Autism spectrum disorder and birth spacing: Findings from the study to explore early development (SEED) / Laura A. SCHIEVE in Autism Research, 11-1 (January 2018)  

Public ISBD [article]  inAutism Research > 11-1 (January 2018) . - p.81-94 Titre : Autism spectrum disorder and birth spacing: Findings from the study to explore early development (SEED) Type de document : texte imprimé Auteurs : Laura A. SCHIEVE, Auteur ; Lin H. TIAN, Auteur ; Carolyn DREWS-BOTSCH, Auteur ; Gayle C. WINDHAM, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Julie L. DANIELS, Auteur ; Li-Ching LEE, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur Article en page(s) : p.81-94 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  developmental disabilities  birth spacing  epidemiology  risk factor Index. décimale : PER Périodiques Résumé : Previous studies of autism spectrum disorder (ASD) and birth spacing had limitations; few examined phenotypic case subtypes or explored underlying mechanisms for associations and none assessed whether other (non ASD) developmental disabilities (DDs) were associated with birth spacing. We assessed associations between inter?pregnancy interval (IPI) and both ASD and other DDs using data from the Study to Explore Early Development, a multi?site case?control study with rigorous case?finding and case?classification methods and detailed data collection on maternal reproductive history. Our sample included 356 ASD cases, 627 DD cases, and 524 population (POP) controls born in second or later births. ASD and DD cases were further sub?divided according to whether the child had intellectual disability (ID). ASD cases were also sub?divided by ASD symptom severity, and DD cases were subdivided by presence of some ASD symptoms (indicated on an autism screener). Odds ratios, adjusted for maternal?child sociodemographic factors, (aORs) and 95% confidence intervals were derived from logistic regression models. Among term births, ASD was associated with both IPI <18 months (aOR 1.5 [1.1 2.2]) and ≥60 months (1.5 [0.99 2.4]). Both short and long IPI associations were stronger among ASD cases with high severity scores (aORs 2.0 [1.3 3.3] and 1.8 [0.99 3.2], respectively). Associations were unchanged after adding several factors potentially related to the causal pathway to regression models. DD was not associated with either short or long IPI?overall, among term births, or in any subgroup examined. These findings extend those from previous studies and further inform recommendations on optimal pregnancy spacing. Autism Res 2018, 11: 81 94. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We investigated whether the amount of time between pregnancies was associated autism spectrum disorder (ASD) or other developmental disabilities (DD) in children. ASD was increased in second and later?born children who were conceived less than 18 months or 60 or more months after the mother's previous birth. Other DDs were not associated with birth spacing. En ligne : https://doi.org/10.1002/aur.1887 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333 [article] Autism spectrum disorder and birth spacing: Findings from the study to explore early development (SEED) [texte imprimé] / Laura A. SCHIEVE, Auteur ; Lin H. TIAN, Auteur ; Carolyn DREWS-BOTSCH, Auteur ; Gayle C. WINDHAM, Auteur ; Craig J. NEWSCHAFFER, Auteur ; Julie L. DANIELS, Auteur ; Li-Ching LEE, Auteur ; Lisa A. CROEN, Auteur ; M. Daniele FALLIN, Auteur . - p.81-94. Langues : Anglais (eng) in Autism Research > 11-1 (January 2018) . - p.81-94 Mots-clés : autism spectrum disorder  developmental disabilities  birth spacing  epidemiology  risk factor Index. décimale : PER Périodiques Résumé : Previous studies of autism spectrum disorder (ASD) and birth spacing had limitations; few examined phenotypic case subtypes or explored underlying mechanisms for associations and none assessed whether other (non ASD) developmental disabilities (DDs) were associated with birth spacing. We assessed associations between inter?pregnancy interval (IPI) and both ASD and other DDs using data from the Study to Explore Early Development, a multi?site case?control study with rigorous case?finding and case?classification methods and detailed data collection on maternal reproductive history. Our sample included 356 ASD cases, 627 DD cases, and 524 population (POP) controls born in second or later births. ASD and DD cases were further sub?divided according to whether the child had intellectual disability (ID). ASD cases were also sub?divided by ASD symptom severity, and DD cases were subdivided by presence of some ASD symptoms (indicated on an autism screener). Odds ratios, adjusted for maternal?child sociodemographic factors, (aORs) and 95% confidence intervals were derived from logistic regression models. Among term births, ASD was associated with both IPI <18 months (aOR 1.5 [1.1 2.2]) and ≥60 months (1.5 [0.99 2.4]). Both short and long IPI associations were stronger among ASD cases with high severity scores (aORs 2.0 [1.3 3.3] and 1.8 [0.99 3.2], respectively). Associations were unchanged after adding several factors potentially related to the causal pathway to regression models. DD was not associated with either short or long IPI?overall, among term births, or in any subgroup examined. These findings extend those from previous studies and further inform recommendations on optimal pregnancy spacing. Autism Res 2018, 11: 81 94. ? 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary We investigated whether the amount of time between pregnancies was associated autism spectrum disorder (ASD) or other developmental disabilities (DD) in children. ASD was increased in second and later?born children who were conceived less than 18 months or 60 or more months after the mother's previous birth. Other DDs were not associated with birth spacing. En ligne : https://doi.org/10.1002/aur.1887 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=333

Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite case?control analysis replicated across two independent samples / Lisa D. WIGGINS in Autism Research, 15-3 (March 2022)  

Public ISBD [article]  inAutism Research > 15-3 (March 2022) . - p.539-550 Titre : Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite case?control analysis replicated across two independent samples Type de document : texte imprimé Auteurs : Lisa D. WIGGINS, Auteur ; Lin H. TIAN, Auteur ; Eric RUBENSTEIN, Auteur ; Laura A. SCHIEVE, Auteur ; Julie L. DANIELS, Auteur ; Karen PAZOL, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Brian D. BARGER, Auteur ; Eric J. MOODY, Auteur ; Steven A. ROSENBERG, Auteur ; Chyrise BRADLEY, Auteur ; Melanie HSU, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur ; Deborah CHRISTENSEN, Auteur ; Tessa CRUME, Auteur ; Juhi PANDEY, Auteur ; Susan E. LEVY, Auteur Article en page(s) : p.539-550 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The heterogeneous nature of children with symptoms of autism spectrum disorder (ASD) makes it difficult to identify risk factors and effective treatment options. We sought to identify behavioral and developmental features that best define the heterogeneity and homogeneity in 2 5-year-old children classified with ASD and subthreshold ASD characteristics. Children were enrolled in a multisite case?control study of ASD. Detailed behavioral and developmental data were gathered by maternal telephone interview, parent-administered questionnaires, child cognitive evaluation, and ASD diagnostic measures. Participants with a positive ASD screen score or prior ASD diagnosis were referred for comprehensive evaluation. Children in the ASD group met study criteria based on this evaluation; children who did not meet study criteria were categorized as having subthreshold ASD characteristics. There were 1480 children classified as ASD (81.6% boys) and 594 children classified as having subthreshold ASD characteristics (70.2% boys) in the sample. Factors associated with dysregulation (e.g., aggression, anxiety/depression, sleep problems) followed by developmental abilities (e.g., expressive and receptive language skills) most contributed to heterogeneity in both groups of children. Atypical sensory response contributed to homogeneity in children classified as ASD but not those with subthreshold characteristics. These findings suggest that dysregulation and developmental abilities are clinical features that can impact functioning in children with ASD and other DD, and that documenting these features in pediatric records may help meet the needs of the individual child. Sensory dysfunction could be considered a core feature of ASD and thus used to inform more targeted screening, evaluation, treatment, and research efforts. Lay summary The diverse nature of autism spectrum disorder (ASD) makes it difficult to find risk factors and treatment options. We identified the most dissimilar and most similar symptom(s) in children classified as ASD and as having subthreshold ASD characteristics. Factors associated with dysregulation and developmental abilities contributed to diversity in both groups of children. Sensory dysfunction was the most common symptom in children with ASD but not those with subthreshold characteristics. Findings can inform clinical practice and research. En ligne : https://doi.org/10.1002/aur.2663 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Features that best define the heterogeneity and homogeneity of autism in preschool-age children: A multisite case?control analysis replicated across two independent samples [texte imprimé] / Lisa D. WIGGINS, Auteur ; Lin H. TIAN, Auteur ; Eric RUBENSTEIN, Auteur ; Laura A. SCHIEVE, Auteur ; Julie L. DANIELS, Auteur ; Karen PAZOL, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Brian D. BARGER, Auteur ; Eric J. MOODY, Auteur ; Steven A. ROSENBERG, Auteur ; Chyrise BRADLEY, Auteur ; Melanie HSU, Auteur ; Cordelia ROBINSON ROSENBERG, Auteur ; Deborah CHRISTENSEN, Auteur ; Tessa CRUME, Auteur ; Juhi PANDEY, Auteur ; Susan E. LEVY, Auteur . - p.539-550. Langues : Anglais (eng) in Autism Research > 15-3 (March 2022) . - p.539-550 Index. décimale : PER Périodiques Résumé : Abstract The heterogeneous nature of children with symptoms of autism spectrum disorder (ASD) makes it difficult to identify risk factors and effective treatment options. We sought to identify behavioral and developmental features that best define the heterogeneity and homogeneity in 2 5-year-old children classified with ASD and subthreshold ASD characteristics. Children were enrolled in a multisite case?control study of ASD. Detailed behavioral and developmental data were gathered by maternal telephone interview, parent-administered questionnaires, child cognitive evaluation, and ASD diagnostic measures. Participants with a positive ASD screen score or prior ASD diagnosis were referred for comprehensive evaluation. Children in the ASD group met study criteria based on this evaluation; children who did not meet study criteria were categorized as having subthreshold ASD characteristics. There were 1480 children classified as ASD (81.6% boys) and 594 children classified as having subthreshold ASD characteristics (70.2% boys) in the sample. Factors associated with dysregulation (e.g., aggression, anxiety/depression, sleep problems) followed by developmental abilities (e.g., expressive and receptive language skills) most contributed to heterogeneity in both groups of children. Atypical sensory response contributed to homogeneity in children classified as ASD but not those with subthreshold characteristics. These findings suggest that dysregulation and developmental abilities are clinical features that can impact functioning in children with ASD and other DD, and that documenting these features in pediatric records may help meet the needs of the individual child. Sensory dysfunction could be considered a core feature of ASD and thus used to inform more targeted screening, evaluation, treatment, and research efforts. Lay summary The diverse nature of autism spectrum disorder (ASD) makes it difficult to find risk factors and treatment options. We identified the most dissimilar and most similar symptom(s) in children classified as ASD and as having subthreshold ASD characteristics. Factors associated with dysregulation and developmental abilities contributed to diversity in both groups of children. Sensory dysfunction was the most common symptom in children with ASD but not those with subthreshold characteristics. Findings can inform clinical practice and research. En ligne : https://doi.org/10.1002/aur.2663 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development / Lisa D. WIGGINS in Journal of Autism and Developmental Disorders, 47-11 (November 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3634-3645 Titre : Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development Type de document : texte imprimé Auteurs : Lisa D. WIGGINS, Auteur ; Lin H. TIAN, Auteur ; Susan E. LEVY, Auteur ; Catherine E. RICE, Auteur ; Li-Ching LEE, Auteur ; Laura A. SCHIEVE, Auteur ; Juhi PANDEY, Auteur ; Jena DANIELS, Auteur ; Lisa BLASKEY, Auteur ; Susan HEPBURN, Auteur ; Rebecca LANDA, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; William THOMPSON, Auteur Article en page(s) : p.3634-3645 Langues : Anglais (eng) Mots-clés : Autism  Autism spectrum disorder  Characterization  Phenotypes  Subgroups Index. décimale : PER Périodiques Résumé : The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. En ligne : http://dx.doi.org/10.1007/s10803-017-3280-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325 [article] Homogeneous Subgroups of Young Children with Autism Improve Phenotypic Characterization in the Study to Explore Early Development [texte imprimé] / Lisa D. WIGGINS, Auteur ; Lin H. TIAN, Auteur ; Susan E. LEVY, Auteur ; Catherine E. RICE, Auteur ; Li-Ching LEE, Auteur ; Laura A. SCHIEVE, Auteur ; Juhi PANDEY, Auteur ; Jena DANIELS, Auteur ; Lisa BLASKEY, Auteur ; Susan HEPBURN, Auteur ; Rebecca LANDA, Auteur ; Rebecca EDMONDSON PRETZEL, Auteur ; William THOMPSON, Auteur . - p.3634-3645. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-11 (November 2017) . - p.3634-3645 Mots-clés : Autism  Autism spectrum disorder  Characterization  Phenotypes  Subgroups Index. décimale : PER Périodiques Résumé : The objective of this study was to identify homogenous classes of young children with autism spectrum disorder (ASD) to improve phenotypic characterization. Children were enrolled in the Study to Explore Early Development between 2 and 5 years of age. 707 children were classified with ASD after a comprehensive evaluation with strict diagnostic algorithms. Four classes of children with ASD were identified from latent class analysis: mild language delay with cognitive rigidity, mild language and motor delay with dysregulation, general developmental delay, and significant developmental delay with repetitive motor behaviors. We conclude that a four-class phenotypic model of children with ASD best describes our data and improves phenotypic characterization of young children with ASD. Implications for screening, diagnosis, and research are discussed. En ligne : http://dx.doi.org/10.1007/s10803-017-3280-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=325

Mapping the Relationship between Dysmorphology and Cognitive, Behavioral, and Developmental Outcomes in Children with Autism Spectrum Disorder / Lin H. TIAN in Autism Research, 13-7 (July 2020)  

Public ISBD [article]  inAutism Research > 13-7 (July 2020) . - p.1227-1238 Titre : Mapping the Relationship between Dysmorphology and Cognitive, Behavioral, and Developmental Outcomes in Children with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Lin H. TIAN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Patricia M. DIETZ, Auteur ; Arthur S. AYLSWORTH, Auteur ; Ellen R. ELIAS, Auteur ; Julie E. HOOVER-FONG, Auteur ; Naomi J.L. MEEKS, Auteur ; Margaret C. SOUDERS, Auteur ; Anne C.H. TSAI, Auteur ; Elaine H. ZACKAI, Auteur ; Aimee A. ALEXANDER, Auteur ; Nicole F. DOWLING, Auteur ; Stuart K. SHAPIRA, Auteur Article en page(s) : p.1227-1238 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  dysmorphic features  dysmorphology severity  intellectual disability  neurodevelopment Index. décimale : PER Périodiques Résumé : Previous studies investigating the association between dysmorphology and cognitive, behavioral, and developmental outcomes among individuals with autism spectrum disorder (ASD) have been limited by the binary classification of dysmorphology and lack of comparison groups. We assessed the association using a continuous measure of dysmorphology severity (DS) in preschool children aged 2-5 years (322 with ASD and intellectual disability [ID], 188 with ASD without ID, and 371 without ASD from the general population [POP]). In bivariate analyses, an inverse association between DS and expressive language, receptive language, fine motor, and visual reception skills was observed in children with ASD and ID. An inverse association of DS with fine motor and visual reception skills, but not expressive language and receptive language, was found in children with ASD without ID. No associations were observed in POP children. These results persisted after exclusion of children with known genetic syndromes or major morphologic anomalies. Quantile regression models showed that the inverse relationships remained significant after adjustment for sex, race/ethnicity, maternal education, family income, study site, and preterm birth. DS was not associated with autistic traits or autism symptom severity, behaviors, or regression among children with ASD with or without ID. Thus, DS was associated with a global impairment of cognitive functioning in children with ASD and ID, but only with fine motor and visual reception deficits in children with ASD without ID. A better understanding is needed for mechanisms that explain the association between DS and cognitive impairment in children with different disorders. Autism Res 2020, 13: 1227-1238. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined whether having more dysmorphic features (DFs) was related to developmental problems among children with autism spectrum disorder (ASD) with or without intellectual disability (ID), and children without ASD from the general population (POP). Children with ASD and ID had more language, movement, and learning issues as the number of DFs increased. Children with ASD without ID had more movement and learning issues as the number of DFs increased. These relationships were not observed in the POP group. Implications are discussed. En ligne : http://dx.doi.org/10.1002/aur.2314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Mapping the Relationship between Dysmorphology and Cognitive, Behavioral, and Developmental Outcomes in Children with Autism Spectrum Disorder [texte imprimé] / Lin H. TIAN, Auteur ; Lisa D. WIGGINS, Auteur ; Laura A. SCHIEVE, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Patricia M. DIETZ, Auteur ; Arthur S. AYLSWORTH, Auteur ; Ellen R. ELIAS, Auteur ; Julie E. HOOVER-FONG, Auteur ; Naomi J.L. MEEKS, Auteur ; Margaret C. SOUDERS, Auteur ; Anne C.H. TSAI, Auteur ; Elaine H. ZACKAI, Auteur ; Aimee A. ALEXANDER, Auteur ; Nicole F. DOWLING, Auteur ; Stuart K. SHAPIRA, Auteur . - p.1227-1238. Langues : Anglais (eng) in Autism Research > 13-7 (July 2020) . - p.1227-1238 Mots-clés : autism spectrum disorder  dysmorphic features  dysmorphology severity  intellectual disability  neurodevelopment Index. décimale : PER Périodiques Résumé : Previous studies investigating the association between dysmorphology and cognitive, behavioral, and developmental outcomes among individuals with autism spectrum disorder (ASD) have been limited by the binary classification of dysmorphology and lack of comparison groups. We assessed the association using a continuous measure of dysmorphology severity (DS) in preschool children aged 2-5 years (322 with ASD and intellectual disability [ID], 188 with ASD without ID, and 371 without ASD from the general population [POP]). In bivariate analyses, an inverse association between DS and expressive language, receptive language, fine motor, and visual reception skills was observed in children with ASD and ID. An inverse association of DS with fine motor and visual reception skills, but not expressive language and receptive language, was found in children with ASD without ID. No associations were observed in POP children. These results persisted after exclusion of children with known genetic syndromes or major morphologic anomalies. Quantile regression models showed that the inverse relationships remained significant after adjustment for sex, race/ethnicity, maternal education, family income, study site, and preterm birth. DS was not associated with autistic traits or autism symptom severity, behaviors, or regression among children with ASD with or without ID. Thus, DS was associated with a global impairment of cognitive functioning in children with ASD and ID, but only with fine motor and visual reception deficits in children with ASD without ID. A better understanding is needed for mechanisms that explain the association between DS and cognitive impairment in children with different disorders. Autism Res 2020, 13: 1227-1238. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We examined whether having more dysmorphic features (DFs) was related to developmental problems among children with autism spectrum disorder (ASD) with or without intellectual disability (ID), and children without ASD from the general population (POP). Children with ASD and ID had more language, movement, and learning issues as the number of DFs increased. Children with ASD without ID had more movement and learning issues as the number of DFs increased. These relationships were not observed in the POP group. Implications are discussed. En ligne : http://dx.doi.org/10.1002/aur.2314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

A Novel Approach to Dysmorphology to Enhance the Phenotypic Classification of Autism Spectrum Disorder in the Study to Explore Early Development / Stuart K. SHAPIRA in Journal of Autism and Developmental Disorders, 49-5 (May 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.2184-2202 Titre : A Novel Approach to Dysmorphology to Enhance the Phenotypic Classification of Autism Spectrum Disorder in the Study to Explore Early Development Type de document : texte imprimé Auteurs : Stuart K. SHAPIRA, Auteur ; Lin H. TIAN, Auteur ; Arthur S. AYLSWORTH, Auteur ; Ellen R. ELIAS, Auteur ; Julie E. HOOVER-FONG, Auteur ; Naomi J.L. MEEKS, Auteur ; Margaret C. SOUDERS, Auteur ; Anne C.H. TSAI, Auteur ; Elaine H. ZACKAI, Auteur ; Aimee A. ALEXANDER, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Laura A. SCHIEVE, Auteur Article en page(s) : p.2184-2202 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Birth defects  Dysmorphic features  Dysmorphology  Genetic disorders  Morphologic anomalies  Phenotypic classification  Race/ethnicity Index. décimale : PER Périodiques Résumé : The presence of multiple dysmorphic features in some children with autism spectrum disorder (ASD) might identify distinct ASD phenotypes and serve as potential markers for understanding causes and prognoses. To evaluate dysmorphology in ASD, children aged 3-6 years with ASD and non-ASD population controls (POP) from the Study to Explore Early Development were evaluated using a novel, systematic dysmorphology review approach. Separate analyses were conducted for non-Hispanic White, non-Hispanic Black, and Hispanic children. In each racial/ethnic group, ~ 17% of ASD cases were Dysmorphic compared with ~ 5% of POP controls. The ASD-POP differential was not explained by known genetic disorders or birth defects. In future epidemiologic studies, subgrouping ASD cases as Dysmorphic vs. Non-dysmorphic might help delineate risk factors for ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-03899-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] A Novel Approach to Dysmorphology to Enhance the Phenotypic Classification of Autism Spectrum Disorder in the Study to Explore Early Development [texte imprimé] / Stuart K. SHAPIRA, Auteur ; Lin H. TIAN, Auteur ; Arthur S. AYLSWORTH, Auteur ; Ellen R. ELIAS, Auteur ; Julie E. HOOVER-FONG, Auteur ; Naomi J.L. MEEKS, Auteur ; Margaret C. SOUDERS, Auteur ; Anne C.H. TSAI, Auteur ; Elaine H. ZACKAI, Auteur ; Aimee A. ALEXANDER, Auteur ; Marshalyn YEARGIN-ALLSOPP, Auteur ; Laura A. SCHIEVE, Auteur . - p.2184-2202. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-5 (May 2019) . - p.2184-2202 Mots-clés : Autism spectrum disorder  Birth defects  Dysmorphic features  Dysmorphology  Genetic disorders  Morphologic anomalies  Phenotypic classification  Race/ethnicity Index. décimale : PER Périodiques Résumé : The presence of multiple dysmorphic features in some children with autism spectrum disorder (ASD) might identify distinct ASD phenotypes and serve as potential markers for understanding causes and prognoses. To evaluate dysmorphology in ASD, children aged 3-6 years with ASD and non-ASD population controls (POP) from the Study to Explore Early Development were evaluated using a novel, systematic dysmorphology review approach. Separate analyses were conducted for non-Hispanic White, non-Hispanic Black, and Hispanic children. In each racial/ethnic group, ~ 17% of ASD cases were Dysmorphic compared with ~ 5% of POP controls. The ASD-POP differential was not explained by known genetic disorders or birth defects. In future epidemiologic studies, subgrouping ASD cases as Dysmorphic vs. Non-dysmorphic might help delineate risk factors for ASD. En ligne : http://dx.doi.org/10.1007/s10803-019-03899-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Prevalence of Developmental, Psychiatric, and Neurologic Conditions in Older Siblings of Children with and without Autism Spectrum Disorder: Study to Explore Early Development / Victoria L. FIELDS in Journal of Autism and Developmental Disorders, 55-11 (November 2025)  

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