Appropriateness of the TOBY Application, an iPad Intervention for Children with Autism Spectrum Disorder: A Thematic Approach / D. PARSONS in Journal of Autism and Developmental Disorders, 49-10 (October 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-10 (October 2019) . - p.4053-4066 Titre : Appropriateness of the TOBY Application, an iPad Intervention for Children with Autism Spectrum Disorder: A Thematic Approach Type de document : Texte imprimé et/ou numérique Auteurs : D. PARSONS, Auteur ; Nathan J. WILSON, Auteur ; S. VAZ, Auteur ; H. LEE, Auteur ; R. CORDIER, Auteur Article en page(s) : p.4053-4066 Langues : Anglais (eng) Mots-clés : Appropriateness  Early intervention  Information technology Index. décimale : PER Périodiques Résumé : This study aimed to explore the appropriateness of an ICT intervention, the Therapeutic Outcomes by You application (TOBY app), from the perspectives of the parents. Parental experiences of twenty-four parents of a child with ASD who had participated in a three-month trial using the TOBY app were collected using semi-structured interviews. Thematic analysis was conducted and themes were mapped against an appropriateness framework. Collectively, parents felt the TOBY app was relevant and important to them and their children's needs, while expressing partial support of the TOBY app as: a positive experience for them and their children, beneficial for them and their children, a socially and ecological valid intervention, and an intervention that supported change and continuation in the skills learnt. En ligne : http://dx.doi.org/10.1007/s10803-019-04115-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407 [article] Appropriateness of the TOBY Application, an iPad Intervention for Children with Autism Spectrum Disorder: A Thematic Approach [Texte imprimé et/ou numérique] / D. PARSONS, Auteur ; Nathan J. WILSON, Auteur ; S. VAZ, Auteur ; H. LEE, Auteur ; R. CORDIER, Auteur . - p.4053-4066. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-10 (October 2019) . - p.4053-4066 Mots-clés : Appropriateness  Early intervention  Information technology Index. décimale : PER Périodiques Résumé : This study aimed to explore the appropriateness of an ICT intervention, the Therapeutic Outcomes by You application (TOBY app), from the perspectives of the parents. Parental experiences of twenty-four parents of a child with ASD who had participated in a three-month trial using the TOBY app were collected using semi-structured interviews. Thematic analysis was conducted and themes were mapped against an appropriateness framework. Collectively, parents felt the TOBY app was relevant and important to them and their children's needs, while expressing partial support of the TOBY app as: a positive experience for them and their children, beneficial for them and their children, a socially and ecological valid intervention, and an intervention that supported change and continuation in the skills learnt. En ligne : http://dx.doi.org/10.1007/s10803-019-04115-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=407

A Driver Training Program Intervention for Student Drivers with Autism Spectrum Disorder: A Multi-site Randomised Controlled Trial / P. VINDIN in Journal of Autism and Developmental Disorders, 51-10 (October 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3707-3721 Titre : A Driver Training Program Intervention for Student Drivers with Autism Spectrum Disorder: A Multi-site Randomised Controlled Trial Type de document : Texte imprimé et/ou numérique Auteurs : P. VINDIN, Auteur ; R. CORDIER, Auteur ; Nathan J. WILSON, Auteur ; H. LEE, Auteur Article en page(s) : p.3707-3721 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/therapy  Automobile Driving  Behavior Therapy  Humans  Students  Young Adult  Autism spectrum disorder  Community mobility  Driving training  Learner drivers  Transportation Index. décimale : PER Périodiques Résumé : The purpose of this multi-site randomised controlled trial was to evaluate the effectiveness of a Driving Training Program, an intervention designed for student drivers with autism spectrum disorder (ASD). Participants were 72 student drivers with ASD (ages 16-31) who were randomly assigned to an intervention or control group. Student drivers received ten driving lessons with a professional driving instructor via a standardised driving route. The Driving Performance Checklist was used as the outcome measure to evaluate the driving performance of student drivers during on-road pre- and post-observational drives. Both groups showed an improvement in driving performance, however, the extent of improvement between groups was not significant. Findings showed promising intervention efficacy for training student drivers with ASD to drive. En ligne : http://dx.doi.org/10.1007/s10803-020-04825-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453 [article] A Driver Training Program Intervention for Student Drivers with Autism Spectrum Disorder: A Multi-site Randomised Controlled Trial [Texte imprimé et/ou numérique] / P. VINDIN, Auteur ; R. CORDIER, Auteur ; Nathan J. WILSON, Auteur ; H. LEE, Auteur . - p.3707-3721. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-10 (October 2021) . - p.3707-3721 Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/therapy  Automobile Driving  Behavior Therapy  Humans  Students  Young Adult  Autism spectrum disorder  Community mobility  Driving training  Learner drivers  Transportation Index. décimale : PER Périodiques Résumé : The purpose of this multi-site randomised controlled trial was to evaluate the effectiveness of a Driving Training Program, an intervention designed for student drivers with autism spectrum disorder (ASD). Participants were 72 student drivers with ASD (ages 16-31) who were randomly assigned to an intervention or control group. Student drivers received ten driving lessons with a professional driving instructor via a standardised driving route. The Driving Performance Checklist was used as the outcome measure to evaluate the driving performance of student drivers during on-road pre- and post-observational drives. Both groups showed an improvement in driving performance, however, the extent of improvement between groups was not significant. Findings showed promising intervention efficacy for training student drivers with ASD to drive. En ligne : http://dx.doi.org/10.1007/s10803-020-04825-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=453

Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity / N. SARN in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 41 p. Titre : Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity Type de document : Texte imprimé et/ou numérique Auteurs : N. SARN, Auteur ; S. THACKER, Auteur ; H. LEE, Auteur ; C. ENG, Auteur Article en page(s) : 41 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Complement  Microglia  Mouse model  Neurodegeneration  Neuroinflammation  Oxytocin  PTEN mutation  Social impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) has a strong genetic etiology. Germline mutation in the tumor suppressor gene PTEN is one of the best described monogenic risk cases for ASD. Animal modeling of cell-specific Pten loss or mutation has provided insight into how disruptions to the function of PTEN affect neurodevelopment, neurobiology, and social behavior. As such, there is a growing need to understand more about how various aspects of PTEN activity and cell-compartment-specific functions, contribute to certain neurological or behavior phenotypes. METHODS: To understand more about the relationship between Pten localization and downstream effects on neurophenotypes, we generated the nuclear-predominant Pten(Y68H/+) mouse, which is identical to the genotype of some PTEN-ASD individuals. We subjected the Pten(Y68H/+) mouse to morphological and behavioral phenotyping, including the three-chamber sociability, open field, rotarod, and marble burying tests. We subsequently performed in vivo and in vitro cellular phenotyping and concluded the work with a transcriptomic survey of the Pten(Y68H/+) cortex, which profiled gene expression. RESULTS: We observe a significant increase in P-Akt downstream of canonical Pten signaling, macrocephaly, decreased sociability, decreased preference for novel social stimuli, increased repetitive behavior, and increased thigmotaxis in Pten(Y68H/+) six-week-old (P40) mice. In addition, we found significant microglial activation with increased expression of complement and neuroinflammatory proteins in vivo and in vitro accompanied by enhanced phagocytosis. These observations were subsequently validated with RNA-seq and qRT-PCR, which revealed overexpression of many genes involved in neuroinflammation and neuronal function, including oxytocin. Oxytocin transcript was fivefold overexpressed (P?=?0.0018), and oxytocin protein was strongly overexpressed in the Pten(Y68H/+) hypothalamus. CONCLUSIONS: The nuclear-predominant Pten(Y68H/+) model has clarified that Pten dysfunction links to microglial pathology and this associates with increased Akt signaling. We also demonstrate that Pten dysfunction associates with changes in the oxytocin system, an important connection between a prominent ASD risk gene and a potent neuroendocrine regulator of social behavior. These cellular and molecular pathologies may related to the observed changes in social behavior. Ultimately, the findings from this work may reveal important biomarkers and/or novel therapeutic modalities that could be explored in individuals with germline mutations in PTEN with ASD. En ligne : http://dx.doi.org/10.1186/s13229-021-00448-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity [Texte imprimé et/ou numérique] / N. SARN, Auteur ; S. THACKER, Auteur ; H. LEE, Auteur ; C. ENG, Auteur . - 41 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 41 p. Mots-clés : Autism spectrum disorder  Complement  Microglia  Mouse model  Neurodegeneration  Neuroinflammation  Oxytocin  PTEN mutation  Social impairment Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) has a strong genetic etiology. Germline mutation in the tumor suppressor gene PTEN is one of the best described monogenic risk cases for ASD. Animal modeling of cell-specific Pten loss or mutation has provided insight into how disruptions to the function of PTEN affect neurodevelopment, neurobiology, and social behavior. As such, there is a growing need to understand more about how various aspects of PTEN activity and cell-compartment-specific functions, contribute to certain neurological or behavior phenotypes. METHODS: To understand more about the relationship between Pten localization and downstream effects on neurophenotypes, we generated the nuclear-predominant Pten(Y68H/+) mouse, which is identical to the genotype of some PTEN-ASD individuals. We subjected the Pten(Y68H/+) mouse to morphological and behavioral phenotyping, including the three-chamber sociability, open field, rotarod, and marble burying tests. We subsequently performed in vivo and in vitro cellular phenotyping and concluded the work with a transcriptomic survey of the Pten(Y68H/+) cortex, which profiled gene expression. RESULTS: We observe a significant increase in P-Akt downstream of canonical Pten signaling, macrocephaly, decreased sociability, decreased preference for novel social stimuli, increased repetitive behavior, and increased thigmotaxis in Pten(Y68H/+) six-week-old (P40) mice. In addition, we found significant microglial activation with increased expression of complement and neuroinflammatory proteins in vivo and in vitro accompanied by enhanced phagocytosis. These observations were subsequently validated with RNA-seq and qRT-PCR, which revealed overexpression of many genes involved in neuroinflammation and neuronal function, including oxytocin. Oxytocin transcript was fivefold overexpressed (P?=?0.0018), and oxytocin protein was strongly overexpressed in the Pten(Y68H/+) hypothalamus. CONCLUSIONS: The nuclear-predominant Pten(Y68H/+) model has clarified that Pten dysfunction links to microglial pathology and this associates with increased Akt signaling. We also demonstrate that Pten dysfunction associates with changes in the oxytocin system, an important connection between a prominent ASD risk gene and a potent neuroendocrine regulator of social behavior. These cellular and molecular pathologies may related to the observed changes in social behavior. Ultimately, the findings from this work may reveal important biomarkers and/or novel therapeutic modalities that could be explored in individuals with germline mutations in PTEN with ASD. En ligne : http://dx.doi.org/10.1186/s13229-021-00448-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Rigorous Translation and Cultural Adaptation of an Autism Screening Tool: First Years Inventory as a Case Study / M. DUBAY in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3917-3928 Titre : Rigorous Translation and Cultural Adaptation of an Autism Screening Tool: First Years Inventory as a Case Study Type de document : Texte imprimé et/ou numérique Auteurs : M. DUBAY, Auteur ; Linda R. WATSON, Auteur ; Grace T. BARANEK, Auteur ; H. LEE, Auteur ; C. ROJEVIC, Auteur ; W. BRINSON, Auteur ; D. SMITH, Auteur ; J. SIDERIS, Auteur Article en page(s) : p.3917-3928 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  Cross-Cultural Comparison  Humans  Psychometrics  Surveys and Questionnaires  Translating  Translations  Assessment  Autism  Cultural adaptation  Screening  Translation Index. décimale : PER Périodiques Résumé : Screening tools for autism spectrum disorders serve a vital role in early identification of all children who may need evaluation and support. Recent studies suggest that traditional methods used in this field to translate such tools may be insufficient for maintaining linguistic, construct, or technical equivalence, resulting in screening tools that do not meet high psychometric standards in the new population. This study implemented a rigorous translation and cultural adaptation process by translating the First Years Inventory v3.1 (Baranek et al. First year inventory (FYI) 3.1. University of North Carolina at Chapel Hill Chapel Hill, NC, 2003) for a US-based Spanish-speaking population. A description of this process is provided with results from data collected during each phase. The unique challenges that were identified and addressed are detailed for future translation teams. En ligne : http://dx.doi.org/10.1007/s10803-020-04837-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Rigorous Translation and Cultural Adaptation of an Autism Screening Tool: First Years Inventory as a Case Study [Texte imprimé et/ou numérique] / M. DUBAY, Auteur ; Linda R. WATSON, Auteur ; Grace T. BARANEK, Auteur ; H. LEE, Auteur ; C. ROJEVIC, Auteur ; W. BRINSON, Auteur ; D. SMITH, Auteur ; J. SIDERIS, Auteur . - p.3917-3928. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-11 (November 2021) . - p.3917-3928 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  Cross-Cultural Comparison  Humans  Psychometrics  Surveys and Questionnaires  Translating  Translations  Assessment  Autism  Cultural adaptation  Screening  Translation Index. décimale : PER Périodiques Résumé : Screening tools for autism spectrum disorders serve a vital role in early identification of all children who may need evaluation and support. Recent studies suggest that traditional methods used in this field to translate such tools may be insufficient for maintaining linguistic, construct, or technical equivalence, resulting in screening tools that do not meet high psychometric standards in the new population. This study implemented a rigorous translation and cultural adaptation process by translating the First Years Inventory v3.1 (Baranek et al. First year inventory (FYI) 3.1. University of North Carolina at Chapel Hill Chapel Hill, NC, 2003) for a US-based Spanish-speaking population. A description of this process is provided with results from data collected during each phase. The unique challenges that were identified and addressed are detailed for future translation teams. En ligne : http://dx.doi.org/10.1007/s10803-020-04837-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

The effect of chronic prenatal hypoxia on the development of mature neurons in the cerebellum / K. SO in Journal of Neurodevelopmental Disorders, 5-1 (December 2013)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 5-1 (December 2013) . - p.17 Titre : The effect of chronic prenatal hypoxia on the development of mature neurons in the cerebellum Type de document : Texte imprimé et/ou numérique Auteurs : K. SO, Auteur ; Y. CHUNG, Auteur ; H. LEE, Auteur ; E. KIM, Auteur ; Y. JEON, Auteur Article en page(s) : p.17 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse intrauterine circumstances can result in abnormal brain development, and can contribute to many neurological disorders such as cerebral palsy and cognitive and behavioral deficits. These neurological problems are caused by conditions that cause chronic placental insufficiency (CPI), such as hypoxia and acidemia. Hypoxia has been implicated in structural alterations of the cerebellum during development; however, the changes to the cerebellar external granular layer (EGL) induced by chronic prenatal hypoxia are not well understood. We therefore investigated the effect of chronic prenatal hypoxia on the development of mature neurons in the EGL using the guinea pig CPI model. METHODS: Unilateral uterine artery ligation was performed at 30 to 32 days of gestation (dg) - with term defined as approximately 67 dg. At 50 dg, 60 dg, and one week after birth, fetuses and newborns were sacrificed and assigned to either the growth-restricted (GR) or control (no ligation) group. After fixation, dissection, and sectioning of cerebellar tissue from these animals, immunohistochemistry was performed with antibodies raised to hypoxia-induced factor 1alpha (Hif1alpha), Pax6, NeuroD, and NeuN. RESULTS: The induction of hypoxia was confirmed by the presence of Hif1alpha immunoreactivity in the EGL of the GR (but not control) fetuses. The only other cellular immunoreactivity found in any of the tissues was to the NeuN antibody, which is a marker of mature neurons. The proportion of NeuN-immunoreactive (NeuN-IR) cells to the total number of cells in the EGL did not differ between the GR and control groups at 50 and 60 dg. The density of NeuN-IR cells was greater in GR fetuses than in controls at 60 dg (P < 0.05) but not at 50 dg. At one week after birth, the EGL was just one cell thick, and only a few NeuN-IR cells could be observed in both groups. TUNEL assays performed to enable the evaluation of apoptosis in the cerebellar EGL revealed that cell death was not affected by hypoxia at 50 dg, 60 dg, and one week after birth. CONCLUSION: These findings indicate that chronic prenatal hypoxia affects the process of neuronal production late in fetal life, but that this effect does not persist postnatally. En ligne : http://dx.doi.org/10.1186/1866-1955-5-17 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=345 [article] The effect of chronic prenatal hypoxia on the development of mature neurons in the cerebellum [Texte imprimé et/ou numérique] / K. SO, Auteur ; Y. CHUNG, Auteur ; H. LEE, Auteur ; E. KIM, Auteur ; Y. JEON, Auteur . - p.17. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 5-1 (December 2013) . - p.17 Index. décimale : PER Périodiques Résumé : BACKGROUND: Adverse intrauterine circumstances can result in abnormal brain development, and can contribute to many neurological disorders such as cerebral palsy and cognitive and behavioral deficits. These neurological problems are caused by conditions that cause chronic placental insufficiency (CPI), such as hypoxia and acidemia. Hypoxia has been implicated in structural alterations of the cerebellum during development; however, the changes to the cerebellar external granular layer (EGL) induced by chronic prenatal hypoxia are not well understood. We therefore investigated the effect of chronic prenatal hypoxia on the development of mature neurons in the EGL using the guinea pig CPI model. METHODS: Unilateral uterine artery ligation was performed at 30 to 32 days of gestation (dg) - with term defined as approximately 67 dg. At 50 dg, 60 dg, and one week after birth, fetuses and newborns were sacrificed and assigned to either the growth-restricted (GR) or control (no ligation) group. After fixation, dissection, and sectioning of cerebellar tissue from these animals, immunohistochemistry was performed with antibodies raised to hypoxia-induced factor 1alpha (Hif1alpha), Pax6, NeuroD, and NeuN. RESULTS: The induction of hypoxia was confirmed by the presence of Hif1alpha immunoreactivity in the EGL of the GR (but not control) fetuses. The only other cellular immunoreactivity found in any of the tissues was to the NeuN antibody, which is a marker of mature neurons. The proportion of NeuN-immunoreactive (NeuN-IR) cells to the total number of cells in the EGL did not differ between the GR and control groups at 50 and 60 dg. The density of NeuN-IR cells was greater in GR fetuses than in controls at 60 dg (P < 0.05) but not at 50 dg. At one week after birth, the EGL was just one cell thick, and only a few NeuN-IR cells could be observed in both groups. TUNEL assays performed to enable the evaluation of apoptosis in the cerebellar EGL revealed that cell death was not affected by hypoxia at 50 dg, 60 dg, and one week after birth. CONCLUSION: These findings indicate that chronic prenatal hypoxia affects the process of neuronal production late in fetal life, but that this effect does not persist postnatally. En ligne : http://dx.doi.org/10.1186/1866-1955-5-17 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=345

---

1 (1 - 5 / 5)