Autism severity aggregates with family psychiatric history in a community-based autism sample / D. SIPSOCK in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2524-2532 Titre : Autism severity aggregates with family psychiatric history in a community-based autism sample Type de document : Texte imprimé et/ou numérique Auteurs : D. SIPSOCK, Auteur ; H. TOKADJIAN, Auteur ; G. RIGHI, Auteur ; E. M. MORROW, Auteur ; S. J. SHEINKOPF, Auteur Article en page(s) : p.2524-2532 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications/genetics  Autistic Disorder/genetics  Family  Humans  Longitudinal Studies  Registries  autism spectrum disorder  disease severity  family medical history  population study  registry Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine family psychiatric history in individuals with autism spectrum disorder (ASD) and its association with clinical presentation. Participants were 798 individuals with a clinical diagnosis of ASD, confirmed by the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), enrolled in Rhode Island Consortium for Autism Research and Treatment, a statewide research registry. Prior research suggests a specific behavioral phenotype in individuals with ASD who have family members with psychiatric diagnoses, including higher IQ and less severe language impairment. However, studies have not specifically investigated autism severity. We hypothesized that increased psychiatric family history would be associated with increased autism severity symptoms. Results show a strong association of increased burden of first-degree family psychiatric history with higher autism symptom severity as measured by Social Responsiveness Scale, Second Edition (SRS-2), but not with ADOS-2 severity scores, IQ, or adaptive functioning. These findings support the importance of investigating the contribution of psychiatric family history toward clinical ASD presentation. LAY SUMMARY: This study explored how family psychiatric history is related to clinical presentation of Autism Spectrum Disorder (ASD). Higher amounts of first-degree family psychiatric history was associated with higher autism symptom severity as measured by the Social Responsiveness Scale, Second Edition (SRS-2). The contribution of psychiatric family history requires ongoing investigation. En ligne : http://dx.doi.org/10.1002/aur.2625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Autism severity aggregates with family psychiatric history in a community-based autism sample [Texte imprimé et/ou numérique] / D. SIPSOCK, Auteur ; H. TOKADJIAN, Auteur ; G. RIGHI, Auteur ; E. M. MORROW, Auteur ; S. J. SHEINKOPF, Auteur . - p.2524-2532. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2524-2532 Mots-clés : Autism Spectrum Disorder/complications/genetics  Autistic Disorder/genetics  Family  Humans  Longitudinal Studies  Registries  autism spectrum disorder  disease severity  family medical history  population study  registry Index. décimale : PER Périodiques Résumé : The purpose of this study was to examine family psychiatric history in individuals with autism spectrum disorder (ASD) and its association with clinical presentation. Participants were 798 individuals with a clinical diagnosis of ASD, confirmed by the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), enrolled in Rhode Island Consortium for Autism Research and Treatment, a statewide research registry. Prior research suggests a specific behavioral phenotype in individuals with ASD who have family members with psychiatric diagnoses, including higher IQ and less severe language impairment. However, studies have not specifically investigated autism severity. We hypothesized that increased psychiatric family history would be associated with increased autism severity symptoms. Results show a strong association of increased burden of first-degree family psychiatric history with higher autism symptom severity as measured by Social Responsiveness Scale, Second Edition (SRS-2), but not with ADOS-2 severity scores, IQ, or adaptive functioning. These findings support the importance of investigating the contribution of psychiatric family history toward clinical ASD presentation. LAY SUMMARY: This study explored how family psychiatric history is related to clinical presentation of Autism Spectrum Disorder (ASD). Higher amounts of first-degree family psychiatric history was associated with higher autism symptom severity as measured by the Social Responsiveness Scale, Second Edition (SRS-2). The contribution of psychiatric family history requires ongoing investigation. En ligne : http://dx.doi.org/10.1002/aur.2625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study / B. C. KAVANAUGH in Autism Research, 15-1 (January 2022)  

Public ISBD [article]  inAutism Research > 15-1 (January 2022) . - p.86-92 Titre : Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study Type de document : Texte imprimé et/ou numérique Auteurs : B. C. KAVANAUGH, Auteur ; T. GABERT, Auteur ; R. N. JONES, Auteur ; S. J. SHEINKOPF, Auteur ; E. M. MORROW, Auteur Article en page(s) : p.86-92 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Female  Humans  Mothers  Parents  Rhode Island  neuropsychiatric disorders  parental age  repetitive behaviors  restricted Index. décimale : PER Périodiques Résumé : Advanced parental age at offspring birth has been associated with autism spectrum disorder (ASD). The objective of the current study was to investigate associations between parental age at birth and autism severity. The Rhode Island Consortium for Autism Research and Treatment (RI-CART) study represents a community-based sample with a range of autism severity, including participants with and without ASD. This study involved participants (n = 1178) enrolled in RI-CART with available mother and father ages at birth. Primary data points included the age of mother and father at the participant's birth and results from the Autism Diagnostic Observation Schedule - Second Edition (ADOS-2). Mothers were 1.7?years older at the time of birth of the child with ASD, as compared to mothers of offspring without ASD. Fathers of children with ASD were 1.6?years older at the time of birth than fathers of children without ASD. The age of both parents at offspring birth displayed a positive, statistically significant association with overall ASD severity and the severity of restricted/repetitive behaviors. This finding was driven by the association between parental age and the severity of compulsions or rituals. Intelligence and adaptive functioning did not moderate the relationship between parental age and ASD severity. This study extends prior research to show that advanced parental age at birth is associated with the severity as well as the presence of ASD in offspring. En ligne : http://dx.doi.org/10.1002/aur.2648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Parental age and autism severity in the Rhode Island Consortium for Autism Research and Treatment (RI-CART) study [Texte imprimé et/ou numérique] / B. C. KAVANAUGH, Auteur ; T. GABERT, Auteur ; R. N. JONES, Auteur ; S. J. SHEINKOPF, Auteur ; E. M. MORROW, Auteur . - p.86-92. Langues : Anglais (eng) in Autism Research > 15-1 (January 2022) . - p.86-92 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Female  Humans  Mothers  Parents  Rhode Island  neuropsychiatric disorders  parental age  repetitive behaviors  restricted Index. décimale : PER Périodiques Résumé : Advanced parental age at offspring birth has been associated with autism spectrum disorder (ASD). The objective of the current study was to investigate associations between parental age at birth and autism severity. The Rhode Island Consortium for Autism Research and Treatment (RI-CART) study represents a community-based sample with a range of autism severity, including participants with and without ASD. This study involved participants (n = 1178) enrolled in RI-CART with available mother and father ages at birth. Primary data points included the age of mother and father at the participant's birth and results from the Autism Diagnostic Observation Schedule - Second Edition (ADOS-2). Mothers were 1.7?years older at the time of birth of the child with ASD, as compared to mothers of offspring without ASD. Fathers of children with ASD were 1.6?years older at the time of birth than fathers of children without ASD. The age of both parents at offspring birth displayed a positive, statistically significant association with overall ASD severity and the severity of restricted/repetitive behaviors. This finding was driven by the association between parental age and the severity of compulsions or rituals. Intelligence and adaptive functioning did not moderate the relationship between parental age and ASD severity. This study extends prior research to show that advanced parental age at birth is associated with the severity as well as the presence of ASD in offspring. En ligne : http://dx.doi.org/10.1002/aur.2648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Perception of Cry Characteristics in 1-Month-Old Infants Later Diagnosed with Autism Spectrum Disorder / M. S. ENGLISH in Journal of Autism and Developmental Disorders, 49-3 (March 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.834-844 Titre : Perception of Cry Characteristics in 1-Month-Old Infants Later Diagnosed with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : M. S. ENGLISH, Auteur ; E. J. TENENBAUM, Auteur ; T. P. LEVINE, Auteur ; B. M. LESTER, Auteur ; S. J. SHEINKOPF, Auteur Article en page(s) : p.834-844 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Communication & language  Cry  Infancy Index. décimale : PER Périodiques Résumé : This study investigates parental perceptions of cries of 1-month-old infants later diagnosed with autism spectrum disorder (ASD) and non-ASD controls. Parents of children with and without ASD listened to cry recordings of infants later diagnosed with ASD and comparison infants and rated them on cry perception scales. Parents completed the Broad Autism Phenotype Questionnaire (BAPQ) to assess the potential relations between traits associated with autism and cry perception. Across parents, ASD infant cries were rated as more distressed, less typical, and reflecting greater pain, with no significant differences between parent groups. Parents of children with ASD scored higher on the BAPQ compared to parents of children without ASD. Follow up analyses explored the relations between BAPQ score and cry ratings. En ligne : http://dx.doi.org/10.1007/s10803-018-3788-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Perception of Cry Characteristics in 1-Month-Old Infants Later Diagnosed with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / M. S. ENGLISH, Auteur ; E. J. TENENBAUM, Auteur ; T. P. LEVINE, Auteur ; B. M. LESTER, Auteur ; S. J. SHEINKOPF, Auteur . - p.834-844. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-3 (March 2019) . - p.834-844 Mots-clés : Autism spectrum disorders  Communication & language  Cry  Infancy Index. décimale : PER Périodiques Résumé : This study investigates parental perceptions of cries of 1-month-old infants later diagnosed with autism spectrum disorder (ASD) and non-ASD controls. Parents of children with and without ASD listened to cry recordings of infants later diagnosed with ASD and comparison infants and rated them on cry perception scales. Parents completed the Broad Autism Phenotype Questionnaire (BAPQ) to assess the potential relations between traits associated with autism and cry perception. Across parents, ASD infant cries were rated as more distressed, less typical, and reflecting greater pain, with no significant differences between parent groups. Parents of children with ASD scored higher on the BAPQ compared to parents of children without ASD. Follow up analyses explored the relations between BAPQ score and cry ratings. En ligne : http://dx.doi.org/10.1007/s10803-018-3788-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Predictors of Inpatient Psychiatric Hospitalization for Children and Adolescents with Autism Spectrum Disorder / G. RIGHI in Journal of Autism and Developmental Disorders, 48-11 (November 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3647-3657 Titre : Predictors of Inpatient Psychiatric Hospitalization for Children and Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : G. RIGHI, Auteur ; J. BENEVIDES, Auteur ; C. MAZEFSKY, Auteur ; M. SIEGEL, Auteur ; S. J. SHEINKOPF, Auteur ; E. M. MORROW, Auteur Article en page(s) : p.3647-3657 Langues : Anglais (eng) Mots-clés : Autism inpatient collection (AIC)  Autism spectrum disorder  Children and adolescents  Inpatient psychiatric hospitalization Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is associated with significant healthcare expenditures and a greater utilization of psychiatric health services. High utilization may not be evenly distributed across individuals with ASD. The objective of this study was to identify individual and family characteristics that increase the risk of psychiatric hospitalization. Naturalistic study of two age- and gender-matched ASD cohorts, inpatients enrolled in the Autism Inpatient Collection (AIC) and outpatients enrolled in the Rhode Island Consortium of Autism Research and Treatment (RI-CART), revealed a number of factors associated with hospitalization. Multiple logistic regression analyses revealed that adaptive functioning, ASD symptom severity, primary caregiver's marital status, the presence of mood disorders, and the presence of sleep problems independently increased the risk of psychiatric hospitalization. En ligne : http://dx.doi.org/10.1007/s10803-017-3154-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Predictors of Inpatient Psychiatric Hospitalization for Children and Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / G. RIGHI, Auteur ; J. BENEVIDES, Auteur ; C. MAZEFSKY, Auteur ; M. SIEGEL, Auteur ; S. J. SHEINKOPF, Auteur ; E. M. MORROW, Auteur . - p.3647-3657. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-11 (November 2018) . - p.3647-3657 Mots-clés : Autism inpatient collection (AIC)  Autism spectrum disorder  Children and adolescents  Inpatient psychiatric hospitalization Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is associated with significant healthcare expenditures and a greater utilization of psychiatric health services. High utilization may not be evenly distributed across individuals with ASD. The objective of this study was to identify individual and family characteristics that increase the risk of psychiatric hospitalization. Naturalistic study of two age- and gender-matched ASD cohorts, inpatients enrolled in the Autism Inpatient Collection (AIC) and outpatients enrolled in the Rhode Island Consortium of Autism Research and Treatment (RI-CART), revealed a number of factors associated with hospitalization. Multiple logistic regression analyses revealed that adaptive functioning, ASD symptom severity, primary caregiver's marital status, the presence of mood disorders, and the presence of sleep problems independently increased the risk of psychiatric hospitalization. En ligne : http://dx.doi.org/10.1007/s10803-017-3154-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Sensitivity to audio-visual synchrony and its relation to language abilities in children with and without ASD / G. RIGHI in Autism Research, 11-4 (April 2018)  

Public ISBD [article]  inAutism Research > 11-4 (April 2018) . - p.645-653 Titre : Sensitivity to audio-visual synchrony and its relation to language abilities in children with and without ASD Type de document : Texte imprimé et/ou numérique Auteurs : G. RIGHI, Auteur ; E. J. TENENBAUM, Auteur ; C. MCCORMICK, Auteur ; M. BLOSSOM, Auteur ; Dima AMSO, Auteur ; S. J. SHEINKOPF, Auteur Article en page(s) : p.645-653 Langues : Anglais (eng) Mots-clés : audio-visual synchrony  autism  eye-tracking  language development Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is often accompanied by deficits in speech and language processing. Speech processing relies heavily on the integration of auditory and visual information, and it has been suggested that the ability to detect correspondence between auditory and visual signals helps to lay the foundation for successful language development. The goal of the present study was to examine whether young children with ASD show reduced sensitivity to temporal asynchronies in a speech processing task when compared to typically developing controls, and to examine how this sensitivity might relate to language proficiency. Using automated eye tracking methods, we found that children with ASD failed to demonstrate sensitivity to asynchronies of 0.3s, 0.6s, or 1.0s between a video of a woman speaking and the corresponding audio track. In contrast, typically developing children who were language-matched to the ASD group, were sensitive to both 0.6s and 1.0s asynchronies. We also demonstrated that individual differences in sensitivity to audiovisual asynchronies and individual differences in orientation to relevant facial features were both correlated with scores on a standardized measure of language abilities. Results are discussed in the context of attention to visual language and audio-visual processing as potential precursors to language impairment in ASD. Autism Res 2018, 11: 645-653. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Speech processing relies heavily on the integration of auditory and visual information, and it has been suggested that the ability to detect correspondence between auditory and visual signals helps to lay the foundation for successful language development. The goal of the present study was to explore whether children with ASD process audio-visual synchrony in ways comparable to their typically developing peers, and the relationship between preference for synchrony and language ability. Results showed that there are differences in attention to audiovisual synchrony between typically developing children and children with ASD. Preference for synchrony was related to the language abilities of children across groups. En ligne : http://dx.doi.org/10.1002/aur.1918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] Sensitivity to audio-visual synchrony and its relation to language abilities in children with and without ASD [Texte imprimé et/ou numérique] / G. RIGHI, Auteur ; E. J. TENENBAUM, Auteur ; C. MCCORMICK, Auteur ; M. BLOSSOM, Auteur ; Dima AMSO, Auteur ; S. J. SHEINKOPF, Auteur . - p.645-653. Langues : Anglais (eng) in Autism Research > 11-4 (April 2018) . - p.645-653 Mots-clés : audio-visual synchrony  autism  eye-tracking  language development Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is often accompanied by deficits in speech and language processing. Speech processing relies heavily on the integration of auditory and visual information, and it has been suggested that the ability to detect correspondence between auditory and visual signals helps to lay the foundation for successful language development. The goal of the present study was to examine whether young children with ASD show reduced sensitivity to temporal asynchronies in a speech processing task when compared to typically developing controls, and to examine how this sensitivity might relate to language proficiency. Using automated eye tracking methods, we found that children with ASD failed to demonstrate sensitivity to asynchronies of 0.3s, 0.6s, or 1.0s between a video of a woman speaking and the corresponding audio track. In contrast, typically developing children who were language-matched to the ASD group, were sensitive to both 0.6s and 1.0s asynchronies. We also demonstrated that individual differences in sensitivity to audiovisual asynchronies and individual differences in orientation to relevant facial features were both correlated with scores on a standardized measure of language abilities. Results are discussed in the context of attention to visual language and audio-visual processing as potential precursors to language impairment in ASD. Autism Res 2018, 11: 645-653. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Speech processing relies heavily on the integration of auditory and visual information, and it has been suggested that the ability to detect correspondence between auditory and visual signals helps to lay the foundation for successful language development. The goal of the present study was to explore whether children with ASD process audio-visual synchrony in ways comparable to their typically developing peers, and the relationship between preference for synchrony and language ability. Results showed that there are differences in attention to audiovisual synchrony between typically developing children and children with ASD. Preference for synchrony was related to the language abilities of children across groups. En ligne : http://dx.doi.org/10.1002/aur.1918 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

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