Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits / Jannath BEGUM-ALI in Journal of Child Psychology and Psychiatry, 63-9 (September 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1057-1067 Titre : Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits Type de document : texte imprimé Auteurs : Jannath BEGUM-ALI, Auteur ; Amy GOODWIN, Auteur ; Luke MASON, Auteur ; Greg PASCO, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emily J.H. JONES, Auteur Article en page(s) : p.1057-1067 Langues : Anglais (eng) Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnosis  Autism Spectrum Disorder  Child  Electroencephalography  Female  Humans  Infant  Male  Prospective Studies  Theta Rhythm  Attention deficit hyperactivity disorder  autism spectrum disorder  infancy  theta-beta ratio Index. décimale : PER Périodiques Résumé : BACKGROUND: Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prospective studies of infants with an elevated likelihood of developing ADHD. METHODS: We used a prospective design to examine an oscillatory electroencephalography profile that has been widely studied in both children and adults with ADHD - the balance between lower and higher frequencies operationalised as the theta-beta ratio (TBR). In the present study, we examined TBR in 136 10-month-old infants (72 male and 64 female) with/without an elevated likelihood of developing ADHD and/or a comparison disorder (Autism Spectrum Disorder; ASD). RESULTS: Infants with a first-degree relative with ADHD demonstrated lower TBR than infants without a first-degree relative with ADHD. Further, lower TBR at 10months was positively associated with temperament dimensions conceptually related to ADHD at 2years. TBR was not altered in infants with a family history of ASD. CONCLUSIONS: This is the first demonstration that alterations in TBR are present prior to behavioural symptoms of ADHD. However, these alterations manifest differently than those sometimes observed in older children with an ADHD diagnosis. Importantly, altered TBR was not seen in infants at elevated likelihood of developing ASD, suggesting a degree of specificity to ADHD. Taken together, these findings demonstrate that there are brain changes associated with a family history of ADHD observable in the first year of life. En ligne : http://dx.doi.org/10.1111/jcpp.13563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486 [article] Altered theta-beta ratio in infancy associates with family history of ADHD and later ADHD-relevant temperamental traits [texte imprimé] / Jannath BEGUM-ALI, Auteur ; Amy GOODWIN, Auteur ; Luke MASON, Auteur ; Greg PASCO, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emily J.H. JONES, Auteur . - p.1057-1067. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-9 (September 2022) . - p.1057-1067 Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnosis  Autism Spectrum Disorder  Child  Electroencephalography  Female  Humans  Infant  Male  Prospective Studies  Theta Rhythm  Attention deficit hyperactivity disorder  autism spectrum disorder  infancy  theta-beta ratio Index. décimale : PER Périodiques Résumé : BACKGROUND: Uncovering the neural mechanisms that underlie symptoms of attention deficit hyperactivity disorder (ADHD) requires studying brain development prior to the emergence of behavioural difficulties. One new approach to this is prospective studies of infants with an elevated likelihood of developing ADHD. METHODS: We used a prospective design to examine an oscillatory electroencephalography profile that has been widely studied in both children and adults with ADHD - the balance between lower and higher frequencies operationalised as the theta-beta ratio (TBR). In the present study, we examined TBR in 136 10-month-old infants (72 male and 64 female) with/without an elevated likelihood of developing ADHD and/or a comparison disorder (Autism Spectrum Disorder; ASD). RESULTS: Infants with a first-degree relative with ADHD demonstrated lower TBR than infants without a first-degree relative with ADHD. Further, lower TBR at 10months was positively associated with temperament dimensions conceptually related to ADHD at 2years. TBR was not altered in infants with a family history of ASD. CONCLUSIONS: This is the first demonstration that alterations in TBR are present prior to behavioural symptoms of ADHD. However, these alterations manifest differently than those sometimes observed in older children with an ADHD diagnosis. Importantly, altered TBR was not seen in infants at elevated likelihood of developing ASD, suggesting a degree of specificity to ADHD. Taken together, these findings demonstrate that there are brain changes associated with a family history of ADHD observable in the first year of life. En ligne : http://dx.doi.org/10.1111/jcpp.13563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=486

Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders / Mark H. JOHNSON in Journal of Child Psychology and Psychiatry, 62-5 (May 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.610-630 Titre : Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders Type de document : texte imprimé Auteurs : Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Emily J.H. JONES, Auteur Article en page(s) : p.610-630 Langues : Anglais (eng) Mots-clés : Neurodevelopmental disorders  autism spectrum disorders  brain development Index. décimale : PER Périodiques Résumé : We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood. En ligne : http://dx.doi.org/10.1111/jcpp.13372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders [texte imprimé] / Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Emily J.H. JONES, Auteur . - p.610-630. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.610-630 Mots-clés : Neurodevelopmental disorders  autism spectrum disorders  brain development Index. décimale : PER Périodiques Résumé : We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood. En ligne : http://dx.doi.org/10.1111/jcpp.13372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism / Greg PASCO ; Jannath Begum ALI ; Mark H. JOHNSON ; Emily J.H. JONES ; Tony CHARMAN in Autism Research, 16-11 (November 2023)  

Public ISBD [article]  inAutism Research > 16-11 (November 2023) . - p.2184-2197 Titre : Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism Type de document : texte imprimé Auteurs : Greg PASCO, Auteur ; Jannath Begum ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J.H. JONES, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.2184-2197 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. However, the inter-relationships between the two domains over development and emerging autistic traits are not fully established. We studied language and motor development using standardized observational and parent-report measures in infants with (n=271) and without (n=137) a family history of autism across four waves of data collection from 10 to 36 months. We used Random Intercept Cross-Lagged Panel Models to examine contemporaneous and longitudinal associations between language and motor developments in both elevated and typical likelihood groups. We estimated paths between language and motor abilities at 10, 14, 24, and 36 months and autism trait scores at 36 months, to test whether the domains were interrelated and how they related to emerging autism traits. Results revealed consistent bidirectional Expressive Language (EL) and Fine Motor (FM) cross-lagged effects from 10 to 24 and a unidirectional EL to FM effect from 24 to 36 months as well as significantly correlated random intercepts between Gross motor (GM) and Receptive language (RL), indicating stable concurrent associations over time. However, only the associations between GM and RL were associated with later autism traits. Early motor and language are linked, but only gross motor and receptive language are jointly associated with autistic traits in infants with an autism family history. En ligne : https://doi.org/10.1002/aur.3023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517 [article] Associations between early language, motor abilities, and later autism traits in infants with typical and elevated likelihood of autism [texte imprimé] / Greg PASCO, Auteur ; Jannath Begum ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J.H. JONES, Auteur ; Tony CHARMAN, Auteur . - p.2184-2197. Langues : Anglais (eng) in Autism Research > 16-11 (November 2023) . - p.2184-2197 Index. décimale : PER Périodiques Résumé : Abstract Slower acquisition of language and motor milestones are common in infants with later autism and studies have indicated that motor skills predict the rate of language development, suggesting these domains of development may be interlinked. However, the inter-relationships between the two domains over development and emerging autistic traits are not fully established. We studied language and motor development using standardized observational and parent-report measures in infants with (n=271) and without (n=137) a family history of autism across four waves of data collection from 10 to 36 months. We used Random Intercept Cross-Lagged Panel Models to examine contemporaneous and longitudinal associations between language and motor developments in both elevated and typical likelihood groups. We estimated paths between language and motor abilities at 10, 14, 24, and 36 months and autism trait scores at 36 months, to test whether the domains were interrelated and how they related to emerging autism traits. Results revealed consistent bidirectional Expressive Language (EL) and Fine Motor (FM) cross-lagged effects from 10 to 24 and a unidirectional EL to FM effect from 24 to 36 months as well as significantly correlated random intercepts between Gross motor (GM) and Receptive language (RL), indicating stable concurrent associations over time. However, only the associations between GM and RL were associated with later autism traits. Early motor and language are linked, but only gross motor and receptive language are jointly associated with autistic traits in infants with an autism family history. En ligne : https://doi.org/10.1002/aur.3023 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=517

Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits / Alexandra HENDRY in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4085-4105 Titre : Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits Type de document : texte imprimé Auteurs : Alexandra HENDRY, Auteur ; Emily J.H. JONES, Auteur ; Rachael BEDFORD, Auteur ; Linn ANDERSSON KONKE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Karin C. BROCKI, Auteur ; Ellen DEMURIE, Auteur ; Mark H. JOHNSON, Auteur ; Mirjam K.J. PIJL, Auteur ; Herbert ROEYERS, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.4085-4105 Langues : Anglais (eng) Mots-clés : Adhd  Attention  Atypical development  Autism  Infant  Intermediate phenotype  lecturer for Shire/Takeda, Medice, Roche, Eli Lilly, Prima Psychiatry, and SB  Education and Psychological Consulting AB. He receives royalties for text books and  diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Charman discloses that he  has served as a consultant to F. Hoffmann-La Roche Ltd and has received royalties  from Sage Publications and Guilford Publications. All other authors report no  conflict of interest. Index. décimale : PER Périodiques Résumé : Autism is frequently associated with difficulties with top-down attentional control, which impact on individuals' mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N = 294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7-9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years. En ligne : http://dx.doi.org/10.1007/s10803-020-04465-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits [texte imprimé] / Alexandra HENDRY, Auteur ; Emily J.H. JONES, Auteur ; Rachael BEDFORD, Auteur ; Linn ANDERSSON KONKE, Auteur ; Jannath BEGUM-ALI, Auteur ; Sven BÖLTE, Auteur ; Karin C. BROCKI, Auteur ; Ellen DEMURIE, Auteur ; Mark H. JOHNSON, Auteur ; Mirjam K.J. PIJL, Auteur ; Herbert ROEYERS, Auteur ; Tony CHARMAN, Auteur . - p.4085-4105. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4085-4105 Mots-clés : Adhd  Attention  Atypical development  Autism  Infant  Intermediate phenotype  lecturer for Shire/Takeda, Medice, Roche, Eli Lilly, Prima Psychiatry, and SB  Education and Psychological Consulting AB. He receives royalties for text books and  diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Charman discloses that he  has served as a consultant to F. Hoffmann-La Roche Ltd and has received royalties  from Sage Publications and Guilford Publications. All other authors report no  conflict of interest. Index. décimale : PER Périodiques Résumé : Autism is frequently associated with difficulties with top-down attentional control, which impact on individuals' mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N = 294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7-9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years. En ligne : http://dx.doi.org/10.1007/s10803-020-04465-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder / Elena Serena PICCARDI in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder Type de document : texte imprimé Auteurs : Elena Serena PICCARDI, Auteur ; Jannath BEGUM ALI, Auteur ; Emily J.H. JONES, Auteur ; Luke MASON, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Teodora GLIGA, Auteur ; BASIS/STAARS TEAM, Auteur Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Humans  Infant  Perception  Phenotype  Protective Factors  Alpha amplitude desynchronization  Attention deficit hyperactivity disorder  Autism spectrum disorder  Eeg  Infant sibling design  Repetition suppression  Tactile sensory processing  Tactile sensory seeking Index. décimale : PER Périodiques Résumé : BACKGROUNDS: Atypicalities in tactile processing are reported in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) but it remains unknown if they precede and associate with the traits of these disorders emerging in childhood. We investigated behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of ASD and/or ADHD compared to infants at typical likelihood of the disorders. Further, we assessed the specificity of associations between infant markers and later ASD or ADHD traits. METHODS: Ninety-one 10-month-old infants participated in the study (n = 44 infants at elevated likelihood of ASD; n = 20 infants at elevated likelihood of ADHD; n = 9 infants at elevated likelihood of ASD and ADHD; n = 18 infants at typical likelihood of the disorders). Behavioural and EEG responses to pairs of tactile stimuli were experimentally recorded and concurrent parental reports of tactile responsiveness were collected. ASD and ADHD traits were measured at 24 months through standardized assessment (ADOS-2) and parental report (ECBQ), respectively. RESULTS: There was no effect of infants' likelihood status on behavioural markers of tactile sensory processing. Conversely, increased ASD likelihood associated with reduced neural repetition suppression to tactile input. Reduced neural repetition suppression at 10 months significantly predicted ASD (but not ADHD) traits at 24 months across the entire sample. Elevated tactile sensory seeking at 10 months moderated the relationship between early reduced neural repetition suppression and later ASD traits. CONCLUSIONS: Reduced tactile neural repetition suppression is an early marker of later ASD traits in infants at elevated likelihood of ASD or ADHD, suggesting that a common pathway to later ASD traits exists despite different familial backgrounds. Elevated tactile sensory seeking may act as a protective factor, mitigating the relationship between early tactile neural repetition suppression and later ASD traits. En ligne : https://dx.doi.org/10.1186/s11689-020-09334-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573 [article] Behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of autism spectrum disorder and/or attention deficit hyperactivity disorder [texte imprimé] / Elena Serena PICCARDI, Auteur ; Jannath BEGUM ALI, Auteur ; Emily J.H. JONES, Auteur ; Luke MASON, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Teodora GLIGA, Auteur ; BASIS/STAARS TEAM, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder  Humans  Infant  Perception  Phenotype  Protective Factors  Alpha amplitude desynchronization  Attention deficit hyperactivity disorder  Autism spectrum disorder  Eeg  Infant sibling design  Repetition suppression  Tactile sensory processing  Tactile sensory seeking Index. décimale : PER Périodiques Résumé : BACKGROUNDS: Atypicalities in tactile processing are reported in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) but it remains unknown if they precede and associate with the traits of these disorders emerging in childhood. We investigated behavioural and neural markers of tactile sensory processing in infants at elevated likelihood of ASD and/or ADHD compared to infants at typical likelihood of the disorders. Further, we assessed the specificity of associations between infant markers and later ASD or ADHD traits. METHODS: Ninety-one 10-month-old infants participated in the study (n = 44 infants at elevated likelihood of ASD; n = 20 infants at elevated likelihood of ADHD; n = 9 infants at elevated likelihood of ASD and ADHD; n = 18 infants at typical likelihood of the disorders). Behavioural and EEG responses to pairs of tactile stimuli were experimentally recorded and concurrent parental reports of tactile responsiveness were collected. ASD and ADHD traits were measured at 24 months through standardized assessment (ADOS-2) and parental report (ECBQ), respectively. RESULTS: There was no effect of infants' likelihood status on behavioural markers of tactile sensory processing. Conversely, increased ASD likelihood associated with reduced neural repetition suppression to tactile input. Reduced neural repetition suppression at 10 months significantly predicted ASD (but not ADHD) traits at 24 months across the entire sample. Elevated tactile sensory seeking at 10 months moderated the relationship between early reduced neural repetition suppression and later ASD traits. CONCLUSIONS: Reduced tactile neural repetition suppression is an early marker of later ASD traits in infants at elevated likelihood of ASD or ADHD, suggesting that a common pathway to later ASD traits exists despite different familial backgrounds. Elevated tactile sensory seeking may act as a protective factor, mitigating the relationship between early tactile neural repetition suppression and later ASD traits. En ligne : https://dx.doi.org/10.1186/s11689-020-09334-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=573

Brain adaptation and alternative developmental trajectories / Mark H. JOHNSON in Development and Psychopathology, 27-2 (May 2015)  

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Developmental trajectories in infants and pre-school children with Neurofibromatosis 1 / Hannah SLEVIN in Molecular Autism, 15 (2024)  

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Disrupted visual attention relates to cognitive development in infants with Neurofibromatosis Type 1 / Jannath BEGUM-ALI in Journal of Neurodevelopmental Disorders, 17 (2025)  

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Early differences in auditory processing relate to Autism Spectrum Disorder traits in infants with Neurofibromatosis Type I / Jannath BEGUM-ALI in Journal of Neurodevelopmental Disorders, 13 (2021)  

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Early Motor Differences in Infants at Elevated Likelihood of Autism Spectrum Disorder and/or Attention Deficit Hyperactivity Disorder / Jannath BEGUM-ALI in Journal of Autism and Developmental Disorders, 50-12 (December 2020)  

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Editorial perspective: Leaving the baby in the bathwater in neurodevelopmental research / Sam WASS in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

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Editorial Perspective: The paradox of precision health in early development - building large samples to yield individual-level measures / Pasco FEARON ; Andrew PICKLES ; Emily J.H. JONES in Journal of Child Psychology and Psychiatry, 65-7 (July 2024)  

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EEG hyper-connectivity in high-risk infants is associated with later autism / Elena V. OREKHOVA in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

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Erratum to: Sex differences in the association between infant markers and later autistic traits / Rachael BEDFORD in Molecular Autism, 7 (2016)  

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Eye-Tracking Reveals Absent Repetition Learning Across the Autism Spectrum: Evidence From a Passive Viewing Task / Sebastian B. GAIGG in Autism Research, 13-11 (November 2020)  

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