Adolescent functional network connectivity prospectively predicts adult anxiety symptoms related to perceived COVID-19 economic adversity / Felicia A. HARDI in Journal of Child Psychology and Psychiatry, 64-6 (June 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.918-929 Titre : Adolescent functional network connectivity prospectively predicts adult anxiety symptoms related to perceived COVID-19 economic adversity Type de document : texte imprimé Auteurs : Felicia A. HARDI, Auteur ; Leigh G. GOETSCHIUS, Auteur ; Vonnie MCLOYD, Auteur ; Nestor L. LOPEZ-DURAN, Auteur ; Colter MITCHELL, Auteur ; Luke W. HYDE, Auteur ; Adriene M. BELTZ, Auteur ; Christopher S. MONK, Auteur Article en page(s) : p.918-929 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Stressful events, such as the COVID-19 pandemic, are major contributors to anxiety and depression, but only a subset of individuals develop psychopathology. In a population-based sample (N = 174) with a high representation of marginalized individuals, this study examined adolescent functional network connectivity as a marker of susceptibility to anxiety and depression in the context of adverse experiences. Methods Data-driven network-based subgroups were identified using an unsupervised community detection algorithm within functional neural connectivity. Neuroimaging data collected during emotion processing (age 15) were extracted from a priori regions of interest linked to anxiety and depression. Symptoms were self-reported at ages 15, 17, and 21 (during COVID-19). During COVID-19, participants reported on pandemic-related economic adversity. Differences across subgroup networks were first examined, then subgroup membership and subgroup-adversity interaction were tested to predict change in symptoms over time. Results Two subgroups were identified: Subgroup A, characterized by relatively greater neural network variation (i.e., heterogeneity) and density with more connections involving the amygdala, subgenual cingulate, and ventral striatum; and the more homogenous Subgroup B, with more connections involving the insula and dorsal anterior cingulate. Accounting for initial symptoms, subgroup A individuals had greater increases in symptoms across time (??= .138, p = .042), and this result remained after adjusting for additional covariates (??= .194, p = .023). Furthermore, there was a subgroup-adversity interaction: compared with Subgroup B, Subgroup A reported greater anxiety during the pandemic in response to reported economic adversity (??= .307, p = .006), and this remained after accounting for initial symptoms and many covariates (??= .237, p = .021). Conclusions A subgrouping algorithm identified young adults who were susceptible to adversity using their personalized functional network profiles derived from a priori brain regions. These results highlight potential prospective neural signatures involving heterogeneous emotion networks that predict individuals at the greatest risk for anxiety when experiencing adverse events. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13749 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Adolescent functional network connectivity prospectively predicts adult anxiety symptoms related to perceived COVID-19 economic adversity [texte imprimé] / Felicia A. HARDI, Auteur ; Leigh G. GOETSCHIUS, Auteur ; Vonnie MCLOYD, Auteur ; Nestor L. LOPEZ-DURAN, Auteur ; Colter MITCHELL, Auteur ; Luke W. HYDE, Auteur ; Adriene M. BELTZ, Auteur ; Christopher S. MONK, Auteur . - p.918-929. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.918-929 Index. décimale : PER Périodiques Résumé : Background Stressful events, such as the COVID-19 pandemic, are major contributors to anxiety and depression, but only a subset of individuals develop psychopathology. In a population-based sample (N = 174) with a high representation of marginalized individuals, this study examined adolescent functional network connectivity as a marker of susceptibility to anxiety and depression in the context of adverse experiences. Methods Data-driven network-based subgroups were identified using an unsupervised community detection algorithm within functional neural connectivity. Neuroimaging data collected during emotion processing (age 15) were extracted from a priori regions of interest linked to anxiety and depression. Symptoms were self-reported at ages 15, 17, and 21 (during COVID-19). During COVID-19, participants reported on pandemic-related economic adversity. Differences across subgroup networks were first examined, then subgroup membership and subgroup-adversity interaction were tested to predict change in symptoms over time. Results Two subgroups were identified: Subgroup A, characterized by relatively greater neural network variation (i.e., heterogeneity) and density with more connections involving the amygdala, subgenual cingulate, and ventral striatum; and the more homogenous Subgroup B, with more connections involving the insula and dorsal anterior cingulate. Accounting for initial symptoms, subgroup A individuals had greater increases in symptoms across time (??= .138, p = .042), and this result remained after adjusting for additional covariates (??= .194, p = .023). Furthermore, there was a subgroup-adversity interaction: compared with Subgroup B, Subgroup A reported greater anxiety during the pandemic in response to reported economic adversity (??= .307, p = .006), and this remained after accounting for initial symptoms and many covariates (??= .237, p = .021). Conclusions A subgrouping algorithm identified young adults who were susceptible to adversity using their personalized functional network profiles derived from a priori brain regions. These results highlight potential prospective neural signatures involving heterogeneous emotion networks that predict individuals at the greatest risk for anxiety when experiencing adverse events. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13749 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing / Melissa K. PECKINS ; Colter MITCHELL ; Vonnie MCLOYD ; Jeanne BROOKS-GUNN ; Luke W. HYDE ; Christopher S. MONK in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.1954-1970 Titre : Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing Type de document : texte imprimé Auteurs : Melissa K. PECKINS, Auteur ; Colter MITCHELL, Auteur ; Vonnie MCLOYD, Auteur ; Jeanne BROOKS-GUNN, Auteur ; Luke W. HYDE, Auteur ; Christopher S. MONK, Auteur Article en page(s) : p.1954-1970 Langues : Anglais (eng) Mots-clés : Adversity-specific  childhood adversity  cumulative  sensitivity periods  youth psychopathology Index. décimale : PER Périodiques Résumé : Associations between adversity and youth psychopathology likely vary based on the types and timing of experiences. Major theories suggest that the impact of childhood adversity may either be cumulative in type (the more types of adversity, the worse outcomes) or in timing (the longer exposure, the worse outcomes) or, alternatively, specific concerning the type (e.g., parenting, home, neighborhood) or the timing of adversity (e.g., specific developmental periods). In a longitudinal sample from the Future of Families and Wellbeing Study (N = 4,210), we evaluated these competing hypotheses using a data-driven structured life-course modeling approach using risk factors examined at child age 1 (infancy), 3 (toddlerhood), 5 (early childhood), and 9 (middle childhood). Results showed that exposures to more types of adversity for longer durations (i.e., cumulative in both type and timing) best predicted youth psychopathology. Adversities that occurred at age 9 were better predictors of youth psychopathology as compared to those experienced earlier, except for neglect, which was predictive of internalizing symptoms when experienced at age 3. Throughout childhood (across ages 1-9), aside from the accumulation of all adversities, parental stress and low collective efficacy were the strongest predictors of internalizing symptoms, whereas psychological aggression was predictive of externalizing symptoms. En ligne : https://dx.doi.org/10.1017/S0954579424001512 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Childhood adversity and adolescent mental health: Examining cumulative and specificity effects across contexts and developmental timing [texte imprimé] / Melissa K. PECKINS, Auteur ; Colter MITCHELL, Auteur ; Vonnie MCLOYD, Auteur ; Jeanne BROOKS-GUNN, Auteur ; Luke W. HYDE, Auteur ; Christopher S. MONK, Auteur . - p.1954-1970. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.1954-1970 Mots-clés : Adversity-specific  childhood adversity  cumulative  sensitivity periods  youth psychopathology Index. décimale : PER Périodiques Résumé : Associations between adversity and youth psychopathology likely vary based on the types and timing of experiences. Major theories suggest that the impact of childhood adversity may either be cumulative in type (the more types of adversity, the worse outcomes) or in timing (the longer exposure, the worse outcomes) or, alternatively, specific concerning the type (e.g., parenting, home, neighborhood) or the timing of adversity (e.g., specific developmental periods). In a longitudinal sample from the Future of Families and Wellbeing Study (N = 4,210), we evaluated these competing hypotheses using a data-driven structured life-course modeling approach using risk factors examined at child age 1 (infancy), 3 (toddlerhood), 5 (early childhood), and 9 (middle childhood). Results showed that exposures to more types of adversity for longer durations (i.e., cumulative in both type and timing) best predicted youth psychopathology. Adversities that occurred at age 9 were better predictors of youth psychopathology as compared to those experienced earlier, except for neglect, which was predictive of internalizing symptoms when experienced at age 3. Throughout childhood (across ages 1-9), aside from the accumulation of all adversities, parental stress and low collective efficacy were the strongest predictors of internalizing symptoms, whereas psychological aggression was predictive of externalizing symptoms. En ligne : https://dx.doi.org/10.1017/S0954579424001512 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Differential associations of parental harshness and parental disengagement with overall cortisol output at 15 years: Implications for adolescent mental health / Jenalee R. DOOM in Development and Psychopathology, 34-1 (February 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-1 (February 2022) . - p.129-146 Titre : Differential associations of parental harshness and parental disengagement with overall cortisol output at 15 years: Implications for adolescent mental health Type de document : texte imprimé Auteurs : Jenalee R. DOOM, Auteur ; Melissa K. PECKINS, Auteur ; Tyler C. HEIN, Auteur ; Hailey L. DOTTERER, Auteur ; Colter MITCHELL, Auteur ; Nestor L. LOPEZ-DURAN, Auteur ; Jeanne BROOKS-GUNN, Auteur ; Sara MCLANAHAN, Auteur ; Luke W. HYDE, Auteur ; James L. ABELSON, Auteur ; Christopher S. MONK, Auteur Article en page(s) : p.129-146 Langues : Anglais (eng) Mots-clés : adolescence  depressive symptoms  hair cortisol  parental disengagement  parental harshness Index. décimale : PER Périodiques Résumé : Psychosocial stress in childhood and adolescence is linked to stress system dysregulation, although few studies have examined the relative impacts of parental harshness and parental disengagement. This study prospectively tested whether parental harshness and disengagement show differential associations with overall cortisol output in adolescence. Associations between overall cortisol output and adolescent mental health problems were tested concurrently. Adolescents from the Fragile Families and Child Wellbeing Study (FFCWS) provided hair samples for cortisol assay at 15 years (N = 171). Caregivers reported on parental harshness and disengagement experiences at 1, 3, 5, 9, and 15 years, and adolescents reported at 15 years. Both parent and adolescent reported depressive and anxiety symptoms and antisocial behaviors at 15. Greater parental harshness from 1 15 years, and harshness reported at 15 years in particular, was associated with higher overall cortisol output at 15. Greater parental disengagement from 1 15 years, and disengagement at 1 year specifically, was associated with lower cortisol output. There were no significant associations between cortisol output and depressive symptoms, anxiety symptoms, or antisocial behaviors. These results suggest that the unique variances of parental harshness and disengagement may have opposing associations with cortisol output at 15 years, with unclear implications for adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579420000954 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Differential associations of parental harshness and parental disengagement with overall cortisol output at 15 years: Implications for adolescent mental health [texte imprimé] / Jenalee R. DOOM, Auteur ; Melissa K. PECKINS, Auteur ; Tyler C. HEIN, Auteur ; Hailey L. DOTTERER, Auteur ; Colter MITCHELL, Auteur ; Nestor L. LOPEZ-DURAN, Auteur ; Jeanne BROOKS-GUNN, Auteur ; Sara MCLANAHAN, Auteur ; Luke W. HYDE, Auteur ; James L. ABELSON, Auteur ; Christopher S. MONK, Auteur . - p.129-146. Langues : Anglais (eng) in Development and Psychopathology > 34-1 (February 2022) . - p.129-146 Mots-clés : adolescence  depressive symptoms  hair cortisol  parental disengagement  parental harshness Index. décimale : PER Périodiques Résumé : Psychosocial stress in childhood and adolescence is linked to stress system dysregulation, although few studies have examined the relative impacts of parental harshness and parental disengagement. This study prospectively tested whether parental harshness and disengagement show differential associations with overall cortisol output in adolescence. Associations between overall cortisol output and adolescent mental health problems were tested concurrently. Adolescents from the Fragile Families and Child Wellbeing Study (FFCWS) provided hair samples for cortisol assay at 15 years (N = 171). Caregivers reported on parental harshness and disengagement experiences at 1, 3, 5, 9, and 15 years, and adolescents reported at 15 years. Both parent and adolescent reported depressive and anxiety symptoms and antisocial behaviors at 15. Greater parental harshness from 1 15 years, and harshness reported at 15 years in particular, was associated with higher overall cortisol output at 15. Greater parental disengagement from 1 15 years, and disengagement at 1 year specifically, was associated with lower cortisol output. There were no significant associations between cortisol output and depressive symptoms, anxiety symptoms, or antisocial behaviors. These results suggest that the unique variances of parental harshness and disengagement may have opposing associations with cortisol output at 15 years, with unclear implications for adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579420000954 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting / Jillian Lee WIGGINS in Development and Psychopathology, 27-4 (Part 1) (November 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1295-1312 Titre : Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting Type de document : texte imprimé Auteurs : Jillian Lee WIGGINS, Auteur ; Colter MITCHELL, Auteur ; Luke W. HYDE, Auteur ; Christopher S. MONK, Auteur Année de publication : 2015 Article en page(s) : p.1295-1312 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Psychological disorders co-occur often in children, but little has been done to document the types of conjoint pathways internalizing and externalizing symptoms may take from the crucial early period of toddlerhood or how harsh parenting may overlap with early symptom codevelopment. To examine symptom codevelopment trajectories, we identified latent classes of individuals based on internalizing and externalizing symptoms across ages 3–9 and found three symptom codevelopment classes: normative symptoms (low), severe-decreasing symptoms (initially high but rapidly declining), and severe symptoms (high) trajectories. Next, joint models examined how parenting trajectories overlapped with internalizing and externalizing symptom trajectories. These trajectory classes demonstrated that, normatively, harsh parenting increased after toddlerhood, but the severe symptoms class was characterized by a higher level and a steeper increase in harsh parenting and the severe-decreasing class by high, stable harsh parenting. In addition, a transactional model examined the bidirectional relationships among internalizing and externalizing symptoms and harsh parenting because they may cascade over time in this early period. Harsh parenting uniquely contributed to externalizing symptoms, controlling for internalizing symptoms, but not vice versa. In addition, internalizing symptoms appeared to be a mechanism by which externalizing symptoms increase. Results highlight the importance of accounting for both internalizing and externalizing symptoms from an early age to understand risk for developing psychopathology and the role harsh parenting plays in influencing these trajectories. En ligne : http://dx.doi.org/10.1017/S0954579414001412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Identifying early pathways of risk and resilience: The codevelopment of internalizing and externalizing symptoms and the role of harsh parenting [texte imprimé] / Jillian Lee WIGGINS, Auteur ; Colter MITCHELL, Auteur ; Luke W. HYDE, Auteur ; Christopher S. MONK, Auteur . - 2015 . - p.1295-1312. Langues : Anglais (eng) in Development and Psychopathology > 27-4 (Part 1) (November 2015) . - p.1295-1312 Index. décimale : PER Périodiques Résumé : Psychological disorders co-occur often in children, but little has been done to document the types of conjoint pathways internalizing and externalizing symptoms may take from the crucial early period of toddlerhood or how harsh parenting may overlap with early symptom codevelopment. To examine symptom codevelopment trajectories, we identified latent classes of individuals based on internalizing and externalizing symptoms across ages 3–9 and found three symptom codevelopment classes: normative symptoms (low), severe-decreasing symptoms (initially high but rapidly declining), and severe symptoms (high) trajectories. Next, joint models examined how parenting trajectories overlapped with internalizing and externalizing symptom trajectories. These trajectory classes demonstrated that, normatively, harsh parenting increased after toddlerhood, but the severe symptoms class was characterized by a higher level and a steeper increase in harsh parenting and the severe-decreasing class by high, stable harsh parenting. In addition, a transactional model examined the bidirectional relationships among internalizing and externalizing symptoms and harsh parenting because they may cascade over time in this early period. Harsh parenting uniquely contributed to externalizing symptoms, controlling for internalizing symptoms, but not vice versa. In addition, internalizing symptoms appeared to be a mechanism by which externalizing symptoms increase. Results highlight the importance of accounting for both internalizing and externalizing symptoms from an early age to understand risk for developing psychopathology and the role harsh parenting plays in influencing these trajectories. En ligne : http://dx.doi.org/10.1017/S0954579414001412 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

Methylome-wide association study of multidimensional resilience / S. Alexandra BURT ; Colter MITCHELL ; Kelly L. KLUMP ; Luke W. HYDE ; Shaunna L. CLARK in Development and Psychopathology, 37-4 (October 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-4 (October 2025) . - p.1730-1741 Titre : Methylome-wide association study of multidimensional resilience Type de document : texte imprimé Auteurs : S. Alexandra BURT, Auteur ; Colter MITCHELL, Auteur ; Kelly L. KLUMP, Auteur ; Luke W. HYDE, Auteur ; Shaunna L. CLARK, Auteur Article en page(s) : p.1730-1741 Langues : Anglais (eng) Mots-clés : DNA methylation  Youth  epigenetics  neighborhood disadvantage  resilience Index. décimale : PER Périodiques Résumé : Although resilient youth provide an important model of successful adaptation to adversity, we know relatively little about the origins of their positive outcomes, particularly the role of biological mechanisms. The current study employed a series of methylome-wide association studies to identify methylomic biomarkers of resilience in a unique sample of 276 twins within 141 families residing in disadvantaged neighborhoods. Results revealed methylome-wide significant differentially methylated probes (DMPs) for social and academic resilience and suggestive DMPs for psychological resilience and resilience across domains. Pathway analyses informed our understanding of the biological underpinnings of significant differentially methylated probes. Monozygotic twin difference analyses were then employed to narrow in on DMPs that were specifically environmental in origin. Our findings suggest that alterations in the DNA methylome may be implicated in youth resilience to neighborhood adversity and that some of the suggestive DMPs may be environmentally engendered. Importantly, our ability to replicate our findings in a well-powered sample was hindered by the scarcity of twin samples with youth exposed to moderate to substantial levels of adversity. Thus, although preliminary, the present study is the first to identify DNA methylation biomarkers of academic and social resilience. En ligne : https://dx.doi.org/10.1017/S0954579424001330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567 [article] Methylome-wide association study of multidimensional resilience [texte imprimé] / S. Alexandra BURT, Auteur ; Colter MITCHELL, Auteur ; Kelly L. KLUMP, Auteur ; Luke W. HYDE, Auteur ; Shaunna L. CLARK, Auteur . - p.1730-1741. Langues : Anglais (eng) in Development and Psychopathology > 37-4 (October 2025) . - p.1730-1741 Mots-clés : DNA methylation  Youth  epigenetics  neighborhood disadvantage  resilience Index. décimale : PER Périodiques Résumé : Although resilient youth provide an important model of successful adaptation to adversity, we know relatively little about the origins of their positive outcomes, particularly the role of biological mechanisms. The current study employed a series of methylome-wide association studies to identify methylomic biomarkers of resilience in a unique sample of 276 twins within 141 families residing in disadvantaged neighborhoods. Results revealed methylome-wide significant differentially methylated probes (DMPs) for social and academic resilience and suggestive DMPs for psychological resilience and resilience across domains. Pathway analyses informed our understanding of the biological underpinnings of significant differentially methylated probes. Monozygotic twin difference analyses were then employed to narrow in on DMPs that were specifically environmental in origin. Our findings suggest that alterations in the DNA methylome may be implicated in youth resilience to neighborhood adversity and that some of the suggestive DMPs may be environmentally engendered. Importantly, our ability to replicate our findings in a well-powered sample was hindered by the scarcity of twin samples with youth exposed to moderate to substantial levels of adversity. Thus, although preliminary, the present study is the first to identify DNA methylation biomarkers of academic and social resilience. En ligne : https://dx.doi.org/10.1017/S0954579424001330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=567

Prospective longitudinal associations between harsh parenting and corticolimbic function during adolescence / Arianna M. GARD in Development and Psychopathology, 34-3 (August 2022)  

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School connectedness as a protective factor against childhood exposure to violence and social deprivation: A longitudinal study of adaptive and maladaptive outcomes / Leigh G. GOETSCHIUS in Development and Psychopathology, 35-3 (August 2023)  

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