Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents / Justine Nienke PANNEKOEK in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1317-1327 Titre : Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Justine Nienke PANNEKOEK, Auteur ; S. J. A. VAN DER WERFF, Auteur ; Paul H. F. MEENS, Auteur ; Bianca G. VAN DEN BULK, Auteur ; Dietsje D. JOLLES, Auteur ; Ilya M. VEER, Auteur ; Natasja D. J. VAN LANG, Auteur ; Serge A. R. B. ROMBOUTS, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Robert R. J. M. VERMEIREN, Auteur Article en page(s) : p.1317-1327 Langues : Anglais (eng) Mots-clés : Resting-state  adolescents  depression  anxiety Index. décimale : PER Périodiques Résumé : Background Depression is prevalent and typically has its onset in adolescence. Resting-state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting-state functional connectivity (RSFC) is examined using seed regions-of-interest (ROIs) associated with three networks: the limbic network, the default mode network (DMN) and the salience network. Methods Twenty-six treatment-naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair-wise matched healthy controls underwent resting-state fMRI. The three networks were investigated using a seed-based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (dACC; salience network) and bilateral posterior cingulate cortex (default mode network). Results Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC, as well as with right occipito-parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network. En ligne : http://dx.doi.org/10.1111/jcpp.12266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents [Texte imprimé et/ou numérique] / Justine Nienke PANNEKOEK, Auteur ; S. J. A. VAN DER WERFF, Auteur ; Paul H. F. MEENS, Auteur ; Bianca G. VAN DEN BULK, Auteur ; Dietsje D. JOLLES, Auteur ; Ilya M. VEER, Auteur ; Natasja D. J. VAN LANG, Auteur ; Serge A. R. B. ROMBOUTS, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Robert R. J. M. VERMEIREN, Auteur . - p.1317-1327. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1317-1327 Mots-clés : Resting-state  adolescents  depression  anxiety Index. décimale : PER Périodiques Résumé : Background Depression is prevalent and typically has its onset in adolescence. Resting-state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting-state functional connectivity (RSFC) is examined using seed regions-of-interest (ROIs) associated with three networks: the limbic network, the default mode network (DMN) and the salience network. Methods Twenty-six treatment-naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair-wise matched healthy controls underwent resting-state fMRI. The three networks were investigated using a seed-based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (dACC; salience network) and bilateral posterior cingulate cortex (default mode network). Results Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC, as well as with right occipito-parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network. En ligne : http://dx.doi.org/10.1111/jcpp.12266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Adolescent boys with an autism spectrum disorder and their experience of sexuality: An interpretative phenomenological analysis / Jeroen DEWINTER in Autism, 21-1 (January 2017)  

Public ISBD [article]  inAutism > 21-1 (January 2017) . - p.75-82 Titre : Adolescent boys with an autism spectrum disorder and their experience of sexuality: An interpretative phenomenological analysis Type de document : Texte imprimé et/ou numérique Auteurs : Jeroen DEWINTER, Auteur ; Hanna Van PARYS, Auteur ; Robert R. J. M. VERMEIREN, Auteur ; Chijs van NIEUWENHUIZEN, Auteur Article en page(s) : p.75-82 Langues : Anglais (eng) Mots-clés : adolescents  autism  interpretative phenomenological analysis  qualitative research  sexuality Index. décimale : PER Périodiques Résumé : This qualitative study explored how adolescent boys with autism spectrum disorder experience their sexuality. Previous research has demonstrated that sexuality is a developmental task for boys with autism spectrum disorder, as it is for their peers. Case studies have suggested a relation between autism spectrum disorder and atypical sexual development; empirical studies on this subject, however, are scant and inconsistent. This study is based on interviews with eight boys, aged 16–20?years, with Asperger’s disorder or autistic disorder. Interpretative phenomenological analysis of the data revealed three major themes relating to (a) how they experience sexual feelings, think about sexuality and think about themselves as sexual beings; (b) how they perceive messages relating to sexuality in their surroundings; and (c) how they experience finding and having a partner and partnered sex. We believe that attention to these themes is needed in assessment, education and further research. En ligne : http://dx.doi.org/10.1177/1362361315627134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Adolescent boys with an autism spectrum disorder and their experience of sexuality: An interpretative phenomenological analysis [Texte imprimé et/ou numérique] / Jeroen DEWINTER, Auteur ; Hanna Van PARYS, Auteur ; Robert R. J. M. VERMEIREN, Auteur ; Chijs van NIEUWENHUIZEN, Auteur . - p.75-82. Langues : Anglais (eng) in Autism > 21-1 (January 2017) . - p.75-82 Mots-clés : adolescents  autism  interpretative phenomenological analysis  qualitative research  sexuality Index. décimale : PER Périodiques Résumé : This qualitative study explored how adolescent boys with autism spectrum disorder experience their sexuality. Previous research has demonstrated that sexuality is a developmental task for boys with autism spectrum disorder, as it is for their peers. Case studies have suggested a relation between autism spectrum disorder and atypical sexual development; empirical studies on this subject, however, are scant and inconsistent. This study is based on interviews with eight boys, aged 16–20?years, with Asperger’s disorder or autistic disorder. Interpretative phenomenological analysis of the data revealed three major themes relating to (a) how they experience sexual feelings, think about sexuality and think about themselves as sexual beings; (b) how they perceive messages relating to sexuality in their surroundings; and (c) how they experience finding and having a partner and partnered sex. We believe that attention to these themes is needed in assessment, education and further research. En ligne : http://dx.doi.org/10.1177/1362361315627134 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Autistic symptoms in childhood arrestees: longitudinal association with delinquent behavior / Charlotte A. M. L. GELUK in Journal of Child Psychology and Psychiatry, 53-2 (February 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-2 (February 2012) . - p.160-167 Titre : Autistic symptoms in childhood arrestees: longitudinal association with delinquent behavior Type de document : Texte imprimé et/ou numérique Auteurs : Charlotte A. M. L. GELUK, Auteur ; Lucres M. C. JANSEN, Auteur ; Robert R. J. M. VERMEIREN, Auteur ; Theo A. DORELEIJERS, Auteur ; Lieke VAN DOMBURGH, Auteur ; Annelies A. DE BILDT, Auteur ; Jos W. R. TWISK, Auteur ; Catharina A. HARTMAN, Auteur Année de publication : 2012 Article en page(s) : p.160-167 Langues : Anglais (eng) Mots-clés : Pervasive developmental disorder  delinquency  externalizing disorder  longitudinal study Index. décimale : PER Périodiques Résumé : Background:  To compare childhood arrestees with matched comparison groups on levels of autistic symptoms and to assess the unique predictive value of autistic symptoms for future delinquent behavior in childhood arrestees. Methods:  Childhood first-time arrestees (n = 308, baseline age 10.7 ± 1.5 years) were followed up for 2 years. Autistic symptoms, externalizing disorders and delinquent behavior were assessed yearly. Childhood arrestees were compared on autistic symptoms with matched (age, gender) general population and clinical autism spectrum disorder samples. The predictive value of autistic symptoms for delinquent behavior was analyzed using generalized estimating equations. Results:  At each assessment, levels of autistic symptoms in childhood arrestees were in between levels found in the general population and autism spectrum disorder samples. Autistic symptoms were positively associated with delinquent behavior in childhood arrestees, even after adjustment for externalizing disorders: IRR (incidence rate ratio) 1.23; 95% CI 1.11–1.36 and IRR 1.29; 95% CI 1.15–1.45 for core autistic symptoms and total symptom score, respectively. Conclusions:  Autistic symptoms are more prevalent in childhood arrestees compared to the general population and are uniquely associated with future delinquent behavior. Attention should, therefore, be given to the possible presence of autism related symptomatology in these children. Implications for diagnostic assessment and intervention need further investigation. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02456.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150 [article] Autistic symptoms in childhood arrestees: longitudinal association with delinquent behavior [Texte imprimé et/ou numérique] / Charlotte A. M. L. GELUK, Auteur ; Lucres M. C. JANSEN, Auteur ; Robert R. J. M. VERMEIREN, Auteur ; Theo A. DORELEIJERS, Auteur ; Lieke VAN DOMBURGH, Auteur ; Annelies A. DE BILDT, Auteur ; Jos W. R. TWISK, Auteur ; Catharina A. HARTMAN, Auteur . - 2012 . - p.160-167. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-2 (February 2012) . - p.160-167 Mots-clés : Pervasive developmental disorder  delinquency  externalizing disorder  longitudinal study Index. décimale : PER Périodiques Résumé : Background:  To compare childhood arrestees with matched comparison groups on levels of autistic symptoms and to assess the unique predictive value of autistic symptoms for future delinquent behavior in childhood arrestees. Methods:  Childhood first-time arrestees (n = 308, baseline age 10.7 ± 1.5 years) were followed up for 2 years. Autistic symptoms, externalizing disorders and delinquent behavior were assessed yearly. Childhood arrestees were compared on autistic symptoms with matched (age, gender) general population and clinical autism spectrum disorder samples. The predictive value of autistic symptoms for delinquent behavior was analyzed using generalized estimating equations. Results:  At each assessment, levels of autistic symptoms in childhood arrestees were in between levels found in the general population and autism spectrum disorder samples. Autistic symptoms were positively associated with delinquent behavior in childhood arrestees, even after adjustment for externalizing disorders: IRR (incidence rate ratio) 1.23; 95% CI 1.11–1.36 and IRR 1.29; 95% CI 1.15–1.45 for core autistic symptoms and total symptom score, respectively. Conclusions:  Autistic symptoms are more prevalent in childhood arrestees compared to the general population and are uniquely associated with future delinquent behavior. Attention should, therefore, be given to the possible presence of autism related symptomatology in these children. Implications for diagnostic assessment and intervention need further investigation. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02456.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=150

Detained adolescent females’ multiple mental health and adjustment problem outcomes in young adulthood / E. VAN DER MOLEN in Journal of Child Psychology and Psychiatry, 54-9 (September 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-9 (September 2013) . - p.950-957 Titre : Detained adolescent females’ multiple mental health and adjustment problem outcomes in young adulthood Type de document : Texte imprimé et/ou numérique Auteurs : E. VAN DER MOLEN, Auteur ; Robert R. J. M. VERMEIREN, Auteur ; A. A. KRABBENDAM, Auteur ; A. T. F. BEEKMAN, Auteur ; Theo A. DORELEIJERS, Auteur ; L. M. C. JANSEN, Auteur Article en page(s) : p.950-957 Langues : Anglais (eng) Mots-clés : Follow-up  detention  females  adult outcome Index. décimale : PER Périodiques Résumé : Background: Although prior studies have shown that detained females are marked by significant adverse circumstances, little is known about their adult outcomes. Method: Prospective follow-up study of 184 (80.4% of original sample of 229) detained adolescent females who were reassessed 4.5 (SD = 0.6) years later in young adulthood (mean age = 20.0, SD = 1.4) on mental health and adjustment outcomes. Associations between these outcomes and detained females’ behavior problems and offense history were examined. Results: In the total sample, 59.0% had one or more mental health problems at follow-up, whereas 96.2% were facing at least one adjustment problem. Subjects with a personality disorder (PD) reported more adjustment problems compared to subjects without PD. Mental health and adjustment problems in young adulthood were predicted by detained adolescent females’ behavior problems and offense history. Conclusion: Detained adolescent females suffered from multiple mental health and adjustment problems in young adulthood. Females who developed PD were most impaired. Results of this study underline the compelling need for continued and gender-specific interventions. The identification of predictors during detention for poor adult outcomes can serve as targets for intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] Detained adolescent females’ multiple mental health and adjustment problem outcomes in young adulthood [Texte imprimé et/ou numérique] / E. VAN DER MOLEN, Auteur ; Robert R. J. M. VERMEIREN, Auteur ; A. A. KRABBENDAM, Auteur ; A. T. F. BEEKMAN, Auteur ; Theo A. DORELEIJERS, Auteur ; L. M. C. JANSEN, Auteur . - p.950-957. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-9 (September 2013) . - p.950-957 Mots-clés : Follow-up  detention  females  adult outcome Index. décimale : PER Périodiques Résumé : Background: Although prior studies have shown that detained females are marked by significant adverse circumstances, little is known about their adult outcomes. Method: Prospective follow-up study of 184 (80.4% of original sample of 229) detained adolescent females who were reassessed 4.5 (SD = 0.6) years later in young adulthood (mean age = 20.0, SD = 1.4) on mental health and adjustment outcomes. Associations between these outcomes and detained females’ behavior problems and offense history were examined. Results: In the total sample, 59.0% had one or more mental health problems at follow-up, whereas 96.2% were facing at least one adjustment problem. Subjects with a personality disorder (PD) reported more adjustment problems compared to subjects without PD. Mental health and adjustment problems in young adulthood were predicted by detained adolescent females’ behavior problems and offense history. Conclusion: Detained adolescent females suffered from multiple mental health and adjustment problems in young adulthood. Females who developed PD were most impaired. Results of this study underline the compelling need for continued and gender-specific interventions. The identification of predictors during detention for poor adult outcomes can serve as targets for intervention. En ligne : http://dx.doi.org/10.1111/jcpp.12044 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits / Eduard T. KLAPWIJK in Journal of Child Psychology and Psychiatry, 57-6 (June 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.737-747 Titre : Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits Type de document : Texte imprimé et/ou numérique Auteurs : Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Olivier F. COLINS, Auteur ; Godfried M. MARIJNISSEN, Auteur ; Arne POPMA, Auteur ; Natasja D. J. VAN LANG, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Robert R. J. M. VERMEIREN, Auteur Article en page(s) : p.737-747 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  callous-unemotional  conduct disorder  emotions  empathy  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Deficits in empathy are reported in autism spectrum disorders (ASD) and also underlie antisocial behavior of individuals with conduct disorder and callous-unemotional traits (CD/CU+). Many studies suggest that individuals with ASD are typically impaired in cognitive aspects of empathy, and individuals with CD/CU+ typically in affective aspects. In the current study, we compared the neural correlates of cognitive and affective aspects of empathy between youth with ASD and youth with CD/CU+. Methods Functional magnetic resonance imaging (fMRI) was used to assess boys with ASD (N = 23), boys with CD/CU+ (N = 23), and typically developing (TD) boys (N = 33), aged 15–19 years. Angry and fearful faces were presented and participants were asked to either infer the emotional state from the face (other-task; emotion recognition) or to judge their own emotional response to the face (self-task; emotional resonance). Results During emotion recognition, boys with ASD showed reduced responses compared to the other groups in the ventromedial prefrontal cortex (vmPFC). During emotional resonance, the CD/CU+ and ASD groups showed reduced amygdala responses compared to the TD controls, boys with ASD showed reduced responses in bilateral hippocampus, and the CD/CU+ boys showed reduced responses in the inferior frontal gyrus (IFG) and anterior insula (AI). Conclusion Results suggest differential abnormal brain responses associated with specific aspects of empathic functioning in ASD and CD/CU+. Decreased amygdala responses in ASD and CD/CU+ might point to impaired emotion processing in both disorders, whereas reduced vmPFC responses suggest problems in processing cognitive aspects of empathy in ASD. Reduced IFG/AI responses, finally, suggest decreased emotional resonance in CD/CU+. En ligne : http://dx.doi.org/10.1111/jcpp.12498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289 [article] Different brain responses during empathy in autism spectrum disorders versus conduct disorder and callous-unemotional traits [Texte imprimé et/ou numérique] / Eduard T. KLAPWIJK, Auteur ; Moji AGHAJANI, Auteur ; Olivier F. COLINS, Auteur ; Godfried M. MARIJNISSEN, Auteur ; Arne POPMA, Auteur ; Natasja D. J. VAN LANG, Auteur ; Nic J. A. VAN DER WEE, Auteur ; Robert R. J. M. VERMEIREN, Auteur . - p.737-747. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-6 (June 2016) . - p.737-747 Mots-clés : Autism spectrum disorders  callous-unemotional  conduct disorder  emotions  empathy  functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : Background Deficits in empathy are reported in autism spectrum disorders (ASD) and also underlie antisocial behavior of individuals with conduct disorder and callous-unemotional traits (CD/CU+). Many studies suggest that individuals with ASD are typically impaired in cognitive aspects of empathy, and individuals with CD/CU+ typically in affective aspects. In the current study, we compared the neural correlates of cognitive and affective aspects of empathy between youth with ASD and youth with CD/CU+. Methods Functional magnetic resonance imaging (fMRI) was used to assess boys with ASD (N = 23), boys with CD/CU+ (N = 23), and typically developing (TD) boys (N = 33), aged 15–19 years. Angry and fearful faces were presented and participants were asked to either infer the emotional state from the face (other-task; emotion recognition) or to judge their own emotional response to the face (self-task; emotional resonance). Results During emotion recognition, boys with ASD showed reduced responses compared to the other groups in the ventromedial prefrontal cortex (vmPFC). During emotional resonance, the CD/CU+ and ASD groups showed reduced amygdala responses compared to the TD controls, boys with ASD showed reduced responses in bilateral hippocampus, and the CD/CU+ boys showed reduced responses in the inferior frontal gyrus (IFG) and anterior insula (AI). Conclusion Results suggest differential abnormal brain responses associated with specific aspects of empathic functioning in ASD and CD/CU+. Decreased amygdala responses in ASD and CD/CU+ might point to impaired emotion processing in both disorders, whereas reduced vmPFC responses suggest problems in processing cognitive aspects of empathy in ASD. Reduced IFG/AI responses, finally, suggest decreased emotional resonance in CD/CU+. En ligne : http://dx.doi.org/10.1111/jcpp.12498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=289

Differential Fairness Decisions and Brain Responses After Expressed Emotions of Others in Boys with Autism Spectrum Disorders / Eduard T. KLAPWIJK in Journal of Autism and Developmental Disorders, 47-8 (August 2017)  

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Gender differences between adolescents with autism in emergency psychiatry / P. SO in Autism, 25-8 (November 2021)  

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Girls’ childhood trajectories of disruptive behavior predict adjustment problems in early adolescence / Elsa VAN DER MOLEN in Journal of Child Psychology and Psychiatry, 56-7 (July 2015)  

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Maternal Characteristics Predicting Young Girls' Disruptive Behavior / Elsa VAN DER MOLEN in Journal of Clinical Child & Adolescent Psychology, 40-2 (March-April 2011)  

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Parental Awareness of Sexual Experience in Adolescent Boys With Autism Spectrum Disorder / J. DEWINTER in Journal of Autism and Developmental Disorders, 46-2 (February 2016)  

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Psychopathic traits, victim distress and aggression in children / Yoast VAN BAARDEWIJK in Journal of Child Psychology and Psychiatry, 50-6 (June 2009)  

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Research Review: The effectiveness of multidimensional family therapy in treating adolescents with multiple behavior problems – a meta-analysis / Thimo M. VAN DER POL in Journal of Child Psychology and Psychiatry, 58-5 (May 2017)  

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Sexual Behavior in High-Functioning Male Adolescents and Young Adults with Autism Spectrum Disorder / Hans HELLEMANS in Journal of Autism and Developmental Disorders, 37-2 (February 2007)  

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Sexuality and Autistic-Like Symptoms in Juvenile Sex Offenders: A Follow-Up After 8 Years / M. Ewoud BAARSMA in Journal of Autism and Developmental Disorders, 46-8 (August 2016)  

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Sexuality in Adolescent Boys with Autism Spectrum Disorder: Self-reported Behaviours and Attitudes / Jeroen DEWINTER in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

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