Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Africa / L. FRANZ in Autism, 26-1 (January 2022)  

Public ISBD [article]  inAutism > 26-1 (January 2022) . - p.270-275 Titre : Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Africa Type de document : Texte imprimé et/ou numérique Auteurs : L. FRANZ, Auteur ; J. HOWARD, Auteur ; M. VILJOEN, Auteur ; L. SIKICH, Auteur ; Tara CHANDRASEKHAR, Auteur ; S. H. KOLLINS, Auteur ; L. LEE, Auteur ; M. NDLOVU, Auteur ; Maura SABATOS-DEVITO, Auteur ; N. SERIS, Auteur ; N. SHABALALA, Auteur ; M. SPANOS, Auteur ; P. J. DE VRIES, Auteur ; G. DAWSON, Auteur Article en page(s) : p.270-275 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/therapy  Autistic Disorder  Covid-19  Caregivers  Child  Humans  Mentoring  SARS-CoV-2  South Africa  Telemedicine  United States  adaptation  autism spectrum disorder  caregiver coaching  digital divide  telehealth  Research and Development, Akili Interactive, LabCorp, Inc, Roche Pharmaceutical  Company, and Tris Pharma, is a consultant for Apple, Inc., Gerson Lehrman Group,  Guidepoint, Inc, Axial Ventures, Teva Pharmaceutical, and is CEO of DASIO, LLC. She  has received book royalties from Guilford Press, Oxford University Press, and  Springer Nature Press. Howard reports personal fees from Roche. Index. décimale : PER Périodiques Résumé : COVID-19 caused many autism spectrum disorder caregiver-coaching studies to move to telehealth. Telehealth can increase the diversity of people who take part in research. This matters because most autism spectrum disorder studies have included people who have resources, are White, and live in North America and Europe. When study participants are similar, it is hard to understand which interventions can help different types of people who live in different parts of the world. While telehealth may allow more people to take part in research, it needs to "fit" the local context and consider the "digital divide" because many people around the world have no access to computers and the Internet. This short report describes changes to two research studies that include caregiver coaching based on the Early Start Denver Model in the United States and South Africa. We describe how the local context, including technology and Internet access, guided the telehealth approach. By doing so, we highlight ways to make telehealth available to more people around the world. The pandemic can help us understand how telehealth can "fit" diverse places and support high-quality research. It is important that study changes are tracked and we assess how well the changes work. COVID-19 telehealth changes to caregiver coaching can result in new ways to reach more people around the world. En ligne : http://dx.doi.org/10.1177/13623613211022585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Pragmatic adaptations of telehealth-delivered caregiver coaching for children with autism in the context of COVID-19: Perspectives from the United States and South Africa [Texte imprimé et/ou numérique] / L. FRANZ, Auteur ; J. HOWARD, Auteur ; M. VILJOEN, Auteur ; L. SIKICH, Auteur ; Tara CHANDRASEKHAR, Auteur ; S. H. KOLLINS, Auteur ; L. LEE, Auteur ; M. NDLOVU, Auteur ; Maura SABATOS-DEVITO, Auteur ; N. SERIS, Auteur ; N. SHABALALA, Auteur ; M. SPANOS, Auteur ; P. J. DE VRIES, Auteur ; G. DAWSON, Auteur . - p.270-275. Langues : Anglais (eng) in Autism > 26-1 (January 2022) . - p.270-275 Mots-clés : Autism Spectrum Disorder/therapy  Autistic Disorder  Covid-19  Caregivers  Child  Humans  Mentoring  SARS-CoV-2  South Africa  Telemedicine  United States  adaptation  autism spectrum disorder  caregiver coaching  digital divide  telehealth  Research and Development, Akili Interactive, LabCorp, Inc, Roche Pharmaceutical  Company, and Tris Pharma, is a consultant for Apple, Inc., Gerson Lehrman Group,  Guidepoint, Inc, Axial Ventures, Teva Pharmaceutical, and is CEO of DASIO, LLC. She  has received book royalties from Guilford Press, Oxford University Press, and  Springer Nature Press. Howard reports personal fees from Roche. Index. décimale : PER Périodiques Résumé : COVID-19 caused many autism spectrum disorder caregiver-coaching studies to move to telehealth. Telehealth can increase the diversity of people who take part in research. This matters because most autism spectrum disorder studies have included people who have resources, are White, and live in North America and Europe. When study participants are similar, it is hard to understand which interventions can help different types of people who live in different parts of the world. While telehealth may allow more people to take part in research, it needs to "fit" the local context and consider the "digital divide" because many people around the world have no access to computers and the Internet. This short report describes changes to two research studies that include caregiver coaching based on the Early Start Denver Model in the United States and South Africa. We describe how the local context, including technology and Internet access, guided the telehealth approach. By doing so, we highlight ways to make telehealth available to more people around the world. The pandemic can help us understand how telehealth can "fit" diverse places and support high-quality research. It is important that study changes are tracked and we assess how well the changes work. COVID-19 telehealth changes to caregiver coaching can result in new ways to reach more people around the world. En ligne : http://dx.doi.org/10.1177/13623613211022585 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

A scalable computational approach to assessing response to name in toddlers with autism / S. PEROCHON in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1120-1131 Titre : A scalable computational approach to assessing response to name in toddlers with autism Type de document : Texte imprimé et/ou numérique Auteurs : S. PEROCHON, Auteur ; M. DI MARTINO, Auteur ; R. E. AIELLO, Auteur ; J. BAKER, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Z. CHANG, Auteur ; S. COMPTON, Auteur ; N. DAVIS, Auteur ; B. EICHNER, Auteur ; S. ESPINOSA, Auteur ; J. FLOWERS, Auteur ; L. FRANZ, Auteur ; M. GAGLIANO, Auteur ; A. HARRIS, Auteur ; J. HOWARD, Auteur ; S. H. KOLLINS, Auteur ; E. M. PERRIN, Auteur ; P. RAJ, Auteur ; M. SPANOS, Auteur ; B. WALTER, Auteur ; G. SAPIRO, Auteur ; G. DAWSON, Auteur Article en page(s) : p.1120-1131 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  Child, Preschool  Humans  Infant  Autism spectrum disorders  assessment  behavioral measures  screening. Index. décimale : PER Périodiques Résumé : BACKGROUND: This study is part of a larger research program focused on developing objective, scalable tools for digital behavioral phenotyping. We evaluated whether a digital app delivered on a smartphone or tablet using computer vision analysis (CVA) can elicit and accurately measure one of the most common early autism symptoms, namely failure to respond to a name call. METHODS: During a pediatric primary care well-child visit, 910 toddlers, 17-37 months old, were administered an app on an iPhone or iPad consisting of brief movies during which the child's name was called three times by an examiner standing behind them. Thirty-seven toddlers were subsequently diagnosed with autism spectrum disorder (ASD). Name calls and children's behavior were recorded by the camera embedded in the device, and children's head turns were coded by both CVA and a human. RESULTS: CVA coding of response to name was found to be comparable to human coding. Based on CVA, children with ASD responded to their name significantly less frequently than children without ASD. CVA also revealed that children with ASD who did orient to their name exhibited a longer latency before turning their head. Combining information about both the frequency and the delay in response to name improved the ability to distinguish toddlers with and without ASD. CONCLUSIONS: A digital app delivered on an iPhone or iPad in real-world settings using computer vision analysis to quantify behavior can reliably detect a key early autism symptom-failure to respond to name. Moreover, the higher resolution offered by CVA identified a delay in head turn in toddlers with ASD who did respond to their name. Digital phenotyping is a promising methodology for early assessment of ASD symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.13381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] A scalable computational approach to assessing response to name in toddlers with autism [Texte imprimé et/ou numérique] / S. PEROCHON, Auteur ; M. DI MARTINO, Auteur ; R. E. AIELLO, Auteur ; J. BAKER, Auteur ; Kimberly L. H. CARPENTER, Auteur ; Z. CHANG, Auteur ; S. COMPTON, Auteur ; N. DAVIS, Auteur ; B. EICHNER, Auteur ; S. ESPINOSA, Auteur ; J. FLOWERS, Auteur ; L. FRANZ, Auteur ; M. GAGLIANO, Auteur ; A. HARRIS, Auteur ; J. HOWARD, Auteur ; S. H. KOLLINS, Auteur ; E. M. PERRIN, Auteur ; P. RAJ, Auteur ; M. SPANOS, Auteur ; B. WALTER, Auteur ; G. SAPIRO, Auteur ; G. DAWSON, Auteur . - p.1120-1131. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1120-1131 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder/diagnosis  Child  Child, Preschool  Humans  Infant  Autism spectrum disorders  assessment  behavioral measures  screening. Index. décimale : PER Périodiques Résumé : BACKGROUND: This study is part of a larger research program focused on developing objective, scalable tools for digital behavioral phenotyping. We evaluated whether a digital app delivered on a smartphone or tablet using computer vision analysis (CVA) can elicit and accurately measure one of the most common early autism symptoms, namely failure to respond to a name call. METHODS: During a pediatric primary care well-child visit, 910 toddlers, 17-37 months old, were administered an app on an iPhone or iPad consisting of brief movies during which the child's name was called three times by an examiner standing behind them. Thirty-seven toddlers were subsequently diagnosed with autism spectrum disorder (ASD). Name calls and children's behavior were recorded by the camera embedded in the device, and children's head turns were coded by both CVA and a human. RESULTS: CVA coding of response to name was found to be comparable to human coding. Based on CVA, children with ASD responded to their name significantly less frequently than children without ASD. CVA also revealed that children with ASD who did orient to their name exhibited a longer latency before turning their head. Combining information about both the frequency and the delay in response to name improved the ability to distinguish toddlers with and without ASD. CONCLUSIONS: A digital app delivered on an iPhone or iPad in real-world settings using computer vision analysis to quantify behavior can reliably detect a key early autism symptom-failure to respond to name. Moreover, the higher resolution offered by CVA identified a delay in head turn in toddlers with ASD who did respond to their name. Digital phenotyping is a promising methodology for early assessment of ASD symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.13381 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder / R. K. GREENE in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 12 p. Titre : The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : R. K. GREENE, Auteur ; M. SPANOS, Auteur ; C. ALDERMAN, Auteur ; E. WALSH, Auteur ; Joshua BIZZELL, Auteur ; M. G. MOSNER, Auteur ; J. L. KINARD, Auteur ; G. D. STUBER, Auteur ; Tara CHANDRASEKHAR, Auteur ; L. C. POLITTE, Auteur ; L. SIKICH, Auteur ; Gabriel S. DICHTER, Auteur Année de publication : 2018 Article en page(s) : 12 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Oxytocin  Reward  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Intranasal oxytocin (OT) has been shown to improve social communication functioning of individuals with autism spectrum disorder (ASD) and, thus, has received considerable interest as a potential ASD therapeutic agent. Although preclinical research indicates that OT modulates the functional output of the mesocorticolimbic dopamine system that processes rewards, no clinical brain imaging study to date has examined the effects of OT on this system using a reward processing paradigm. To address this, we used an incentive delay task to examine the effects of a single dose of intranasal OT, versus placebo (PLC), on neural responses to social and nonsocial rewards in children with ASD. METHODS: In this placebo-controlled double-blind study, 28 children and adolescents with ASD (age: M = 13.43 years, SD = 2.36) completed two fMRI scans, one after intranasal OT administration and one after PLC administration. During both scanning sessions, participants completed social and nonsocial incentive delay tasks. Task-based neural activation and connectivity were examined to assess the impact of OT relative to PLC on mesocorticolimbic brain responses to social and nonsocial reward anticipation and outcomes. RESULTS: Central analyses compared the OT and PLC conditions. During nonsocial reward anticipation, there was greater activation in the right nucleus accumbens (NAcc), left anterior cingulate cortex (ACC), bilateral orbital frontal cortex (OFC), left superior frontal cortex, and right frontal pole (FP) during the OT condition relative to PLC. Alternatively, during social reward anticipation and outcomes, there were no significant increases in brain activation during the OT condition relative to PLC. A Treatment Group x Reward Condition interaction revealed relatively greater activation in the right NAcc, right caudate nucleus, left ACC, and right OFC during nonsocial relative to social reward anticipation during the OT condition relative to PLC. Additionally, these analyses revealed greater activation during nonsocial reward outcomes during the OT condition relative to PLC in the right OFC and left FP. Finally, functional connectivity analyses generally revealed changes in frontostriatal connections during the OT condition relative to PLC in response to nonsocial, but not social, rewards. CONCLUSIONS: The effects of intranasal OT administration on mesocorticolimbic brain systems that process rewards in ASD were observable primarily during the processing of nonsocial incentive salience stimuli. These findings have implications for understanding the effects of OT on neural systems that process rewards, as well as for experimental trials of novel ASD treatments developed to ameliorate social communication impairments in ASD. En ligne : http://dx.doi.org/10.1186/s11689-018-9228-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] The effects of intranasal oxytocin on reward circuitry responses in children with autism spectrum disorder [Texte imprimé et/ou numérique] / R. K. GREENE, Auteur ; M. SPANOS, Auteur ; C. ALDERMAN, Auteur ; E. WALSH, Auteur ; Joshua BIZZELL, Auteur ; M. G. MOSNER, Auteur ; J. L. KINARD, Auteur ; G. D. STUBER, Auteur ; Tara CHANDRASEKHAR, Auteur ; L. C. POLITTE, Auteur ; L. SIKICH, Auteur ; Gabriel S. DICHTER, Auteur . - 2018 . - 12 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 12 p. Mots-clés : Autism spectrum disorder  Oxytocin  Reward  fMRI Index. décimale : PER Périodiques Résumé : BACKGROUND: Intranasal oxytocin (OT) has been shown to improve social communication functioning of individuals with autism spectrum disorder (ASD) and, thus, has received considerable interest as a potential ASD therapeutic agent. Although preclinical research indicates that OT modulates the functional output of the mesocorticolimbic dopamine system that processes rewards, no clinical brain imaging study to date has examined the effects of OT on this system using a reward processing paradigm. To address this, we used an incentive delay task to examine the effects of a single dose of intranasal OT, versus placebo (PLC), on neural responses to social and nonsocial rewards in children with ASD. METHODS: In this placebo-controlled double-blind study, 28 children and adolescents with ASD (age: M = 13.43 years, SD = 2.36) completed two fMRI scans, one after intranasal OT administration and one after PLC administration. During both scanning sessions, participants completed social and nonsocial incentive delay tasks. Task-based neural activation and connectivity were examined to assess the impact of OT relative to PLC on mesocorticolimbic brain responses to social and nonsocial reward anticipation and outcomes. RESULTS: Central analyses compared the OT and PLC conditions. During nonsocial reward anticipation, there was greater activation in the right nucleus accumbens (NAcc), left anterior cingulate cortex (ACC), bilateral orbital frontal cortex (OFC), left superior frontal cortex, and right frontal pole (FP) during the OT condition relative to PLC. Alternatively, during social reward anticipation and outcomes, there were no significant increases in brain activation during the OT condition relative to PLC. A Treatment Group x Reward Condition interaction revealed relatively greater activation in the right NAcc, right caudate nucleus, left ACC, and right OFC during nonsocial relative to social reward anticipation during the OT condition relative to PLC. Additionally, these analyses revealed greater activation during nonsocial reward outcomes during the OT condition relative to PLC in the right OFC and left FP. Finally, functional connectivity analyses generally revealed changes in frontostriatal connections during the OT condition relative to PLC in response to nonsocial, but not social, rewards. CONCLUSIONS: The effects of intranasal OT administration on mesocorticolimbic brain systems that process rewards in ASD were observable primarily during the processing of nonsocial incentive salience stimuli. These findings have implications for understanding the effects of OT on neural systems that process rewards, as well as for experimental trials of novel ASD treatments developed to ameliorate social communication impairments in ASD. En ligne : http://dx.doi.org/10.1186/s11689-018-9228-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

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