomarkers Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is associated with differences in neurodevelopment and altered metabolism, yet the interplay between brain morphometry, mitochondrial and energy metabolism biomarkers, and autistic traits in adults remains poorly understood. This study investigates the link between brain structure, psychometric measures, and both central and peripheral metabolic biomarkers in adults with ASD. We studied 145 adults, including 74 with ASD and 71 control participants (CON) using high-resolution 3-Tesla MRI to assess cortical thickness, subcortical and global brain volumes. Central energy metabolism was indexed by the posterior-cingulate lactate?+?threonine (Lac+) peak quantified with proton-MRS. We examined associations between biomarkers of mitochondrial function and energy metabolism (including lactate, pyruvate, creatine kinase, and multiple acylcarnitines). Psychometric evaluations included measures of ASD and attention-deficit/hyperactivity disorder (ADHD) symptom severity, as well as other psychiatric comorbidities. Between-group differences and correlations were assessed using robust statistics, controlling for age, sex, image quality, and total intracranial volume. Adults with ASD showed significantly larger bilateral caudate volumes compared to CON. Within the ASD group, higher ADHD symptom severity in childhood correlated with reduced cortical thickness in multiple frontal and temporal regions. Among metabolic markers, acylcarnitine C5:1 was positively associated with right insular cortex thickness, while C18:1-OH and C18:2 levels correlated positively with caudate volume. Caudate nucleus volume is associated not only with an ASD diagnosis but also with specific peripheral energy-metabolism blood markers, such as specific acylcarnitines. Alterations in cortical thickness were also correlated with acylcarnitine levels and, to a greater extent, with co-occurring ADHD symptoms. While alterations in cortical thickness and basal ganglia structure have been previously described in ASD and comorbid ADHD, the linkage between mitochondrial and energy metabolism biomarkers with neuroanatomical alterations in ASD is, to our knowledge, a novel observation that warrants further investigation. En ligne : https://doi.org/10.1002/aur.70288 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Linking Brain Morphometry to Psychometric Measures and Energy-Metabolic Biomarkers in Adults With Autism Spectrum Disorder [texte imprimé] / Eleonora ESPOSTO, Auteur ; Kathrin NICKEL, Auteur ; Dominique ENDRES, Auteur ; Kimon RUNGE, Auteur ; Katharina DOMSCHKE, Auteur ; Thomas LANGE, Auteur ; Marco REISERT, Auteur ; Anke SCHUMANN, Auteur ; Cinzia NIOLU, Auteur ; Ludger Tebartz VAN ELST, Auteur ; Simon MAIER, Auteur . - p.e70288. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70288 Mots-clés : acylcarnitines  autism spectrum disorder  brain morphometry  cortical thickness  magnetic resonance spectroscopy  mitochondrial energy biomarkers Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is associated with differences in neurodevelopment and altered metabolism, yet the interplay between brain morphometry, mitochondrial and energy metabolism biomarkers, and autistic traits in adults remains poorly understood. This study investigates the link between brain structure, psychometric measures, and both central and peripheral metabolic biomarkers in adults with ASD. We studied 145 adults, including 74 with ASD and 71 control participants (CON) using high-resolution 3-Tesla MRI to assess cortical thickness, subcortical and global brain volumes. Central energy metabolism was indexed by the posterior-cingulate lactate?+?threonine (Lac+) peak quantified with proton-MRS. We examined associations between biomarkers of mitochondrial function and energy metabolism (including lactate, pyruvate, creatine kinase, and multiple acylcarnitines). Psychometric evaluations included measures of ASD and attention-deficit/hyperactivity disorder (ADHD) symptom severity, as well as other psychiatric comorbidities. Between-group differences and correlations were assessed using robust statistics, controlling for age, sex, image quality, and total intracranial volume. Adults with ASD showed significantly larger bilateral caudate volumes compared to CON. Within the ASD group, higher ADHD symptom severity in childhood correlated with reduced cortical thickness in multiple frontal and temporal regions. Among metabolic markers, acylcarnitine C5:1 was positively associated with right insular cortex thickness, while C18:1-OH and C18:2 levels correlated positively with caudate volume. Caudate nucleus volume is associated not only with an ASD diagnosis but also with specific peripheral energy-metabolism blood markers, such as specific acylcarnitines. Alterations in cortical thickness were also correlated with acylcarnitine levels and, to a greater extent, with co-occurring ADHD symptoms. While alterations in cortical thickness and basal ganglia structure have been previously described in ASD and comorbid ADHD, the linkage between mitochondrial and energy metabolism biomarkers with neuroanatomical alterations in ASD is, to our knowledge, a novel observation that warrants further investigation. En ligne : https://doi.org/10.1002/aur.70288 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity / Juan KOU in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70289 Titre : The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity Type de document : texte imprimé Auteurs : Juan KOU, Auteur ; Mengyuan YANG, Auteur ; Lan ZHANG, Auteur ; Jiao LE, Auteur ; Lihui HUANG, Auteur ; Yi LEI, Auteur Article en page(s) : p.e70289 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is characterized by difficulties in social interaction, as individuals with ASD process social cues like gestures and facial expressions in a unique way. Despite this knowledge, the exact neurophysiological mechanisms driving these differences and their direct impact on clinical symptoms remain unclear.?This study delves deeper into understanding the neurophysiological mechanisms involved in social cue integration, moving beyond mere behavioral observations. Specifically, we investigated how autistic children and typically developing (TD) peers process congruent and incongruent social signals in everyday situations.?We compared 34 male autistic (2.5?6?years) versus 34 TD children via eye-tracking and functional near-infrared spectroscopy to measure gaze, pupil dilation, and frontal activation during gesture-face integration. TD children exhibited heightened attention to happy faces while maintaining equal attention to neutral faces and gestures when reward gestures were paired. The ASD group did not demonstrate an effective processing strategy. ASD children exhibited heightened pupil dilation and anterior prefrontal cortex (aPFC) activation in all conditions. Crucially, their gaze patterns and aPFC activation significantly correlated with poorer adaptive functioning and positively predicted autism severity. Autistic children go through a distinct, neurologically demanding, and inefficient process to integrate multimodal social cues. This inefficient compensatory attempt results in a metabolically costly physiological state, which is directly connected to the core challenges of ASD. The identified features provide a preliminary proof-of-concept for objective biomarkers, offering quantifiable, physiological indices of severity, thus enabling the development of targeted neurocognitive interventions. En ligne : https://doi.org/10.1002/aur.70289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity [texte imprimé] / Juan KOU, Auteur ; Mengyuan YANG, Auteur ; Lan ZHANG, Auteur ; Jiao LE, Auteur ; Lihui HUANG, Auteur ; Yi LEI, Auteur . - p.e70289. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70289 Index. décimale : PER Périodiques Résumé : ABSTRACT Autism Spectrum Disorder (ASD) is characterized by difficulties in social interaction, as individuals with ASD process social cues like gestures and facial expressions in a unique way. Despite this knowledge, the exact neurophysiological mechanisms driving these differences and their direct impact on clinical symptoms remain unclear.?This study delves deeper into understanding the neurophysiological mechanisms involved in social cue integration, moving beyond mere behavioral observations. Specifically, we investigated how autistic children and typically developing (TD) peers process congruent and incongruent social signals in everyday situations.?We compared 34 male autistic (2.5?6?years) versus 34 TD children via eye-tracking and functional near-infrared spectroscopy to measure gaze, pupil dilation, and frontal activation during gesture-face integration. TD children exhibited heightened attention to happy faces while maintaining equal attention to neutral faces and gestures when reward gestures were paired. The ASD group did not demonstrate an effective processing strategy. ASD children exhibited heightened pupil dilation and anterior prefrontal cortex (aPFC) activation in all conditions. Crucially, their gaze patterns and aPFC activation significantly correlated with poorer adaptive functioning and positively predicted autism severity. Autistic children go through a distinct, neurologically demanding, and inefficient process to integrate multimodal social cues. This inefficient compensatory attempt results in a metabolically costly physiological state, which is directly connected to the core challenges of ASD. The identified features provide a preliminary proof-of-concept for objective biomarkers, offering quantifiable, physiological indices of severity, thus enabling the development of targeted neurocognitive interventions. En ligne : https://doi.org/10.1002/aur.70289 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Effects of Peer Exclusion on Prosocial Behavior in Autistic Children Placed in Regular Classrooms: The Mediating Role of Inhibitory Control / Shuman WU in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70290 Titre : Effects of Peer Exclusion on Prosocial Behavior in Autistic Children Placed in Regular Classrooms: The Mediating Role of Inhibitory Control Type de document : texte imprimé Auteurs : Shuman WU, Auteur ; Yongmei ZENG, Auteur ; Siyi HUANG, Auteur Article en page(s) : p.e70290 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  inhibitory control  peer exclusion  placed in regular classrooms  prosocial behavior Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children placed in regular classrooms are frequently exposed to peer exclusion, yet the mechanisms underlying the impairment of their prosocial behavior remain unclear. The mediating role of inhibitory control warrants urgent investigation. This study aims to explore the mechanisms through which peer exclusion influences prosocial behavior in autistic children placed in regular classrooms, paying specific attention to the mediating role of inhibitory control. Convenience sampling is used to recruit autistic children placed in regular classrooms from several cities in Guangdong Province, China. A cross-validation approach combining a questionnaire survey (Study 1, N?=?158) and an experimental design (Study 2, N?=?128) is used to assess children's perceived peer exclusion, inhibitory control, and prosocial behavior. Results show that peer exclusion not only negatively predicts autistic children's prosocial behavior directly, but also indirectly weakens prosocial performance by depleting their inhibitory control resources. Inhibitory control partially mediates this relationship, accounting for 16.32% (Study 1) and 29.10% (Study 2) of the mediating effect, respectively. These findings reveal the underlying pathway through which peer exclusion influences social behavior in autistic children from the perspective of cognitive resource depletion, providing empirical support for intervention models integrating environmental support and cognitive training in inclusive education. En ligne : https://doi.org/10.1002/aur.70290 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Effects of Peer Exclusion on Prosocial Behavior in Autistic Children Placed in Regular Classrooms: The Mediating Role of Inhibitory Control [texte imprimé] / Shuman WU, Auteur ; Yongmei ZENG, Auteur ; Siyi HUANG, Auteur . - p.e70290. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70290 Mots-clés : autism spectrum disorder  inhibitory control  peer exclusion  placed in regular classrooms  prosocial behavior Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children placed in regular classrooms are frequently exposed to peer exclusion, yet the mechanisms underlying the impairment of their prosocial behavior remain unclear. The mediating role of inhibitory control warrants urgent investigation. This study aims to explore the mechanisms through which peer exclusion influences prosocial behavior in autistic children placed in regular classrooms, paying specific attention to the mediating role of inhibitory control. Convenience sampling is used to recruit autistic children placed in regular classrooms from several cities in Guangdong Province, China. A cross-validation approach combining a questionnaire survey (Study 1, N?=?158) and an experimental design (Study 2, N?=?128) is used to assess children's perceived peer exclusion, inhibitory control, and prosocial behavior. Results show that peer exclusion not only negatively predicts autistic children's prosocial behavior directly, but also indirectly weakens prosocial performance by depleting their inhibitory control resources. Inhibitory control partially mediates this relationship, accounting for 16.32% (Study 1) and 29.10% (Study 2) of the mediating effect, respectively. These findings reveal the underlying pathway through which peer exclusion influences social behavior in autistic children from the perspective of cognitive resource depletion, providing empirical support for intervention models integrating environmental support and cognitive training in inclusive education. En ligne : https://doi.org/10.1002/aur.70290 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

“People Think I'm a Fraud”: A Shared Autistic Experience Across Vastly Different Profiles / Mary DOHERTY in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70292 Titre : “People Think I'm a Fraud”: A Shared Autistic Experience Across Vastly Different Profiles Type de document : texte imprimé Auteurs : Mary DOHERTY, Auteur Article en page(s) : p.e70292 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70292 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] “People Think I'm a Fraud”: A Shared Autistic Experience Across Vastly Different Profiles [texte imprimé] / Mary DOHERTY, Auteur . - p.e70292. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70292 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1002/aur.70292 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

Motor Disorders in Autism: From Comorbidity to Core Criterion / Mohamed JABER in Autism Research, 19-7 (July 2026)  

Public ISBD [article]  inAutism Research > 19-7 (July 2026) . - p.e70293 Titre : Motor Disorders in Autism: From Comorbidity to Core Criterion Type de document : texte imprimé Auteurs : Mohamed JABER, Auteur Article en page(s) : p.e70293 Langues : Anglais (eng) Mots-clés : ASD  basal ganglia  cerebellum  diagnosis criteria  embodied cognition  gait  motor screening  neurodevelopment Index. décimale : PER Périodiques Résumé : ABSTRACT While repetitive movements are recognized as a diagnostic hallmark of Autism Spectrum Disorder (ASD) in frameworks such as the DSM and ICD, other motor disturbances, including gait atypicalities and postural control difficulties, have historically been overlooked or framed as secondary comorbidities. This discrepancy persists despite growing evidence that motor signs in ASD are fundamental rather than incidental. Some of these motor and gait signs may be discernable early and could potentially forecast subsequent communication outcomes in certain cohorts. The current focus on observable behaviors in diagnostic systems may thus benefit from integration of motor dimensions, which could enhance early identification and support tailored interventions. Available experimental and clinical findings converge to indicate that motor dysfunctions in ASD are neither epiphenomena nor peripheral. They map onto cerebellar and basal ganglia dysfunction, impaired multisensory integration, and disrupted emotion?motor coupling that may impact cognitive and social outcomes. Future directions must go beyond the current phenotypical characterization of ASD. Motor screening could be integrated into early pediatric surveillance, and interdisciplinary motor-based interventions embedded into individualized care. More factually, we contend that motor and gait signs, beyond restricted and repetitive movements, should be incorporated into future revisions of DSM and ICD as diagnostic criteria for ASD. This would not only improve sensitivity to early and mild ASD phenotypes but also realign autism diagnosis with its neurological foundation. Recognizing motor specificities as an integrated part of ASD demands a paradigm shift: pediatricians and psychiatrists must embrace an embodied, motor-informed model of autism, bridging it with neurology to transform both diagnosis and care. En ligne : https://doi.org/10.1002/aur.70293 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] Motor Disorders in Autism: From Comorbidity to Core Criterion [texte imprimé] / Mohamed JABER, Auteur . - p.e70293. Langues : Anglais (eng) in Autism Research > 19-7 (July 2026) . - p.e70293 Mots-clés : ASD  basal ganglia  cerebellum  diagnosis criteria  embodied cognition  gait  motor screening  neurodevelopment Index. décimale : PER Périodiques Résumé : ABSTRACT While repetitive movements are recognized as a diagnostic hallmark of Autism Spectrum Disorder (ASD) in frameworks such as the DSM and ICD, other motor disturbances, including gait atypicalities and postural control difficulties, have historically been overlooked or framed as secondary comorbidities. This discrepancy persists despite growing evidence that motor signs in ASD are fundamental rather than incidental. Some of these motor and gait signs may be discernable early and could potentially forecast subsequent communication outcomes in certain cohorts. The current focus on observable behaviors in diagnostic systems may thus benefit from integration of motor dimensions, which could enhance early identification and support tailored interventions. Available experimental and clinical findings converge to indicate that motor dysfunctions in ASD are neither epiphenomena nor peripheral. They map onto cerebellar and basal ganglia dysfunction, impaired multisensory integration, and disrupted emotion?motor coupling that may impact cognitive and social outcomes. Future directions must go beyond the current phenotypical characterization of ASD. Motor screening could be integrated into early pediatric surveillance, and interdisciplinary motor-based interventions embedded into individualized care. More factually, we contend that motor and gait signs, beyond restricted and repetitive movements, should be incorporated into future revisions of DSM and ICD as diagnostic criteria for ASD. This would not only improve sensitivity to early and mild ASD phenotypes but also realign autism diagnosis with its neurological foundation. Recognizing motor specificities as an integrated part of ASD demands a paradigm shift: pediatricians and psychiatrists must embrace an embodied, motor-informed model of autism, bridging it with neurology to transform both diagnosis and care. En ligne : https://doi.org/10.1002/aur.70293 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589