Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function / Eleni A. DEMETRIOU in Autism, 25-8 (November 2021)  

Public ISBD [article]  inAutism > 25-8 (November 2021) . - p.2223-2237 Titre : Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function Type de document : Texte imprimé et/ou numérique Auteurs : Eleni A. DEMETRIOU, Auteur ; K. L. PEPPER, Auteur ; S. H. PARK, Auteur ; L. PELLICANO, Auteur ; Y. J. C. SONG, Auteur ; S. L. NAISMITH, Auteur ; I. B. HICKIE, Auteur ; E. E. THOMAS, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : p.2223-2237 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Cognition  Executive Function  Female  Humans  Male  Neuropsychological Tests  Self Report  Sex Characteristics  Behavioural Rating Inventory of Executive Function  Cambridge Neuropsychological Test Automated Battery  autism spectrum disorder  executive function  sex differences Index. décimale : PER Périodiques Résumé : Research comparing females and males with a diagnosis of autism suggests that there are sex differences in some characteristics such as behaviour regulation. One area not studied in detail is whether females and males with autism perform differently in tests of cognitive ability. The results of previous research are quite mixed. One explanation may be that some research comparing females and males with autism did not include a neurotypical control group for comparison. As a result, it is not clear whether the sex differences in cognitive ability observed in people with autism are similar to differences between neurotypical males and females. To better understand whether there are unique differences between males and females with autism, it is important to also compare them with neurotypical males and females. In our research, we included a neurotypical group and compared males and females with and without a diagnosis of autism. We found that the sex differences in autism are similar to what we observe in males and females without autism. Our study showed that compared with males, females (with and without autism) do better in assessments of processing speed, cognitive flexibility, verbal learning and memory and semantic fluency. Our results suggest that although females show different cognitive performance to males, these sex differences were not specific to the group with a diagnosis of autism. En ligne : http://dx.doi.org/10.1177/13623613211014991 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Autism spectrum disorder: An examination of sex differences in neuropsychological and self-report measures of executive and non-executive cognitive function [Texte imprimé et/ou numérique] / Eleni A. DEMETRIOU, Auteur ; K. L. PEPPER, Auteur ; S. H. PARK, Auteur ; L. PELLICANO, Auteur ; Y. J. C. SONG, Auteur ; S. L. NAISMITH, Auteur ; I. B. HICKIE, Auteur ; E. E. THOMAS, Auteur ; A. J. GUASTELLA, Auteur . - p.2223-2237. Langues : Anglais (eng) in Autism > 25-8 (November 2021) . - p.2223-2237 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Cognition  Executive Function  Female  Humans  Male  Neuropsychological Tests  Self Report  Sex Characteristics  Behavioural Rating Inventory of Executive Function  Cambridge Neuropsychological Test Automated Battery  autism spectrum disorder  executive function  sex differences Index. décimale : PER Périodiques Résumé : Research comparing females and males with a diagnosis of autism suggests that there are sex differences in some characteristics such as behaviour regulation. One area not studied in detail is whether females and males with autism perform differently in tests of cognitive ability. The results of previous research are quite mixed. One explanation may be that some research comparing females and males with autism did not include a neurotypical control group for comparison. As a result, it is not clear whether the sex differences in cognitive ability observed in people with autism are similar to differences between neurotypical males and females. To better understand whether there are unique differences between males and females with autism, it is important to also compare them with neurotypical males and females. In our research, we included a neurotypical group and compared males and females with and without a diagnosis of autism. We found that the sex differences in autism are similar to what we observe in males and females without autism. Our study showed that compared with males, females (with and without autism) do better in assessments of processing speed, cognitive flexibility, verbal learning and memory and semantic fluency. Our results suggest that although females show different cognitive performance to males, these sex differences were not specific to the group with a diagnosis of autism. En ligne : http://dx.doi.org/10.1177/13623613211014991 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder / A. MASI in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 63p. Titre : Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. MASI, Auteur ; E. J. BREEN, Auteur ; Gail A. ALVARES, Auteur ; N. GLOZIER, Auteur ; I. B. HICKIE, Auteur ; A. HUNT, Auteur ; J. HUI, Auteur ; J. BEILBY, Auteur ; D. RAVINE, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : 63p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Behavior  Cytokine  Pediatric  Severity Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding of the biological mechanisms driving pathophysiology is evolving. Immune system aberrations, as identified through cytokine profiles, are believed to have a role in ASD. Altered cytokine levels may facilitate identification of ASD subtypes as well as provide biological markers of response to effective treatments. Research exploring the relationship between cytokine profiles and ASD symptoms is, however, in its infancy. The objective of this study was to explore relationships between cytokine levels and the severity of ASD and other clinical traits. Methods: Multiplex assay techniques were used to measure levels of 27 cytokines in plasma samples from a cohort of 144 children diagnosed with ASD. Results: Overall, results showed a significant negative association between platelet-derived growth factor (PDGF)-BB, and the severity of ASD symptoms. Furthermore, a significant interaction with sex suggested a different immune profile for females compared to males. ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1beta, IL-8, MIP-1beta, and VEGF, in females, but not in males. Conclusions: Results of the present study suggest that an altered cytokine response or profile is associated with the severity of ASD-related symptoms, with sex a potential modifier of this relationship. Further research in larger populations which recognizes the importance of sex comparisons and longitudinal assessments are now required to extend and further describe the role of the immune system in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0176-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Cytokine levels and associations with symptom severity in male and female children with autism spectrum disorder [Texte imprimé et/ou numérique] / A. MASI, Auteur ; E. J. BREEN, Auteur ; Gail A. ALVARES, Auteur ; N. GLOZIER, Auteur ; I. B. HICKIE, Auteur ; A. HUNT, Auteur ; J. HUI, Auteur ; J. BEILBY, Auteur ; D. RAVINE, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; A. J. GUASTELLA, Auteur . - 63p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 63p. Mots-clés : Autism spectrum disorder  Behavior  Cytokine  Pediatric  Severity Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorders (ASDs) are complex, pervasive, and heterogeneous neurodevelopmental conditions with varying trajectories, significant male bias and largely unknown etiology. However, an understanding of the biological mechanisms driving pathophysiology is evolving. Immune system aberrations, as identified through cytokine profiles, are believed to have a role in ASD. Altered cytokine levels may facilitate identification of ASD subtypes as well as provide biological markers of response to effective treatments. Research exploring the relationship between cytokine profiles and ASD symptoms is, however, in its infancy. The objective of this study was to explore relationships between cytokine levels and the severity of ASD and other clinical traits. Methods: Multiplex assay techniques were used to measure levels of 27 cytokines in plasma samples from a cohort of 144 children diagnosed with ASD. Results: Overall, results showed a significant negative association between platelet-derived growth factor (PDGF)-BB, and the severity of ASD symptoms. Furthermore, a significant interaction with sex suggested a different immune profile for females compared to males. ASD symptom severity was negatively associated with levels of 4 cytokines, IL-1beta, IL-8, MIP-1beta, and VEGF, in females, but not in males. Conclusions: Results of the present study suggest that an altered cytokine response or profile is associated with the severity of ASD-related symptoms, with sex a potential modifier of this relationship. Further research in larger populations which recognizes the importance of sex comparisons and longitudinal assessments are now required to extend and further describe the role of the immune system in ASD. En ligne : http://dx.doi.org/10.1186/s13229-017-0176-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress / S. H. PARK in Autism, 23-7 (October 2019)  

Public ISBD [article]  inAutism > 23-7 (October 2019) . - p.1675-1686 Titre : Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress Type de document : Texte imprimé et/ou numérique Auteurs : S. H. PARK, Auteur ; Y. J. C. SONG, Auteur ; Eleni A. DEMETRIOU, Auteur ; K. L. PEPPER, Auteur ; A. NORTON, Auteur ; E. E. THOMAS, Auteur ; I. B. HICKIE, Auteur ; D. F. HERMENS, Auteur ; N. GLOZIER, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : p.1675-1686 Langues : Anglais (eng) Mots-clés : developmental disorders  distress  health services  mental health  treatment  well being Index. décimale : PER Périodiques Résumé : In this study, we consecutively recruited treatment-seeking young autistic adults without intellectual impairment aged 16-30 years who presented to a mental health service and evaluated general health (distress, quality of life, and disability), functioning (work loss days and social functioning), and mood symptoms (depression, anxiety, and stress) in those diagnosed with autism spectrum disorder (n = 96). This group was compared to young adults presenting to the same service with primary mental health disorders (depression, n = 343; bipolar, n = 132; psychosis, n = 166; and anxiety, n = 303). This study also investigated the influence of mood symptoms on general health and functioning in the autism spectrum disorder group. Young autistic adults reported significant general health and functioning impairments that were of similar degree to those presenting with primary mental health disorders. Interestingly, the autistic group also reported similarly high levels of mood symptoms to those with primary depressive and anxiety disorders. In the autistic group, depressive symptoms were strongly associated with distress, quality of life, and work loss days, while stress symptoms were strongly associated with disability. This study highlights further research, and mental health services are required specifically targeting young autistic adults to address their significant unmet needs. En ligne : http://dx.doi.org/10.1177/1362361318823925 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406 [article] Disability, functioning, and quality of life among treatment-seeking young autistic adults and its relation to depression, anxiety, and stress [Texte imprimé et/ou numérique] / S. H. PARK, Auteur ; Y. J. C. SONG, Auteur ; Eleni A. DEMETRIOU, Auteur ; K. L. PEPPER, Auteur ; A. NORTON, Auteur ; E. E. THOMAS, Auteur ; I. B. HICKIE, Auteur ; D. F. HERMENS, Auteur ; N. GLOZIER, Auteur ; A. J. GUASTELLA, Auteur . - p.1675-1686. Langues : Anglais (eng) in Autism > 23-7 (October 2019) . - p.1675-1686 Mots-clés : developmental disorders  distress  health services  mental health  treatment  well being Index. décimale : PER Périodiques Résumé : In this study, we consecutively recruited treatment-seeking young autistic adults without intellectual impairment aged 16-30 years who presented to a mental health service and evaluated general health (distress, quality of life, and disability), functioning (work loss days and social functioning), and mood symptoms (depression, anxiety, and stress) in those diagnosed with autism spectrum disorder (n = 96). This group was compared to young adults presenting to the same service with primary mental health disorders (depression, n = 343; bipolar, n = 132; psychosis, n = 166; and anxiety, n = 303). This study also investigated the influence of mood symptoms on general health and functioning in the autism spectrum disorder group. Young autistic adults reported significant general health and functioning impairments that were of similar degree to those presenting with primary mental health disorders. Interestingly, the autistic group also reported similarly high levels of mood symptoms to those with primary depressive and anxiety disorders. In the autistic group, depressive symptoms were strongly associated with distress, quality of life, and work loss days, while stress symptoms were strongly associated with disability. This study highlights further research, and mental health services are required specifically targeting young autistic adults to address their significant unmet needs. En ligne : http://dx.doi.org/10.1177/1362361318823925 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=406

Evidence of a reduced role for circumscribed interests in the social attention patterns of children with Autism Spectrum Disorder / Z. AMBARCHI in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3999-4011 Titre : Evidence of a reduced role for circumscribed interests in the social attention patterns of children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Z. AMBARCHI, Auteur ; K. A. BOULTON, Auteur ; R. THAPA, Auteur ; E. E. THOMAS, Auteur ; M. M. DEMAYO, Auteur ; N. J. SASSON, Auteur ; I. B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur Article en page(s) : p.3999-4011 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Reduced social attention is characteristic of Autism Spectrum Disorder (ASD). It has been suggested to result from an early onset and excessive influence of circumscribed interests (CIs) on gaze behaviour, compared to typically developing (TYP) individuals. To date, these findings have been mixed. The current eye-tracking study utilised a visual preference paradigm to investigate the influence of CI versus non-CI objects on attention patterns in children with ASD (aged 3-12 years, n=37) and their age-matched TYP peers (n=30). Compared to TYP, social and object attention was reduced in the ASD group irrespective of the presence of CIs. Results suggest a reduced role for CIs and extend recent evidence of atypical attention patterns across social and non-social domains in ASD. En ligne : https://doi.org/10.1007/s10803-022-05638-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] Evidence of a reduced role for circumscribed interests in the social attention patterns of children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Z. AMBARCHI, Auteur ; K. A. BOULTON, Auteur ; R. THAPA, Auteur ; E. E. THOMAS, Auteur ; M. M. DEMAYO, Auteur ; N. J. SASSON, Auteur ; I. B. HICKIE, Auteur ; Adam J. GUASTELLA, Auteur . - p.3999-4011. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3999-4011 Index. décimale : PER Périodiques Résumé : Reduced social attention is characteristic of Autism Spectrum Disorder (ASD). It has been suggested to result from an early onset and excessive influence of circumscribed interests (CIs) on gaze behaviour, compared to typically developing (TYP) individuals. To date, these findings have been mixed. The current eye-tracking study utilised a visual preference paradigm to investigate the influence of CI versus non-CI objects on attention patterns in children with ASD (aged 3-12 years, n=37) and their age-matched TYP peers (n=30). Compared to TYP, social and object attention was reduced in the ASD group irrespective of the presence of CIs. Results suggest a reduced role for CIs and extend recent evidence of atypical attention patterns across social and non-social domains in ASD. En ligne : https://doi.org/10.1007/s10803-022-05638-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Perceptions of social and work functioning are related to social anxiety and executive function in autistic adults / A. WOOLARD in Autism, 25-7 (October 2021)  

Public ISBD [article]  inAutism > 25-7 (October 2021) . - p.2124-2134 Titre : Perceptions of social and work functioning are related to social anxiety and executive function in autistic adults Type de document : Texte imprimé et/ou numérique Auteurs : A. WOOLARD, Auteur ; E. STRATTON, Auteur ; Eleni A. DEMETRIOU, Auteur ; Kelsie A. BOULTON, Auteur ; E. PELLICANO, Auteur ; N. GLOZIER, Auteur ; V. GIBBS, Auteur ; N. ROGERSON, Auteur ; P. QUINN, Auteur ; I. B. HICKIE, Auteur ; A. J. GUASTELLA, Auteur Article en page(s) : p.2124-2134 Langues : Anglais (eng) Mots-clés : Adult  Anxiety  Autism Spectrum Disorder  Autistic Disorder  Executive Function  Humans  Perception  executive function  functional ability  social anxiety  social functioning  work functioning Index. décimale : PER Périodiques Résumé : Many autistic adults have trouble in social situations and at work. Researchers do not know exactly why autistic people might find it difficult in these environments, and no studies to date have looked the way anxiety or other cognitive processes might affect autistic peoples' ability to socialise and succeed in getting and keeping jobs. Anxiety (how much you worry) and difficulty with getting stuff done or switching attention (known as executive function) can be concerns for autistic people and may contribute to social and work difficulties. This study looked at the relationships between the way autistic people perceived their anxiety and executive functioning and their ability to socialise and work. Sixty-two autistic participants completed questionnaires related to their ability to socialise and work, their social anxiety and their executive function. We found that participants who thought that they had poorer ability to work also found themselves to have more difficulties with executive function and they were more socially anxious. Our results showed that how autistic participants perceived their social anxiety and executive function were important in their perception of their social skills and work ability. This study supports the idea that anxiety and executive function could be targeted in interventions to support autistic people and their social and work outcomes. En ligne : http://dx.doi.org/10.1177/13623613211013664 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Perceptions of social and work functioning are related to social anxiety and executive function in autistic adults [Texte imprimé et/ou numérique] / A. WOOLARD, Auteur ; E. STRATTON, Auteur ; Eleni A. DEMETRIOU, Auteur ; Kelsie A. BOULTON, Auteur ; E. PELLICANO, Auteur ; N. GLOZIER, Auteur ; V. GIBBS, Auteur ; N. ROGERSON, Auteur ; P. QUINN, Auteur ; I. B. HICKIE, Auteur ; A. J. GUASTELLA, Auteur . - p.2124-2134. Langues : Anglais (eng) in Autism > 25-7 (October 2021) . - p.2124-2134 Mots-clés : Adult  Anxiety  Autism Spectrum Disorder  Autistic Disorder  Executive Function  Humans  Perception  executive function  functional ability  social anxiety  social functioning  work functioning Index. décimale : PER Périodiques Résumé : Many autistic adults have trouble in social situations and at work. Researchers do not know exactly why autistic people might find it difficult in these environments, and no studies to date have looked the way anxiety or other cognitive processes might affect autistic peoples' ability to socialise and succeed in getting and keeping jobs. Anxiety (how much you worry) and difficulty with getting stuff done or switching attention (known as executive function) can be concerns for autistic people and may contribute to social and work difficulties. This study looked at the relationships between the way autistic people perceived their anxiety and executive functioning and their ability to socialise and work. Sixty-two autistic participants completed questionnaires related to their ability to socialise and work, their social anxiety and their executive function. We found that participants who thought that they had poorer ability to work also found themselves to have more difficulties with executive function and they were more socially anxious. Our results showed that how autistic participants perceived their social anxiety and executive function were important in their perception of their social skills and work ability. This study supports the idea that anxiety and executive function could be targeted in interventions to support autistic people and their social and work outcomes. En ligne : http://dx.doi.org/10.1177/13623613211013664 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Reduced heart rate variability in adults with autism spectrum disorder / R. THAPA in Autism Research, 12-6 (June 2019)  

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Replication of the psychometric properties of the WHODAS-II in individuals with autism spectrum disorder / S. H. PARK in Autism Research, 12-12 (December)  

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The Feasibility of Magnetic Resonance Imaging in a Non-Selective Comprehensive Clinical Trial in Pediatric Autism Spectrum Disorder / Marilena M. DEMAYO in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

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Validation of the 36-item and 12-item self-report World Health Organization Disability Assessment Schedule II (WHODAS-II) in individuals with autism spectrum disorder / S. H. PARK in Autism Research, 12-7 (July 2019)  

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