Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study / Laura TURRIZIANI in Autism Research, 15-1 (January 2022)  

Public ISBD [article]  inAutism Research > 15-1 (January 2022) . - p.56-69 Titre : Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study Type de document : texte imprimé Auteurs : Laura TURRIZIANI, Auteur ; Arianna RICCIARDELLO, Auteur ; Francesca CUCINOTTA, Auteur ; Fabiana BELLOMO, Auteur ; Giada TURTURO, Auteur ; Maria BONCODDO, Auteur ; Silvestro MIRABELLI, Auteur ; Maria Luisa SCATTONI, Auteur ; Maddalena ROSSI, Auteur ; Antonio M. PERSICO, Auteur Article en page(s) : p.56-69 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications  Autistic Disorder/complications  Behavioral Symptoms  Child  Child, Preschool  Constipation/complications  Cresols/urine  Gastrointestinal Microbiome  Gastrointestinal Motility  Humans  Prospective Studies  4-cresol  anxiety  autism  autism spectrum disorder  biomarkers  constipation  microbiota Index. décimale : PER Périodiques Résumé : Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors. Young autistic children with chronic constipation display higher urinary, and foecal concentrations of p-cresol, an aromatic compound produced by gut bacteria, known to negatively affect brain function. Acute p-cresol administration to BTBR mice enhances anxiety, hyperactivity and stereotypic behaviors, while blunting social interaction. This study was undertaken to prospectively assess the behavioral effects of gut mobilization in young autistic children with chronic constipation, and to verify their possible correlation with urinary p-cresol. To this aim, 21 chronically constipated autistic children 2-8 years old were evaluated before (T0), 1 month (T1), and 6 months (T2) after intestinal mobilization, recording Bristol stool scale scores, urinary p-cresol concentrations, and behavioral scores for social interaction deficits, stereotypic behaviors, anxiety, and hyperactivity. Gut mobilization yielded a progressive and highly significant decrease in all behavioral symptoms over the 6-month study period. Urinary p-cresol levels displayed variable trends not significantly correlated with changes in behavioral parameters, mainly increasing at T1 and decreasing at T2. These results support gut mobilization as a simple strategy to ameliorate ASD symptoms, as well as comorbid anxiety and hyperactivity, in chronically constipated children. Variation in p-cresol absorption seemingly provides limited contributions, if any, to these behavioral changes. Further research will be needed to address the relative role of reduced abdominal discomfort following mobilization, as compared to specific modifications in microbiome composition and in gut bacteria-derived neuroactive compounds. En ligne : http://dx.doi.org/10.1002/aur.2639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study [texte imprimé] / Laura TURRIZIANI, Auteur ; Arianna RICCIARDELLO, Auteur ; Francesca CUCINOTTA, Auteur ; Fabiana BELLOMO, Auteur ; Giada TURTURO, Auteur ; Maria BONCODDO, Auteur ; Silvestro MIRABELLI, Auteur ; Maria Luisa SCATTONI, Auteur ; Maddalena ROSSI, Auteur ; Antonio M. PERSICO, Auteur . - p.56-69. Langues : Anglais (eng) in Autism Research > 15-1 (January 2022) . - p.56-69 Mots-clés : Autism Spectrum Disorder/complications  Autistic Disorder/complications  Behavioral Symptoms  Child  Child, Preschool  Constipation/complications  Cresols/urine  Gastrointestinal Microbiome  Gastrointestinal Motility  Humans  Prospective Studies  4-cresol  anxiety  autism  autism spectrum disorder  biomarkers  constipation  microbiota Index. décimale : PER Périodiques Résumé : Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors. Young autistic children with chronic constipation display higher urinary, and foecal concentrations of p-cresol, an aromatic compound produced by gut bacteria, known to negatively affect brain function. Acute p-cresol administration to BTBR mice enhances anxiety, hyperactivity and stereotypic behaviors, while blunting social interaction. This study was undertaken to prospectively assess the behavioral effects of gut mobilization in young autistic children with chronic constipation, and to verify their possible correlation with urinary p-cresol. To this aim, 21 chronically constipated autistic children 2-8 years old were evaluated before (T0), 1 month (T1), and 6 months (T2) after intestinal mobilization, recording Bristol stool scale scores, urinary p-cresol concentrations, and behavioral scores for social interaction deficits, stereotypic behaviors, anxiety, and hyperactivity. Gut mobilization yielded a progressive and highly significant decrease in all behavioral symptoms over the 6-month study period. Urinary p-cresol levels displayed variable trends not significantly correlated with changes in behavioral parameters, mainly increasing at T1 and decreasing at T2. These results support gut mobilization as a simple strategy to ameliorate ASD symptoms, as well as comorbid anxiety and hyperactivity, in chronically constipated children. Variation in p-cresol absorption seemingly provides limited contributions, if any, to these behavioral changes. Further research will be needed to address the relative role of reduced abdominal discomfort following mobilization, as compared to specific modifications in microbiome composition and in gut bacteria-derived neuroactive compounds. En ligne : http://dx.doi.org/10.1002/aur.2639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Syndrome de Williams: phénotype clinique et bases génétiques / Pauline MONIN in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E., 160 (Juin 2019)

Public ISBD [article]  inApproche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 160 (Juin 2019) . - p.209-306 Titre : Syndrome de Williams: phénotype clinique et bases génétiques Type de document : texte imprimé Auteurs : Pauline MONIN, Auteur ; Damien SANLAVILLE, Auteur ; Maddalena ROSSI, Auteur Article en page(s) : p.209-306 Langues : Français (fre) Mots-clés : Microdélétion 7q1 1.23  Syndrome des gènes contigus  Sténose artérielle  Déficience intellectuelle  Dysmorphie Index. décimale : PER Périodiques Résumé : Le syndrome de Williams est une maladie génétique caractérisée par une atteinte multi-systémique associant une atteinte cardiovasculaire, des particularités morphologiques du visage, des anomalies du tissu conjonctif, une déficience intellectuelle avec un profil cognitif caractéristique, un retard de croissance, et des anomalies endocriniennes. Le syndrome de Williams est lié à une microdélétion hétérozygote récurrente de 1,55 à 1,84 MB en 7q 11.23, emportant 28 gènes. Les objectifs de cette publication sont de décrire le phénotype clinique associé au syndrome de Williams et de détailler les bases génétiques du syndrome ainsi que les relations génotype-phénotype identifiées à ce jour. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402 [article] Syndrome de Williams: phénotype clinique et bases génétiques [texte imprimé] / Pauline MONIN, Auteur ; Damien SANLAVILLE, Auteur ; Maddalena ROSSI, Auteur . - p.209-306. Langues : Français (fre) in Approche Neuropsychologique des Apprentissages chez l'Enfant - A.N.A.E. > 160 (Juin 2019) . - p.209-306 Mots-clés : Microdélétion 7q1 1.23  Syndrome des gènes contigus  Sténose artérielle  Déficience intellectuelle  Dysmorphie Index. décimale : PER Périodiques Résumé : Le syndrome de Williams est une maladie génétique caractérisée par une atteinte multi-systémique associant une atteinte cardiovasculaire, des particularités morphologiques du visage, des anomalies du tissu conjonctif, une déficience intellectuelle avec un profil cognitif caractéristique, un retard de croissance, et des anomalies endocriniennes. Le syndrome de Williams est lié à une microdélétion hétérozygote récurrente de 1,55 à 1,84 MB en 7q 11.23, emportant 28 gènes. Les objectifs de cette publication sont de décrire le phénotype clinique associé au syndrome de Williams et de détailler les bases génétiques du syndrome ainsi que les relations génotype-phénotype identifiées à ce jour. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=402

The Role of Microbiota Metabolites Propionic Acid, p-Cresol, and 4-Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review / Laura SANDONI in Autism Research, 19-5 (May 2026)  

Public ISBD [article]  inAutism Research > 19-5 (May 2026) . - p.e70237 Titre : The Role of Microbiota Metabolites Propionic Acid, p-Cresol, and 4-Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review Type de document : texte imprimé Auteurs : Laura SANDONI, Auteur ; Lisa ASTA, Auteur ; Nicole GIOMPAOLO, Auteur ; Rinvil RENALDI, Auteur ; Alberto AMARETTI, Auteur ; Maddalena ROSSI, Auteur ; Antonio M. PERSICO, Auteur Article en page(s) : p.e70237 Langues : Anglais (eng) Mots-clés : 4-ethylphenyl sulfate  autism spectrum disorder  gut microbiota  gut-brain axis  propionic acid  p-cresol Index. décimale : PER Périodiques Résumé : ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis. Thousands of different bacterial strains are found in the human gut, which produce numerous metabolites that can enter the bloodstream and often pass the blood?brain barrier, potentially influencing neurodevelopment and brain function. This systematic review aims to provide a comprehensive outlook on the role of three metabolic compounds derived from gut bacteria, propionic acid (PPA), p-cresol, and 4-ethylphenyl sulfate (4-EPS), in modulating neuronal function and conferring susceptibility to ASD. To achieve this, we screened 411 records collected through a systematic search of current scientific literature in PubMed, Web of Science, and Scopus, ultimately reviewing a total of 90 records, which included data from ASD human cohorts as well as animal and cellular models of autism. Human studies provided compelling evidence of altered metabolic profiles in ASD individuals, especially for PPA and p-cresol, but also to a smaller extent, for 4-EPS. Furthermore, data obtained from the exposure of experimental models to each one of these three metabolic compounds identified several behavioral anomalies induced in treated animals and highlighted common neurobiological mechanisms. Overall, current literature supports the contribution of gut metabolites to ASD susceptibility and/or a significant modulatory role on the clinical expression of ASD, strongly encouraging further research in the field in order to improve autism diagnostics and management. En ligne : https://doi.org/10.1002/aur.70237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587 [article] The Role of Microbiota Metabolites Propionic Acid, p-Cresol, and 4-Ethylphenyl Sulfate in Autism Susceptibility: A Systematic Review [texte imprimé] / Laura SANDONI, Auteur ; Lisa ASTA, Auteur ; Nicole GIOMPAOLO, Auteur ; Rinvil RENALDI, Auteur ; Alberto AMARETTI, Auteur ; Maddalena ROSSI, Auteur ; Antonio M. PERSICO, Auteur . - p.e70237. Langues : Anglais (eng) in Autism Research > 19-5 (May 2026) . - p.e70237 Mots-clés : 4-ethylphenyl sulfate  autism spectrum disorder  gut microbiota  gut-brain axis  propionic acid  p-cresol Index. décimale : PER Périodiques Résumé : ABSTRACT The etiopathogenesis of Autism Spectrum Disorder (ASD) encompasses complex interactions between genetic and environmental risk factors. The high prevalence of gastrointestinal disorders in autistic individuals has propelled a growing interest in the possible involvement of gut dysbiosis in ASD pathogenesis. Thousands of different bacterial strains are found in the human gut, which produce numerous metabolites that can enter the bloodstream and often pass the blood?brain barrier, potentially influencing neurodevelopment and brain function. This systematic review aims to provide a comprehensive outlook on the role of three metabolic compounds derived from gut bacteria, propionic acid (PPA), p-cresol, and 4-ethylphenyl sulfate (4-EPS), in modulating neuronal function and conferring susceptibility to ASD. To achieve this, we screened 411 records collected through a systematic search of current scientific literature in PubMed, Web of Science, and Scopus, ultimately reviewing a total of 90 records, which included data from ASD human cohorts as well as animal and cellular models of autism. Human studies provided compelling evidence of altered metabolic profiles in ASD individuals, especially for PPA and p-cresol, but also to a smaller extent, for 4-EPS. Furthermore, data obtained from the exposure of experimental models to each one of these three metabolic compounds identified several behavioral anomalies induced in treated animals and highlighted common neurobiological mechanisms. Overall, current literature supports the contribution of gut metabolites to ASD susceptibility and/or a significant modulatory role on the clinical expression of ASD, strongly encouraging further research in the field in order to improve autism diagnostics and management. En ligne : https://doi.org/10.1002/aur.70237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=587

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