Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions / Paula KRAKOWIAK in Autism Research, 10-1 (January 2017)  

Public ISBD [article]  inAutism Research > 10-1 (January 2017) . - p.89-98 Titre : Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions Type de document : Texte imprimé et/ou numérique Auteurs : Paula KRAKOWIAK, Auteur ; Cheryl K. WALKER, Auteur ; Daniel J. TANCREDI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur Article en page(s) : p.89-98 Langues : Anglais (eng) Mots-clés : autism  pregnancy  maternal autoantibodies  anti-fetal brain autoantibodies  metabolic conditions  diabetes Index. décimale : PER Périodiques Résumé : Approximately 23% of mothers of children with autism spectrum disorder (ASD) produce specific patterns of autoantibodies to fetal brain proteins that have been detected in only 1% of mothers of typically developing children. The biological mechanisms underlying the development of ASD-specific maternal autoantibodies are poorly understood. We sought to determine whether ASD-specific maternal autoantibodies identified postnatally were associated with metabolic conditions (MCs) during gestation. Participants were 227 mothers of 2–5 year old children with confirmed ASD, enrolled in CHARGE (Childhood Autism Risk from Genetics and the Environment) between January 2003 and April 2008, and from whom blood samples were collected and analyzed for anti-fetal brain autoantibodies (Ab+). MCs included diabetes, hypertensive disorders, and prepregnancy obesity or overweight, ascertained from medical records or structured telephone interviews. Log-linear regression models were performed to estimate prevalence ratios and 95% confidence intervals (CI) based on robust standard errors. Fifty-six (25%) mothers were Ab+. Ab+ prevalence was higher among mothers with diabetes, hypertensive disorders, or overweight compared to healthy mothers, but differences were not statistically significant. In a subset of 145 mothers whose children exhibited severe ASD (31 Ab+), those diagnosed with type 2 or gestational diabetes were 2.7-fold more likely to be Ab+ (95% CI 1.1, 6.6), controlling for delivery payer and smoking. Gestational diabetes specifically was associated with a 3.2-fold increased Ab+ prevalence (95% CI 1.2, 8.6). In this exploratory study, mothers whose children had severe ASD and who experienced diabetes were more likely to have anti-fetal brain autoantibodies 2–5 years later. En ligne : http://dx.doi.org/10.1002/aur.1657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Autism-specific maternal anti-fetal brain autoantibodies are associated with metabolic conditions [Texte imprimé et/ou numérique] / Paula KRAKOWIAK, Auteur ; Cheryl K. WALKER, Auteur ; Daniel J. TANCREDI, Auteur ; Irva HERTZ-PICCIOTTO, Auteur ; Judy VAN DE WATER, Auteur . - p.89-98. Langues : Anglais (eng) in Autism Research > 10-1 (January 2017) . - p.89-98 Mots-clés : autism  pregnancy  maternal autoantibodies  anti-fetal brain autoantibodies  metabolic conditions  diabetes Index. décimale : PER Périodiques Résumé : Approximately 23% of mothers of children with autism spectrum disorder (ASD) produce specific patterns of autoantibodies to fetal brain proteins that have been detected in only 1% of mothers of typically developing children. The biological mechanisms underlying the development of ASD-specific maternal autoantibodies are poorly understood. We sought to determine whether ASD-specific maternal autoantibodies identified postnatally were associated with metabolic conditions (MCs) during gestation. Participants were 227 mothers of 2–5 year old children with confirmed ASD, enrolled in CHARGE (Childhood Autism Risk from Genetics and the Environment) between January 2003 and April 2008, and from whom blood samples were collected and analyzed for anti-fetal brain autoantibodies (Ab+). MCs included diabetes, hypertensive disorders, and prepregnancy obesity or overweight, ascertained from medical records or structured telephone interviews. Log-linear regression models were performed to estimate prevalence ratios and 95% confidence intervals (CI) based on robust standard errors. Fifty-six (25%) mothers were Ab+. Ab+ prevalence was higher among mothers with diabetes, hypertensive disorders, or overweight compared to healthy mothers, but differences were not statistically significant. In a subset of 145 mothers whose children exhibited severe ASD (31 Ab+), those diagnosed with type 2 or gestational diabetes were 2.7-fold more likely to be Ab+ (95% CI 1.1, 6.6), controlling for delivery payer and smoking. Gestational diabetes specifically was associated with a 3.2-fold increased Ab+ prevalence (95% CI 1.2, 8.6). In this exploratory study, mothers whose children had severe ASD and who experienced diabetes were more likely to have anti-fetal brain autoantibodies 2–5 years later. En ligne : http://dx.doi.org/10.1002/aur.1657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Higher autism in children of women with psychiatric diagnoses / Bridget M. WIECKOWSKI in Research in Autism Spectrum Disorders, 33 (January 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 33 (January 2017) . - p.10-20 Titre : Higher autism in children of women with psychiatric diagnoses Type de document : Texte imprimé et/ou numérique Auteurs : Bridget M. WIECKOWSKI, Auteur ; Yelda MUKHTAR, Auteur ; John J. LEE, Auteur ; Guibo XING, Auteur ; Cheryl K. WALKER, Auteur Article en page(s) : p.10-20 Langues : Anglais (eng) Mots-clés : ASD  Epidemiology  Women  Depression  Pregnancy Index. décimale : PER Périodiques Résumé : To determine the extent to which medical record history of maternal psychiatric diagnoses was associated with offspring autism risk in a large, socio-demographically diverse birth cohort. This retrospective cohort study linked hospital discharge records for 8,951,763 California singleton births occurring 1/1/91-12/31/08 from the Office of Statewide Health Planning and Development with diagnostic and service records from the Department of Developmental Services. Medical records documenting maternal mood and anxiety disorders and schizophrenia ICD-9-CM codes were identified, and 42,423 children were categorized with a DSM-IV diagnosis of ‘autistic disorder’. Log-linear Poisson models explored the relationships between maternal psychiatric disorders and autism, adjusting for maternal education, race, country of birth, and parental age. Results Rates of maternal psychiatric diagnoses were lower than expected for the population, reflecting under-recognition and under-reporting by inpatient clinicians. In adjusted analyses, mothers diagnosed with one individual psychiatric condition were 1.2–2.8 times more likely to have a child who developed autism. Mothers diagnosed with any one or more psychiatric condition were twice as likely to have a child with autism compared with unaffected or unreported women (RR = 1.97; 95% CI 1.83–2.12). Women with a documented inpatient medical record history of psychiatric diagnosis were nearly twice as likely as women without such diagnoses to have a child later diagnosed with autism. These findings highlight the need for routine prenatal screening for psychiatric conditions, as well as enhanced neurobehavioral assessment of children born to these mothers to detect early autism signs and optimize intervention timeliness. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.10.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Higher autism in children of women with psychiatric diagnoses [Texte imprimé et/ou numérique] / Bridget M. WIECKOWSKI, Auteur ; Yelda MUKHTAR, Auteur ; John J. LEE, Auteur ; Guibo XING, Auteur ; Cheryl K. WALKER, Auteur . - p.10-20. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 33 (January 2017) . - p.10-20 Mots-clés : ASD  Epidemiology  Women  Depression  Pregnancy Index. décimale : PER Périodiques Résumé : To determine the extent to which medical record history of maternal psychiatric diagnoses was associated with offspring autism risk in a large, socio-demographically diverse birth cohort. This retrospective cohort study linked hospital discharge records for 8,951,763 California singleton births occurring 1/1/91-12/31/08 from the Office of Statewide Health Planning and Development with diagnostic and service records from the Department of Developmental Services. Medical records documenting maternal mood and anxiety disorders and schizophrenia ICD-9-CM codes were identified, and 42,423 children were categorized with a DSM-IV diagnosis of ‘autistic disorder’. Log-linear Poisson models explored the relationships between maternal psychiatric disorders and autism, adjusting for maternal education, race, country of birth, and parental age. Results Rates of maternal psychiatric diagnoses were lower than expected for the population, reflecting under-recognition and under-reporting by inpatient clinicians. In adjusted analyses, mothers diagnosed with one individual psychiatric condition were 1.2–2.8 times more likely to have a child who developed autism. Mothers diagnosed with any one or more psychiatric condition were twice as likely to have a child with autism compared with unaffected or unreported women (RR = 1.97; 95% CI 1.83–2.12). Women with a documented inpatient medical record history of psychiatric diagnosis were nearly twice as likely as women without such diagnoses to have a child later diagnosed with autism. These findings highlight the need for routine prenatal screening for psychiatric conditions, as well as enhanced neurobehavioral assessment of children born to these mothers to detect early autism signs and optimize intervention timeliness. En ligne : http://dx.doi.org/10.1016/j.rasd.2016.10.004 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study / Ousseny ZERBO in Journal of Autism and Developmental Disorders, 43-1 (January 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.25-33 Titre : Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study Type de document : Texte imprimé et/ou numérique Auteurs : Ousseny ZERBO, Auteur ; Ana-Maria IOSIF, Auteur ; Cheryl K. WALKER, Auteur ; Sally OZONOFF, Auteur ; Robin L. HANSEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur Année de publication : 2013 Article en page(s) : p.25-33 Langues : Anglais (eng) Mots-clés : Maternal influenza  Fever  Autism  Anti-fever medication Index. décimale : PER Périodiques Résumé : We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99). En ligne : http://dx.doi.org/10.1007/s10803-012-1540-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 [article] Is Maternal Influenza or Fever During Pregnancy Associated with Autism or Developmental Delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) Study [Texte imprimé et/ou numérique] / Ousseny ZERBO, Auteur ; Ana-Maria IOSIF, Auteur ; Cheryl K. WALKER, Auteur ; Sally OZONOFF, Auteur ; Robin L. HANSEN, Auteur ; Irva HERTZ-PICCIOTTO, Auteur . - 2013 . - p.25-33. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-1 (January 2013) . - p.25-33 Mots-clés : Maternal influenza  Fever  Autism  Anti-fever medication Index. décimale : PER Périodiques Résumé : We analyzed data from case groups of 538 children with autism spectrum disorders (ASD) and 163 with developmental delays (DD), and from 421 typically developing controls to assess associations with maternal influenza or fever during pregnancy. Exposure information was obtained by telephone interviews, and outcomes were clinically confirmed. Though neither ASD nor DD was associated with influenza, both were associated with maternal fever during pregnancy: OR's (odds ratios) were 2.12 (95 % CI 1.17, 3.84) and 2.50 (95 % CI 1.20, 5.20) respectively. However, the fever-associated ASD risk was attenuated among mothers who reported taking antipyretic medications (OR = 1.30, 95 % CI 0.59, 2.84), but remained elevated for those who did not (OR = 2.55, 95 % CI 1.30, 4.99). En ligne : http://dx.doi.org/10.1007/s10803-012-1540-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187

Placental methylome analysis from a prospective autism study / D. I. SCHROEDER in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 51p. Titre : Placental methylome analysis from a prospective autism study Type de document : Texte imprimé et/ou numérique Auteurs : D. I. SCHROEDER, Auteur ; Rebecca J. SCHMIDT, Auteur ; F. K. CRARY-DOOLEY, Auteur ; Cheryl K. WALKER, Auteur ; S. OZONOFF, Auteur ; Daniel J. TANCREDI, Auteur ; I. HERTZ-PICCIOTTO, Auteur ; J. M. LASALLE, Auteur Article en page(s) : 51p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Biomarkers/metabolism  Child, Preschool  DNA Methylation  Early Diagnosis  Enhancer Elements, Genetic  Epigenesis, Genetic  Female  Genome, Human  Genome-Wide Association Study  High-Throughput Nucleotide Sequencing  Humans  Infant, Newborn  Intercellular Signaling Peptides and Proteins/genetics/metabolism  Male  Membrane Proteins/genetics/metabolism  Placenta/metabolism  Pregnancy  Biomarkers  DNA methylation  Epigenetics  Genomics  Methylome  Placenta Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are increasingly prevalent neurodevelopmental disorders that are behaviorally diagnosed in early childhood. Most ASD cases likely arise from a complex mixture of genetic and environmental factors, an interface where the epigenetic marks of DNA methylation may be useful as risk biomarkers. The placenta is a potentially useful surrogate tissue characterized by a methylation pattern of partially methylated domains (PMDs) and highly methylated domains (HMDs) reflective of methylation patterns observed in the early embryo. METHODS: In this study, we investigated human term placentas from the MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) prospective study by whole genome bisulfite sequencing. We also examined the utility of PMD/HMDs in detecting methylation differences consistent with ASD diagnosis at age three. RESULTS: We found that while human placental methylomes have highly reproducible PMD and HMD locations, there is a greater variation between individuals in methylation levels over PMDs than HMDs due to both sampling and individual variability. In a comparison of methylation differences in placental samples from 24 ASD and 23 typically developing (TD) children, a HMD containing a putative fetal brain enhancer near DLL1 was found to reach genome-wide significance and was validated for significantly higher methylation in ASD by pyrosequencing. CONCLUSIONS: These results suggest that the placenta could be an informative surrogate tissue for predictive ASD biomarkers in high-risk families. En ligne : http://dx.doi.org/10.1186/s13229-016-0114-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] Placental methylome analysis from a prospective autism study [Texte imprimé et/ou numérique] / D. I. SCHROEDER, Auteur ; Rebecca J. SCHMIDT, Auteur ; F. K. CRARY-DOOLEY, Auteur ; Cheryl K. WALKER, Auteur ; S. OZONOFF, Auteur ; Daniel J. TANCREDI, Auteur ; I. HERTZ-PICCIOTTO, Auteur ; J. M. LASALLE, Auteur . - 51p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 51p. Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Biomarkers/metabolism  Child, Preschool  DNA Methylation  Early Diagnosis  Enhancer Elements, Genetic  Epigenesis, Genetic  Female  Genome, Human  Genome-Wide Association Study  High-Throughput Nucleotide Sequencing  Humans  Infant, Newborn  Intercellular Signaling Peptides and Proteins/genetics/metabolism  Male  Membrane Proteins/genetics/metabolism  Placenta/metabolism  Pregnancy  Biomarkers  DNA methylation  Epigenetics  Genomics  Methylome  Placenta Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorders (ASD) are increasingly prevalent neurodevelopmental disorders that are behaviorally diagnosed in early childhood. Most ASD cases likely arise from a complex mixture of genetic and environmental factors, an interface where the epigenetic marks of DNA methylation may be useful as risk biomarkers. The placenta is a potentially useful surrogate tissue characterized by a methylation pattern of partially methylated domains (PMDs) and highly methylated domains (HMDs) reflective of methylation patterns observed in the early embryo. METHODS: In this study, we investigated human term placentas from the MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) prospective study by whole genome bisulfite sequencing. We also examined the utility of PMD/HMDs in detecting methylation differences consistent with ASD diagnosis at age three. RESULTS: We found that while human placental methylomes have highly reproducible PMD and HMD locations, there is a greater variation between individuals in methylation levels over PMDs than HMDs due to both sampling and individual variability. In a comparison of methylation differences in placental samples from 24 ASD and 23 typically developing (TD) children, a HMD containing a putative fetal brain enhancer near DLL1 was found to reach genome-wide significance and was validated for significantly higher methylation in ASD by pyrosequencing. CONCLUSIONS: These results suggest that the placenta could be an informative surrogate tissue for predictive ASD biomarkers in high-risk families. En ligne : http://dx.doi.org/10.1186/s13229-016-0114-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

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