Characterizing Sleep in Adolescents and Adults with Autism Spectrum Disorders / S. E. GOLDMAN in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1682-1695 Titre : Characterizing Sleep in Adolescents and Adults with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : S. E. GOLDMAN, Auteur ; M. L. ALDER, Auteur ; Helen J. BURGESS, Auteur ; B. A. CORBETT, Auteur ; R. HUNDLEY, Auteur ; D. WOFFORD, Auteur ; D. B. FAWKES, Auteur ; L. WANG, Auteur ; M. L. LAUDENSLAGER, Auteur ; B. A. MALOW, Auteur Article en page(s) : p.1682-1695 Langues : Anglais (eng) Mots-clés : Melatonin  Cortisol  Actigraphy  Adolescent  Sleep  Wake  Scale  Hygiene Index. décimale : PER Périodiques Résumé : We studied 28 adolescents/young adults with autism spectrum disorders (ASD) and 13 age/sex matched individuals of typical development (TD). Structured sleep histories, validated questionnaires, actigraphy (4 weeks), and salivary cortisol and melatonin (4 days each) were collected. Compared to those with TD, adolescents/young adults with ASD had longer sleep latencies and more difficulty going to bed and falling asleep. Morning cortisol, evening cortisol, and the morning-evening difference in cortisol did not differ by diagnosis (ASD vs. TD). Dim light melatonin onsets (DLMOs) averaged across participants were not different for the ASD and TD participants. Average participant scores indicated aspects of poor sleep hygiene in both groups. Insomnia in ASD is multifactorial and not solely related to physiological factors. En ligne : http://dx.doi.org/10.1007/s10803-017-3089-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Characterizing Sleep in Adolescents and Adults with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / S. E. GOLDMAN, Auteur ; M. L. ALDER, Auteur ; Helen J. BURGESS, Auteur ; B. A. CORBETT, Auteur ; R. HUNDLEY, Auteur ; D. WOFFORD, Auteur ; D. B. FAWKES, Auteur ; L. WANG, Auteur ; M. L. LAUDENSLAGER, Auteur ; B. A. MALOW, Auteur . - p.1682-1695. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1682-1695 Mots-clés : Melatonin  Cortisol  Actigraphy  Adolescent  Sleep  Wake  Scale  Hygiene Index. décimale : PER Périodiques Résumé : We studied 28 adolescents/young adults with autism spectrum disorders (ASD) and 13 age/sex matched individuals of typical development (TD). Structured sleep histories, validated questionnaires, actigraphy (4 weeks), and salivary cortisol and melatonin (4 days each) were collected. Compared to those with TD, adolescents/young adults with ASD had longer sleep latencies and more difficulty going to bed and falling asleep. Morning cortisol, evening cortisol, and the morning-evening difference in cortisol did not differ by diagnosis (ASD vs. TD). Dim light melatonin onsets (DLMOs) averaged across participants were not different for the ASD and TD participants. Average participant scores indicated aspects of poor sleep hygiene in both groups. Insomnia in ASD is multifactorial and not solely related to physiological factors. En ligne : http://dx.doi.org/10.1007/s10803-017-3089-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Comparing oxytocin and cortisol regulation in a double-blind, placebo-controlled, hydrocortisone challenge pilot study in children with autism and typical development / B. A. CORBETT in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.32 Titre : Comparing oxytocin and cortisol regulation in a double-blind, placebo-controlled, hydrocortisone challenge pilot study in children with autism and typical development Type de document : Texte imprimé et/ou numérique Auteurs : B. A. CORBETT, Auteur ; Karen L. BALES, Auteur ; D. SWAIN, Auteur ; K. SANDERS, Auteur ; T. A. WEINSTEIN, Auteur ; L. J. MUGLIA, Auteur Article en page(s) : p.32 Langues : Anglais (eng) Mots-clés : Arginine vasopressin  Autism  Autism spectrum disorder  Cortisol  Hormone  Hydrocortisone  LHPA axis  Oxytocin  Stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with autism spectrum disorder (ASD) show marked impairment in social functioning and poor adaptation to new and changing contexts, which may be influenced by underlying regulatory processes. Oxytocin (OT) and cortisol are key neuromodulators of biological and behavioral responses, show a synergistic effect, and have been implicated in the neuropathological profile in ASD. However, they are rarely investigated together. The purpose of the pilot study was to evaluate the relationship between cortisol and OT in children with ASD under baseline and physiological stress (hydrocortisone challenge) conditions. Arginine vasopressin (AVP), structurally similar to OT, was also examined. METHODS: A double-blind, placebo-controlled, randomly assigned, crossover design was employed in 25 children 8-to-12 years with ASD (N = 14) or typical development (TD, N = 11). A low dose of hydrocortisone and placebo were administered via liquid suspension. Analysis of variance (ANOVA) was used to examine the within-subject factor "Condition" (hydrocortisone/placebo) and "Time" (pre and post) and the between-subject factor "Group" (ASD vs. TD). Pearson correlations examined the relationship between hormone levels and clinical profile. RESULTS: There was a significant Time x Condition x Group interaction F (1.23) = 4.18, p = 0.05 showing a rise in OT during the experimental condition (hydrocortisone) and a drop during the placebo condition for the TD group but not the ASD group. There were no group differences for AVP. Hormone levels were associated with social profiles. CONCLUSIONS: For the TD group, an inverse relationship was observed. OT increased during physiological challenge suggesting that OT played a stress-buffering role during cortisol administration. In contrast for the ASD group, OT remained unchanged or decreased during both the physiological challenge and the placebo condition, suggesting that OT failed to serve as a stress buffer under conditions of physiological stress. While OT has been tied to the social ability of children with ASD, the diminished moderating effect of OT on cortisol may also play a contributory role in the heightened stress often observed in children with ASD. These results contribute to our understanding of the growing complexity of the effects of OT on social behavior as well as the functional interplay and differential regulation OT may have on stress modulation. En ligne : http://dx.doi.org/10.1186/s11689-016-9165-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 [article] Comparing oxytocin and cortisol regulation in a double-blind, placebo-controlled, hydrocortisone challenge pilot study in children with autism and typical development [Texte imprimé et/ou numérique] / B. A. CORBETT, Auteur ; Karen L. BALES, Auteur ; D. SWAIN, Auteur ; K. SANDERS, Auteur ; T. A. WEINSTEIN, Auteur ; L. J. MUGLIA, Auteur . - p.32. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.32 Mots-clés : Arginine vasopressin  Autism  Autism spectrum disorder  Cortisol  Hormone  Hydrocortisone  LHPA axis  Oxytocin  Stress Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with autism spectrum disorder (ASD) show marked impairment in social functioning and poor adaptation to new and changing contexts, which may be influenced by underlying regulatory processes. Oxytocin (OT) and cortisol are key neuromodulators of biological and behavioral responses, show a synergistic effect, and have been implicated in the neuropathological profile in ASD. However, they are rarely investigated together. The purpose of the pilot study was to evaluate the relationship between cortisol and OT in children with ASD under baseline and physiological stress (hydrocortisone challenge) conditions. Arginine vasopressin (AVP), structurally similar to OT, was also examined. METHODS: A double-blind, placebo-controlled, randomly assigned, crossover design was employed in 25 children 8-to-12 years with ASD (N = 14) or typical development (TD, N = 11). A low dose of hydrocortisone and placebo were administered via liquid suspension. Analysis of variance (ANOVA) was used to examine the within-subject factor "Condition" (hydrocortisone/placebo) and "Time" (pre and post) and the between-subject factor "Group" (ASD vs. TD). Pearson correlations examined the relationship between hormone levels and clinical profile. RESULTS: There was a significant Time x Condition x Group interaction F (1.23) = 4.18, p = 0.05 showing a rise in OT during the experimental condition (hydrocortisone) and a drop during the placebo condition for the TD group but not the ASD group. There were no group differences for AVP. Hormone levels were associated with social profiles. CONCLUSIONS: For the TD group, an inverse relationship was observed. OT increased during physiological challenge suggesting that OT played a stress-buffering role during cortisol administration. In contrast for the ASD group, OT remained unchanged or decreased during both the physiological challenge and the placebo condition, suggesting that OT failed to serve as a stress buffer under conditions of physiological stress. While OT has been tied to the social ability of children with ASD, the diminished moderating effect of OT on cortisol may also play a contributory role in the heightened stress often observed in children with ASD. These results contribute to our understanding of the growing complexity of the effects of OT on social behavior as well as the functional interplay and differential regulation OT may have on stress modulation. En ligne : http://dx.doi.org/10.1186/s11689-016-9165-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349

Diagnostic- and sex-based differences in depression symptoms in autistic and neurotypical early adolescents / Jessica M. SCHWARTZMAN in Autism, 26-1 (January 2022)  

Public ISBD [article]  inAutism > 26-1 (January 2022) . - p.256-269 Titre : Diagnostic- and sex-based differences in depression symptoms in autistic and neurotypical early adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Jessica M. SCHWARTZMAN, Auteur ; Z. J. WILLIAMS, Auteur ; B. A. CORBETT, Auteur Article en page(s) : p.256-269 Langues : Anglais (eng) Mots-clés : autism  depression  early adolescent  measurement  peers  sex  financial compensation from the non-profit 501©(3) entity. Zachary Williams serves  on the Family Advisory Committee of the Autism Speaks Autism Treatment Network  Vanderbilt site. He also consults for Roche. Index. décimale : PER Périodiques Résumé : Depression is more common in autistic adolescents than their neurotypical peers, but the effects of diagnosis and sex on the severity and types of depressive symptoms remain unclear. The study explored diagnostic- and sex-based differences in depressive symptoms in 212 autistic and neurotypical early adolescents. Results show that autism spectrum disorder and female may pose elevated risks, and depressive symptoms related to interpersonal problems and negative self-esteem are more frequent in autism spectrum disorder. Autistic males and females endorsed similar severity and type of depressive symptoms, but unique differences emerged when compared to sex-matched neurotypical peers. Exploratory analyses in a clinical subsample of early adolescents with elevated depressive symptoms (Children's Depression Inventory, Second Edition, Total T-score ?60) revealed more endorsement of beliefs of worthlessness in autistic early adolescents. Findings suggest initial intervention targets for treating depression in autistic early adolescents. En ligne : http://dx.doi.org/10.1177/13623613211025895 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Diagnostic- and sex-based differences in depression symptoms in autistic and neurotypical early adolescents [Texte imprimé et/ou numérique] / Jessica M. SCHWARTZMAN, Auteur ; Z. J. WILLIAMS, Auteur ; B. A. CORBETT, Auteur . - p.256-269. Langues : Anglais (eng) in Autism > 26-1 (January 2022) . - p.256-269 Mots-clés : autism  depression  early adolescent  measurement  peers  sex  financial compensation from the non-profit 501©(3) entity. Zachary Williams serves  on the Family Advisory Committee of the Autism Speaks Autism Treatment Network  Vanderbilt site. He also consults for Roche. Index. décimale : PER Périodiques Résumé : Depression is more common in autistic adolescents than their neurotypical peers, but the effects of diagnosis and sex on the severity and types of depressive symptoms remain unclear. The study explored diagnostic- and sex-based differences in depressive symptoms in 212 autistic and neurotypical early adolescents. Results show that autism spectrum disorder and female may pose elevated risks, and depressive symptoms related to interpersonal problems and negative self-esteem are more frequent in autism spectrum disorder. Autistic males and females endorsed similar severity and type of depressive symptoms, but unique differences emerged when compared to sex-matched neurotypical peers. Exploratory analyses in a clinical subsample of early adolescents with elevated depressive symptoms (Children's Depression Inventory, Second Edition, Total T-score ?60) revealed more endorsement of beliefs of worthlessness in autistic early adolescents. Findings suggest initial intervention targets for treating depression in autistic early adolescents. En ligne : http://dx.doi.org/10.1177/13623613211025895 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Differences in anticipatory versus reactive stress to social evaluative threat in adults versus adolescents with autism / Julie LOUNDS TAYLOR in Autism Research, 11-9 (September 2018)  

Public ISBD [article]  inAutism Research > 11-9 (September 2018) . - p.1276-1285 Titre : Differences in anticipatory versus reactive stress to social evaluative threat in adults versus adolescents with autism Type de document : Texte imprimé et/ou numérique Auteurs : Julie LOUNDS TAYLOR, Auteur ; R. A. MUSCATELLO, Auteur ; B. A. CORBETT, Auteur Article en page(s) : p.1276-1285 Langues : Anglais (eng) Mots-clés : HPA axis  adolescence  adults  autism spectrum disorder  cortisol  stress Index. décimale : PER Périodiques Résumé : Social evaluative threat is a potent activator of the hypothalamic-pituitary-adrenocortical (HPA) axis in typically developing (TD) populations. Studies have shown that children and adolescents with autism spectrum disorder (ASD) show a blunted cortisol response to this type of stressor; yet, a previous study in adults with ASD reported a more prototypical stress response. The current study compared 24 adolescents and 17 adults with ASD to investigate a possible developmental lag in autism resulting in a more adaptive stress response to social evaluation with development. Participants were exposed to the trier social stress test (TSST), and salivary cortisol was collected before and after stress induction. Multilevel modeling revealed that relative to adolescents, young adults with ASD evidenced a significant increase in cortisol in response to anticipatory stress, and 23.5% were classified as anticipatory responders. Adolescents, however, had a significant change in slope in response to the TSST, with 37.5% classified as reactive responders. In both groups, the majority of participants did not have a robust stress response to the TSST as would be expected in TD participants. Findings suggest significant differences in the cortisol trajectory; adults with ASD were more likely to show an anticipatory response to being socially evaluated, which was maintained throughout the stressor, whereas the adolescents had a more reactive response pattern with no anticipatory response. Further research is needed to determine if such patterns are adaptive or deleterious, and to determine underlying factors that may contribute to distinct stress profiles and to the overall diminished stress responses. Autism Res 2018, 11: 1276-1285. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Many individuals have increased stress when being socially evaluated. The current study shows that adults with ASD have increased stress in anticipation of a task in which individuals are required to give a speech to unfamiliar raters, while adolescents with ASD tend to show a stress response only during the task itself. Further research is necessary to understand whether developmental influences on stress response in ASD have significant impacts on other areas of functioning often affected by stress. En ligne : http://dx.doi.org/10.1002/aur.1998 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Differences in anticipatory versus reactive stress to social evaluative threat in adults versus adolescents with autism [Texte imprimé et/ou numérique] / Julie LOUNDS TAYLOR, Auteur ; R. A. MUSCATELLO, Auteur ; B. A. CORBETT, Auteur . - p.1276-1285. Langues : Anglais (eng) in Autism Research > 11-9 (September 2018) . - p.1276-1285 Mots-clés : HPA axis  adolescence  adults  autism spectrum disorder  cortisol  stress Index. décimale : PER Périodiques Résumé : Social evaluative threat is a potent activator of the hypothalamic-pituitary-adrenocortical (HPA) axis in typically developing (TD) populations. Studies have shown that children and adolescents with autism spectrum disorder (ASD) show a blunted cortisol response to this type of stressor; yet, a previous study in adults with ASD reported a more prototypical stress response. The current study compared 24 adolescents and 17 adults with ASD to investigate a possible developmental lag in autism resulting in a more adaptive stress response to social evaluation with development. Participants were exposed to the trier social stress test (TSST), and salivary cortisol was collected before and after stress induction. Multilevel modeling revealed that relative to adolescents, young adults with ASD evidenced a significant increase in cortisol in response to anticipatory stress, and 23.5% were classified as anticipatory responders. Adolescents, however, had a significant change in slope in response to the TSST, with 37.5% classified as reactive responders. In both groups, the majority of participants did not have a robust stress response to the TSST as would be expected in TD participants. Findings suggest significant differences in the cortisol trajectory; adults with ASD were more likely to show an anticipatory response to being socially evaluated, which was maintained throughout the stressor, whereas the adolescents had a more reactive response pattern with no anticipatory response. Further research is needed to determine if such patterns are adaptive or deleterious, and to determine underlying factors that may contribute to distinct stress profiles and to the overall diminished stress responses. Autism Res 2018, 11: 1276-1285. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Many individuals have increased stress when being socially evaluated. The current study shows that adults with ASD have increased stress in anticipation of a task in which individuals are required to give a speech to unfamiliar raters, while adolescents with ASD tend to show a stress response only during the task itself. Further research is necessary to understand whether developmental influences on stress response in ASD have significant impacts on other areas of functioning often affected by stress. En ligne : http://dx.doi.org/10.1002/aur.1998 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Differences in Body Mass Index (BMI) in Early Adolescents with Autism Spectrum Disorder Compared to Youth with Typical Development / B. A. CORBETT in Journal of Autism and Developmental Disorders, 51-8 (August 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2790-2799 Titre : Differences in Body Mass Index (BMI) in Early Adolescents with Autism Spectrum Disorder Compared to Youth with Typical Development Type de document : Texte imprimé et/ou numérique Auteurs : B. A. CORBETT, Auteur ; R. A. MUSCATELLO, Auteur ; B. K. HORROCKS, Auteur ; M. E. KLEMENCIC, Auteur ; Yasas TANGUTURI, Auteur Article en page(s) : p.2790-2799 Langues : Anglais (eng) Mots-clés : Adolescent  Adolescent Development/physiology  Autism Spectrum Disorder/diagnosis/epidemiology/physiopathology  Body Mass Index  Child  Female  Humans  Longitudinal Studies  Male  Pediatric Obesity/diagnosis/epidemiology/physiopathology  Adolescence  Autism  Bmi  Puberty  authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : Adolescence is a time of exceptional physical health juxtaposed against significant psychosocial and weight-related problems. The study included 241, 10-to-13-year-old youth with autism spectrum disorder (ASD, N?=?138) or typical development (TD, N?=?103). Standardized exams measured pubertal development, height (HT), weight (WT), heart rate (HR), blood pressure (BP) and Body Mass Index (BMI). Analysis of Variance showed no significant between-group differences for HT, WT, HR, or BP (all p?>?0.05). There was a significant difference in BMI-percentile between the groups (F(1,234)?=?6.05, p?=?0.01). Using hierarchical linear regression, significant predictors of BMI-percentile included diagnosis, pubertal stage and socioeconomic status. Pre-to-early pubescent children with ASD evidence higher BMI percentiles compared to youth with TD suggesting they may be at heightened risk for weight-related health concerns. En ligne : http://dx.doi.org/10.1007/s10803-020-04749-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] Differences in Body Mass Index (BMI) in Early Adolescents with Autism Spectrum Disorder Compared to Youth with Typical Development [Texte imprimé et/ou numérique] / B. A. CORBETT, Auteur ; R. A. MUSCATELLO, Auteur ; B. K. HORROCKS, Auteur ; M. E. KLEMENCIC, Auteur ; Yasas TANGUTURI, Auteur . - p.2790-2799. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-8 (August 2021) . - p.2790-2799 Mots-clés : Adolescent  Adolescent Development/physiology  Autism Spectrum Disorder/diagnosis/epidemiology/physiopathology  Body Mass Index  Child  Female  Humans  Longitudinal Studies  Male  Pediatric Obesity/diagnosis/epidemiology/physiopathology  Adolescence  Autism  Bmi  Puberty  authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : Adolescence is a time of exceptional physical health juxtaposed against significant psychosocial and weight-related problems. The study included 241, 10-to-13-year-old youth with autism spectrum disorder (ASD, N?=?138) or typical development (TD, N?=?103). Standardized exams measured pubertal development, height (HT), weight (WT), heart rate (HR), blood pressure (BP) and Body Mass Index (BMI). Analysis of Variance showed no significant between-group differences for HT, WT, HR, or BP (all p?>?0.05). There was a significant difference in BMI-percentile between the groups (F(1,234)?=?6.05, p?=?0.01). Using hierarchical linear regression, significant predictors of BMI-percentile included diagnosis, pubertal stage and socioeconomic status. Pre-to-early pubescent children with ASD evidence higher BMI percentiles compared to youth with TD suggesting they may be at heightened risk for weight-related health concerns. En ligne : http://dx.doi.org/10.1007/s10803-020-04749-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Examining associations between anxiety and cortisol in high functioning male children with autism / D. M. SIMON in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

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Examining the relationship between face processing and social interaction behavior in children with and without autism spectrum disorder / B. A. CORBETT in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)  

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Job interview training targeting nonverbal communication using an android robot for individuals with autism spectrum disorder / H. KUMAZAKI in Autism, 23-6 (August 2019)  

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Pubertal Development Measurement in Children With and Without Autism Spectrum Disorder: A Comparison Between Physical Exam, Parent- and Self-Report / B. A. CORBETT in Journal of Autism and Developmental Disorders, 49-12 (December 2019)  

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Social competence in autism: A structural equation modeling approach / G. L. SIMMONS in Autism Research, 17-4 (April 2024)  

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The impact of COVID-19 on stress, anxiety, and coping in youth with and without autism and their parents / B. A. CORBETT in Autism Research, 14-7 (July 2021)  

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