Health Services Use and Costs in Individuals with Autism Spectrum Disorder in Germany: Results from a Survey in ASD Outpatient Clinics / J. HOFER in Journal of Autism and Developmental Disorders, 52-2 (February 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.540-552 Titre : Health Services Use and Costs in Individuals with Autism Spectrum Disorder in Germany: Results from a Survey in ASD Outpatient Clinics Type de document : Texte imprimé et/ou numérique Auteurs : J. HOFER, Auteur ; F. HOFFMANN, Auteur ; M. DÖRKS, Auteur ; I. KAMP-BECKER, Auteur ; C. KÜPPER, Auteur ; L. POUSTKA, Auteur ; S. ROEPKE, Auteur ; V. ROESSNER, Auteur ; S. STROTH, Auteur ; N. WOLFF, Auteur ; C. J. BACHMANN, Auteur Article en page(s) : p.540-552 Langues : Anglais (eng) Mots-clés : Ambulatory Care Facilities  Autism Spectrum Disorder/epidemiology/therapy  Female  Germany/epidemiology  Health Care Costs  Humans  Male  Mental Health Services  Adolescents  Adults  Children  Costs  Germany  Health services Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with high services use, but European data on costs are scarce. Utilisation and annual costs of 385 individuals with ASD (aged 4-67 years; 18.2% females; 37.4% IQ? En ligne : http://dx.doi.org/10.1007/s10803-021-04955-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] Health Services Use and Costs in Individuals with Autism Spectrum Disorder in Germany: Results from a Survey in ASD Outpatient Clinics [Texte imprimé et/ou numérique] / J. HOFER, Auteur ; F. HOFFMANN, Auteur ; M. DÖRKS, Auteur ; I. KAMP-BECKER, Auteur ; C. KÜPPER, Auteur ; L. POUSTKA, Auteur ; S. ROEPKE, Auteur ; V. ROESSNER, Auteur ; S. STROTH, Auteur ; N. WOLFF, Auteur ; C. J. BACHMANN, Auteur . - p.540-552. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-2 (February 2022) . - p.540-552 Mots-clés : Ambulatory Care Facilities  Autism Spectrum Disorder/epidemiology/therapy  Female  Germany/epidemiology  Health Care Costs  Humans  Male  Mental Health Services  Adolescents  Adults  Children  Costs  Germany  Health services Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) are associated with high services use, but European data on costs are scarce. Utilisation and annual costs of 385 individuals with ASD (aged 4-67 years; 18.2% females; 37.4% IQ? En ligne : http://dx.doi.org/10.1007/s10803-021-04955-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

How Do Adults with Autism Spectrum Disorder Participate in the Labor Market? A German Multi-center Survey / T. MASLAHATI in Journal of Autism and Developmental Disorders, 52-3 (March 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1066-1076 Titre : How Do Adults with Autism Spectrum Disorder Participate in the Labor Market? A German Multi-center Survey Type de document : Texte imprimé et/ou numérique Auteurs : T. MASLAHATI, Auteur ; C. J. BACHMANN, Auteur ; J. HOFER, Auteur ; C. KÜPPER, Auteur ; S. STROTH, Auteur ; N. WOLFF, Auteur ; L. POUSTKA, Auteur ; V. ROESSNER, Auteur ; I. KAMP-BECKER, Auteur ; F. HOFFMANN, Auteur ; S. ROEPKE, Auteur Article en page(s) : p.1066-1076 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/epidemiology  Cross-Sectional Studies  Employment  Germany  Humans  Occupations  Surveys and Questionnaires  Autism  Autism Spectrum Disorder  Education  Labor Market Index. décimale : PER Périodiques Résumé : International studies show disadvantages for adults with autism spectrum disorder (ASD) in the labor market. Data about their participation in the German labor market are scarce. The aim of this study was to examine the integration of adults with ASD in the German labor market in terms of education, employment and type of occupation by means of a cross-sectional-study, using a postal questionnaire. Findings show above average levels of education for adults with ASD compared to the general population of Germany and simultaneously, below average rates of employment and high rates of financial dependency. That indicates a poor integration of adults with ASD in the German labor market and emphasizes the need for vocational support policies for adults with ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05008-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455 [article] How Do Adults with Autism Spectrum Disorder Participate in the Labor Market? A German Multi-center Survey [Texte imprimé et/ou numérique] / T. MASLAHATI, Auteur ; C. J. BACHMANN, Auteur ; J. HOFER, Auteur ; C. KÜPPER, Auteur ; S. STROTH, Auteur ; N. WOLFF, Auteur ; L. POUSTKA, Auteur ; V. ROESSNER, Auteur ; I. KAMP-BECKER, Auteur ; F. HOFFMANN, Auteur ; S. ROEPKE, Auteur . - p.1066-1076. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-3 (March 2022) . - p.1066-1076 Mots-clés : Adult  Autism Spectrum Disorder/epidemiology  Cross-Sectional Studies  Employment  Germany  Humans  Occupations  Surveys and Questionnaires  Autism  Autism Spectrum Disorder  Education  Labor Market Index. décimale : PER Périodiques Résumé : International studies show disadvantages for adults with autism spectrum disorder (ASD) in the labor market. Data about their participation in the German labor market are scarce. The aim of this study was to examine the integration of adults with ASD in the German labor market in terms of education, employment and type of occupation by means of a cross-sectional-study, using a postal questionnaire. Findings show above average levels of education for adults with ASD compared to the general population of Germany and simultaneously, below average rates of employment and high rates of financial dependency. That indicates a poor integration of adults with ASD in the German labor market and emphasizes the need for vocational support policies for adults with ASD. En ligne : http://dx.doi.org/10.1007/s10803-021-05008-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=455

Identifying Atypical Development: A Role of Day-Care Workers? / D. ZHANG in Journal of Autism and Developmental Disorders, 49-9 (September 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3685-3694 Titre : Identifying Atypical Development: A Role of Day-Care Workers? Type de document : Texte imprimé et/ou numérique Auteurs : D. ZHANG, Auteur ; I. KRIEBER-TOMANTSCHGER, Auteur ; L. POUSTKA, Auteur ; H. ROEYERS, Auteur ; J. SIGAFOOS, Auteur ; Sven BÖLTE, Auteur ; P. B. MARSCHIK, Auteur ; C. EINSPIELER, Auteur Article en page(s) : p.3685-3694 Langues : Anglais (eng) Mots-clés : Day-care workers  Developmental disability  Early identification  Fragile X syndrome  Retrospective video analysis Index. décimale : PER Périodiques Résumé : Identifying the early signs of developmental disability is important for ensuring timely diagnosis and early intervention. Day-care workers may be in a prime position to notice potential developmental deviations, but it is unclear if they can accurately recognize subtle early signs of atypical development. Sixty day-care workers examined home-videos of very young children with fragile X syndrome and typically developing children. Results indicated that most day-care workers can distinguish typical and atypical development in general and might therefore have an important role in early identification. Special work experience and advanced pedagogical training appeared to boost day-care workers' sensitivity to detect atypical features in early development and to provide effective daily surveillance. En ligne : http://dx.doi.org/10.1007/s10803-019-04056-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405 [article] Identifying Atypical Development: A Role of Day-Care Workers? [Texte imprimé et/ou numérique] / D. ZHANG, Auteur ; I. KRIEBER-TOMANTSCHGER, Auteur ; L. POUSTKA, Auteur ; H. ROEYERS, Auteur ; J. SIGAFOOS, Auteur ; Sven BÖLTE, Auteur ; P. B. MARSCHIK, Auteur ; C. EINSPIELER, Auteur . - p.3685-3694. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-9 (September 2019) . - p.3685-3694 Mots-clés : Day-care workers  Developmental disability  Early identification  Fragile X syndrome  Retrospective video analysis Index. décimale : PER Périodiques Résumé : Identifying the early signs of developmental disability is important for ensuring timely diagnosis and early intervention. Day-care workers may be in a prime position to notice potential developmental deviations, but it is unclear if they can accurately recognize subtle early signs of atypical development. Sixty day-care workers examined home-videos of very young children with fragile X syndrome and typically developing children. Results indicated that most day-care workers can distinguish typical and atypical development in general and might therefore have an important role in early identification. Special work experience and advanced pedagogical training appeared to boost day-care workers' sensitivity to detect atypical features in early development and to provide effective daily surveillance. En ligne : http://dx.doi.org/10.1007/s10803-019-04056-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=405

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents / B. RUGGERI in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Titre : Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : B. RUGGERI, Auteur ; C. MACARE, Auteur ; S. STOPPONI, Auteur ; T. JIA, Auteur ; F. M. CARVALHO, Auteur ; G. ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; A. CATTRELL, Auteur ; P. J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; H. FLOR, Auteur ; V. FROUIN, Auteur ; J. GALLINAT, Auteur ; H. GARAVAN, Auteur ; P. GOWLAND, Auteur ; A. HEINZ, Auteur ; B. ITTERMANN, Auteur ; J. L. MARTINOT, Auteur ; M. P. MARTINOT, Auteur ; F. NEES, Auteur ; D. PAPADOPOULOS-ORFANOS, Auteur ; T. PAUS, Auteur ; L. POUSTKA, Auteur ; M. N. SMOLKA, Auteur ; N. C. VETTER, Auteur ; H. WALTER, Auteur ; R. WHELAN, Auteur ; W. H. SOMMER, Auteur ; G. BAKALKIN, Auteur ; R. CICCOCIOPPO, Auteur ; G. SCHUMANN, Auteur Article en page(s) : p.650-658 Langues : Anglais (eng) Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents [Texte imprimé et/ou numérique] / B. RUGGERI, Auteur ; C. MACARE, Auteur ; S. STOPPONI, Auteur ; T. JIA, Auteur ; F. M. CARVALHO, Auteur ; G. ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L. W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; A. CATTRELL, Auteur ; P. J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; H. FLOR, Auteur ; V. FROUIN, Auteur ; J. GALLINAT, Auteur ; H. GARAVAN, Auteur ; P. GOWLAND, Auteur ; A. HEINZ, Auteur ; B. ITTERMANN, Auteur ; J. L. MARTINOT, Auteur ; M. P. MARTINOT, Auteur ; F. NEES, Auteur ; D. PAPADOPOULOS-ORFANOS, Auteur ; T. PAUS, Auteur ; L. POUSTKA, Auteur ; M. N. SMOLKA, Auteur ; N. C. VETTER, Auteur ; H. WALTER, Auteur ; R. WHELAN, Auteur ; W. H. SOMMER, Auteur ; G. BAKALKIN, Auteur ; R. CICCOCIOPPO, Auteur ; G. SCHUMANN, Auteur . - p.650-658. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder / Nico BAST in Autism Research, 12-11 (November 2019)  

Public ISBD [article]  inAutism Research > 12-11 (November 2019) . - p.1680-1692 Titre : Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Nico BAST, Auteur ; Tobias BANASCHEWSKI, Auteur ; I. DZIOBEK, Auteur ; Daniel BRANDEIS, Auteur ; L. POUSTKA, Auteur ; C. M. FREITAG, Auteur Article en page(s) : p.1680-1692 Langues : Anglais (eng) Mots-clés : attention modulation  biomarker  eye tracking  pupillary reactivity  sensory processing Index. décimale : PER Périodiques Résumé : Progression of pupil dilation (PD) in response to visual stimuli may indicate distinct internal processes. No study has been performed on PD progression during a social cognition task. Here, we describe PD progression during the Movie for the Assessment of Social Cognition (MASC) test in n = 23 adolescents with Autism Spectrum Disorder (ASD) and n = 24 age, IQ and sex-matched neurotypical controls (NTC). The MASC consists of 43 video sequences depicting human social interactions, each followed by a multiple-choice question concerning characters' mental states. PD progression data were extracted by eye tracking and controlled for fixation behavior. Segmenting PD progression during video sequences by principal component analysis, three sequential PD components were unveiled. In ASD compared with NTC, a distinct PD progression was observed with increased constriction amplitude, increased dilation latency, and increased dilation amplitude that correlated with PD progression components. These components predicted social cognition performance. The first and second PD components correlated positively with MASC behavioral performance in ASD but negatively in NTC. These PD components may be interpreted as indicators of sensory-perceptual processing and attention function. In ASD, aberrant sensory-perceptual processing and attention function could contribute to attenuated social cognition performance. This needs to be tested by additional studies combining the respective cognitive tests and the outlined PD progression analysis. Phasic activity of the locus coeruleus-norepinephrine system is discussed as putatively shared underlying mechanism. Autism Res2019. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: In adolescents with autism, we found an altered pupil dilation during watching scenes of human interactions. Early pupil dilation correlated positively with the number of correct answers to questions about the shown human interactions. Our findings suggest that aberrant sensory processing and attention function may contribute to altered social cognition in autism. En ligne : http://dx.doi.org/10.1002/aur.2178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Pupil Dilation Progression Modulates Aberrant Social Cognition in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Nico BAST, Auteur ; Tobias BANASCHEWSKI, Auteur ; I. DZIOBEK, Auteur ; Daniel BRANDEIS, Auteur ; L. POUSTKA, Auteur ; C. M. FREITAG, Auteur . - p.1680-1692. Langues : Anglais (eng) in Autism Research > 12-11 (November 2019) . - p.1680-1692 Mots-clés : attention modulation  biomarker  eye tracking  pupillary reactivity  sensory processing Index. décimale : PER Périodiques Résumé : Progression of pupil dilation (PD) in response to visual stimuli may indicate distinct internal processes. No study has been performed on PD progression during a social cognition task. Here, we describe PD progression during the Movie for the Assessment of Social Cognition (MASC) test in n = 23 adolescents with Autism Spectrum Disorder (ASD) and n = 24 age, IQ and sex-matched neurotypical controls (NTC). The MASC consists of 43 video sequences depicting human social interactions, each followed by a multiple-choice question concerning characters' mental states. PD progression data were extracted by eye tracking and controlled for fixation behavior. Segmenting PD progression during video sequences by principal component analysis, three sequential PD components were unveiled. In ASD compared with NTC, a distinct PD progression was observed with increased constriction amplitude, increased dilation latency, and increased dilation amplitude that correlated with PD progression components. These components predicted social cognition performance. The first and second PD components correlated positively with MASC behavioral performance in ASD but negatively in NTC. These PD components may be interpreted as indicators of sensory-perceptual processing and attention function. In ASD, aberrant sensory-perceptual processing and attention function could contribute to attenuated social cognition performance. This needs to be tested by additional studies combining the respective cognitive tests and the outlined PD progression analysis. Phasic activity of the locus coeruleus-norepinephrine system is discussed as putatively shared underlying mechanism. Autism Res2019. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: In adolescents with autism, we found an altered pupil dilation during watching scenes of human interactions. Early pupil dilation correlated positively with the number of correct answers to questions about the shown human interactions. Our findings suggest that aberrant sensory processing and attention function may contribute to altered social cognition in autism. En ligne : http://dx.doi.org/10.1002/aur.2178 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Real-World Experiences in Autistic Adult Diagnostic Services and Post-diagnostic Support and Alignment with Services Guidelines: Results from the ASDEU Study / M. L. SCATTONI in Journal of Autism and Developmental Disorders, 51-11 (November 2021)  

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Willingness to try and lifetime use of complementary and alternative medicine in children and adolescents with autism spectrum disorder in Germany: A survey of parents / J. HOFER in Autism, 23-7 (October 2019)  

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