Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder / Angelina VERNETTI in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1476-1488 Titre : Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Angelina VERNETTI, Auteur ; Frederick SHIC, Auteur ; Laura BOCCANFUSO, Auteur ; Suzanne MACARI, Auteur ; Finola KANE-GRADE, Auteur ; Anna MILGRAMM, Auteur ; Emily HILTON, Auteur ; Perrine HEYMANN, Auteur ; Matthew S GOODWIN, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1476-1488 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Past studies in autism spectrum disorder (ASD) indicate atypical peripheral physiological arousal. However, the conditions under which these atypicalities arise and their link with behavioral emotional expressions and core ASD symptoms remain uncertain. Given the importance of physiological arousal in affective, learning, and cognitive processes, the current study examined changes in skin conductance level (?SCL) in 41 toddlers with ASD (mean age: 22.7?months, SD: 2.9) and 32 age-matched toddlers with typical development (TD) (mean age: 21.6 months, SD: 3.6) in response to probes designed to induce anger, joy, and fear emotions. The magnitude of ?SCL was comparable during anger (P =?0.206, d =?0.30) and joy (P =?0.996, d =?0.01) conditions, but significantly lower during the fear condition (P =?0.001, d =?0.83) in toddlers with ASD compared to TD peers. In the combined samples, ?SCL positively correlated with intensity of behavioral emotional expressivity during the anger (r[71] = 0.36, P =?0.002) and fear (r[68] = 0.32, P =?0.007) conditions, but not in the joy (r[69] = ?0.15, P =?0.226) condition. Finally, ?SCL did not associate with autism symptom severity in any emotion-eliciting condition in the ASD group. Toddlers with ASD displayed attenuated ?SCL to situations aimed at eliciting fear, which may forecast the emergence of highly prevalent internalizing and externalizing problems in this population. The study putatively identifies ?SCL as a dimension not associated with severity of autism but with behavioral responses in negatively emotionally challenging events and provides support for the feasibility, validity, and incipient utility of examining ?SCL in response to emotional challenges in very young children. Lay Summary Physiological arousal was measured in toddlers with autism exposed to frustrating, pleasant, and threatening tasks. Compared to typically developing peers, toddlers with autism showed comparable arousal responses to frustrating and pleasant events, but lower responses to threatening events. Importantly, physiological arousal and behavioral expressions were aligned during frustrating and threatening events, inviting exploration of physiological arousal to measure responses to emotional challenges. Furthermore, this study advances the understanding of precursors to emotional and behavioral problems common in older children with autism. Autism Res 2020, 13: 1476–1488. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2374 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Atypical Emotional Electrodermal Activity in Toddlers with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Angelina VERNETTI, Auteur ; Frederick SHIC, Auteur ; Laura BOCCANFUSO, Auteur ; Suzanne MACARI, Auteur ; Finola KANE-GRADE, Auteur ; Anna MILGRAMM, Auteur ; Emily HILTON, Auteur ; Perrine HEYMANN, Auteur ; Matthew S GOODWIN, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1476-1488. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1476-1488 Index. décimale : PER Périodiques Résumé : Past studies in autism spectrum disorder (ASD) indicate atypical peripheral physiological arousal. However, the conditions under which these atypicalities arise and their link with behavioral emotional expressions and core ASD symptoms remain uncertain. Given the importance of physiological arousal in affective, learning, and cognitive processes, the current study examined changes in skin conductance level (?SCL) in 41 toddlers with ASD (mean age: 22.7?months, SD: 2.9) and 32 age-matched toddlers with typical development (TD) (mean age: 21.6 months, SD: 3.6) in response to probes designed to induce anger, joy, and fear emotions. The magnitude of ?SCL was comparable during anger (P =?0.206, d =?0.30) and joy (P =?0.996, d =?0.01) conditions, but significantly lower during the fear condition (P =?0.001, d =?0.83) in toddlers with ASD compared to TD peers. In the combined samples, ?SCL positively correlated with intensity of behavioral emotional expressivity during the anger (r[71] = 0.36, P =?0.002) and fear (r[68] = 0.32, P =?0.007) conditions, but not in the joy (r[69] = ?0.15, P =?0.226) condition. Finally, ?SCL did not associate with autism symptom severity in any emotion-eliciting condition in the ASD group. Toddlers with ASD displayed attenuated ?SCL to situations aimed at eliciting fear, which may forecast the emergence of highly prevalent internalizing and externalizing problems in this population. The study putatively identifies ?SCL as a dimension not associated with severity of autism but with behavioral responses in negatively emotionally challenging events and provides support for the feasibility, validity, and incipient utility of examining ?SCL in response to emotional challenges in very young children. Lay Summary Physiological arousal was measured in toddlers with autism exposed to frustrating, pleasant, and threatening tasks. Compared to typically developing peers, toddlers with autism showed comparable arousal responses to frustrating and pleasant events, but lower responses to threatening events. Importantly, physiological arousal and behavioral expressions were aligned during frustrating and threatening events, inviting exploration of physiological arousal to measure responses to emotional challenges. Furthermore, this study advances the understanding of precursors to emotional and behavioral problems common in older children with autism. Autism Res 2020, 13: 1476–1488. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2374 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability / Abigail BANGERTER in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 31 p. Titre : Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability Type de document : Texte imprimé et/ou numérique Auteurs : Abigail BANGERTER, Auteur ; Meenakshi CHATTERJEE, Auteur ; Joseph MANFREDONIA, Auteur ; Nikolay V. MANYAKOV, Auteur ; Seth NESS, Auteur ; Matthew A. BOICE, Auteur ; Andrew SKALKIN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : 31 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Emotional regulation  Emotions  Facial expression  Impulsive behavior  LLC, and may hold company equity. AS was an employee of Janssen Research &  Development at the time of the study. MSG has received research and consulting  funding from Janssen Research & Development. GD is on the Scientific Advisory Boards  of Janssen Research & Development  Akili, Inc.  LabCorp, Inc.  and Roche  Pharmaceutical Company  is a consultant for Apple, Inc  Gerson Lehrman Group  Guidepoint, Inc.  and Axial Ventures  has received grant funding from Janssen  Research & Development  and is the CEO of DASIO, LLC. GD receives royalties from  Guilford Press, Springer, and Oxford University Press. RH received reimbursement for  consultation from Janssen Research & Development. BL has received research grant  funding from the NIH  is a consultant to Janssen Research & Development, the  Illinois Children’s Healthcare Foundation  and is a board member of the Brain  Research Foundation. FS is on the Scientific Advisory Board, is a consultant to and  received grant funding from Janssen Research & Development, and has also received  grant funding from Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent of this discrepancy is limited and inconsistent. Use of automated facial expression detection technology enables accurate and efficient tracking of facial expressions that has potential to identify individual response differences. METHODS: Children and adults with ASD (N = 124) and typically developing (TD, N = 41) were shown short clips of "funny videos." Using automated facial analysis software, we investigated differences between ASD and TD groups and within the ASD group in evidence of facial action unit (AU) activation related to the expression of positive facial expression, in particular, a smile. RESULTS: Individuals with ASD on average showed less evidence of facial AUs (AU12, AU6) relating to positive facial expression, compared to the TD group (p < .05, r = -?0.17). Using Gaussian mixture model for clustering, we identified two distinct distributions within the ASD group, which were then compared to the TD group. One subgroup (n = 35), termed "over-responsive," expressed more intense positive facial expressions in response to the videos than the TD group (p < .001, r = 0.31). The second subgroup (n = 89), ("under-responsive"), displayed fewer, less intense positive facial expressions in response to videos than the TD group (p < .001; r = -?0.36). The over-responsive subgroup differed from the under-responsive subgroup in age and caregiver-reported impulsivity (p < .05, r = 0.21). Reduced expression in the under-responsive, but not the over-responsive group, was related to caregiver-reported social withdrawal (p < .01, r = -?0.3). LIMITATIONS: This exploratory study does not account for multiple comparisons, and future work will have to ascertain the strength and reproducibility of all results. Reduced displays of positive facial expressions do not mean individuals with ASD do not experience positive emotions. CONCLUSIONS: Individuals with ASD differed from the TD group in their facial expressions of positive emotion in response to "funny videos." Identification of subgroups based on response may help in parsing heterogeneity in ASD and enable targeting of treatment based on subtypes. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02299700. Registration date: November 24, 2014. En ligne : http://dx.doi.org/10.1186/s13229-020-00327-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Automated recognition of spontaneous facial expression in individuals with autism spectrum disorder: parsing response variability [Texte imprimé et/ou numérique] / Abigail BANGERTER, Auteur ; Meenakshi CHATTERJEE, Auteur ; Joseph MANFREDONIA, Auteur ; Nikolay V. MANYAKOV, Auteur ; Seth NESS, Auteur ; Matthew A. BOICE, Auteur ; Andrew SKALKIN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur . - 31 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 31 p. Mots-clés : Autism spectrum disorder  Emotional regulation  Emotions  Facial expression  Impulsive behavior  LLC, and may hold company equity. AS was an employee of Janssen Research &  Development at the time of the study. MSG has received research and consulting  funding from Janssen Research & Development. GD is on the Scientific Advisory Boards  of Janssen Research & Development  Akili, Inc.  LabCorp, Inc.  and Roche  Pharmaceutical Company  is a consultant for Apple, Inc  Gerson Lehrman Group  Guidepoint, Inc.  and Axial Ventures  has received grant funding from Janssen  Research & Development  and is the CEO of DASIO, LLC. GD receives royalties from  Guilford Press, Springer, and Oxford University Press. RH received reimbursement for  consultation from Janssen Research & Development. BL has received research grant  funding from the NIH  is a consultant to Janssen Research & Development, the  Illinois Children’s Healthcare Foundation  and is a board member of the Brain  Research Foundation. FS is on the Scientific Advisory Board, is a consultant to and  received grant funding from Janssen Research & Development, and has also received  grant funding from Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Reduction or differences in facial expression are a core diagnostic feature of autism spectrum disorder (ASD), yet evidence regarding the extent of this discrepancy is limited and inconsistent. Use of automated facial expression detection technology enables accurate and efficient tracking of facial expressions that has potential to identify individual response differences. METHODS: Children and adults with ASD (N = 124) and typically developing (TD, N = 41) were shown short clips of "funny videos." Using automated facial analysis software, we investigated differences between ASD and TD groups and within the ASD group in evidence of facial action unit (AU) activation related to the expression of positive facial expression, in particular, a smile. RESULTS: Individuals with ASD on average showed less evidence of facial AUs (AU12, AU6) relating to positive facial expression, compared to the TD group (p < .05, r = -?0.17). Using Gaussian mixture model for clustering, we identified two distinct distributions within the ASD group, which were then compared to the TD group. One subgroup (n = 35), termed "over-responsive," expressed more intense positive facial expressions in response to the videos than the TD group (p < .001, r = 0.31). The second subgroup (n = 89), ("under-responsive"), displayed fewer, less intense positive facial expressions in response to videos than the TD group (p < .001; r = -?0.36). The over-responsive subgroup differed from the under-responsive subgroup in age and caregiver-reported impulsivity (p < .05, r = 0.21). Reduced expression in the under-responsive, but not the over-responsive group, was related to caregiver-reported social withdrawal (p < .01, r = -?0.3). LIMITATIONS: This exploratory study does not account for multiple comparisons, and future work will have to ascertain the strength and reproducibility of all results. Reduced displays of positive facial expressions do not mean individuals with ASD do not experience positive emotions. CONCLUSIONS: Individuals with ASD differed from the TD group in their facial expressions of positive emotion in response to "funny videos." Identification of subgroups based on response may help in parsing heterogeneity in ASD and enable targeting of treatment based on subtypes. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02299700. Registration date: November 24, 2014. En ligne : http://dx.doi.org/10.1186/s13229-020-00327-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder / Abigail BANGERTER in Journal of Autism and Developmental Disorders, 50-6 (June 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2090-2101 Titre : Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Abigail BANGERTER, Auteur ; Seth NESS, Auteur ; David LEWIN, Auteur ; Michael G. AMAN, Auteur ; Anna J. ESBENSEN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Fred SHIC, Auteur ; Mark OPLER, Auteur ; Kai Fai HO, Auteur ; Gahan PANDINA, Auteur Article en page(s) : p.2090-2101 Langues : Anglais (eng) Mots-clés : Assessment  Autism spectrum disorder  Caregiver-reported outcomes  Clinical trials  Rating scales and instruments  hold company stocks/stock options. Anna Esbensen has consulted with Roche on outcome  measures in Down syndrome and ProPhase LLC. Robert Hendren received reimbursement  for consultation from Janssen Research & Development, LLC. Michael Aman has received  research contracts, consulted with, served on advisory boards, or done investigator  training for AMO Pharma, Bracket, CogState, Inc., CogState Clinical Trials, Ltd.,  Coronado Biosciences, Forest Research, Hoffman-La Roche, Lumos Pharma, MedAvante,  Inc., Ovid Therapeutics  ProPhase LLC, Supernus Pharmaceuticals, Zynerba  Pharmaceuticals, and Yamo Pharmaceuticals. He receives royalties from Slosson  Educational Publications. Geraldine Dawson is on the Scientific Advisory Boards of  Janssen Research and Development, LabCorp, and Akili, Inc., a consultant to Roche  has received grant funding from Janssen Research and Development, LLC and  PerkinElmer  and, receives royalties from Guilford Press and Oxford University  Press. Index. décimale : PER Périodiques Résumé : There is a need for measures to track symptom change in autism spectrum disorder (ASD). We conducted a validation study on a revised version of the Autism Behavior Inventory (ABI), and a short form (ABI-S). Caregivers of individuals (6-54 years) with confirmed diagnoses of ASD (N?=?144) completed the ABI and other rating scales at 4 time points. Scale consistency for each domain, 3-5 day test-retest reliability, and construct validity, determined by comparison to pre-specified scales, were all good. Change in the ABI was congruent with changes in other instruments. Collectively, results suggest incipient suitability of the ABI as a measure of changes in core and associated symptoms of ASD.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-019-03965-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425 [article] Clinical Validation of the Autism Behavior Inventory: Caregiver-Rated Assessment of Core and Associated Symptoms of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Abigail BANGERTER, Auteur ; Seth NESS, Auteur ; David LEWIN, Auteur ; Michael G. AMAN, Auteur ; Anna J. ESBENSEN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Fred SHIC, Auteur ; Mark OPLER, Auteur ; Kai Fai HO, Auteur ; Gahan PANDINA, Auteur . - p.2090-2101. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-6 (June 2020) . - p.2090-2101 Mots-clés : Assessment  Autism spectrum disorder  Caregiver-reported outcomes  Clinical trials  Rating scales and instruments  hold company stocks/stock options. Anna Esbensen has consulted with Roche on outcome  measures in Down syndrome and ProPhase LLC. Robert Hendren received reimbursement  for consultation from Janssen Research & Development, LLC. Michael Aman has received  research contracts, consulted with, served on advisory boards, or done investigator  training for AMO Pharma, Bracket, CogState, Inc., CogState Clinical Trials, Ltd.,  Coronado Biosciences, Forest Research, Hoffman-La Roche, Lumos Pharma, MedAvante,  Inc., Ovid Therapeutics  ProPhase LLC, Supernus Pharmaceuticals, Zynerba  Pharmaceuticals, and Yamo Pharmaceuticals. He receives royalties from Slosson  Educational Publications. Geraldine Dawson is on the Scientific Advisory Boards of  Janssen Research and Development, LabCorp, and Akili, Inc., a consultant to Roche  has received grant funding from Janssen Research and Development, LLC and  PerkinElmer  and, receives royalties from Guilford Press and Oxford University  Press. Index. décimale : PER Périodiques Résumé : There is a need for measures to track symptom change in autism spectrum disorder (ASD). We conducted a validation study on a revised version of the Autism Behavior Inventory (ABI), and a short form (ABI-S). Caregivers of individuals (6-54 years) with confirmed diagnoses of ASD (N?=?144) completed the ABI and other rating scales at 4 time points. Scale consistency for each domain, 3-5 day test-retest reliability, and construct validity, determined by comparison to pre-specified scales, were all good. Change in the ABI was congruent with changes in other instruments. Collectively, results suggest incipient suitability of the ABI as a measure of changes in core and associated symptoms of ASD.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-019-03965-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=425

Social attention to activities in children and adults with autism spectrum disorder: effects of context and age / Dzmitry A. KALIUKHOVICH in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 79 p. Titre : Social attention to activities in children and adults with autism spectrum disorder: effects of context and age Type de document : Texte imprimé et/ou numérique Auteurs : Dzmitry A. KALIUKHOVICH, Auteur ; Nikolay V. MANYAKOV, Auteur ; Abigail BANGERTER, Auteur ; Seth NESS, Auteur ; Andrew SKALKIN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert L. HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Caitlin M. HUDAC, Auteur ; Jessica BRADSHAW, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : 79 p. Langues : Anglais (eng) Mots-clés : Activity monitoring  Autism spectrum disorder  Biomarkers  Eye tracking  Social attention  Skalkin (at the time of study conduct), and Gahan Pandina are employees of Janssen  Research & Development, LLC and hold company stocks/stock options. Matthew Goodwin  has received research and consulting funding from Janssen Research & Development,  LLC. Geraldine Dawson is on the Scientific Advisory Boards of Janssen Research and  Development, Akili, Inc., LabCorp, Inc., and Roche Pharmaceutical Company, a  consultant for Apple, Inc, Gerson Lehrman Group, Guidepoint, Inc., Teva  Pharmaceuticals, Tris Pharma, Inc., and Axial Ventures, has received grant funding  from Janssen Research and Development, and is CEO of DASIO, LLC. Dawson has  developed technology that has been licensed and Dawson and Duke University have  benefited financially. Dawson receives royalties from Guilford Press, Springer, and  Oxford University Press. Robert Hendren received reimbursement for consultation from  Janssen Research & Development, LLC. Bennett Leventhal has received research grant  funding from the NIH, is a consultant to Janssen Research and Development, LLC and  the Illinois Children’s Healthcare Foundation, and is a board member of the Brain  Research Foundation. Frederick Shic is on the Scientific Advisory Board of and is a  consultant to Janssen Research and Development, LLC, and has received grant funding  from Janssen Research and Development LLC, and Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Diminished visual monitoring of faces and activities of others is an early feature of autism spectrum disorder (ASD). It is uncertain whether deficits in activity monitoring, identified using a homogeneous set of stimuli, persist throughout the lifespan in ASD, and thus, whether they could serve as a biological indicator ("biomarker") of ASD. We investigated differences in visual attention during activity monitoring in children and adult participants with autism compared to a control group of participants without autism. METHODS: Eye movements of participants with autism (n?=?122; mean age [SD]?=?14.5 [8.0] years) and typically developing (TD) controls (n?=?40, age?=?16.4 [13.3] years) were recorded while they viewed a series of videos depicting two female actors conversing while interacting with their hands over a shared task. Actors either continuously focused their gaze on each other's face (mutual gaze) or on the shared activity area (shared focus). Mean percentage looking time was computed for the activity area, actors' heads, and their bodies. RESULTS: Compared to TD participants, participants with ASD looked longer at the activity area (mean % looking time: 58.5% vs. 53.8%, p??60] limited the ability to include individuals with substantial intellectual disability. CONCLUSIONS: Differences in attention to faces could constitute a feature discriminative between individuals with and without ASD across the lifespan, whereas between-group differences in looking at activities may shift with development. These findings may have applications in the search for underlying biological indicators specific to ASD. Trial registration ClinicalTrials.gov identifier NCT02668991. En ligne : http://dx.doi.org/10.1186/s13229-020-00388-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Social attention to activities in children and adults with autism spectrum disorder: effects of context and age [Texte imprimé et/ou numérique] / Dzmitry A. KALIUKHOVICH, Auteur ; Nikolay V. MANYAKOV, Auteur ; Abigail BANGERTER, Auteur ; Seth NESS, Auteur ; Andrew SKALKIN, Auteur ; Matthew S GOODWIN, Auteur ; Geraldine DAWSON, Auteur ; Robert L. HENDREN, Auteur ; Bennett L. LEVENTHAL, Auteur ; Caitlin M. HUDAC, Auteur ; Jessica BRADSHAW, Auteur ; Frederick SHIC, Auteur ; Gahan PANDINA, Auteur . - 79 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 79 p. Mots-clés : Activity monitoring  Autism spectrum disorder  Biomarkers  Eye tracking  Social attention  Skalkin (at the time of study conduct), and Gahan Pandina are employees of Janssen  Research & Development, LLC and hold company stocks/stock options. Matthew Goodwin  has received research and consulting funding from Janssen Research & Development,  LLC. Geraldine Dawson is on the Scientific Advisory Boards of Janssen Research and  Development, Akili, Inc., LabCorp, Inc., and Roche Pharmaceutical Company, a  consultant for Apple, Inc, Gerson Lehrman Group, Guidepoint, Inc., Teva  Pharmaceuticals, Tris Pharma, Inc., and Axial Ventures, has received grant funding  from Janssen Research and Development, and is CEO of DASIO, LLC. Dawson has  developed technology that has been licensed and Dawson and Duke University have  benefited financially. Dawson receives royalties from Guilford Press, Springer, and  Oxford University Press. Robert Hendren received reimbursement for consultation from  Janssen Research & Development, LLC. Bennett Leventhal has received research grant  funding from the NIH, is a consultant to Janssen Research and Development, LLC and  the Illinois Children’s Healthcare Foundation, and is a board member of the Brain  Research Foundation. Frederick Shic is on the Scientific Advisory Board of and is a  consultant to Janssen Research and Development, LLC, and has received grant funding  from Janssen Research and Development LLC, and Roche. Index. décimale : PER Périodiques Résumé : BACKGROUND: Diminished visual monitoring of faces and activities of others is an early feature of autism spectrum disorder (ASD). It is uncertain whether deficits in activity monitoring, identified using a homogeneous set of stimuli, persist throughout the lifespan in ASD, and thus, whether they could serve as a biological indicator ("biomarker") of ASD. We investigated differences in visual attention during activity monitoring in children and adult participants with autism compared to a control group of participants without autism. METHODS: Eye movements of participants with autism (n?=?122; mean age [SD]?=?14.5 [8.0] years) and typically developing (TD) controls (n?=?40, age?=?16.4 [13.3] years) were recorded while they viewed a series of videos depicting two female actors conversing while interacting with their hands over a shared task. Actors either continuously focused their gaze on each other's face (mutual gaze) or on the shared activity area (shared focus). Mean percentage looking time was computed for the activity area, actors' heads, and their bodies. RESULTS: Compared to TD participants, participants with ASD looked longer at the activity area (mean % looking time: 58.5% vs. 53.8%, p??60] limited the ability to include individuals with substantial intellectual disability. CONCLUSIONS: Differences in attention to faces could constitute a feature discriminative between individuals with and without ASD across the lifespan, whereas between-group differences in looking at activities may shift with development. These findings may have applications in the search for underlying biological indicators specific to ASD. Trial registration ClinicalTrials.gov identifier NCT02668991. En ligne : http://dx.doi.org/10.1186/s13229-020-00388-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

The relationship between autism symptoms and arousal level in toddlers with autism spectrum disorder, as measured by electrodermal activity / Emily Barbara PRINCE in Autism, 21-4 (May 2017)  

Public ISBD [article]  inAutism > 21-4 (May 2017) . - p.504-508 Titre : The relationship between autism symptoms and arousal level in toddlers with autism spectrum disorder, as measured by electrodermal activity Type de document : Texte imprimé et/ou numérique Auteurs : Emily Barbara PRINCE, Auteur ; Elizabeth S KIM, Auteur ; Carla A. WALL, Auteur ; Eugenia GISIN, Auteur ; Matthew S GOODWIN, Auteur ; Elizabeth SCHOEN SIMMONS, Auteur ; Kasia CHAWARSKA, Auteur ; Frederick SHIC, Auteur Article en page(s) : p.504-508 Langues : Anglais (eng) Mots-clés : ASD  electrodermal activity  galvanic skin response  language  naturalistic environment  play  skin conductance  toddlers Index. décimale : PER Périodiques Résumé : Electrodermal activity was examined as a measure of physiological arousal within a naturalistic play context in 2-year-old toddlers (N?=?27) with and without autism spectrum disorder. Toddlers with autism spectrum disorder were found to have greater increases in skin conductance level than their typical peers in response to administered play activities. In the autism spectrum disorder group, a positive relationship was observed between restrictive and repetitive behaviors and skin conductance level increases in response to mechanical toys, whereas the opposite pattern was observed for passive toys. This preliminary study is the first to examine electrodermal activity levels in toddlers with autism spectrum disorder during play-based, naturalistic settings, and it highlights the potential for electrodermal activity as a measure of individual variability within autism spectrum disorder and early development. En ligne : http://dx.doi.org/10.1177/1362361316648816 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] The relationship between autism symptoms and arousal level in toddlers with autism spectrum disorder, as measured by electrodermal activity [Texte imprimé et/ou numérique] / Emily Barbara PRINCE, Auteur ; Elizabeth S KIM, Auteur ; Carla A. WALL, Auteur ; Eugenia GISIN, Auteur ; Matthew S GOODWIN, Auteur ; Elizabeth SCHOEN SIMMONS, Auteur ; Kasia CHAWARSKA, Auteur ; Frederick SHIC, Auteur . - p.504-508. Langues : Anglais (eng) in Autism > 21-4 (May 2017) . - p.504-508 Mots-clés : ASD  electrodermal activity  galvanic skin response  language  naturalistic environment  play  skin conductance  toddlers Index. décimale : PER Périodiques Résumé : Electrodermal activity was examined as a measure of physiological arousal within a naturalistic play context in 2-year-old toddlers (N?=?27) with and without autism spectrum disorder. Toddlers with autism spectrum disorder were found to have greater increases in skin conductance level than their typical peers in response to administered play activities. In the autism spectrum disorder group, a positive relationship was observed between restrictive and repetitive behaviors and skin conductance level increases in response to mechanical toys, whereas the opposite pattern was observed for passive toys. This preliminary study is the first to examine electrodermal activity levels in toddlers with autism spectrum disorder during play-based, naturalistic settings, and it highlights the potential for electrodermal activity as a measure of individual variability within autism spectrum disorder and early development. En ligne : http://dx.doi.org/10.1177/1362361316648816 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

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