Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development / Eric RUBENSTEIN in Autism, 23-2 (February 2019)  

Public ISBD [article]  inAutism > 23-2 (February 2019) . - p.436-448 Titre : Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development Type de document : texte imprimé Auteurs : Eric RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; Catherine BRADLEY, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Eric J. MOODY, Auteur ; Juhi PANDEY, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Annie G. HOWARD, Auteur ; Andrew F. OLSHAN, Auteur ; Brian W. PENCE, Auteur ; Jena DANIELS, Auteur Article en page(s) : p.436-448 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotypes  subgrouping Index. décimale : PER Périodiques Résumé : The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. En ligne : http://dx.doi.org/10.1177/1362361317753563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383 [article] Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development [texte imprimé] / Eric RUBENSTEIN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; Catherine BRADLEY, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Eric J. MOODY, Auteur ; Juhi PANDEY, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Annie G. HOWARD, Auteur ; Andrew F. OLSHAN, Auteur ; Brian W. PENCE, Auteur ; Jena DANIELS, Auteur . - p.436-448. Langues : Anglais (eng) in Autism > 23-2 (February 2019) . - p.436-448 Mots-clés : autism spectrum disorder  broader autism phenotype  endophenotypes  subgrouping Index. décimale : PER Périodiques Résumé : The autism spectrum disorder phenotype varies by social and communication ability and co-occurring developmental, behavioral, and medical conditions. Etiology is also diverse, with myriad potential genetic origins and environmental risk factors. Examining the influence of parental broader autism phenotype-a set of sub-clinical characteristics of autism spectrum disorder-on child autism spectrum disorder phenotypes may help reduce heterogeneity in potential genetic predisposition for autism spectrum disorder. We assessed the associations between parental broader autism phenotype and child phenotype among children of age 30-68 months enrolled in the Study to Explore Early Development (N = 707). Child autism spectrum disorder phenotype was defined by a replication of latent classes derived from multiple developmental and behavioral measures: Mild Language Delay with Cognitive Rigidity, Mild Language and Motor Delay with Dysregulation (e.g. anxiety/depression), General Developmental Delay, and Significant Developmental Delay with Repetitive Motor Behaviors. Scores on the Social Responsiveness Scale-Adult measured parent broader autism phenotype. Broader autism phenotype in at least one parent was associated with a child having increased odds of being classified as mild language and motor delay with dysregulation compared to significant developmental delay with repetitive motor behaviors (odds ratio: 2.44; 95% confidence interval: 1.16, 5.09). Children of parents with broader autism phenotype were more likely to have a phenotype qualitatively similar to broader autism phenotype presentation; this may have implications for etiologic research. En ligne : http://dx.doi.org/10.1177/1362361317753563 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=383

Autism Spectrum Disorder Identification, Diagnosis, and Navigation of Services: Learning From the Voices of Caregivers / Elizabeth R. CRAIS in Focus on Autism and Other Developmental Disabilities, 35-4 (December 2020)  

Public ISBD [article]  inFocus on Autism and Other Developmental Disabilities > 35-4 (December 2020) . - p.246-256 Titre : Autism Spectrum Disorder Identification, Diagnosis, and Navigation of Services: Learning From the Voices of Caregivers Type de document : texte imprimé Auteurs : Elizabeth R. CRAIS, Auteur ; Cara S. MCCOMISH, Auteur ; Emily F. KERTCHER, Auteur ; Steve HOOPER, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Lucia MENDEZ, Auteur ; Michelle VILLALOBOS, Auteur Article en page(s) : p.246-256 Langues : Anglais (eng) Mots-clés : ASD  caregiver perspectives  screening  diagnosis  access  service systems Index. décimale : PER Périodiques Résumé : This study explored caregivers’ perspectives on facilitators and barriers to screening, diagnosis, and identifying and accessing other services for young children with autism spectrum disorder (ASD); and caregivers’ suggestions for improving the process. Eight focus groups with 55 caregivers were conducted. Four groups had a mix of White, African American, and Asian caregivers, and to gain broader populations, we recruited two groups of Spanish-speaking and two groups of American Indian caregivers. Some caregivers reported that their child and they received excellent services; however, the majority reported concerns about the services they and their child received. The findings also indicated a lower age of diagnosis and a smaller gap between concerns and diagnosis for White non-Hispanic children compared with Hispanic non-White children. Caregivers had many suggestions for ways to improve the process. En ligne : http://dx.doi.org/10.1177/1088357620922165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Autism Spectrum Disorder Identification, Diagnosis, and Navigation of Services: Learning From the Voices of Caregivers [texte imprimé] / Elizabeth R. CRAIS, Auteur ; Cara S. MCCOMISH, Auteur ; Emily F. KERTCHER, Auteur ; Steve HOOPER, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Lucia MENDEZ, Auteur ; Michelle VILLALOBOS, Auteur . - p.246-256. Langues : Anglais (eng) in Focus on Autism and Other Developmental Disabilities > 35-4 (December 2020) . - p.246-256 Mots-clés : ASD  caregiver perspectives  screening  diagnosis  access  service systems Index. décimale : PER Périodiques Résumé : This study explored caregivers’ perspectives on facilitators and barriers to screening, diagnosis, and identifying and accessing other services for young children with autism spectrum disorder (ASD); and caregivers’ suggestions for improving the process. Eight focus groups with 55 caregivers were conducted. Four groups had a mix of White, African American, and Asian caregivers, and to gain broader populations, we recruited two groups of Spanish-speaking and two groups of American Indian caregivers. Some caregivers reported that their child and they received excellent services; however, the majority reported concerns about the services they and their child received. The findings also indicated a lower age of diagnosis and a smaller gap between concerns and diagnosis for White non-Hispanic children compared with Hispanic non-White children. Caregivers had many suggestions for ways to improve the process. En ligne : http://dx.doi.org/10.1177/1088357620922165 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

A Distinct Three-Factor Structure of Restricted and Repetitive Behaviors in an Epidemiologically Sound Sample of Preschool-Age Children with Autism Spectrum Disorder / Laura HIRUMA in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3456-3468 Titre : A Distinct Three-Factor Structure of Restricted and Repetitive Behaviors in an Epidemiologically Sound Sample of Preschool-Age Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Laura HIRUMA, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Amanda L. TAPIA, Auteur ; James W. BODFISH, Auteur ; Catherine BRADLEY, Auteur ; Lisa D. WIGGINS, Auteur ; Melanie HSU, Auteur ; Li-Ching LEE, Auteur ; Susan E. LEVY, Auteur ; Jena DANIELS, Auteur Article en page(s) : p.3456-3468 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Child  Child, Preschool  Cognition  Factor Analysis, Statistical  Humans  Stereotyped Behavior  Autism spectrum disorder (ASD)  Exploratory factor analysis  Preschool children  Restricted and repetitive behaviors (RRB) Index. décimale : PER Périodiques Résumé : Prior studies investigating restricted and repetitive behavior (RRB) subtypes within autism spectrum disorder (ASD) have found varied factor structures for symptom groupings, in part, due to variation in symptom measurement and broad sample age ranges. This study examined RRBs among 827 preschool-age children, ages 35 to 71 months, through an exploratory factor analysis of RRB items from the Autism Diagnostic Interview-Revised (ADI-R) collected through the Study to Explore Early Development. The factor structures of RRBs among children with confirmed ASD versus those with non-autism developmental concerns were qualitatively compared. Correlations between RRB factors and participant characteristics were examined in the ASD group. Three conceptually well-defined factors characterized as repetitive sensorimotor behaviors (RSMB), insistence on sameness (IS), and a novel stereotyped speech (SPEECH) factor emerged for the ASD group only. Distinct factors were supported by different clinical correlates. Findings have implications for improving differential diagnosis and understanding of ASD symptomatology in this age range. En ligne : http://dx.doi.org/10.1007/s10803-020-04776-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] A Distinct Three-Factor Structure of Restricted and Repetitive Behaviors in an Epidemiologically Sound Sample of Preschool-Age Children with Autism Spectrum Disorder [texte imprimé] / Laura HIRUMA, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Amanda L. TAPIA, Auteur ; James W. BODFISH, Auteur ; Catherine BRADLEY, Auteur ; Lisa D. WIGGINS, Auteur ; Melanie HSU, Auteur ; Li-Ching LEE, Auteur ; Susan E. LEVY, Auteur ; Jena DANIELS, Auteur . - p.3456-3468. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3456-3468 Mots-clés : Autism Spectrum Disorder/diagnosis/epidemiology  Autistic Disorder  Child  Child, Preschool  Cognition  Factor Analysis, Statistical  Humans  Stereotyped Behavior  Autism spectrum disorder (ASD)  Exploratory factor analysis  Preschool children  Restricted and repetitive behaviors (RRB) Index. décimale : PER Périodiques Résumé : Prior studies investigating restricted and repetitive behavior (RRB) subtypes within autism spectrum disorder (ASD) have found varied factor structures for symptom groupings, in part, due to variation in symptom measurement and broad sample age ranges. This study examined RRBs among 827 preschool-age children, ages 35 to 71 months, through an exploratory factor analysis of RRB items from the Autism Diagnostic Interview-Revised (ADI-R) collected through the Study to Explore Early Development. The factor structures of RRBs among children with confirmed ASD versus those with non-autism developmental concerns were qualitatively compared. Correlations between RRB factors and participant characteristics were examined in the ASD group. Three conceptually well-defined factors characterized as repetitive sensorimotor behaviors (RSMB), insistence on sameness (IS), and a novel stereotyped speech (SPEECH) factor emerged for the ASD group only. Distinct factors were supported by different clinical correlates. Findings have implications for improving differential diagnosis and understanding of ASD symptomatology in this age range. En ligne : http://dx.doi.org/10.1007/s10803-020-04776-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Family Experiences with the Diagnosis of Autism Spectrum Disorder: System Barriers and Facilitators of Efficient Diagnosis / M. MARTINEZ in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2368-2378 Titre : Family Experiences with the Diagnosis of Autism Spectrum Disorder: System Barriers and Facilitators of Efficient Diagnosis Type de document : texte imprimé Auteurs : M. MARTINEZ, Auteur ; Kathleen C. THOMAS, Auteur ; C.S. WILLIAMS, Auteur ; R. CHRISTIAN, Auteur ; Elizabeth R. CRAIS, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Stephen R. HOOPER, Auteur Article en page(s) : p.2368-2378 Langues : Anglais (eng) Mots-clés : Age at diagnosis  Autism  Policy Index. décimale : PER Périodiques Résumé : This paper examines family experiences with the efficiency of ASD diagnosis. Children were age 8 or younger with ASD (n = 450). Outcomes were delay from first parent concern to diagnosis, shifting diagnoses, and being told child did not have ASD. Predictors were screening, travel distance, and problems finding providers. Logit models were used to examine associations. Screening was associated with reduced delay in diagnosis; problems finding providers were associated with greater delay. Screening, travel distance, and delay in diagnosis were associated with shifting diagnoses and being told child did not have ASD. Physician and parent training in communication and addressing mental health professional shortages and maldistribution may improve the diagnosis experiences of families of children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3493-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Family Experiences with the Diagnosis of Autism Spectrum Disorder: System Barriers and Facilitators of Efficient Diagnosis [texte imprimé] / M. MARTINEZ, Auteur ; Kathleen C. THOMAS, Auteur ; C.S. WILLIAMS, Auteur ; R. CHRISTIAN, Auteur ; Elizabeth R. CRAIS, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; Stephen R. HOOPER, Auteur . - p.2368-2378. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-7 (July 2018) . - p.2368-2378 Mots-clés : Age at diagnosis  Autism  Policy Index. décimale : PER Périodiques Résumé : This paper examines family experiences with the efficiency of ASD diagnosis. Children were age 8 or younger with ASD (n = 450). Outcomes were delay from first parent concern to diagnosis, shifting diagnoses, and being told child did not have ASD. Predictors were screening, travel distance, and problems finding providers. Logit models were used to examine associations. Screening was associated with reduced delay in diagnosis; problems finding providers were associated with greater delay. Screening, travel distance, and delay in diagnosis were associated with shifting diagnoses and being told child did not have ASD. Physician and parent training in communication and addressing mental health professional shortages and maldistribution may improve the diagnosis experiences of families of children with ASD. En ligne : http://dx.doi.org/10.1007/s10803-018-3493-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development / Lisa D. WIGGINS in Journal of Autism and Developmental Disorders, 47-11 (November 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3634-3645 Titre : Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development Type de document : texte imprimé Auteurs : Lisa D. WIGGINS, Auteur ; Lin H. TIAN, Auteur ; Susan E. LEVY, Auteur ; Catherine E. RICE, Auteur ; Li-Ching LEE, Auteur ; Laura A. SCHIEVE, Auteur ; Juhi PANDEY, Auteur ; Jena DANIELS, Auteur ; Lisa BLASKEY, Auteur ; Susan HEPBURN, Auteur ; Rebecca LANDA, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; William THOMPSON, Auteur Article en page(s) : p.3634-3645 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Characterization  Phenotypes  Subgroups Index. décimale : PER Périodiques Résumé : The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. En ligne : http://dx.doi.org/10.1007/s10803-017-3280-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325 [article] Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development [texte imprimé] / Lisa D. WIGGINS, Auteur ; Lin H. TIAN, Auteur ; Susan E. LEVY, Auteur ; Catherine E. RICE, Auteur ; Li-Ching LEE, Auteur ; Laura A. SCHIEVE, Auteur ; Juhi PANDEY, Auteur ; Jena DANIELS, Auteur ; Lisa BLASKEY, Auteur ; Susan HEPBURN, Auteur ; Rebecca LANDA, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; William THOMPSON, Auteur . - p.3634-3645. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3634-3645 Mots-clés : Autism  Autism spectrum disorder  Characterization  Phenotypes  Subgroups Index. décimale : PER Périodiques Résumé : The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. En ligne : http://dx.doi.org/10.1007/s10803-017-3280-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325

The Broader Autism Phenotype in Mothers is Associated with Increased Discordance Between Maternal-Reported and Clinician-Observed Instruments that Measure Child Autism Spectrum Disorder / Eric RUBENSTEIN in Journal of Autism and Developmental Disorders, 47-10 (October 2017)  

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