Advancing the RDoC initiative through the assessment of caregiver social processes / Lucy S. KING in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1648-1664 Titre : Advancing the RDoC initiative through the assessment of caregiver social processes Type de document : texte imprimé Auteurs : Lucy S. KING, Auteur ; Virginia C. SALO, Auteur ; Autumn KUJAWA, Auteur ; Kathryn L. HUMPHREYS, Auteur Article en page(s) : p.1648-1664 Langues : Anglais (eng) Mots-clés : caregiving  developmental psychopathology  parent–child relationship  RDoC  social processes Index. décimale : PER Périodiques Résumé : The relationships infants and young children have with their caregivers are fundamental to their survival and well-being. Theorists and researchers across disciplines have attempted to describe and assess the variation in these relationships, leading to a general acceptance that caregiving is critical to understanding child functioning, including developmental psychopathology. At the same time, we lack consensus on how to assess these fundamental relationships. In the present paper, we first review research documenting the importance of the caregiver–child relationship in understanding environmental risk for psychopathology. Second, we propose that the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative provides a useful framework for extending the study of children's risk for psychopathology by assessing their caregivers’ social processes. Third, we describe the units of analysis for caregiver social processes, documenting how the specific subconstructs in the domain of social processes are relevant to the goal of enhancing knowledge of developmental psychopathology. Lastly, we highlight how past research can inform new directions in the study of caregiving and the parent–child relationship through this innovative extension of the RDoC initiative. En ligne : http://dx.doi.org/10.1017/S095457942100064X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Advancing the RDoC initiative through the assessment of caregiver social processes [texte imprimé] / Lucy S. KING, Auteur ; Virginia C. SALO, Auteur ; Autumn KUJAWA, Auteur ; Kathryn L. HUMPHREYS, Auteur . - p.1648-1664. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1648-1664 Mots-clés : caregiving  developmental psychopathology  parent–child relationship  RDoC  social processes Index. décimale : PER Périodiques Résumé : The relationships infants and young children have with their caregivers are fundamental to their survival and well-being. Theorists and researchers across disciplines have attempted to describe and assess the variation in these relationships, leading to a general acceptance that caregiving is critical to understanding child functioning, including developmental psychopathology. At the same time, we lack consensus on how to assess these fundamental relationships. In the present paper, we first review research documenting the importance of the caregiver–child relationship in understanding environmental risk for psychopathology. Second, we propose that the National Institute of Mental Health's Research Domain Criteria (RDoC) initiative provides a useful framework for extending the study of children's risk for psychopathology by assessing their caregivers’ social processes. Third, we describe the units of analysis for caregiver social processes, documenting how the specific subconstructs in the domain of social processes are relevant to the goal of enhancing knowledge of developmental psychopathology. Lastly, we highlight how past research can inform new directions in the study of caregiving and the parent–child relationship through this innovative extension of the RDoC initiative. En ligne : http://dx.doi.org/10.1017/S095457942100064X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Correlates and predictors of the severity of suicidal ideation in adolescence: an examination of brain connectomics and psychosocial characteristics / Jaclyn S. KIRSHENBAUM in Journal of Child Psychology and Psychiatry, 63-6 (June 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-6 (June 2022) . - p.701-714 Titre : Correlates and predictors of the severity of suicidal ideation in adolescence: an examination of brain connectomics and psychosocial characteristics Type de document : texte imprimé Auteurs : Jaclyn S. KIRSHENBAUM, Auteur ; Rajpreet CHAHAL, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Anthony J. GIFUNI, Auteur ; Dana MASTROVITO, Auteur ; Saché M. COURY, Auteur ; Rachel L. WEISENBURGER, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.701-714 Langues : Anglais (eng) Mots-clés : Suicidal ideation  adolescence  graph theory  internalizing and externalizing symptoms  resting-state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicidal ideation (SI) typically emerges during adolescence but is challenging to predict. Given the potentially lethal consequences of SI, it is important to identify neurobiological and psychosocial variables explaining the severity of SI in adolescents. METHODS: In 106 participants (59 female) recruited from the community, we assessed psychosocial characteristics and obtained resting-state fMRI data in early adolescence (baseline: aged 9-13 years). Across 250 brain regions, we assessed local graph theory-based properties of interconnectedness: local efficiency, eigenvector centrality, nodal degree, within-module z-score, and participation coefficient. Four years later (follow-up: ages 13-19 years), participants self-reported their SI severity. We used least absolute shrinkage and selection operator (LASSO) regressions to identify a linear combination of psychosocial and brain-based variables that best explain the severity of SI symptoms at follow-up. Nested-cross-validation yielded model performance statistics for all LASSO models. RESULTS: A combination of psychosocial and brain-based variables explained subsequent severity of SI (R(2 ) =?.55); the strongest was internalizing and externalizing symptom severity at follow-up. Follow-up LASSO regressions of psychosocial-only and brain-based-only variables indicated that psychosocial-only variables explained 55% of the variance in SI severity; in contrast, brain-based-only variables performed worse than the null model. CONCLUSIONS: A linear combination of baseline and follow-up psychosocial variables best explained the severity of SI. Follow-up analyses indicated that graph theory resting-state metrics did not increase the prediction of the severity of SI in adolescents. Attending to internalizing and externalizing symptoms is important in early adolescence; resting-state connectivity properties other than local graph theory metrics might yield a stronger prediction of the severity of SI. En ligne : http://dx.doi.org/10.1111/jcpp.13512 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475 [article] Correlates and predictors of the severity of suicidal ideation in adolescence: an examination of brain connectomics and psychosocial characteristics [texte imprimé] / Jaclyn S. KIRSHENBAUM, Auteur ; Rajpreet CHAHAL, Auteur ; Tiffany C. HO, Auteur ; Lucy S. KING, Auteur ; Anthony J. GIFUNI, Auteur ; Dana MASTROVITO, Auteur ; Saché M. COURY, Auteur ; Rachel L. WEISENBURGER, Auteur ; Ian H. GOTLIB, Auteur . - p.701-714. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-6 (June 2022) . - p.701-714 Mots-clés : Suicidal ideation  adolescence  graph theory  internalizing and externalizing symptoms  resting-state fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Suicidal ideation (SI) typically emerges during adolescence but is challenging to predict. Given the potentially lethal consequences of SI, it is important to identify neurobiological and psychosocial variables explaining the severity of SI in adolescents. METHODS: In 106 participants (59 female) recruited from the community, we assessed psychosocial characteristics and obtained resting-state fMRI data in early adolescence (baseline: aged 9-13 years). Across 250 brain regions, we assessed local graph theory-based properties of interconnectedness: local efficiency, eigenvector centrality, nodal degree, within-module z-score, and participation coefficient. Four years later (follow-up: ages 13-19 years), participants self-reported their SI severity. We used least absolute shrinkage and selection operator (LASSO) regressions to identify a linear combination of psychosocial and brain-based variables that best explain the severity of SI symptoms at follow-up. Nested-cross-validation yielded model performance statistics for all LASSO models. RESULTS: A combination of psychosocial and brain-based variables explained subsequent severity of SI (R(2 ) =?.55); the strongest was internalizing and externalizing symptom severity at follow-up. Follow-up LASSO regressions of psychosocial-only and brain-based-only variables indicated that psychosocial-only variables explained 55% of the variance in SI severity; in contrast, brain-based-only variables performed worse than the null model. CONCLUSIONS: A linear combination of baseline and follow-up psychosocial variables best explained the severity of SI. Follow-up analyses indicated that graph theory resting-state metrics did not increase the prediction of the severity of SI in adolescents. Attending to internalizing and externalizing symptoms is important in early adolescence; resting-state connectivity properties other than local graph theory metrics might yield a stronger prediction of the severity of SI. En ligne : http://dx.doi.org/10.1111/jcpp.13512 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=475

Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty / Katharina KIRCANSKI in Development and Psychopathology, 31-3 (August 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Titre : Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty Type de document : texte imprimé Auteurs : Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1011-1022 Langues : Anglais (eng) Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403 [article] Early life stress, cortisol, frontolimbic connectivity, and depressive symptoms during puberty [texte imprimé] / Katharina KIRCANSKI, Auteur ; Lucinda M. SISK, Auteur ; Tiffany C. HO, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Lucy S. KING, Auteur ; Natalie L. COLICH, Auteur ; Sarah J. ORDAZ, Auteur ; Ian H. GOTLIB, Auteur . - p.1011-1022. Langues : Anglais (eng) in Development and Psychopathology > 31-3 (August 2019) . - p.1011-1022 Mots-clés : cortisol  depression  diffusion tensor imaging  emotion dysregulation  early life stress  puberty Index. décimale : PER Périodiques Résumé : Early life stress (ELS) is a risk factor for the development of depression in adolescence; the mediating neurobiological mechanisms, however, are unknown. In this study, we examined in early pubertal youth the associations among ELS, cortisol stress responsivity, and white matter microstructure of the uncinate fasciculus and the fornix, two key frontolimbic tracts; we also tested whether and how these variables predicted depressive symptoms in later puberty. A total of 208 participants (117 females; M age = 11.37 years; M Tanner stage = 2.03) provided data across two or more assessment modalities: ELS; salivary cortisol levels during a psychosocial stress task; diffusion magnetic resonance imaging; and depressive symptoms. In early puberty there were significant associations between higher ELS and decreased cortisol production, and between decreased cortisol production and increased fractional anisotropy in the uncinate fasciculus. Further, increased fractional anisotropy in the uncinate fasciculus predicted higher depressive symptoms in later puberty, above and beyond earlier symptoms. In post hoc analyses, we found that sex moderated several additional associations. We discuss these findings within a broader conceptual model linking ELS, emotion dysregulation, and depression across the transition through puberty, and contend that brain circuits implicated in the control of hypothalamic–pituitary–adrenal axis function should be a focus of continued research. En ligne : http://dx.doi.org/10.1017/S0954579419000555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=403

Large-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study / Jonas G. MILLER ; Nima AGHAEEPOUR ; Lucy S. KING ; David K. STEVENSON ; Gary M. SHAW ; Ronald J. WONG ; Ian H. GOTLIB in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1098-1107 Titre : Large-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study Type de document : texte imprimé Auteurs : Jonas G. MILLER, Auteur ; Nima AGHAEEPOUR, Auteur ; Lucy S. KING, Auteur ; David K. STEVENSON, Auteur ; Gary M. SHAW, Auteur ; Ronald J. WONG, Auteur ; Ian H. GOTLIB, Auteur Article en page(s) : p.1098-1107 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Understanding the prenatal origins of children's psychopathology is a fundamental goal in developmental and clinical science. Recent research suggests that inflammation during pregnancy can trigger a cascade of fetal programming changes that contribute to vulnerability for the emergence of psychopathology. Most studies, however, have focused on a handful of proinflammatory cytokines and have not explored a range of prenatal biological pathways that may be involved in increasing postnatal risk for emotional and behavioral difficulties. Methods Using extreme gradient boosted machine learning models, we explored large-scale proteomics, considering over 1,000 proteins from first trimester blood samples, to predict behavior in early childhood. Mothers reported on their 3- to 5-year-old children's (N = 89, 51% female) temperament (Child Behavior Questionnaire) and psychopathology (Child Behavior Checklist). Results We found that machine learning models of prenatal proteomics predict 5%-10% of the variance in children's sadness, perceptual sensitivity, attention problems, and emotional reactivity. Enrichment analyses identified immune function, nervous system development, and cell signaling pathways as being particularly important in predicting children's outcomes. Conclusions Our findings, though exploratory, suggest processes in early pregnancy that are related to functioning in early childhood. Predictive features included far more proteins than have been considered in prior work. Specifically, proteins implicated in inflammation, in the development of the central nervous system, and in key cell-signaling pathways were enriched in relation to child temperament and psychopathology measures. En ligne : https://doi.org/10.1111/jcpp.13948 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] Large-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study [texte imprimé] / Jonas G. MILLER, Auteur ; Nima AGHAEEPOUR, Auteur ; Lucy S. KING, Auteur ; David K. STEVENSON, Auteur ; Gary M. SHAW, Auteur ; Ronald J. WONG, Auteur ; Ian H. GOTLIB, Auteur . - p.1098-1107. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1098-1107 Index. décimale : PER Périodiques Résumé : Background Understanding the prenatal origins of children's psychopathology is a fundamental goal in developmental and clinical science. Recent research suggests that inflammation during pregnancy can trigger a cascade of fetal programming changes that contribute to vulnerability for the emergence of psychopathology. Most studies, however, have focused on a handful of proinflammatory cytokines and have not explored a range of prenatal biological pathways that may be involved in increasing postnatal risk for emotional and behavioral difficulties. Methods Using extreme gradient boosted machine learning models, we explored large-scale proteomics, considering over 1,000 proteins from first trimester blood samples, to predict behavior in early childhood. Mothers reported on their 3- to 5-year-old children's (N = 89, 51% female) temperament (Child Behavior Questionnaire) and psychopathology (Child Behavior Checklist). Results We found that machine learning models of prenatal proteomics predict 5%-10% of the variance in children's sadness, perceptual sensitivity, attention problems, and emotional reactivity. Enrichment analyses identified immune function, nervous system development, and cell signaling pathways as being particularly important in predicting children's outcomes. Conclusions Our findings, though exploratory, suggest processes in early pregnancy that are related to functioning in early childhood. Predictive features included far more proteins than have been considered in prior work. Specifically, proteins implicated in inflammation, in the development of the central nervous system, and in key cell-signaling pathways were enriched in relation to child temperament and psychopathology measures. En ligne : https://doi.org/10.1111/jcpp.13948 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

Parenting Stress and Stressful Life Events Among Caregivers of Toddler Siblings of Autistic and Non-Autistic Children / Jennifer E. MAGNUSON in Autism Research, 19-5 (May 2026)  

Public ISBD [article]  inAutism Research > 19-5 (May 2026) . - p.e70217 Titre : Parenting Stress and Stressful Life Events Among Caregivers of Toddler Siblings of Autistic and Non-Autistic Children Type de document : texte imprimé Auteurs : Jennifer E. MAGNUSON, Auteur ; Lucy S. KING, Auteur ; Jacob I. FELDMAN, Auteur ; S. Madison CLARK, Auteur ; Grace PULLIAM, Auteur ; Kacie DUNHAM-CARR, Auteur ; Alexandra GOLDEN, Auteur ; Bahar Keçeli KAYSıLı, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Tiffany G. WOYNAROSKI, Auteur Article en page(s) : p.e70217 Langues : Anglais (eng) Mots-clés : autism  caregiving  infant siblings  measurement  parent mental health  stress Index. décimale : PER Périodiques Résumé : ABSTRACT This study measured experiences of parenting stress and stressful life events in caregivers of families with a toddler who has either an autistic or non-autistic older sibling(s). Caregivers of toddlers (12?18?months old) with older autistic siblings (Sibs-autism; n?=?58) and toddlers with older non-autistic siblings (Sibs-NA; n?=?46) completed questionnaires assessing stress related to parenting their toddler and their exposure to stressful life events since their toddler's birth. We compared levels of parenting stress and stressful life events between caregivers of Sibs-autism and Sibs-NA and examined the association between these measures. Caregivers of Sibs-autism reported significantly higher levels of parenting stress and stressful life events relative to caregivers of Sibs-NA, with small to moderate effects. Parenting stress and stressful life events were moderately correlated. Across these groups of caregivers, parenting stress and stressful life events appear to be related, but partially distinct aspects of caregiver stress. These findings highlight the importance of assessing multiple aspects of stress to better understand how stress may influence both caregiver wellbeing and the development of children with autistic siblings. En ligne : https://doi.org/10.1002/aur.70217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587 [article] Parenting Stress and Stressful Life Events Among Caregivers of Toddler Siblings of Autistic and Non-Autistic Children [texte imprimé] / Jennifer E. MAGNUSON, Auteur ; Lucy S. KING, Auteur ; Jacob I. FELDMAN, Auteur ; S. Madison CLARK, Auteur ; Grace PULLIAM, Auteur ; Kacie DUNHAM-CARR, Auteur ; Alexandra GOLDEN, Auteur ; Bahar Keçeli KAYSıLı, Auteur ; Kathryn L. HUMPHREYS, Auteur ; Tiffany G. WOYNAROSKI, Auteur . - p.e70217. Langues : Anglais (eng) in Autism Research > 19-5 (May 2026) . - p.e70217 Mots-clés : autism  caregiving  infant siblings  measurement  parent mental health  stress Index. décimale : PER Périodiques Résumé : ABSTRACT This study measured experiences of parenting stress and stressful life events in caregivers of families with a toddler who has either an autistic or non-autistic older sibling(s). Caregivers of toddlers (12?18?months old) with older autistic siblings (Sibs-autism; n?=?58) and toddlers with older non-autistic siblings (Sibs-NA; n?=?46) completed questionnaires assessing stress related to parenting their toddler and their exposure to stressful life events since their toddler's birth. We compared levels of parenting stress and stressful life events between caregivers of Sibs-autism and Sibs-NA and examined the association between these measures. Caregivers of Sibs-autism reported significantly higher levels of parenting stress and stressful life events relative to caregivers of Sibs-NA, with small to moderate effects. Parenting stress and stressful life events were moderately correlated. Across these groups of caregivers, parenting stress and stressful life events appear to be related, but partially distinct aspects of caregiver stress. These findings highlight the importance of assessing multiple aspects of stress to better understand how stress may influence both caregiver wellbeing and the development of children with autistic siblings. En ligne : https://doi.org/10.1002/aur.70217 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587

A person-centered approach to the assessment of early life stress: Associations with the volume of stress-sensitive brain regions in early adolescence / Lucy S. KING in Development and Psychopathology, 31-2 (May 2019)  

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The association between early life stress and prefrontal cortex activation during implicit emotion regulation is moderated by sex in early adolescence / Natalie L. COLICH in Development and Psychopathology, 29-5 (December 2017)  

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Trajectories of post-traumatic stress disorder symptoms among youth exposed to both natural and technological disasters / Joy D. OSOFSKY in Journal of Child Psychology and Psychiatry, 56-12 (December 2015)  

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