Abstract Analogical Reasoning in High-Functioning Children with Autism Spectrum Disorders / Adam E. GREEN in Autism Research, 7-6 (December 2014)  

Public ISBD [article]  inAutism Research > 7-6 (December 2014) . - p.677-686 Titre : Abstract Analogical Reasoning in High-Functioning Children with Autism Spectrum Disorders Type de document : texte imprimé Auteurs : Adam E. GREEN, Auteur ; Lauren KENWORTHY, Auteur ; Maya G. MOSNER, Auteur ; Natalie M. GALLAGHER, Auteur ; Edward W. FEARON, Auteur ; Carlos D. BALHANA, Auteur ; Benjamin E. YERYS, Auteur Article en page(s) : p.677-686 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  analogical reasoning  development  social cognition Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) exhibit a deficit in spontaneously recognizing abstract similarities that are crucial for generalizing learning to new situations. This may contribute to deficits in the development of appropriate schemas for navigating novel situations, including social interactions. Analogical reasoning is the central cognitive mechanism that enables typically developing children to understand abstract similarities between different situations. Intriguingly, studies of high-functioning children with ASD point to a relative cognitive strength in basic, nonabstract forms of analogical reasoning. If this analogical reasoning ability extends to abstract analogical reasoning (i.e., between superficially dissimilar situations), it may provide a bridge between a cognitive capability and core ASD deficits in areas such as generalization and categorization. This study tested whether preserved analogical reasoning abilities in ASD can be extended to abstract analogical reasoning, using photographs of real-world items and situations. Abstractness of the analogies was determined via a quantitative measure of semantic distance derived from latent semantic analysis. Children with ASD performed as well as typically developing children at identifying abstract analogical similarities when explicitly instructed to apply analogical reasoning. Individual differences in abstract analogical reasoning ability predicted individual differences in a measure of social function in the ASD group. Preliminary analyses indicated that children with ASD, but not typically developing children, showed an effect of age on abstract analogical reasoning. These results provide new evidence that children with ASD are capable of identifying abstract similarities through analogical reasoning, pointing to abstract analogical reasoning as a potential lever for improving generalization skills and social function in ASD. En ligne : http://dx.doi.org/10.1002/aur.1411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256 [article] Abstract Analogical Reasoning in High-Functioning Children with Autism Spectrum Disorders [texte imprimé] / Adam E. GREEN, Auteur ; Lauren KENWORTHY, Auteur ; Maya G. MOSNER, Auteur ; Natalie M. GALLAGHER, Auteur ; Edward W. FEARON, Auteur ; Carlos D. BALHANA, Auteur ; Benjamin E. YERYS, Auteur . - p.677-686. Langues : Anglais (eng) in Autism Research > 7-6 (December 2014) . - p.677-686 Mots-clés : autism spectrum disorders  analogical reasoning  development  social cognition Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) exhibit a deficit in spontaneously recognizing abstract similarities that are crucial for generalizing learning to new situations. This may contribute to deficits in the development of appropriate schemas for navigating novel situations, including social interactions. Analogical reasoning is the central cognitive mechanism that enables typically developing children to understand abstract similarities between different situations. Intriguingly, studies of high-functioning children with ASD point to a relative cognitive strength in basic, nonabstract forms of analogical reasoning. If this analogical reasoning ability extends to abstract analogical reasoning (i.e., between superficially dissimilar situations), it may provide a bridge between a cognitive capability and core ASD deficits in areas such as generalization and categorization. This study tested whether preserved analogical reasoning abilities in ASD can be extended to abstract analogical reasoning, using photographs of real-world items and situations. Abstractness of the analogies was determined via a quantitative measure of semantic distance derived from latent semantic analysis. Children with ASD performed as well as typically developing children at identifying abstract analogical similarities when explicitly instructed to apply analogical reasoning. Individual differences in abstract analogical reasoning ability predicted individual differences in a measure of social function in the ASD group. Preliminary analyses indicated that children with ASD, but not typically developing children, showed an effect of age on abstract analogical reasoning. These results provide new evidence that children with ASD are capable of identifying abstract similarities through analogical reasoning, pointing to abstract analogical reasoning as a potential lever for improving generalization skills and social function in ASD. En ligne : http://dx.doi.org/10.1002/aur.1411 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=256

Adaptive Behavior in Youth with Autism Spectrum Disorder: The Role of Flexibility / Jennifer R. BERTOLLO in Journal of Autism and Developmental Disorders, 50-1 (January 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.42-50 Titre : Adaptive Behavior in Youth with Autism Spectrum Disorder: The Role of Flexibility Type de document : texte imprimé Auteurs : Jennifer R. BERTOLLO, Auteur ; John F. STRANG, Auteur ; Laura G. ANTHONY, Auteur ; Lauren KENWORTHY, Auteur ; Gregory L. WALLACE, Auteur ; Benjamin E. YERYS, Auteur Article en page(s) : p.42-50 Langues : Anglais (eng) Mots-clés : Adaptive behavior  Autism spectrum disorder  Executive function  Flexibility Index. décimale : PER Périodiques Résumé : Cognitive and behavioral flexibility are important predictors of adaptive behavior in school-age autistic youth. While prior research has utilized broad measures of flexibility, the current study uses the multi-dimensional Flexibility Scale-Revised to examine which specific flexibility skills relate to adaptive functioning. Through parent-report measures on 216 autistic youth, flexibility explained 22.2% of variance in adaptive socialization skills (p < 0.001). Specifically, Social Flexibility accounted for significant variance in adaptive socialization skills, while Transitions/Change approached significance. In exploratory analyses, flexibility explained 11.5% of variance in Communication skills (p < 0.001). This pattern remained after controlling for co-occurring ADHD symptoms. The current study helps to refine the relationship between flexibility and adaptive behavior, which may ultimately help to inform more targeted interventions. En ligne : http://dx.doi.org/10.1007/s10803-019-04220-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 [article] Adaptive Behavior in Youth with Autism Spectrum Disorder: The Role of Flexibility [texte imprimé] / Jennifer R. BERTOLLO, Auteur ; John F. STRANG, Auteur ; Laura G. ANTHONY, Auteur ; Lauren KENWORTHY, Auteur ; Gregory L. WALLACE, Auteur ; Benjamin E. YERYS, Auteur . - p.42-50. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-1 (January 2020) . - p.42-50 Mots-clés : Adaptive behavior  Autism spectrum disorder  Executive function  Flexibility Index. décimale : PER Périodiques Résumé : Cognitive and behavioral flexibility are important predictors of adaptive behavior in school-age autistic youth. While prior research has utilized broad measures of flexibility, the current study uses the multi-dimensional Flexibility Scale-Revised to examine which specific flexibility skills relate to adaptive functioning. Through parent-report measures on 216 autistic youth, flexibility explained 22.2% of variance in adaptive socialization skills (p < 0.001). Specifically, Social Flexibility accounted for significant variance in adaptive socialization skills, while Transitions/Change approached significance. In exploratory analyses, flexibility explained 11.5% of variance in Communication skills (p < 0.001). This pattern remained after controlling for co-occurring ADHD symptoms. The current study helps to refine the relationship between flexibility and adaptive behavior, which may ultimately help to inform more targeted interventions. En ligne : http://dx.doi.org/10.1007/s10803-019-04220-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414

Altered reward system reactivity for personalized circumscribed interests in autism / Gregor KOHLS in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 9p. Titre : Altered reward system reactivity for personalized circumscribed interests in autism Type de document : texte imprimé Auteurs : Gregor KOHLS, Auteur ; Ligia ANTEZANA, Auteur ; Maya G. MOSNER, Auteur ; Robert T. SCHULTZ, Auteur ; Benjamin E. YERYS, Auteur Article en page(s) : 9p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Caudate nucleus  Circumscribed interests  Functional magnetic resonance imaging  Motivation  Restricted and repetitive behaviors and interests  Reward  Reward system  Striatum Index. décimale : PER Périodiques Résumé : Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs). Methods: We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task's ecological validity compared to still pictures that are often used in this line of research. Results: Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus' responsiveness was related to greater social impairment. Conclusions: The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families. En ligne : http://dx.doi.org/10.1186/s13229-018-0195-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354 [article] Altered reward system reactivity for personalized circumscribed interests in autism [texte imprimé] / Gregor KOHLS, Auteur ; Ligia ANTEZANA, Auteur ; Maya G. MOSNER, Auteur ; Robert T. SCHULTZ, Auteur ; Benjamin E. YERYS, Auteur . - 9p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 9p. Mots-clés : Autism spectrum disorders  Caudate nucleus  Circumscribed interests  Functional magnetic resonance imaging  Motivation  Restricted and repetitive behaviors and interests  Reward  Reward system  Striatum Index. décimale : PER Périodiques Résumé : Background: Neurobiological research in autism spectrum disorders (ASD) has paid little attention on brain mechanisms that cause and maintain restricted and repetitive behaviors and interests (RRBIs). Evidence indicates an imbalance in the brain's reward system responsiveness to social and non-social stimuli may contribute to both social deficits and RRBIs. Thus, this study's central aim was to compare brain responsiveness to individual RRBI (i.e., circumscribed interests), with social rewards (i.e., social approval), in youth with ASD relative to typically developing controls (TDCs). Methods: We conducted a 3T functional magnetic resonance imaging (fMRI) study to investigate the blood-oxygenation-level-dependent effect of personalized circumscribed interest rewards versus social rewards in 39 youth with ASD relative to 22 TDC. To probe the reward system, we employed short video clips as reinforcement in an instrumental incentive delay task. This optimization increased the task's ecological validity compared to still pictures that are often used in this line of research. Results: Compared to TDCs, youth with ASD had stronger reward system responses for CIs mostly within the non-social realm (e.g., video games) than social rewards (e.g., approval). Additionally, this imbalance within the caudate nucleus' responsiveness was related to greater social impairment. Conclusions: The current data support the idea of reward system dysfunction that may contribute to enhanced motivation for RRBIs in ASD, accompanied by diminished motivation for social engagement. If a dysregulated reward system indeed supports the emergence and maintenance of social and non-social symptoms of ASD, then strategically targeting the reward system in future treatment endeavors may allow for more efficacious treatment practices that help improve outcomes for individuals with ASD and their families. En ligne : http://dx.doi.org/10.1186/s13229-018-0195-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=354

Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder / Benjamin E. YERYS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 32 p. Titre : Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder Type de document : texte imprimé Auteurs : Benjamin E. YERYS, Auteur ; John D. HERRINGTON, Auteur ; Gregory K. BARTLEY, Auteur ; Hua-Shan LIU, Auteur ; John A. DETRE, Auteur ; Robert T. SCHULTZ, Auteur Année de publication : 2018 Article en page(s) : 32 p. Langues : Anglais (eng) Mots-clés : Autism  Blood flow  Faces  Mri  Social cognition  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Research on neurobiological markers of autism spectrum disorder (ASD) has been elusive. However, radionuclide studies of cerebral blood flow (CBF) have shown decreased blood flow (hypoperfusion) in the temporal lobes of individuals with ASD across ages and intelligence. This observation fits with current neuroscientific models that implicate temporal regions in social perception and social cognition. Arterial spin labeled perfusion MRI allows noninvasive quantification of regional CBF as part of a multimodal MRI protocol. This method is almost entirely absent from ASD research to date. Our a priori hypothesis was that children with ASD would present with hypoperfusion in the temporal lobes-most notably the fusiform gyrus (given its prominent role in ASD social perception deficits). We also sought to examine the reproducibility of CBF measures, and their relationship to individual differences in facial recognition and ASD symptoms. METHODS: A total of 58 males (33 with ASD) between the ages of 12 and 17 years participated in the study. All children completed two arterial spin labeling and structural (T1) scans using a 3 T Siemens Verio scanner approximately 8 weeks apart, as well as behavioral testing at time 1 that included diagnostic measures and the Benton Facial Recognition Test. CBF was the key dependent variable, as was facial recognition performance, and ASD symptoms. The two scans were used for reliability analyses. RESULTS: The ASD group showed hypoperfusion in the bilateral fusiform gyrus and in right inferior temporal gyrus. Intra-class correlations showed moderate to good reliability across time within both groups, and no diagnostic group x time interactions. CBF in the left fusiform gyrus was significantly positively correlated with facial recognition. No significant correlations were observed with core ASD symptoms. CONCLUSIONS: Arterial spin labeling revealed hypoperfusion in children with ASD in regions critical to social perception and cognition. The left fusiform gyrus plays an important role in facial recognition, and greater CBF in this region was correlated with more normative facial recognition performance in children with ASD. This study takes an important first step in establishing CBF of the temporal lobes as a reliable marker of ASD. En ligne : http://dx.doi.org/10.1186/s11689-018-9250-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder [texte imprimé] / Benjamin E. YERYS, Auteur ; John D. HERRINGTON, Auteur ; Gregory K. BARTLEY, Auteur ; Hua-Shan LIU, Auteur ; John A. DETRE, Auteur ; Robert T. SCHULTZ, Auteur . - 2018 . - 32 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 32 p. Mots-clés : Autism  Blood flow  Faces  Mri  Social cognition  Social perception Index. décimale : PER Périodiques Résumé : BACKGROUND: Research on neurobiological markers of autism spectrum disorder (ASD) has been elusive. However, radionuclide studies of cerebral blood flow (CBF) have shown decreased blood flow (hypoperfusion) in the temporal lobes of individuals with ASD across ages and intelligence. This observation fits with current neuroscientific models that implicate temporal regions in social perception and social cognition. Arterial spin labeled perfusion MRI allows noninvasive quantification of regional CBF as part of a multimodal MRI protocol. This method is almost entirely absent from ASD research to date. Our a priori hypothesis was that children with ASD would present with hypoperfusion in the temporal lobes-most notably the fusiform gyrus (given its prominent role in ASD social perception deficits). We also sought to examine the reproducibility of CBF measures, and their relationship to individual differences in facial recognition and ASD symptoms. METHODS: A total of 58 males (33 with ASD) between the ages of 12 and 17 years participated in the study. All children completed two arterial spin labeling and structural (T1) scans using a 3 T Siemens Verio scanner approximately 8 weeks apart, as well as behavioral testing at time 1 that included diagnostic measures and the Benton Facial Recognition Test. CBF was the key dependent variable, as was facial recognition performance, and ASD symptoms. The two scans were used for reliability analyses. RESULTS: The ASD group showed hypoperfusion in the bilateral fusiform gyrus and in right inferior temporal gyrus. Intra-class correlations showed moderate to good reliability across time within both groups, and no diagnostic group x time interactions. CBF in the left fusiform gyrus was significantly positively correlated with facial recognition. No significant correlations were observed with core ASD symptoms. CONCLUSIONS: Arterial spin labeling revealed hypoperfusion in children with ASD in regions critical to social perception and cognition. The left fusiform gyrus plays an important role in facial recognition, and greater CBF in this region was correlated with more normative facial recognition performance in children with ASD. This study takes an important first step in establishing CBF of the temporal lobes as a reliable marker of ASD. En ligne : http://dx.doi.org/10.1186/s11689-018-9250-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Attention Deficit Hyperactivity Disorder in Autism Spectrum Disorder: A High-Risk Co-Occurring Condition / Benjamin E. YERYS

Public ISBD in The Oxford Handbook of Autism and Co-Occurring Psychiatric Conditions / Susan W. WHITE Titre : Attention Deficit Hyperactivity Disorder in Autism Spectrum Disorder: A High-Risk Co-Occurring Condition Type de document : texte imprimé Auteurs : Benjamin E. YERYS, Auteur Année de publication : 2020 Importance : p.159-176 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : This chapter will review the available evidence on individuals with co-occurring diagnoses of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). This chapter contends that children diagnosed with both disorders (ASD+ADHD) are a subset of the ASD population that is at risk for delayed recognition of their ASD diagnosis, poor treatment response, and poorer functional outcomes compared to those with ASD without ADHD. Specifically, the chapter highlights the best estimates of the prevalence of the comorbidity, the developmental trajectory of people with co-occurring ASD and ADHD, how ADHD symptoms change across development, overlapping genetic and neurobiological risk factors, psychometrics of ADHD diagnostic instruments in an ASD population, neuropsychological and functional impairments associated with co-occurring ASD and ADHD, and the current state of evidence-based treatment for both ASD and ADHD symptoms. Finally, the chapter discusses fruitful avenues of research for improving understanding of this high-risk comorbidity so that mechanism-to-treatment pathways for ADHD in children with ASD can be better developed. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 in The Oxford Handbook of Autism and Co-Occurring Psychiatric Conditions / Susan W. WHITE Attention Deficit Hyperactivity Disorder in Autism Spectrum Disorder: A High-Risk Co-Occurring Condition [texte imprimé] / Benjamin E. YERYS, Auteur . - 2020 . - p.159-176. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Résumé : This chapter will review the available evidence on individuals with co-occurring diagnoses of autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). This chapter contends that children diagnosed with both disorders (ASD+ADHD) are a subset of the ASD population that is at risk for delayed recognition of their ASD diagnosis, poor treatment response, and poorer functional outcomes compared to those with ASD without ADHD. Specifically, the chapter highlights the best estimates of the prevalence of the comorbidity, the developmental trajectory of people with co-occurring ASD and ADHD, how ADHD symptoms change across development, overlapping genetic and neurobiological risk factors, psychometrics of ADHD diagnostic instruments in an ASD population, neuropsychological and functional impairments associated with co-occurring ASD and ADHD, and the current state of evidence-based treatment for both ASD and ADHD symptoms. Finally, the chapter discusses fruitful avenues of research for improving understanding of this high-risk comorbidity so that mechanism-to-treatment pathways for ADHD in children with ASD can be better developed. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

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Attention deficit/hyperactivity disorder symptoms moderate cognition and behavior in children with autism spectrum disorders / Benjamin E. YERYS in Autism Research, 2-6 (December 2009)  

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Brief Report: Generalization Weaknesses in Verbally Fluent Children and Adolescents with Autism Spectrum Disorder / Ashley B. DE MARCHENA in Journal of Autism and Developmental Disorders, 45-10 (October 2015)  

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Brief Report: Healthcare Providers' Discussions Regarding Transportation and Driving with Autistic and Non-autistic Patients / Emma B. SARTIN ; Rachel K. MYERS ; Christina LABOWS ; Kristina B. METZGER ; Meghan E. CAREY ; Benjamin E. YERYS ; Catherine C. McDonald ; Cynthia J. MOLLEN ; Allison E. CURRY in Journal of Autism and Developmental Disorders, 53-6 (June 2023)  

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Brief Report: Impaired Flexible Item Selection Task (FIST) in School-Age Children with Autism Spectrum Disorders / Benjamin E. YERYS in Journal of Autism and Developmental Disorders, 42-9 (September 2012)  

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Brief Report: Performance-Based Executive Functioning Abilities are Associated with Caregiver Report of Adaptive Functioning in Autism Spectrum Disorder / Manisha D. UDHNANI in Journal of Autism and Developmental Disorders, 50-12 (December 2020)  

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Brief Report: Pilot Study of a Novel Interactive Digital Treatment to Improve Cognitive Control in Children with Autism Spectrum Disorder and Co-occurring ADHD Symptoms / Benjamin E. YERYS in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

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Caregiver perspectives on interventions for behavior challenges in autistic children / Jessica E. TSCHIDA in Research in Autism Spectrum Disorders, 81 (March 2021)  

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Characterizing the Factor Structure of Parent Reported Executive Function in Autism Spectrum Disorders: The Impact of Cognitive Inflexibility / Yael GRANADER in Journal of Autism and Developmental Disorders, 44-12 (December 2014)  

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Co-occurring ADHD symptoms in autistic adults are associated with less independence in daily living activities and lower subjective quality of life / Benjamin E. YERYS in Autism, 26-8 (November 2022)  

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Critical region within 22q11.2 linked to higher rate of autism spectrum disorder / Caitlin C. CLEMENTS in Molecular Autism, 8 (2017)  

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