Altered pre-ejection period response to social evaluative threat in adolescents with autism spectrum disorder / E. Kale EDMISTON in Research in Autism Spectrum Disorders, 36 (April 2017)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 36 (April 2017) . - p.57-65 Titre : Altered pre-ejection period response to social evaluative threat in adolescents with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. Kale EDMISTON, Auteur ; Rachael A. MUSCATELLO, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.57-65 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Pre-ejection period  Social evaluative threat  Adolescence  Social behavior Index. décimale : PER Périodiques Résumé : The autonomic nervous system (ANS) is involved in regulating social behavior; Autism Spectrum Disorder (ASD) is characterized by alterations in social behavior and reduced physiological response to threat. We hypothesized that adolescents with ASD would show reduced ANS response to social threat. Methods Eighteen males with ASD and thirteen males with typical development (TD), ages 12 to 17, completed a social threat paradigm while wearing an impedance cardiography apparatus. We calculated pre-ejection period (PEP) and tested for between-group differences in PEP response to social threat. We also conducted correlation analyses between PEP change scores and clinical symptom scales. Results There was an effect of diagnosis on change in PEP from baseline to the onset of social threat (F = 7.60, p = 0.01), with greater changes in PEP in TD compared to ASD. PEP change score and the Social Communication Questionnaire (r = 0.634, p = 0.005) and the ADHD Problems Subscale of the Child Behavior Checklist (r = 0.568, p = 0.014) were correlated. These findings suggest reduced arousal in response to social threat in ASD, with preliminary evidence that reduced sympathetic activation is associated with increased social behavior symptoms. En ligne : http://dx.doi.org/10.1016/j.rasd.2017.01.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304 [article] Altered pre-ejection period response to social evaluative threat in adolescents with autism spectrum disorder [Texte imprimé et/ou numérique] / E. Kale EDMISTON, Auteur ; Rachael A. MUSCATELLO, Auteur ; Blythe A. CORBETT, Auteur . - p.57-65. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 36 (April 2017) . - p.57-65 Mots-clés : Autism spectrum disorder  Pre-ejection period  Social evaluative threat  Adolescence  Social behavior Index. décimale : PER Périodiques Résumé : The autonomic nervous system (ANS) is involved in regulating social behavior; Autism Spectrum Disorder (ASD) is characterized by alterations in social behavior and reduced physiological response to threat. We hypothesized that adolescents with ASD would show reduced ANS response to social threat. Methods Eighteen males with ASD and thirteen males with typical development (TD), ages 12 to 17, completed a social threat paradigm while wearing an impedance cardiography apparatus. We calculated pre-ejection period (PEP) and tested for between-group differences in PEP response to social threat. We also conducted correlation analyses between PEP change scores and clinical symptom scales. Results There was an effect of diagnosis on change in PEP from baseline to the onset of social threat (F = 7.60, p = 0.01), with greater changes in PEP in TD compared to ASD. PEP change score and the Social Communication Questionnaire (r = 0.634, p = 0.005) and the ADHD Problems Subscale of the Child Behavior Checklist (r = 0.568, p = 0.014) were correlated. These findings suggest reduced arousal in response to social threat in ASD, with preliminary evidence that reduced sympathetic activation is associated with increased social behavior symptoms. En ligne : http://dx.doi.org/10.1016/j.rasd.2017.01.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=304

Development and Parasympathetic Regulation in Male and Female Adolescents with Autism Spectrum Disorder: A Two-Timepoint Longitudinal Study / Rachael A. MUSCATELLO in Journal of Autism and Developmental Disorders, 53-9 (September 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3613-3626 Titre : Development and Parasympathetic Regulation in Male and Female Adolescents with Autism Spectrum Disorder: A Two-Timepoint Longitudinal Study Type de document : Texte imprimé et/ou numérique Auteurs : Rachael A. MUSCATELLO, Auteur ; Aaron PACHOL, Auteur ; Alexandra ROMINES, Auteur ; Ian SMITH, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.3613-3626 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Prolonged dysregulation of the autonomic nervous system (ANS) may increase propensity for physical or psychiatric illness. The current study examined differences in respiratory sinus arrhythmia (RSA) regulation in 215 adolescents with or without autism spectrum disorder (ASD) at Time 1 (T1; 10-13 years old) and 1 year later (Time 2; T2). Linear mixed effects models demonstrated lower RSA regulation in ASD, and a small interaction effect, showing blunted change in RSA from T1 to T2. Developmental differences in RSA regulation were particularly notable in females with ASD and those taking psychotropic medications. Results expand previous findings of reduced parasympathetic regulation in ASD by revealing a blunted developmental slope, indicating diagnostic differences may persist or worsen over time, particularly in females. En ligne : https://doi.org/10.1007/s10803-022-05664-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Development and Parasympathetic Regulation in Male and Female Adolescents with Autism Spectrum Disorder: A Two-Timepoint Longitudinal Study [Texte imprimé et/ou numérique] / Rachael A. MUSCATELLO, Auteur ; Aaron PACHOL, Auteur ; Alexandra ROMINES, Auteur ; Ian SMITH, Auteur ; Blythe A. CORBETT, Auteur . - p.3613-3626. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-9 (September 2023) . - p.3613-3626 Index. décimale : PER Périodiques Résumé : Prolonged dysregulation of the autonomic nervous system (ANS) may increase propensity for physical or psychiatric illness. The current study examined differences in respiratory sinus arrhythmia (RSA) regulation in 215 adolescents with or without autism spectrum disorder (ASD) at Time 1 (T1; 10-13 years old) and 1 year later (Time 2; T2). Linear mixed effects models demonstrated lower RSA regulation in ASD, and a small interaction effect, showing blunted change in RSA from T1 to T2. Developmental differences in RSA regulation were particularly notable in females with ASD and those taking psychotropic medications. Results expand previous findings of reduced parasympathetic regulation in ASD by revealing a blunted developmental slope, indicating diagnostic differences may persist or worsen over time, particularly in females. En ligne : https://doi.org/10.1007/s10803-022-05664-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder / Rachael A. MUSCATELLO in Journal of Autism and Developmental Disorders, 52-8 (August 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3427-3442 Titre : Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur Article en page(s) : p.3427-3442 Langues : Anglais (eng) Mots-clés : Adolescent  Autism Spectrum Disorder/diagnosis  Autonomic Nervous System  Humans  Autonomic  Obesity  Parasympathetic  Puberty  Stress  no conflict of interest. Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) may demonstrate atypical autonomic (ANS) responses; however, research remains inconsistent. This study examined parasympathetic response during social evaluation in 241 youth (10-13 years) with ASD (n=138) or typical development (TD; n=103). Diagnosis, age, pubertal development, and body mass index (BMI) were hypothesized to be associated with ANS function. Linear mixed effects models demonstrated lower RSA in ASD relative to TD in a base model with no covariates. However, when accounting for differences in BMI, there was no evidence of atypical parasympathetic regulation in youth with ASD. As lower parasympathetic regulation may increase susceptibility for a number of conditions, it will be important to elucidate the link between BMI and the ANS, especially in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05224-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485 [article] Diagnostic and Physical Effects in Parasympathetic Response to Social Evaluation in Youth With and Without Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Blythe A. CORBETT, Auteur . - p.3427-3442. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-8 (August 2022) . - p.3427-3442 Mots-clés : Adolescent  Autism Spectrum Disorder/diagnosis  Autonomic Nervous System  Humans  Autonomic  Obesity  Parasympathetic  Puberty  Stress  no conflict of interest. Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) may demonstrate atypical autonomic (ANS) responses; however, research remains inconsistent. This study examined parasympathetic response during social evaluation in 241 youth (10-13 years) with ASD (n=138) or typical development (TD; n=103). Diagnosis, age, pubertal development, and body mass index (BMI) were hypothesized to be associated with ANS function. Linear mixed effects models demonstrated lower RSA in ASD relative to TD in a base model with no covariates. However, when accounting for differences in BMI, there was no evidence of atypical parasympathetic regulation in youth with ASD. As lower parasympathetic regulation may increase susceptibility for a number of conditions, it will be important to elucidate the link between BMI and the ANS, especially in ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05224-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=485

Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth / Blythe A. CORBETT in Autism Research, 15-10 (October 2022)  

Public ISBD [article]  inAutism Research > 15-10 (October 2022) . - p.1894-1908 Titre : Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Sara DUFFUS, Auteur ; Sloane SPARKS, Auteur ; Yasas TANGUTURI, Auteur Article en page(s) : p.1894-1908 Langues : Anglais (eng) Mots-clés : adolescence  autism  development  female  puberty Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, pubertal development may be precarious. Pubertal timing and tempo were measured in 244 youth (7.9% Black, 83.3% White, and 8.7% multiracial) with ASD (N = 140) and typical development (N = 104). Pubertal development was measured using Tanner staging of Genital (G, males), Breast (B, females), and pubic hair (PH) in both sexes at Year 1 (10-13 years), Year 2 (11-14 years), and Year 3 (12-15 years). Nonlinear mixed effects models analyzed interindividual differences in timing and tempo. For both sexes, ASD and higher body mass index were associated with earlier pubertal timing. Males generally exhibited faster tempo than females. Linear regression models did not show associations between pubertal timing and internalizing symptoms at time three. Findings showing advanced pubertal maturation in ASD youth suggest greater risk of psychological, social, and physiological challenges. LAY SUMMARY: Youth with ASD have difficulty in social communication and adaption to change, thus puberty may be a challenging transition. The study examined onset (timing) and progression (tempo) of puberty over three years, using physical exam, in 244 adolescents with and without ASD, enrolled at ages 10-13. ASD youth started puberty earlier, while males generally progressed at a faster pace. Further examination of puberty in ASD should identify impact on social, behavioral, and mental health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Examination of pubertal timing and tempo in females and males with autism spectrum disorder compared to typically developing youth [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Rachael A. MUSCATELLO, Auteur ; Ahra KIM, Auteur ; Simon VANDEKAR, Auteur ; Sara DUFFUS, Auteur ; Sloane SPARKS, Auteur ; Yasas TANGUTURI, Auteur . - p.1894-1908. Langues : Anglais (eng) in Autism Research > 15-10 (October 2022) . - p.1894-1908 Mots-clés : adolescence  autism  development  female  puberty Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by impaired social communication and poor adaptation to change; thus, pubertal development may be precarious. Pubertal timing and tempo were measured in 244 youth (7.9% Black, 83.3% White, and 8.7% multiracial) with ASD (N = 140) and typical development (N = 104). Pubertal development was measured using Tanner staging of Genital (G, males), Breast (B, females), and pubic hair (PH) in both sexes at Year 1 (10-13 years), Year 2 (11-14 years), and Year 3 (12-15 years). Nonlinear mixed effects models analyzed interindividual differences in timing and tempo. For both sexes, ASD and higher body mass index were associated with earlier pubertal timing. Males generally exhibited faster tempo than females. Linear regression models did not show associations between pubertal timing and internalizing symptoms at time three. Findings showing advanced pubertal maturation in ASD youth suggest greater risk of psychological, social, and physiological challenges. LAY SUMMARY: Youth with ASD have difficulty in social communication and adaption to change, thus puberty may be a challenging transition. The study examined onset (timing) and progression (tempo) of puberty over three years, using physical exam, in 244 adolescents with and without ASD, enrolled at ages 10-13. ASD youth started puberty earlier, while males generally progressed at a faster pace. Further examination of puberty in ASD should identify impact on social, behavioral, and mental health outcomes. En ligne : http://dx.doi.org/10.1002/aur.2786 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study / Rachael A. MUSCATELLO ; Melissa CYPERSKI ; Eleonora SADIKOVA ; E. Kale EDMISTON ; Trey William MCGONIGLE ; Rachel CALVOSA ; Simon VANDEKAR in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1450-1463 Titre : Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Rachael A. MUSCATELLO, Auteur ; Melissa CYPERSKI, Auteur ; Eleonora SADIKOVA, Auteur ; E. Kale EDMISTON, Auteur ; Trey William MCGONIGLE, Auteur ; Rachel CALVOSA, Auteur ; Simon VANDEKAR, Auteur Article en page(s) : p.1450-1463 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Recent research in autism spectrum disorder (ASD) has suggested a higher prevalence of gender diversity in individuals diagnosed with ASD. Adolescence is a critical period for the consolidation of gender identity, yet the extent to which the experience of gender diversity is stable over adolescence and puberty in autistic youth is poorly understood. The aim of the study was to examine the consistency of gender diversity using the gender diversity screening questionnaire for self- and parent-report of youth (GDSQ-S, GDSQ-P) over a four-year longitudinal study of pubertal development in youth with ASD (N = 140, 36 assigned-female-at birth (AFAB)) and typical development (TD, N = 104, 58 assigned-male-at-birth [AMAB]) and their parents. The extent to which diagnosis (ASD vs. TD), assigned sex (AFAB vs. AMAB) and developmental level (age, puberty) predict GDSQ trajectory over time was explored. There was a significant diagnosis by sex-assigned-at-birth by age interaction for GDSQ-S Gender Diversity, p = 0.002, showing higher scores in autistic AFAB youth over adolescence, and TD AFAB showing initially lower, then increasing levels over adolescence. For GDSQ-P, Gender Incongruence was significantly different between the groups, p = 0.032, showing higher incongruence for autistic AFAB around age 10, decreasing between age 12-14 before increasing again, while TD AFAB evidence the inverse trend. AMAB trends were stable. The significant diagnostic, developmental and sex-based differences indicate AFAB youth experience greater gender diversity that evolves over development. Findings suggest gender identity formation is nuanced and may be influenced by pubertal progression, hormonal patterns, and psychosocial factors. Results underscore the need for enhanced understanding of the unique, dynamic profiles of females-assigned-at-birth. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Gender diversity in autistic and neurotypical youth over adolescence and puberty: A longitudinal study [Texte imprimé et/ou numérique] / Rachael A. MUSCATELLO, Auteur ; Melissa CYPERSKI, Auteur ; Eleonora SADIKOVA, Auteur ; E. Kale EDMISTON, Auteur ; Trey William MCGONIGLE, Auteur ; Rachel CALVOSA, Auteur ; Simon VANDEKAR, Auteur . - p.1450-1463. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1450-1463 Index. décimale : PER Périodiques Résumé : Abstract Recent research in autism spectrum disorder (ASD) has suggested a higher prevalence of gender diversity in individuals diagnosed with ASD. Adolescence is a critical period for the consolidation of gender identity, yet the extent to which the experience of gender diversity is stable over adolescence and puberty in autistic youth is poorly understood. The aim of the study was to examine the consistency of gender diversity using the gender diversity screening questionnaire for self- and parent-report of youth (GDSQ-S, GDSQ-P) over a four-year longitudinal study of pubertal development in youth with ASD (N = 140, 36 assigned-female-at birth (AFAB)) and typical development (TD, N = 104, 58 assigned-male-at-birth [AMAB]) and their parents. The extent to which diagnosis (ASD vs. TD), assigned sex (AFAB vs. AMAB) and developmental level (age, puberty) predict GDSQ trajectory over time was explored. There was a significant diagnosis by sex-assigned-at-birth by age interaction for GDSQ-S Gender Diversity, p = 0.002, showing higher scores in autistic AFAB youth over adolescence, and TD AFAB showing initially lower, then increasing levels over adolescence. For GDSQ-P, Gender Incongruence was significantly different between the groups, p = 0.032, showing higher incongruence for autistic AFAB around age 10, decreasing between age 12-14 before increasing again, while TD AFAB evidence the inverse trend. AMAB trends were stable. The significant diagnostic, developmental and sex-based differences indicate AFAB youth experience greater gender diversity that evolves over development. Findings suggest gender identity formation is nuanced and may be influenced by pubertal progression, hormonal patterns, and psychosocial factors. Results underscore the need for enhanced understanding of the unique, dynamic profiles of females-assigned-at-birth. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Greater gender diversity among autistic children by self-report and parent-report / Blythe A. CORBETT in Autism, 27-1 (January 2023)  

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Investigating Social Competence in a Pilot Randomized Clinical Trial of a Theatre-Based Intervention Enhanced for Adults with Autism Spectrum Disorder / Blythe A. CORBETT ; Alexandra P. KEY ; Mark E. KLEMENCIC ; Rachael A. MUSCATELLO ; Dorita JONES ; Jennifer Pilkington ; Christina BURROUGHS ; Simon VANDEKAR in Journal of Autism and Developmental Disorders, 55-1 (January 2025)  

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Salivary testosterone in male and female youth with and without autism spectrum disorder: considerations of development, sex, and diagnosis / Rachael A. MUSCATELLO in Molecular Autism, 13 (2022)  

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Social context in stress and autism: comparing physiological profiles across two social paradigms in youth with and without autism spectrum disorder / Rachael A. MUSCATELLO in Research in Autism Spectrum Disorders, 112 (April 2024)  

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The developmental trajectory of diurnal cortisol in autistic and neurotypical youth / Blythe A. CORBETT in Development and Psychopathology, 36-4 (October 2024)  

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Trajectory of depressive symptoms over adolescence in autistic and neurotypical youth / Blythe A. CORBETT in Molecular Autism, 15 (2024)  

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