Gender in Voice Perception in Autism / Wouter B. GROEN in Journal of Autism and Developmental Disorders, 38-10 (November 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1819-1826 Titre : Gender in Voice Perception in Autism Type de document : texte imprimé Auteurs : Wouter B. GROEN, Auteur ; Sophie H.N. SWINKELS, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur ; Linda VAN ORSOUW, Auteur ; Marcel P. ZWIERS, Auteur Année de publication : 2008 Article en page(s) : p.1819-1826 Langues : Anglais (eng) Mots-clés : Autism Gender Voice Perception Auditory Index. décimale : PER Périodiques Résumé : Deficits in the perception of social stimuli may contribute to the characteristic impairments in social interaction in high functioning autism (HFA). Although the cortical processing of voice is abnormal in HFA, it is unclear whether this gives rise to impairments in the perception of voice gender. About 20 children with HFA and 20 matched controls were presented with voice fragments that were parametrically morphed in gender. No differences were found in the perception of gender between the two groups of participants, but response times differed significantly. The results suggest that the perception of voice gender is not impaired in HFA, which is consistent with behavioral findings of an unimpaired voice-based identification of age and identity by individuals with autism. The differences in response times suggest that individuals with HFA use different perceptual approaches from those used by typically developing individuals. En ligne : http://dx.doi.org/10.1007/s10803-008-0572-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=640 [article] Gender in Voice Perception in Autism [texte imprimé] / Wouter B. GROEN, Auteur ; Sophie H.N. SWINKELS, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur ; Linda VAN ORSOUW, Auteur ; Marcel P. ZWIERS, Auteur . - 2008 . - p.1819-1826. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-10 (November 2008) . - p.1819-1826 Mots-clés : Autism Gender Voice Perception Auditory Index. décimale : PER Périodiques Résumé : Deficits in the perception of social stimuli may contribute to the characteristic impairments in social interaction in high functioning autism (HFA). Although the cortical processing of voice is abnormal in HFA, it is unclear whether this gives rise to impairments in the perception of voice gender. About 20 children with HFA and 20 matched controls were presented with voice fragments that were parametrically morphed in gender. No differences were found in the perception of gender between the two groups of participants, but response times differed significantly. The results suggest that the perception of voice gender is not impaired in HFA, which is consistent with behavioral findings of an unimpaired voice-based identification of age and identity by individuals with autism. The differences in response times suggest that individuals with HFA use different perceptual approaches from those used by typically developing individuals. En ligne : http://dx.doi.org/10.1007/s10803-008-0572-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=640

Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism / Wouter B. GROEN in Journal of Autism and Developmental Disorders, 39-5 (May 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.742-750 Titre : Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism Type de document : texte imprimé Auteurs : Wouter B. GROEN, Auteur ; Sophie H.N. SWINKELS, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur ; Linda VAN ORSOUW, Auteur ; Marcel P. ZWIERS, Auteur ; Niels ter HUURNE, Auteur Année de publication : 2009 Article en page(s) : p.742-750 Langues : Anglais (eng) Mots-clés : Autism Connectivity Auditory Perception Speech-in-noise Index. décimale : PER Périodiques Résumé : The perceptual pattern in autism has been related to either a specific localized processing deficit or a pathway-independent, complexity-specific anomaly. We examined auditory perception in autism using an auditory disembedding task that required spectral and temporal integration. 23 children with high-functioning-autism and 23 matched controls participated. Participants were presented with two-syllable words embedded in various auditory backgrounds (pink noise, moving ripple, amplitude-modulated pink noise, amplitude-modulated moving ripple) to assess speech-in-noise-reception thresholds. The gain in signal perception of pink noise with temporal dips relative to pink noise without temporal dips was smaller in children with autism (p = 0.008). Thus, the autism group was less able to integrate auditory information present in temporal dips in background sound, supporting the complexity-specific perceptual account. En ligne : http://dx.doi.org/10.1007/s10803-008-0682-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732 [article] Intact Spectral but Abnormal Temporal Processing of Auditory Stimuli in Autism [texte imprimé] / Wouter B. GROEN, Auteur ; Sophie H.N. SWINKELS, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur ; Linda VAN ORSOUW, Auteur ; Marcel P. ZWIERS, Auteur ; Niels ter HUURNE, Auteur . - 2009 . - p.742-750. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-5 (May 2009) . - p.742-750 Mots-clés : Autism Connectivity Auditory Perception Speech-in-noise Index. décimale : PER Périodiques Résumé : The perceptual pattern in autism has been related to either a specific localized processing deficit or a pathway-independent, complexity-specific anomaly. We examined auditory perception in autism using an auditory disembedding task that required spectral and temporal integration. 23 children with high-functioning-autism and 23 matched controls participated. Participants were presented with two-syllable words embedded in various auditory backgrounds (pink noise, moving ripple, amplitude-modulated pink noise, amplitude-modulated moving ripple) to assess speech-in-noise-reception thresholds. The gain in signal perception of pink noise with temporal dips relative to pink noise without temporal dips was smaller in children with autism (p = 0.008). Thus, the autism group was less able to integrate auditory information present in temporal dips in background sound, supporting the complexity-specific perceptual account. En ligne : http://dx.doi.org/10.1007/s10803-008-0682-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=732

The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation / Tony CHARMAN in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 27p. Titre : The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation Type de document : texte imprimé Auteurs : Tony CHARMAN, Auteur ; Eva LOTH, Auteur ; Julian TILLMANN, Auteur ; Daisy CRAWLEY, Auteur ; Caroline WOOLDRIDGE, Auteur ; David GOYARD, Auteur ; Jumana AHMAD, Auteur ; Bonnie AUYEUNG, Auteur ; Sara AMBROSINO, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sarah BAUMEISTER, Auteur ; Christian F. BECKMANN, Auteur ; Sven BÖLTE, Auteur ; Thomas BOURGERON, Auteur ; Carsten BOURS, Auteur ; Michael BRAMMER, Auteur ; Daniel BRANDEIS, Auteur ; Claudia BROGNA, Auteur ; Yvette G.E. DE BRUIJN, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Ineke CORNELISSEN, Auteur ; Flavio DELL'ACQUA, Auteur ; Guillaume DUMAS, Auteur ; Sarah DURSTON, Auteur ; Christine ECKER, Auteur ; Jessica FAULKNER, Auteur ; Vincent FROUIN, Auteur ; Pilar GARCES, Auteur ; Lindsay HAM, Auteur ; Hannah HAYWARD, Auteur ; Joerg F. HIPP, Auteur ; Rosemary J. HOLT, Auteur ; Johan ISAKSSON, Auteur ; Mark Henry JOHNSON, Auteur ; Emily Jane Harrison JONES, Auteur ; Prantik KUNDU, Auteur ; Meng-Chuan LAI, Auteur ; X. Liogier D'ARDHUY, Auteur ; Michael V. LOMBARDO, Auteur ; David J. LYTHGOE, Auteur ; René MANDL, Auteur ; Luke MASON, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Nico MUELLER, Auteur ; Laurence O'DWYER, Auteur ; Marianne OLDEHINKEL, Auteur ; Bob ORANJE, Auteur ; Gahan PANDINA, Auteur ; Antonio M. PERSICO, Auteur ; Barbara RUGGERI, Auteur ; Amber N.V. RUIGROK, Auteur ; Jessica SABET, Auteur ; Roberto SACCO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Emily SIMONOFF, Auteur ; Roberto TORO, Auteur ; Heike TOST, Auteur ; Jack WALDMAN, Auteur ; Steven C.R. WILLIAMS, Auteur ; Marcel P. ZWIERS, Auteur ; Will SPOOREN, Auteur ; Declan G.M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : 27p. Langues : Anglais (eng) Mots-clés : Age  Autism  Autism spectrum disorder  Behaviours  Heterogeneity  Iq  Phenotype  Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers. METHODS: From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms. RESULTS: The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females. CONCLUSIONS: The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials. En ligne : http://dx.doi.org/10.1186/s13229-017-0145-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation [texte imprimé] / Tony CHARMAN, Auteur ; Eva LOTH, Auteur ; Julian TILLMANN, Auteur ; Daisy CRAWLEY, Auteur ; Caroline WOOLDRIDGE, Auteur ; David GOYARD, Auteur ; Jumana AHMAD, Auteur ; Bonnie AUYEUNG, Auteur ; Sara AMBROSINO, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sarah BAUMEISTER, Auteur ; Christian F. BECKMANN, Auteur ; Sven BÖLTE, Auteur ; Thomas BOURGERON, Auteur ; Carsten BOURS, Auteur ; Michael BRAMMER, Auteur ; Daniel BRANDEIS, Auteur ; Claudia BROGNA, Auteur ; Yvette G.E. DE BRUIJN, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Ineke CORNELISSEN, Auteur ; Flavio DELL'ACQUA, Auteur ; Guillaume DUMAS, Auteur ; Sarah DURSTON, Auteur ; Christine ECKER, Auteur ; Jessica FAULKNER, Auteur ; Vincent FROUIN, Auteur ; Pilar GARCES, Auteur ; Lindsay HAM, Auteur ; Hannah HAYWARD, Auteur ; Joerg F. HIPP, Auteur ; Rosemary J. HOLT, Auteur ; Johan ISAKSSON, Auteur ; Mark Henry JOHNSON, Auteur ; Emily Jane Harrison JONES, Auteur ; Prantik KUNDU, Auteur ; Meng-Chuan LAI, Auteur ; X. Liogier D'ARDHUY, Auteur ; Michael V. LOMBARDO, Auteur ; David J. LYTHGOE, Auteur ; René MANDL, Auteur ; Luke MASON, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Nico MUELLER, Auteur ; Laurence O'DWYER, Auteur ; Marianne OLDEHINKEL, Auteur ; Bob ORANJE, Auteur ; Gahan PANDINA, Auteur ; Antonio M. PERSICO, Auteur ; Barbara RUGGERI, Auteur ; Amber N.V. RUIGROK, Auteur ; Jessica SABET, Auteur ; Roberto SACCO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Emily SIMONOFF, Auteur ; Roberto TORO, Auteur ; Heike TOST, Auteur ; Jack WALDMAN, Auteur ; Steven C.R. WILLIAMS, Auteur ; Marcel P. ZWIERS, Auteur ; Will SPOOREN, Auteur ; Declan G.M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur . - 27p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 27p. Mots-clés : Age  Autism  Autism spectrum disorder  Behaviours  Heterogeneity  Iq  Phenotype  Sex Index. décimale : PER Périodiques Résumé : BACKGROUND: The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism spectrum disorder (ASD). The current paper describes the clinical characteristics of the LEAP cohort and examines age, sex and IQ differences in ASD core symptoms and common co-occurring psychiatric symptoms. A companion paper describes the overall design and experimental protocol and outlines the strategy to identify stratification biomarkers. METHODS: From six research centres in four European countries, we recruited 437 children and adults with ASD and 300 controls between the ages of 6 and 30 years with IQs varying between 50 and 148. We conducted in-depth clinical characterisation including a wide range of observational, interview and questionnaire measures of the ASD phenotype, as well as co-occurring psychiatric symptoms. RESULTS: The cohort showed heterogeneity in ASD symptom presentation, with only minimal to moderate site differences on core clinical and cognitive measures. On both parent-report interview and questionnaire measures, ASD symptom severity was lower in adults compared to children and adolescents. The precise pattern of differences varied across measures, but there was some evidence of both lower social symptoms and lower repetitive behaviour severity in adults. Males had higher ASD symptom scores than females on clinician-rated and parent interview diagnostic measures but not on parent-reported dimensional measures of ASD symptoms. In contrast, self-reported ASD symptom severity was higher in adults compared to adolescents, and in adult females compared to males. Higher scores on ASD symptom measures were moderately associated with lower IQ. Both inattentive and hyperactive/impulsive ADHD symptoms were lower in adults than in children and adolescents, and males with ASD had higher levels of inattentive and hyperactive/impulsive ADHD symptoms than females. CONCLUSIONS: The established phenotypic heterogeneity in ASD is well captured in the LEAP cohort. Variation both in core ASD symptom severity and in commonly co-occurring psychiatric symptoms were systematically associated with sex, age and IQ. The pattern of ASD symptom differences with age and sex also varied by whether these were clinician ratings or parent- or self-reported which has important implications for establishing stratification biomarkers and for their potential use as outcome measures in clinical trials. En ligne : http://dx.doi.org/10.1186/s13229-017-0145-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders / Eva LOTH in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 24p. Titre : The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders Type de document : texte imprimé Auteurs : Eva LOTH, Auteur ; Tony CHARMAN, Auteur ; Luke MASON, Auteur ; Julian TILLMANN, Auteur ; Emily Jane Harrison JONES, Auteur ; Caroline WOOLDRIDGE, Auteur ; Jumana AHMAD, Auteur ; Bonnie AUYEUNG, Auteur ; Claudia BROGNA, Auteur ; Sara AMBROSINO, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sarah BAUMEISTER, Auteur ; Christian F. BECKMANN, Auteur ; Michael BRAMMER, Auteur ; Daniel BRANDEIS, Auteur ; Sven BÖLTE, Auteur ; Thomas BOURGERON, Auteur ; Carsten BOURS, Auteur ; Yvette G.E. DE BRUIJN, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Daisy CRAWLEY, Auteur ; Ineke CORNELISSEN, Auteur ; Flavio DELL'ACQUA, Auteur ; Guillaume DUMAS, Auteur ; Sarah DURSTON, Auteur ; Christine ECKER, Auteur ; Jessica FAULKNER, Auteur ; Vincent FROUIN, Auteur ; Pilar GARCES, Auteur ; David GOYARD, Auteur ; Hannah HAYWARD, Auteur ; Lindsay M. HAM, Auteur ; Joerg F. HIPP, Auteur ; Rosemary J. HOLT, Auteur ; Mark Henry JOHNSON, Auteur ; Johan ISAKSSON, Auteur ; Prantik KUNDU, Auteur ; Meng-Chuan LAI, Auteur ; X. Liogier D'ARDHUY, Auteur ; Michael V. LOMBARDO, Auteur ; David J. LYTHGOE, Auteur ; René MANDL, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Nico MUELLER, Auteur ; Laurence O'DWYER, Auteur ; Marianne OLDEHINKEL, Auteur ; Bob ORANJE, Auteur ; Gahan PANDINA, Auteur ; Antonio M. PERSICO, Auteur ; Amber N.V. RUIGROK, Auteur ; Barbara RUGGERI, Auteur ; Jessica SABET, Auteur ; Roberto SACCO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Emily SIMONOFF, Auteur ; Roberto TORO, Auteur ; Heike TOST, Auteur ; Jack WALDMAN, Auteur ; Steven C.R. WILLIAMS, Auteur ; Marcel P. ZWIERS, Auteur ; Will SPOOREN, Auteur ; Declan G.M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur Article en page(s) : 24p. Langues : Anglais (eng) Mots-clés : Biomarkers  Cognition  Eeg  Eye-tracking  Genetics  Mri  Neuroimaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD. METHODS: LEAP includes 437 children and adults with ASD and 300 individuals with typical development or mild intellectual disability. Using an accelerated longitudinal design, each participant is comprehensively characterised in terms of clinical symptoms, comorbidities, functional outcomes, neurocognitive profile, brain structure and function, biochemical markers and genomics. In addition, 51 twin-pairs (of which 36 had one sibling with ASD) are included to identify genetic and environmental factors in phenotypic variability. RESULTS: Here, we describe the demographic characteristics of the cohort, planned analytic stratification approaches, criteria and steps to validate candidate stratification markers, pre-registration procedures to increase transparency, standardisation and data robustness across all analyses, and share some 'lessons learnt'. A clinical characterisation of the cohort is given in the companion paper (Charman et al., accepted). CONCLUSION: We expect that LEAP will enable us to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities, identify biologically and clinically meaningful ASD subgroups, and help us map phenotypic heterogeneity to different aetiologies. En ligne : http://dx.doi.org/10.1186/s13229-017-0146-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders [texte imprimé] / Eva LOTH, Auteur ; Tony CHARMAN, Auteur ; Luke MASON, Auteur ; Julian TILLMANN, Auteur ; Emily Jane Harrison JONES, Auteur ; Caroline WOOLDRIDGE, Auteur ; Jumana AHMAD, Auteur ; Bonnie AUYEUNG, Auteur ; Claudia BROGNA, Auteur ; Sara AMBROSINO, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sarah BAUMEISTER, Auteur ; Christian F. BECKMANN, Auteur ; Michael BRAMMER, Auteur ; Daniel BRANDEIS, Auteur ; Sven BÖLTE, Auteur ; Thomas BOURGERON, Auteur ; Carsten BOURS, Auteur ; Yvette G.E. DE BRUIJN, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Daisy CRAWLEY, Auteur ; Ineke CORNELISSEN, Auteur ; Flavio DELL'ACQUA, Auteur ; Guillaume DUMAS, Auteur ; Sarah DURSTON, Auteur ; Christine ECKER, Auteur ; Jessica FAULKNER, Auteur ; Vincent FROUIN, Auteur ; Pilar GARCES, Auteur ; David GOYARD, Auteur ; Hannah HAYWARD, Auteur ; Lindsay M. HAM, Auteur ; Joerg F. HIPP, Auteur ; Rosemary J. HOLT, Auteur ; Mark Henry JOHNSON, Auteur ; Johan ISAKSSON, Auteur ; Prantik KUNDU, Auteur ; Meng-Chuan LAI, Auteur ; X. Liogier D'ARDHUY, Auteur ; Michael V. LOMBARDO, Auteur ; David J. LYTHGOE, Auteur ; René MANDL, Auteur ; Andreas MEYER-LINDENBERG, Auteur ; Carolin MOESSNANG, Auteur ; Nico MUELLER, Auteur ; Laurence O'DWYER, Auteur ; Marianne OLDEHINKEL, Auteur ; Bob ORANJE, Auteur ; Gahan PANDINA, Auteur ; Antonio M. PERSICO, Auteur ; Amber N.V. RUIGROK, Auteur ; Barbara RUGGERI, Auteur ; Jessica SABET, Auteur ; Roberto SACCO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; Emily SIMONOFF, Auteur ; Roberto TORO, Auteur ; Heike TOST, Auteur ; Jack WALDMAN, Auteur ; Steven C.R. WILLIAMS, Auteur ; Marcel P. ZWIERS, Auteur ; Will SPOOREN, Auteur ; Declan G.M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur . - 24p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 24p. Mots-clés : Biomarkers  Cognition  Eeg  Eye-tracking  Genetics  Mri  Neuroimaging Index. décimale : PER Périodiques Résumé : BACKGROUND: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD. METHODS: LEAP includes 437 children and adults with ASD and 300 individuals with typical development or mild intellectual disability. Using an accelerated longitudinal design, each participant is comprehensively characterised in terms of clinical symptoms, comorbidities, functional outcomes, neurocognitive profile, brain structure and function, biochemical markers and genomics. In addition, 51 twin-pairs (of which 36 had one sibling with ASD) are included to identify genetic and environmental factors in phenotypic variability. RESULTS: Here, we describe the demographic characteristics of the cohort, planned analytic stratification approaches, criteria and steps to validate candidate stratification markers, pre-registration procedures to increase transparency, standardisation and data robustness across all analyses, and share some 'lessons learnt'. A clinical characterisation of the cohort is given in the companion paper (Charman et al., accepted). CONCLUSION: We expect that LEAP will enable us to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities, identify biologically and clinically meaningful ASD subgroups, and help us map phenotypic heterogeneity to different aetiologies. En ligne : http://dx.doi.org/10.1186/s13229-017-0146-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Visual Scanning in Very Young Children with Autism and Their Unaffected Parents / Wouter B. GROEN in Autism Research and Treatment, (January 2012)  

Public ISBD [article]  inAutism Research and Treatment > (January 2012) . - 9 p. Titre : Visual Scanning in Very Young Children with Autism and Their Unaffected Parents Type de document : texte imprimé Auteurs : Wouter B. GROEN, Auteur ; Nanda N. ROMMELSE, Auteur ; Tessa C.J. DE WIT, Auteur ; Marcel P. ZWIERS, Auteur ; Desley VAN MEERENDONCK, Auteur Année de publication : 2012 Article en page(s) : 9 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study of gaze patterns in very young children with autism and their parents included 23 cases (with 16 fathers and 19 mothers) and 46 controls (with 14 fathers and 28 mothers). Children (mean age 3 . 3 ± 1 . 5 years) with autism met DSM-IV and ADOS-G diagnostic criteria. The participants’ gaze patterns were recorded while they viewed four simple movies that did not feature people. In children, severity of autism is related to spending more time watching irrelevant regions in one of the four movies. The mothers of children with autism showed an atypical pattern for three movies, whereas the fathers of children with autism did not show an atypical gaze pattern. The gaze pattern of the mothers was positively correlated with that of their children. The atypical viewing pattern of autistic individuals appears not to be restricted to people and social situations but is also seen in other situations, suggesting that there is a perceptual broad autism phenotype. En ligne : http://dx.doi.org/10.1155/2012/748467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 [article] Visual Scanning in Very Young Children with Autism and Their Unaffected Parents [texte imprimé] / Wouter B. GROEN, Auteur ; Nanda N. ROMMELSE, Auteur ; Tessa C.J. DE WIT, Auteur ; Marcel P. ZWIERS, Auteur ; Desley VAN MEERENDONCK, Auteur . - 2012 . - 9 p. Langues : Anglais (eng) in Autism Research and Treatment > (January 2012) . - 9 p. Index. décimale : PER Périodiques Résumé : This study of gaze patterns in very young children with autism and their parents included 23 cases (with 16 fathers and 19 mothers) and 46 controls (with 14 fathers and 28 mothers). Children (mean age 3 . 3 ± 1 . 5 years) with autism met DSM-IV and ADOS-G diagnostic criteria. The participants’ gaze patterns were recorded while they viewed four simple movies that did not feature people. In children, severity of autism is related to spending more time watching irrelevant regions in one of the four movies. The mothers of children with autism showed an atypical pattern for three movies, whereas the fathers of children with autism did not show an atypical gaze pattern. The gaze pattern of the mothers was positively correlated with that of their children. The atypical viewing pattern of autistic individuals appears not to be restricted to people and social situations but is also seen in other situations, suggesting that there is a perceptual broad autism phenotype. En ligne : http://dx.doi.org/10.1155/2012/748467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155

White matter microstructure and developmental improvement of hyperactive/impulsive symptoms in attention-deficit/hyperactivity disorder / Winke FRANCX in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)  

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