Brief Report: When Large Becomes Slow: Zooming-Out Visual Attention Is Associated to Orienting Deficits in Autism / Luca RONCONI in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2577-2584 Titre : Brief Report: When Large Becomes Slow: Zooming-Out Visual Attention Is Associated to Orienting Deficits in Autism Type de document : texte imprimé Auteurs : Luca RONCONI, Auteur ; M. DEVITA, Auteur ; Massimo MOLTENI, Auteur ; Simone GORI, Auteur ; Andrea FACOETTI, Auteur Article en page(s) : p.2577-2584 Langues : Anglais (eng) Mots-clés : Attention  Autism spectrum disorders  Perception  Vision  Zoom-lens Index. décimale : PER Périodiques Résumé : Previous studies independently demonstrated impairments in rapid orienting/disengagement and zooming-out of spatial attention in autism spectrum disorder (ASD). These attentional mechanisms, however, are not completely independent. Aiming at a more complete picture of spatial attention deficits in ASD, we examined the relationship between orienting and zooming in participants with ASD and typically developing peers. We modified a classical spatial cuing task, presenting two small or large cues in the two visual hemifields and subsequently cueing attention to one of them. Our results demonstrate a sluggish orienting mechanism in ASD only when a large attentional focus is deployed. Moreover, only the sluggish orienting mechanism in the large cues condition predicts the severity in the social-interaction symptomatology in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3506-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Brief Report: When Large Becomes Slow: Zooming-Out Visual Attention Is Associated to Orienting Deficits in Autism [texte imprimé] / Luca RONCONI, Auteur ; M. DEVITA, Auteur ; Massimo MOLTENI, Auteur ; Simone GORI, Auteur ; Andrea FACOETTI, Auteur . - p.2577-2584. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2577-2584 Mots-clés : Attention  Autism spectrum disorders  Perception  Vision  Zoom-lens Index. décimale : PER Périodiques Résumé : Previous studies independently demonstrated impairments in rapid orienting/disengagement and zooming-out of spatial attention in autism spectrum disorder (ASD). These attentional mechanisms, however, are not completely independent. Aiming at a more complete picture of spatial attention deficits in ASD, we examined the relationship between orienting and zooming in participants with ASD and typically developing peers. We modified a classical spatial cuing task, presenting two small or large cues in the two visual hemifields and subsequently cueing attention to one of them. Our results demonstrate a sluggish orienting mechanism in ASD only when a large attentional focus is deployed. Moreover, only the sluggish orienting mechanism in the large cues condition predicts the severity in the social-interaction symptomatology in individuals with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3506-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills / Denis PERUZZO ; Filippo ARRIGONI ; Silvia BUSTI CECCARELLI ; Laura VILLA ; Elisa MANI ; Eleonora MAGGIONI ; Paolo BRAMBILLA ; Maria NOBILE ; Massimo MOLTENI ; Alessandro CRIPPA in Research in Autism, 125 (July 2025)  

Public ISBD [article]  inResearch in Autism > 125 (July 2025) . - p.202626 Titre : Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills Type de document : texte imprimé Auteurs : Denis PERUZZO, Auteur ; Filippo ARRIGONI, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Laura VILLA, Auteur ; Elisa MANI, Auteur ; Eleonora MAGGIONI, Auteur ; Paolo BRAMBILLA, Auteur ; Maria NOBILE, Auteur ; Massimo MOLTENI, Auteur ; Alessandro CRIPPA, Auteur Article en page(s) : p.202626 Langues : Anglais (eng) Mots-clés : Autism  Corpus callosum  Magnetic resonance imaging  Restricted repetitive behaviours  Motor skills Index. décimale : PER Périodiques Résumé : Introduction Along with the core characteristics of the condition, autistic individuals commonly experience motor coordination difficulties, potentially related to a reduced cortical connectivity. Being the largest human commissure, the corpus callosum (CC) plays an essential role in interhemispheric connectivity and has been often involved among autistic atypicalities. This study aimed to investigate the volumes of corpus callosum subregions in a group of drug-naïve, autistic children and to explore its possible associations with both core features and motor coordination skills. Methods Thirty-five autistic children (2.5-12 years) were compared with a group of 35 closely IQ-matched, non-autistic peers. CC was identified and segmented into five subregions using Freesurfer. Callosal volumes were compared between the two groups and correlated with parental ratings of core autistic features as assessed by the Social Responsiveness Scale and with motor features as assessed by the Developmental Coordination Disorder Questionnaire. Associations between CC volume and Autism Diagnostic Observation Schedule scores were also explored in autistic participants. Results Autistic children showed a reduced volume of the central segment of the CC, in the context of a comparable CC total volume. This reduction appeared to be correlated with symptoms of restricted and repetitive behaviours in autistic children. An association between Central CC volume and parental ratings of autistic mannerisms and motor skills was also found across participants, mostly driven by the non-autistic group. Conclusion These findings expand the current knowledge about the neural mechanisms underlying autism, suggesting that the reduced connectivity through the CC might have implications for both core autistic features and motor skills. En ligne : https://doi.org/10.1016/j.reia.2025.202626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Decreased central corpus callosum volume in autistic children is associated with repetitive behaviours and motor skills [texte imprimé] / Denis PERUZZO, Auteur ; Filippo ARRIGONI, Auteur ; Silvia BUSTI CECCARELLI, Auteur ; Laura VILLA, Auteur ; Elisa MANI, Auteur ; Eleonora MAGGIONI, Auteur ; Paolo BRAMBILLA, Auteur ; Maria NOBILE, Auteur ; Massimo MOLTENI, Auteur ; Alessandro CRIPPA, Auteur . - p.202626. Langues : Anglais (eng) in Research in Autism > 125 (July 2025) . - p.202626 Mots-clés : Autism  Corpus callosum  Magnetic resonance imaging  Restricted repetitive behaviours  Motor skills Index. décimale : PER Périodiques Résumé : Introduction Along with the core characteristics of the condition, autistic individuals commonly experience motor coordination difficulties, potentially related to a reduced cortical connectivity. Being the largest human commissure, the corpus callosum (CC) plays an essential role in interhemispheric connectivity and has been often involved among autistic atypicalities. This study aimed to investigate the volumes of corpus callosum subregions in a group of drug-naïve, autistic children and to explore its possible associations with both core features and motor coordination skills. Methods Thirty-five autistic children (2.5-12 years) were compared with a group of 35 closely IQ-matched, non-autistic peers. CC was identified and segmented into five subregions using Freesurfer. Callosal volumes were compared between the two groups and correlated with parental ratings of core autistic features as assessed by the Social Responsiveness Scale and with motor features as assessed by the Developmental Coordination Disorder Questionnaire. Associations between CC volume and Autism Diagnostic Observation Schedule scores were also explored in autistic participants. Results Autistic children showed a reduced volume of the central segment of the CC, in the context of a comparable CC total volume. This reduction appeared to be correlated with symptoms of restricted and repetitive behaviours in autistic children. An association between Central CC volume and parental ratings of autistic mannerisms and motor skills was also found across participants, mostly driven by the non-autistic group. Conclusion These findings expand the current knowledge about the neural mechanisms underlying autism, suggesting that the reduced connectivity through the CC might have implications for both core autistic features and motor skills. En ligne : https://doi.org/10.1016/j.reia.2025.202626 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

Differentiating early sensory profiles in toddlers at elevated likelihood of autism and association with later clinical outcome and diagnosis / Elena CAPELLI ; Chiara CANTIANI ; Carolina BERETTA ; Massimo MOLTENI ; Valentina RIVA in Autism, 28-7 (July 2024)  

Public ISBD [article]  inAutism > 28-7 (July 2024) . - p.1654-1666 Titre : Differentiating early sensory profiles in toddlers at elevated likelihood of autism and association with later clinical outcome and diagnosis Type de document : texte imprimé Auteurs : Elena CAPELLI, Auteur ; Chiara CANTIANI, Auteur ; Carolina BERETTA, Auteur ; Massimo MOLTENI, Auteur ; Valentina RIVA, Auteur Article en page(s) : p.1654-1666 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  development  infancy  sensory  siblings Index. décimale : PER Périodiques Résumé : Sensory features are included in the diagnostic criteria of autism spectrum disorder, and sensory responsiveness may produce "cascading effects" on later development. However, the relation between early sensory profiles and later skills has yet to be defined. This study aims to characterize sensory subgroups in 116 toddlers at elevated likelihood for autism spectrum disorder and test their association with later autistic traits and diagnosis. We used latent class analyses to assess individual differences across sensory patterns, grouping individuals with similar sensory profiles together. The final model was chosen based on a stepwise procedure, starting with a one-class solution, and then adds one class at a time. The Sensory Profile-2 Questionnaire measured clinical sensory features, and four sensory patterns were evaluated (seeking, avoiding, sensitivity, and registration). We investigated sensory subgroups concerning socio-communication skills and restricted/repetitive behaviors at 24 months and the clinical best-estimate diagnosis at 3 years. A three-class solution was favored, and toddlers can be characterized into three homogeneous sensory groups: low seeking, sensory balanced, and high sensitivity. The results showed that the high sensitivity group showed later socio-communicative difficulties and restricted/repetitive behaviors. Children in this class were those with the highest percentage of diagnosis at 3 years (57.9%). These findings provide new insights into the nature of sensory processing and may have implications for personalized support needs. Lay abstract Early sensory responsiveness may produce cascading effects on later development, but the relation between sensory profiles and autistic diagnosis remains unclear. In a longitudinal sample of toddlers at elevated likelihood for autism, we aimed to characterize sensory subgroups and their association with clinical outcomes later on. Three sensory subgroups were described and early sensory sensitivity plays a significant role in later development and diagnosis. This study supported the importance of examining different levels of sensory patterns to dissect the phenotypic heterogeneity in sensory processing. As sensory differences are associated with later developmental outcomes, these results may be critical when designing intervention needs and support for children at increased likelihood for neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1177/13623613231200081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531 [article] Differentiating early sensory profiles in toddlers at elevated likelihood of autism and association with later clinical outcome and diagnosis [texte imprimé] / Elena CAPELLI, Auteur ; Chiara CANTIANI, Auteur ; Carolina BERETTA, Auteur ; Massimo MOLTENI, Auteur ; Valentina RIVA, Auteur . - p.1654-1666. Langues : Anglais (eng) in Autism > 28-7 (July 2024) . - p.1654-1666 Mots-clés : autism spectrum disorder  development  infancy  sensory  siblings Index. décimale : PER Périodiques Résumé : Sensory features are included in the diagnostic criteria of autism spectrum disorder, and sensory responsiveness may produce "cascading effects" on later development. However, the relation between early sensory profiles and later skills has yet to be defined. This study aims to characterize sensory subgroups in 116 toddlers at elevated likelihood for autism spectrum disorder and test their association with later autistic traits and diagnosis. We used latent class analyses to assess individual differences across sensory patterns, grouping individuals with similar sensory profiles together. The final model was chosen based on a stepwise procedure, starting with a one-class solution, and then adds one class at a time. The Sensory Profile-2 Questionnaire measured clinical sensory features, and four sensory patterns were evaluated (seeking, avoiding, sensitivity, and registration). We investigated sensory subgroups concerning socio-communication skills and restricted/repetitive behaviors at 24 months and the clinical best-estimate diagnosis at 3 years. A three-class solution was favored, and toddlers can be characterized into three homogeneous sensory groups: low seeking, sensory balanced, and high sensitivity. The results showed that the high sensitivity group showed later socio-communicative difficulties and restricted/repetitive behaviors. Children in this class were those with the highest percentage of diagnosis at 3 years (57.9%). These findings provide new insights into the nature of sensory processing and may have implications for personalized support needs. Lay abstract Early sensory responsiveness may produce cascading effects on later development, but the relation between sensory profiles and autistic diagnosis remains unclear. In a longitudinal sample of toddlers at elevated likelihood for autism, we aimed to characterize sensory subgroups and their association with clinical outcomes later on. Three sensory subgroups were described and early sensory sensitivity plays a significant role in later development and diagnosis. This study supported the importance of examining different levels of sensory patterns to dissect the phenotypic heterogeneity in sensory processing. As sensory differences are associated with later developmental outcomes, these results may be critical when designing intervention needs and support for children at increased likelihood for neurodevelopmental disorders. En ligne : https://dx.doi.org/10.1177/13623613231200081 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531

Dysfunctions in Infants' Statistical Learning are Related to Parental Autistic Traits / Bettoni ROBERTA in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4621-4631 Titre : Dysfunctions in Infants' Statistical Learning are Related to Parental Autistic Traits Type de document : texte imprimé Auteurs : Bettoni ROBERTA, Auteur ; Valentina RIVA, Auteur ; Chiara CANTIANI, Auteur ; Elena Maria RIBOLDI, Auteur ; Massimo MOLTENI, Auteur ; Viola MACCHI CASSIA, Auteur ; Hermann BULF, Auteur Article en page(s) : p.4621-4631 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Communication  Humans  Parents  Social Skills  Autistic traits  Early marker  Infants  Visual statistical learning Index. décimale : PER Périodiques Résumé : Statistical learning refers to the ability to extract the statistical relations embedded in a sequence, and it plays a crucial role in the development of communicative and social skills that are impacted in the Autism Spectrum Disorder (ASD). Here, we investigated the relationship between infants' SL ability and autistic traits in their parents. Using a visual habituation task, we tested infant offspring of adults (non-diagnosed) who show high (HAT infants) versus low (LAT infants) autistic traits. Results demonstrated that LAT infants learned the statistical structure embedded in a visual sequence, while HAT infants failed. Moreover, infants' SL ability was related to autistic traits in their parents, further suggesting that early dysfunctions in SL might contribute to variabilities in ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-021-04894-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Dysfunctions in Infants' Statistical Learning are Related to Parental Autistic Traits [texte imprimé] / Bettoni ROBERTA, Auteur ; Valentina RIVA, Auteur ; Chiara CANTIANI, Auteur ; Elena Maria RIBOLDI, Auteur ; Massimo MOLTENI, Auteur ; Viola MACCHI CASSIA, Auteur ; Hermann BULF, Auteur . - p.4621-4631. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4621-4631 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Communication  Humans  Parents  Social Skills  Autistic traits  Early marker  Infants  Visual statistical learning Index. décimale : PER Périodiques Résumé : Statistical learning refers to the ability to extract the statistical relations embedded in a sequence, and it plays a crucial role in the development of communicative and social skills that are impacted in the Autism Spectrum Disorder (ASD). Here, we investigated the relationship between infants' SL ability and autistic traits in their parents. Using a visual habituation task, we tested infant offspring of adults (non-diagnosed) who show high (HAT infants) versus low (LAT infants) autistic traits. Results demonstrated that LAT infants learned the statistical structure embedded in a visual sequence, while HAT infants failed. Moreover, infants' SL ability was related to autistic traits in their parents, further suggesting that early dysfunctions in SL might contribute to variabilities in ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-021-04894-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Early developmental trajectories of expressive vocabulary and gesture production in a longitudinal cohort of Italian infants at high-risk for Autism Spectrum Disorder / Valentina RIVA in Autism Research, 14-7 (July 2021)  

Public ISBD [article]  inAutism Research > 14-7 (July 2021) . - p.1421-1433 Titre : Early developmental trajectories of expressive vocabulary and gesture production in a longitudinal cohort of Italian infants at high-risk for Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Valentina RIVA, Auteur ; Angela CARUSO, Auteur ; Fabio APICELLA, Auteur ; Giovanni VALERI, Auteur ; Stefano VICARI, Auteur ; Massimo MOLTENI, Auteur ; Maria Luisa SCATTONI, Auteur Article en page(s) : p.1421-1433 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Child  Gestures  Humans  Infant  Italy  Language Development Disorders  Vocabulary  developmental trajectory  expressive language  gesture  infant sibling Index. décimale : PER Périodiques Résumé : Delays in language are a hallmark feature of Autism Spectrum Disorder (ASD). However, little is known about the predictive role of language developmental trajectories on ASD. The present study aimed at identifying early different language developmental profiles of infants at high familial risk for ASD (HR-ASD) and testing their predictive role on ASD symptoms at 2 years. The role of gestures on socio-communicative skills has also been explored. Trajectories of expressive vocabulary were investigated in 137 HR-ASD infants at 12, 18, and, 24 months of age. Parents were requested to complete the Italian version of the MacArthur-Bates Communicative Development Inventory and ASD symptoms were measured by ADOS-2. Latent class growth analysis defined four trajectories: above average language development group (above-average LD, 18.2%), normal language development group (NLD, 38.7%), late-onset language development group (late-onset LD, 11.7%), and a group of children with stable language delay (SLD, 31.4%). Results showed that the SLD group obtained higher communicative difficulties and restricted/repetitive behavior compared to the other groups. Examining early increase of produced gestures in the different language classes, we found fewer produced gestures between 12 and 18 months in the SLD group compared to the late-onset LD group. The results identified clusters of HR infants who follow similar estimated trajectories based on individual differences in language development. These patterns of early language acquisition, together with produced gestures, may be predictive of later ASD symptoms and useful for planning prompt intervention. LAY SUMMARY: Language/gesture deficits are hallmark features of Autism Spectrum Disorder (ASD), but the predictive role of communicative trajectories on ASD remains unclear. In a longitudinal Italian sample of infants at high familial risk for ASD (HR-ASD), we tested if language trajectories and their link with gestures can predict ASD symptoms. We found four trajectories and HR infants with a stable language delay (SLD) trajectory showed more ASD symptoms later on. SLD infants produced fewer gestures compared to late-onset language development group that show more typical communicative skills. En ligne : http://dx.doi.org/10.1002/aur.2493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 [article] Early developmental trajectories of expressive vocabulary and gesture production in a longitudinal cohort of Italian infants at high-risk for Autism Spectrum Disorder [texte imprimé] / Valentina RIVA, Auteur ; Angela CARUSO, Auteur ; Fabio APICELLA, Auteur ; Giovanni VALERI, Auteur ; Stefano VICARI, Auteur ; Massimo MOLTENI, Auteur ; Maria Luisa SCATTONI, Auteur . - p.1421-1433. Langues : Anglais (eng) in Autism Research > 14-7 (July 2021) . - p.1421-1433 Mots-clés : Autism Spectrum Disorder  Child  Gestures  Humans  Infant  Italy  Language Development Disorders  Vocabulary  developmental trajectory  expressive language  gesture  infant sibling Index. décimale : PER Périodiques Résumé : Delays in language are a hallmark feature of Autism Spectrum Disorder (ASD). However, little is known about the predictive role of language developmental trajectories on ASD. The present study aimed at identifying early different language developmental profiles of infants at high familial risk for ASD (HR-ASD) and testing their predictive role on ASD symptoms at 2 years. The role of gestures on socio-communicative skills has also been explored. Trajectories of expressive vocabulary were investigated in 137 HR-ASD infants at 12, 18, and, 24 months of age. Parents were requested to complete the Italian version of the MacArthur-Bates Communicative Development Inventory and ASD symptoms were measured by ADOS-2. Latent class growth analysis defined four trajectories: above average language development group (above-average LD, 18.2%), normal language development group (NLD, 38.7%), late-onset language development group (late-onset LD, 11.7%), and a group of children with stable language delay (SLD, 31.4%). Results showed that the SLD group obtained higher communicative difficulties and restricted/repetitive behavior compared to the other groups. Examining early increase of produced gestures in the different language classes, we found fewer produced gestures between 12 and 18 months in the SLD group compared to the late-onset LD group. The results identified clusters of HR infants who follow similar estimated trajectories based on individual differences in language development. These patterns of early language acquisition, together with produced gestures, may be predictive of later ASD symptoms and useful for planning prompt intervention. LAY SUMMARY: Language/gesture deficits are hallmark features of Autism Spectrum Disorder (ASD), but the predictive role of communicative trajectories on ASD remains unclear. In a longitudinal Italian sample of infants at high familial risk for ASD (HR-ASD), we tested if language trajectories and their link with gestures can predict ASD symptoms. We found four trajectories and HR infants with a stable language delay (SLD) trajectory showed more ASD symptoms later on. SLD infants produced fewer gestures compared to late-onset language development group that show more typical communicative skills. En ligne : http://dx.doi.org/10.1002/aur.2493 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449

Enhanced motor noise in an autism subtype with poor motor skills / Veronica MANDELLI in Molecular Autism, 15 (2024)  

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Eye-Hand Coordination in Children with High Functioning Autism and Asperger’s Disorder Using a Gap-Overlap Paradigm / Alessandro CRIPPA in Journal of Autism and Developmental Disorders, 43-4 (April 2013)  

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Further Empirical Data on the Psychoeducational Profile-Revised (PEP-R): Reliability and Validation with the Vineland Adaptive Behavior Scales / Susanna VILLA in Journal of Autism and Developmental Disorders, 40-3 (March 2010)  

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Further evidence of complex motor dysfunction in drug naïve children with autism using automatic motion analysis of gait / Maria NOBILE in Autism, 15-3 (May 2011)  

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Maternal caregiving moderates the impact of antenatal maternal cortisol on infant stress regulation / Sarah NAZZARI in Journal of Child Psychology and Psychiatry, 63-8 (August 2022)  

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A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder / Alessandro CRIPPA in Autism, 25-5 (July 2021)  

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A multimethod approach to assessing motor skills in boys and girls with autism spectrum disorder / Alessandro CRIPPA in Autism, 26-5 (July 2022)  

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A multimodal approach can identify specific motor profiles in autism and attention-deficit/hyperactivity disorder / Stefano DE FRANCESCO in Autism Research, 16-8 (August 2023)  

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Navigation and exploration of an urban virtual environment by children with autism spectrum disorder compared to children with typical development / Livia FORNASARI in Research in Autism Spectrum Disorders, 7-8 (August 2013)  

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Prolonged neural encoding of visual information in autism / Luca CASARTELLI ; Alessandra FEDERICI ; Sara BERTONI ; Lorenzo VIGNALI ; Massimo MOLTENI ; Andrea FACOETTI ; Luca RONCONI in Autism Research, 17-1 (January 2024)  

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