Brief Report: Autism Spectrum Disorder and Substance Use Disorder: A Review and Case Study / Ashy C. RENGIT in Journal of Autism and Developmental Disorders, 46-7 (July 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2514-2519 Titre : Brief Report: Autism Spectrum Disorder and Substance Use Disorder: A Review and Case Study Type de document : texte imprimé Auteurs : Ashy C. RENGIT, Auteur ; James W. MCKOWEN, Auteur ; Julie O’BRIEN, Auteur ; Yamini J. HOWE, Auteur ; Christopher J. MCDOUGLE, Auteur Article en page(s) : p.2514-2519 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Substance use disorder  Alcohol dependence Index. décimale : PER Périodiques Résumé : There is limited literature available on the comorbidity between autism spectrum disorder (ASD) and substance use disorder (SUD). This paper reviews existing literature and exemplifies the challenges of treating this population with a case report of an adult male with ASD and DSM-5 alcohol use disorder. This review and case study seeks to illustrate risk factors which predispose individuals with ASD to developing SUD and discuss the obstacles to and modifications of evidence-based treatments for SUD. A review of the therapeutic interventions implemented in the treatment of this young male are described to highlight potential recommendations for the general management of SUD in those with ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2763-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290 [article] Brief Report: Autism Spectrum Disorder and Substance Use Disorder: A Review and Case Study [texte imprimé] / Ashy C. RENGIT, Auteur ; James W. MCKOWEN, Auteur ; Julie O’BRIEN, Auteur ; Yamini J. HOWE, Auteur ; Christopher J. MCDOUGLE, Auteur . - p.2514-2519. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-7 (July 2016) . - p.2514-2519 Mots-clés : Autism  Autism spectrum disorder  Substance use disorder  Alcohol dependence Index. décimale : PER Périodiques Résumé : There is limited literature available on the comorbidity between autism spectrum disorder (ASD) and substance use disorder (SUD). This paper reviews existing literature and exemplifies the challenges of treating this population with a case report of an adult male with ASD and DSM-5 alcohol use disorder. This review and case study seeks to illustrate risk factors which predispose individuals with ASD to developing SUD and discuss the obstacles to and modifications of evidence-based treatments for SUD. A review of the therapeutic interventions implemented in the treatment of this young male are described to highlight potential recommendations for the general management of SUD in those with ASD. En ligne : http://dx.doi.org/10.1007/s10803-016-2763-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=290

Co-occurring conditions in children with Down syndrome and autism: a retrospective study / Noemi A. SPINAZZI in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : Co-occurring conditions in children with Down syndrome and autism: a retrospective study Type de document : texte imprimé Auteurs : Noemi A. SPINAZZI, Auteur ; Jonathan D. SANTORO, Auteur ; Katherine PAWLOWSKI, Auteur ; Gabriel ANZUETO, Auteur ; Yamini J. HOWE, Auteur ; Lina R. PATEL, Auteur ; Nicole T. BAUMER, Auteur Langues : Anglais (eng) Mots-clés : Male  Humans  Female  Autistic Disorder  Down Syndrome/complications/epidemiology  Autism Spectrum Disorder/complications/epidemiology  Retrospective Studies  Prospective Studies  Autism spectrum disorder  Co-occurring medical conditions  Comorbid  Down syndrome  Medical disease  Prevalence Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS) is one of the most common genetic causes of intellectual disability, and it is associated with an increased incidence of numerous co-occurring conditions. Autism spectrum disorder (ASD) is common in persons with DS, with rates reported as high as 39%. However, little is known regarding co-occurring conditions in children with both DS and ASD. METHODS: A single-center retrospective review of prospective longitudinally collected clinical data was performed. Any patient with a confirmed diagnosis of DS evaluated at a large, specialized Down Syndrome Program in a tertiary pediatric medical center between March 2018 and March 2022 was included. A standardized survey which included demographic and clinical questions was administered during each clinical evaluation. RESULTS: In total, 562 individuals with DS were included. The median age was 10 years (IQR: 6.18-13.92). Of this group, 72 (13%) had a co-occurring diagnosis of ASD (DS+ASD). Individuals with DS+ASD were more likely to be male (OR 2.23, CI 1.29-3.84) and had higher odds of a current or prior diagnosis of constipation (OR 2.19, CI 1.31-3.65), gastroesophageal reflux (OR 1.91, CI 1.14-3.21), behavioral feeding difficulties (OR 2.71, CI 1.02-7.19), infantile spasms (OR 6.03, CI 1.79-20.34) and scoliosis (OR 2.73, CI 1.16-6.40). There were lower odds of congenital heart disease in the DS+ASD group (OR 0.56, CI 0.34-0.93). There was no observed difference in prematurity or Neonatal Intensive Care Unit complications between groups. Individuals with DS+ASD had similar odds of having a history of congenital heart defect requiring surgery to those with DS only. Furthermore, there was no difference in rates of autoimmune thyroiditis or celiac disease. There was also no difference in rates of diagnosed co-occurring neurodevelopmental or mental health conditions in this cohort, including anxiety disorders and attention-deficit/hyperactivity disorder. CONCLUSIONS: This study identifies a variety of medical conditions which are more frequent in children with DS+ASD than DS alone, providing important information for the clinical management of these patients. Future research should investigate the role of some of these medical conditions in the development of ASD phenotypes, and whether there may be distinct genetic and metabolic contributions towards these conditions. En ligne : https://dx.doi.org/10.1186/s11689-023-09478-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] Co-occurring conditions in children with Down syndrome and autism: a retrospective study [texte imprimé] / Noemi A. SPINAZZI, Auteur ; Jonathan D. SANTORO, Auteur ; Katherine PAWLOWSKI, Auteur ; Gabriel ANZUETO, Auteur ; Yamini J. HOWE, Auteur ; Lina R. PATEL, Auteur ; Nicole T. BAUMER, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Male  Humans  Female  Autistic Disorder  Down Syndrome/complications/epidemiology  Autism Spectrum Disorder/complications/epidemiology  Retrospective Studies  Prospective Studies  Autism spectrum disorder  Co-occurring medical conditions  Comorbid  Down syndrome  Medical disease  Prevalence Index. décimale : PER Périodiques Résumé : BACKGROUND: Down syndrome (DS) is one of the most common genetic causes of intellectual disability, and it is associated with an increased incidence of numerous co-occurring conditions. Autism spectrum disorder (ASD) is common in persons with DS, with rates reported as high as 39%. However, little is known regarding co-occurring conditions in children with both DS and ASD. METHODS: A single-center retrospective review of prospective longitudinally collected clinical data was performed. Any patient with a confirmed diagnosis of DS evaluated at a large, specialized Down Syndrome Program in a tertiary pediatric medical center between March 2018 and March 2022 was included. A standardized survey which included demographic and clinical questions was administered during each clinical evaluation. RESULTS: In total, 562 individuals with DS were included. The median age was 10 years (IQR: 6.18-13.92). Of this group, 72 (13%) had a co-occurring diagnosis of ASD (DS+ASD). Individuals with DS+ASD were more likely to be male (OR 2.23, CI 1.29-3.84) and had higher odds of a current or prior diagnosis of constipation (OR 2.19, CI 1.31-3.65), gastroesophageal reflux (OR 1.91, CI 1.14-3.21), behavioral feeding difficulties (OR 2.71, CI 1.02-7.19), infantile spasms (OR 6.03, CI 1.79-20.34) and scoliosis (OR 2.73, CI 1.16-6.40). There were lower odds of congenital heart disease in the DS+ASD group (OR 0.56, CI 0.34-0.93). There was no observed difference in prematurity or Neonatal Intensive Care Unit complications between groups. Individuals with DS+ASD had similar odds of having a history of congenital heart defect requiring surgery to those with DS only. Furthermore, there was no difference in rates of autoimmune thyroiditis or celiac disease. There was also no difference in rates of diagnosed co-occurring neurodevelopmental or mental health conditions in this cohort, including anxiety disorders and attention-deficit/hyperactivity disorder. CONCLUSIONS: This study identifies a variety of medical conditions which are more frequent in children with DS+ASD than DS alone, providing important information for the clinical management of these patients. Future research should investigate the role of some of these medical conditions in the development of ASD phenotypes, and whether there may be distinct genetic and metabolic contributions towards these conditions. En ligne : https://dx.doi.org/10.1186/s11689-023-09478-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Female Autism Phenotypes Investigated at Different Levels of Language and Developmental Abilities / Yamini J. HOWE in Journal of Autism and Developmental Disorders, 45-11 (November 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3537-3549 Titre : Female Autism Phenotypes Investigated at Different Levels of Language and Developmental Abilities Type de document : texte imprimé Auteurs : Yamini J. HOWE, Auteur ; Julia A. O’ROURKE, Auteur ; Yvette YATCHMINK, Auteur ; Emma W. VISCIDI, Auteur ; Richard N. JONES, Auteur ; Eric M. MORROW, Auteur Article en page(s) : p.3537-3549 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Sex differences  Diagnosis of autism spectrum disorder Index. décimale : PER Périodiques Résumé : This study investigated the differences in clinical symptoms between females and males with autism spectrum disorder (ASD) across three verbal ability groups (nonverbal, phrase and fluent speech), based on which Autism Diagnostic Observation Schedule module was administered to 5723 individuals in four research datasets. In the Simons Simplex Collection and Autism Treatment Network, females with ASD and phrase or fluent speech had lower cognitive, adaptive, and social abilities than males. In the Autism Genetics Resource Exchange and the Autism Consortium, females with phrase or fluent speech had similar or better adaptive and social abilities than males. Females who were nonverbal had similar cognitive, adaptive, and social abilities as males. Population-based longitudinal studies of verbally fluent females with ASD are needed. En ligne : http://dx.doi.org/10.1007/s10803-015-2501-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Female Autism Phenotypes Investigated at Different Levels of Language and Developmental Abilities [texte imprimé] / Yamini J. HOWE, Auteur ; Julia A. O’ROURKE, Auteur ; Yvette YATCHMINK, Auteur ; Emma W. VISCIDI, Auteur ; Richard N. JONES, Auteur ; Eric M. MORROW, Auteur . - p.3537-3549. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3537-3549 Mots-clés : Autism spectrum disorder  Sex differences  Diagnosis of autism spectrum disorder Index. décimale : PER Périodiques Résumé : This study investigated the differences in clinical symptoms between females and males with autism spectrum disorder (ASD) across three verbal ability groups (nonverbal, phrase and fluent speech), based on which Autism Diagnostic Observation Schedule module was administered to 5723 individuals in four research datasets. In the Simons Simplex Collection and Autism Treatment Network, females with ASD and phrase or fluent speech had lower cognitive, adaptive, and social abilities than males. In the Autism Genetics Resource Exchange and the Autism Consortium, females with phrase or fluent speech had similar or better adaptive and social abilities than males. Females who were nonverbal had similar cognitive, adaptive, and social abilities as males. Population-based longitudinal studies of verbally fluent females with ASD are needed. En ligne : http://dx.doi.org/10.1007/s10803-015-2501-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

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