Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder / Elizabeth BLANK in Journal of Autism and Developmental Disorders, 55-3 (March 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.940-954 Titre : Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Elizabeth BLANK, Auteur ; Donald L. GILBERT, Auteur ; Steve W. WU, Auteur ; Travis LARSH, Auteur ; Rana ELMAGHRABY, Auteur ; Rui LIU, Auteur ; Elizabeth SMITH, Auteur ; Grace WESTERKAMP, Auteur ; Yanchen LIU, Auteur ; Paul S. HORN, Auteur ; Ethan GREENSTEIN, Auteur ; John A. SWEENEY, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur Article en page(s) : p.940-954 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Major depressive disorder (MDD) disproportionately affects those living with autism spectrum disorder (ASD) and is associated with significant impairment and treatment recidivism. En ligne : https://doi.org/10.1007/s10803-024-06244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Accelerated Theta Burst Transcranial Magnetic Stimulation for Refractory Depression in Autism Spectrum Disorder [texte imprimé] / Elizabeth BLANK, Auteur ; Donald L. GILBERT, Auteur ; Steve W. WU, Auteur ; Travis LARSH, Auteur ; Rana ELMAGHRABY, Auteur ; Rui LIU, Auteur ; Elizabeth SMITH, Auteur ; Grace WESTERKAMP, Auteur ; Yanchen LIU, Auteur ; Paul S. HORN, Auteur ; Ethan GREENSTEIN, Auteur ; John A. SWEENEY, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur . - p.940-954. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-3 (March 2025) . - p.940-954 Index. décimale : PER Périodiques Résumé : Major depressive disorder (MDD) disproportionately affects those living with autism spectrum disorder (ASD) and is associated with significant impairment and treatment recidivism. En ligne : https://doi.org/10.1007/s10803-024-06244-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

Digitally-Mediated Social Stories Support Children on the Autism Spectrum Adapting to a Change in a 'Real-World' Context / Elizabeth SMITH in Journal of Autism and Developmental Disorders, 51-2 (February 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.514-526 Titre : Digitally-Mediated Social Stories Support Children on the Autism Spectrum Adapting to a Change in a 'Real-World' Context Type de document : texte imprimé Auteurs : Elizabeth SMITH, Auteur ; Aurora CONSTANTIN, Auteur ; Hilary JOHNSON, Auteur ; Mark BROSNAN, Auteur Article en page(s) : p.514-526 Langues : Anglais (eng) Mots-clés : Adapting to change  Autism  Real-world setting  Social stories Index. décimale : PER Périodiques Résumé : Social Storiesâ„¢ (SS) is a widely used intervention for children on the autism spectrum. A preliminary survey of 103 practitioners highlighted that SS are often used to support adapting to a change. This study investigated the use of digitally-mediated SS to support ten children on the autism spectrum attending a school summer camp. Teacher perceptions of anxiety, understanding and closeness to the goal of the SS were assessed before and after the intervention (prior to the event). The pre- post-intervention comparisons highlighted significant improvements in child understanding, anxiety, and closeness to goal with medium-large effect sizes. The child's understanding and closeness to SS goal post-intervention related to their difficulties with the SS goal and their anxiety during the event. En ligne : http://dx.doi.org/10.1007/s10803-020-04558-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440 [article] Digitally-Mediated Social Stories Support Children on the Autism Spectrum Adapting to a Change in a 'Real-World' Context [texte imprimé] / Elizabeth SMITH, Auteur ; Aurora CONSTANTIN, Auteur ; Hilary JOHNSON, Auteur ; Mark BROSNAN, Auteur . - p.514-526. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-2 (February 2021) . - p.514-526 Mots-clés : Adapting to change  Autism  Real-world setting  Social stories Index. décimale : PER Périodiques Résumé : Social Storiesâ„¢ (SS) is a widely used intervention for children on the autism spectrum. A preliminary survey of 103 practitioners highlighted that SS are often used to support adapting to a change. This study investigated the use of digitally-mediated SS to support ten children on the autism spectrum attending a school summer camp. Teacher perceptions of anxiety, understanding and closeness to the goal of the SS were assessed before and after the intervention (prior to the event). The pre- post-intervention comparisons highlighted significant improvements in child understanding, anxiety, and closeness to goal with medium-large effect sizes. The child's understanding and closeness to SS goal post-intervention related to their difficulties with the SS goal and their anxiety during the event. En ligne : http://dx.doi.org/10.1007/s10803-020-04558-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=440

Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome / Rana ELMAGHRABY in Molecular Autism, 16 (2025)  

Public ISBD [article]  inMolecular Autism > 16 (2025) . - 49 Titre : Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome Type de document : texte imprimé Auteurs : Rana ELMAGHRABY, Auteur ; Yanchen LIU, Auteur ; Priya RAMESH, Auteur ; Grace WESTERKAMP, Auteur ; Meredith A. NELSON, Auteur ; Travis LARSH, Auteur ; Elizabeth SMITH, Auteur ; Donald L. GILBERT, Auteur ; Steve W. WU, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur ; Rana ELMAGHRABY, Auteur ; Yanchen LIU, Auteur ; Priya RAMESH, Auteur ; Grace WESTERKAMP, Auteur ; Meredith A. NELSON, Auteur ; Travis LARSH, Auteur ; Elizabeth SMITH, Auteur ; Donald L. GILBERT, Auteur ; Steve W. WU, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur Article en page(s) : 49 Langues : Anglais (eng) Mots-clés : Humans  Fragile X Syndrome/physiopathology  Male  Female  Cortical Excitability/physiology  Young Adult  Adult  Electroencephalography  Adolescent  Alpha Rhythm  Case-Control Studies  Aperiodic slope  Cortical excitability  Eeg  Fragile X syndrome  Sex differences  Source localization  SpecParam Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X syndrome (FXS) is characterized by cortical hyperexcitability, a core neurophysiological feature that contributes to sensory hypersensitivity, cognitive dysfunction, and other disabling symptoms. This disruption in excitatory-inhibitory balance is a key pharmacological target, yet reliable biomarkers to quantify it noninvasively remain limited. Spectral slope, derived from the aperiodic component of the EEG power spectrum, has emerged as a potential index of cortical excitability. Here, we evaluated spectral slope and theta-alpha peak frequency in individuals with FXS to assess their utility as candidate neurophysiological biomarkers. METHODS: Five minutes of resting state EEG data were collected from 70 subjects with FXS (mean age 20.5 ± 10 years; 32 females) and 71 age-matched controls (mean age 22.2 ± 10.7 years; 30 females). The Spectral Parameterization toolbox (SpecParam) was used to separate periodic and aperiodic components of the source localized power spectra and characterize aperiodic slope and theta-alpha peak frequency. RESULTS: Statistical modeling of aperiodic slope revealed a significant two-way interaction between sex and diagnostic group, but no interaction with brain lobe. Among males, the aperiodic slope was significantly decreased in FXS, indicating greater cortical excitability, compared to typically developing controls (TDC), whereas no difference was observed between FXS and TDC females. For peak alpha frequency, statistical modeling identified significant two-way interactions between sex and diagnostic group, and between brain lobe and diagnostic group, but no significant three-way interaction. LIMITATIONS: This study is limited by the absence of non-invasive measures of cortical fragile X mental retardation protein (FMRP). Additionally, participants were not stratified by mosaic status and FMRP levels were not quantified, which could affect variability and interpretation. CONCLUSION: Compared to traditional band-limited power measures, aperiodic slope provides a more direct and validated index of excitation-inhibition balance. Our findings of reduced aperiodic slope in male subjects with FXS align with preclinical circuit-level evidence of increased excitability in FXS and are consistent with previous findings of reduced individual alpha peak frequency, supporting with thalamocortical dysrhythmia models of FXS. Importantly, aperiodic slope measurements can be applied directly to various modalities of local field potential data, enabling more robust cross-species and translational comparisons. En ligne : https://dx.doi.org/10.1186/s13229-025-00682-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Divergent aperiodic slope and alpha dynamics expose cortical excitability gradients in fragile X syndrome [texte imprimé] / Rana ELMAGHRABY, Auteur ; Yanchen LIU, Auteur ; Priya RAMESH, Auteur ; Grace WESTERKAMP, Auteur ; Meredith A. NELSON, Auteur ; Travis LARSH, Auteur ; Elizabeth SMITH, Auteur ; Donald L. GILBERT, Auteur ; Steve W. WU, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur ; Rana ELMAGHRABY, Auteur ; Yanchen LIU, Auteur ; Priya RAMESH, Auteur ; Grace WESTERKAMP, Auteur ; Meredith A. NELSON, Auteur ; Travis LARSH, Auteur ; Elizabeth SMITH, Auteur ; Donald L. GILBERT, Auteur ; Steve W. WU, Auteur ; Craig A. ERICKSON, Auteur ; Ernest V. PEDAPATI, Auteur . - 49. Langues : Anglais (eng) in Molecular Autism > 16 (2025) . - 49 Mots-clés : Humans  Fragile X Syndrome/physiopathology  Male  Female  Cortical Excitability/physiology  Young Adult  Adult  Electroencephalography  Adolescent  Alpha Rhythm  Case-Control Studies  Aperiodic slope  Cortical excitability  Eeg  Fragile X syndrome  Sex differences  Source localization  SpecParam Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X syndrome (FXS) is characterized by cortical hyperexcitability, a core neurophysiological feature that contributes to sensory hypersensitivity, cognitive dysfunction, and other disabling symptoms. This disruption in excitatory-inhibitory balance is a key pharmacological target, yet reliable biomarkers to quantify it noninvasively remain limited. Spectral slope, derived from the aperiodic component of the EEG power spectrum, has emerged as a potential index of cortical excitability. Here, we evaluated spectral slope and theta-alpha peak frequency in individuals with FXS to assess their utility as candidate neurophysiological biomarkers. METHODS: Five minutes of resting state EEG data were collected from 70 subjects with FXS (mean age 20.5 ± 10 years; 32 females) and 71 age-matched controls (mean age 22.2 ± 10.7 years; 30 females). The Spectral Parameterization toolbox (SpecParam) was used to separate periodic and aperiodic components of the source localized power spectra and characterize aperiodic slope and theta-alpha peak frequency. RESULTS: Statistical modeling of aperiodic slope revealed a significant two-way interaction between sex and diagnostic group, but no interaction with brain lobe. Among males, the aperiodic slope was significantly decreased in FXS, indicating greater cortical excitability, compared to typically developing controls (TDC), whereas no difference was observed between FXS and TDC females. For peak alpha frequency, statistical modeling identified significant two-way interactions between sex and diagnostic group, and between brain lobe and diagnostic group, but no significant three-way interaction. LIMITATIONS: This study is limited by the absence of non-invasive measures of cortical fragile X mental retardation protein (FMRP). Additionally, participants were not stratified by mosaic status and FMRP levels were not quantified, which could affect variability and interpretation. CONCLUSION: Compared to traditional band-limited power measures, aperiodic slope provides a more direct and validated index of excitation-inhibition balance. Our findings of reduced aperiodic slope in male subjects with FXS align with preclinical circuit-level evidence of increased excitability in FXS and are consistent with previous findings of reduced individual alpha peak frequency, supporting with thalamocortical dysrhythmia models of FXS. Importantly, aperiodic slope measurements can be applied directly to various modalities of local field potential data, enabling more robust cross-species and translational comparisons. En ligne : https://dx.doi.org/10.1186/s13229-025-00682-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Infant temperament prospectively predicts general psychopathology in childhood / Santiago MORALES in Development and Psychopathology, 34-3 (August 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-3 (August 2022) . - p.774-783 Titre : Infant temperament prospectively predicts general psychopathology in childhood Type de document : texte imprimé Auteurs : Santiago MORALES, Auteur ; Alva TANG, Auteur ; Maureen E. BOWERS, Auteur ; Natalie V. MILLER, Auteur ; George A. BUZZELL, Auteur ; Elizabeth SMITH, Auteur ; Kaylee SEDDIO, Auteur ; Heather A. HENDERSON, Auteur ; Nathan A. FOX, Auteur Article en page(s) : p.774-783 Langues : Anglais (eng) Mots-clés : general factor  motor activity  p factor  psychopathology  temperament Index. décimale : PER Périodiques Résumé : Recent models of psychopathology suggest the presence of a general factor capturing the shared variance among all symptoms along with specific psychopathology factors (e.g., internalizing and externalizing). However, few studies have examined predictors that may serve as transdiagnostic risk factors for general psychopathology from early development. In the current study we examine, for the first time, whether observed and parent-reported infant temperament dimensions prospectively predict general psychopathology as well as specific psychopathology dimensions (e.g., internalizing and externalizing) across childhood. In a longitudinal cohort (N = 291), temperament dimensions were assessed at 4 months of age. Psychopathology symptoms were assessed at 7, 9, and 12 years of age. A bifactor model was used to estimate general, internalizing, and externalizing psychopathology factors. Across behavioral observations and parent-reports, higher motor activity in infancy significantly predicted greater general psychopathology in mid to late childhood. Moreover, low positive affect was predictive of the internalizing-specific factor. Other temperament dimensions were not related with any of the psychopathology factors after accounting for the general psychopathology factor. The results of this study suggest that infant motor activity may act as an early indicator of transdiagnostic risk. Our findings inform the etiology of general psychopathology and have implications for the early identification for children at risk for psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579420001996 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484 [article] Infant temperament prospectively predicts general psychopathology in childhood [texte imprimé] / Santiago MORALES, Auteur ; Alva TANG, Auteur ; Maureen E. BOWERS, Auteur ; Natalie V. MILLER, Auteur ; George A. BUZZELL, Auteur ; Elizabeth SMITH, Auteur ; Kaylee SEDDIO, Auteur ; Heather A. HENDERSON, Auteur ; Nathan A. FOX, Auteur . - p.774-783. Langues : Anglais (eng) in Development and Psychopathology > 34-3 (August 2022) . - p.774-783 Mots-clés : general factor  motor activity  p factor  psychopathology  temperament Index. décimale : PER Périodiques Résumé : Recent models of psychopathology suggest the presence of a general factor capturing the shared variance among all symptoms along with specific psychopathology factors (e.g., internalizing and externalizing). However, few studies have examined predictors that may serve as transdiagnostic risk factors for general psychopathology from early development. In the current study we examine, for the first time, whether observed and parent-reported infant temperament dimensions prospectively predict general psychopathology as well as specific psychopathology dimensions (e.g., internalizing and externalizing) across childhood. In a longitudinal cohort (N = 291), temperament dimensions were assessed at 4 months of age. Psychopathology symptoms were assessed at 7, 9, and 12 years of age. A bifactor model was used to estimate general, internalizing, and externalizing psychopathology factors. Across behavioral observations and parent-reports, higher motor activity in infancy significantly predicted greater general psychopathology in mid to late childhood. Moreover, low positive affect was predictive of the internalizing-specific factor. Other temperament dimensions were not related with any of the psychopathology factors after accounting for the general psychopathology factor. The results of this study suggest that infant motor activity may act as an early indicator of transdiagnostic risk. Our findings inform the etiology of general psychopathology and have implications for the early identification for children at risk for psychopathology. En ligne : http://dx.doi.org/10.1017/S0954579420001996 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=484

Patterns in Medication Use for Treatment of Depression in Autistic Spectrum Disorder / Ernest V. PEDAPATI ; Kelli C. DOMINICK ; Katherine HARRIS ; Martine LAMY ; Cara FOSDICK ; Lauren SCHMITT ; Rebecca C. SHAFFER ; Elizabeth SMITH ; Meredith WILL ; Christopher J. MCDOUGLE ; Craig A. ERICKSON in Journal of Autism and Developmental Disorders, 55-6 (June 2025)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.1969-1975 Titre : Patterns in Medication Use for Treatment of Depression in Autistic Spectrum Disorder Type de document : texte imprimé Auteurs : Ernest V. PEDAPATI, Auteur ; Kelli C. DOMINICK, Auteur ; Katherine HARRIS, Auteur ; Martine LAMY, Auteur ; Cara FOSDICK, Auteur ; Lauren SCHMITT, Auteur ; Rebecca C. SHAFFER, Auteur ; Elizabeth SMITH, Auteur ; Meredith WILL, Auteur ; Christopher J. MCDOUGLE, Auteur ; Craig A. ERICKSON, Auteur Article en page(s) : p.1969-1975 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Depression impacts many individuals with autism spectrum disorder (ASD), carrying increased risk of functional impairment, hospitalization, and suicide. Prescribing medication to target depression in patients with ASD occurs despite limited available systematic data describing medication management of depression in this population. En ligne : https://doi.org/10.1007/s10803-023-06126-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556 [article] Patterns in Medication Use for Treatment of Depression in Autistic Spectrum Disorder [texte imprimé] / Ernest V. PEDAPATI, Auteur ; Kelli C. DOMINICK, Auteur ; Katherine HARRIS, Auteur ; Martine LAMY, Auteur ; Cara FOSDICK, Auteur ; Lauren SCHMITT, Auteur ; Rebecca C. SHAFFER, Auteur ; Elizabeth SMITH, Auteur ; Meredith WILL, Auteur ; Christopher J. MCDOUGLE, Auteur ; Craig A. ERICKSON, Auteur . - p.1969-1975. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 55-6 (June 2025) . - p.1969-1975 Index. décimale : PER Périodiques Résumé : Depression impacts many individuals with autism spectrum disorder (ASD), carrying increased risk of functional impairment, hospitalization, and suicide. Prescribing medication to target depression in patients with ASD occurs despite limited available systematic data describing medication management of depression in this population. En ligne : https://doi.org/10.1007/s10803-023-06126-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=556

Preschool hyperactivity is associated with long-term economic burden: evidence from a longitudinal health economic analysis of costs incurred across childhood, adolescence and young adulthood / Maria CHOROZOGLOU in Journal of Child Psychology and Psychiatry, 56-9 (September 2015)  

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Temporal synchrony and audiovisual integration of speech and object stimuli in autism / Elizabeth SMITH in Research in Autism Spectrum Disorders, 39 (July 2017)  

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