Comparison of the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) Positive Predictive Value by Race / Yael G. DAI in Journal of Autism and Developmental Disorders, 51-3 (March 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.855-867 Titre : Comparison of the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) Positive Predictive Value by Race Type de document : texte imprimé Auteurs : Yael G. DAI, Auteur ; Katelynn S. PORTO, Auteur ; Mary SKAPEK, Auteur ; Marianne L. BARTON, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Deborah A. FEIN, Auteur ; Diana L. ROBINS, Auteur Article en page(s) : p.855-867 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Early identification  M-chat-r/f  Race  Screening  of M-CHAT LLC, which receives royalties from companies that incorporate the  M-CHAT-R/F into commercial products. Data reported in this manuscript did not incur  any royalties. The remaining authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : The Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) is the most widely used screener for ASD. Despite the comparable rate of ASD in Black and White children, the M-CHAT-R/F was validated on a primarily White, Non-Hispanic sample. Few studies have assessed whether the screener performs adequately with racial minorities. This study compared the M-CHAT-R/F Positive Predictive Value (PPV), for ASD, and for any developmental condition, in Black and White children. We also examined M-CHAT-R/F item-level PPV by race. The PPVs for ASD and other developmental disorders were similar in both racial groups for total score and individual items. Therefore, our findings support the use of the M-CHAT-R/F with Black and White children. En ligne : http://dx.doi.org/10.1007/s10803-020-04428-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443 [article] Comparison of the Modified Checklist for Autism in Toddlers, Revised with Follow-Up (M-CHAT-R/F) Positive Predictive Value by Race [texte imprimé] / Yael G. DAI, Auteur ; Katelynn S. PORTO, Auteur ; Mary SKAPEK, Auteur ; Marianne L. BARTON, Auteur ; Thyde DUMONT-MATHIEU, Auteur ; Deborah A. FEIN, Auteur ; Diana L. ROBINS, Auteur . - p.855-867. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-3 (March 2021) . - p.855-867 Mots-clés : Autism spectrum disorder  Early identification  M-chat-r/f  Race  Screening  of M-CHAT LLC, which receives royalties from companies that incorporate the  M-CHAT-R/F into commercial products. Data reported in this manuscript did not incur  any royalties. The remaining authors declare that they have no conflict of interest. Index. décimale : PER Périodiques Résumé : The Modified Checklist for Autism in Toddlers, Revised, with Follow-Up (M-CHAT-R/F) is the most widely used screener for ASD. Despite the comparable rate of ASD in Black and White children, the M-CHAT-R/F was validated on a primarily White, Non-Hispanic sample. Few studies have assessed whether the screener performs adequately with racial minorities. This study compared the M-CHAT-R/F Positive Predictive Value (PPV), for ASD, and for any developmental condition, in Black and White children. We also examined M-CHAT-R/F item-level PPV by race. The PPVs for ASD and other developmental disorders were similar in both racial groups for total score and individual items. Therefore, our findings support the use of the M-CHAT-R/F with Black and White children. En ligne : http://dx.doi.org/10.1007/s10803-020-04428-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=443

Identifying comorbid ADHD in autism: Attending to the inattentive presentation / Srishti RAU in Research in Autism Spectrum Disorders, 69 (January 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 69 (January 2020) . - p.101468 Titre : Identifying comorbid ADHD in autism: Attending to the inattentive presentation Type de document : texte imprimé Auteurs : Srishti RAU, Auteur ; Mary F. SKAPEK, Auteur ; Kaitlyn TIPLADY, Auteur ; Sydney SEESE, Auteur ; Alison BURNS, Auteur ; Anna Chelsea ARMOUR, Auteur ; Lauren KENWORTHY, Auteur Article en page(s) : p.101468 Langues : Anglais (eng) Mots-clés : ASD  ADHD  Comorbidity  Assessment Index. décimale : PER Périodiques Résumé : Background There are high rates of comorbidity between ADHD and ASD; however, there has been limited work parsing rates by ADHD presentation. In addition, commonly used questionnaires have demonstrated reduced utility in capturing ADHD symptoms in individuals with ASD. We examined the prevalence of comorbid Attention-Deficit/Hyperactivity Disorder (ADHD) parsed by DSM-5 presentation in clinic-referred youth with Autism Spectrum Disorder (ASD) without intellectual disability (ID). We compared common rating scales to determine which most effectively identified comorbid ADHD. Method We examined comorbid ADHD diagnoses from archival assessment data for 419 youth with ASD without ID. We examined diagnostic discriminability of the parent and teacher ADHD Rating Scale (ADHD R-S), and Attention and ADH Problems Scales of the Child Behavior Checklist and Teacher Report Form using receiver operating characteristic (ROC) curves. Hierarchical logistic regression was used to examine measures’ unique contribution to ADHD diagnosis. Results Sixty-one percent of the study sample met DSM-5 criteria for an attention disorder. ADHD, Combined (ADHD-C) represented the largest proportion of ADHD diagnoses (76.8%), followed by Inattentive (ADHD-I;19.7%), Hyperactive/Impulsive (.02%), and Un-/Other Specified (.02%). Measures provided greater diagnostic discriminability in identifying ADHD-C relative to ADHD-I. The ADHD R-S inattentive symptom count provided the greatest discriminability for both subtypes and was the only scale that provided clinically meaningful differentiation between those with ASD only and ASD + ADHD-I. Conclusions These results support using the ADHD R-S to capture comorbid ADHD symptoms in ASD. The findings underscore the need for more thorough examination of inattentive symptoms to rule out ADHD-I. En ligne : https://doi.org/10.1016/j.rasd.2019.101468 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Identifying comorbid ADHD in autism: Attending to the inattentive presentation [texte imprimé] / Srishti RAU, Auteur ; Mary F. SKAPEK, Auteur ; Kaitlyn TIPLADY, Auteur ; Sydney SEESE, Auteur ; Alison BURNS, Auteur ; Anna Chelsea ARMOUR, Auteur ; Lauren KENWORTHY, Auteur . - p.101468. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 69 (January 2020) . - p.101468 Mots-clés : ASD  ADHD  Comorbidity  Assessment Index. décimale : PER Périodiques Résumé : Background There are high rates of comorbidity between ADHD and ASD; however, there has been limited work parsing rates by ADHD presentation. In addition, commonly used questionnaires have demonstrated reduced utility in capturing ADHD symptoms in individuals with ASD. We examined the prevalence of comorbid Attention-Deficit/Hyperactivity Disorder (ADHD) parsed by DSM-5 presentation in clinic-referred youth with Autism Spectrum Disorder (ASD) without intellectual disability (ID). We compared common rating scales to determine which most effectively identified comorbid ADHD. Method We examined comorbid ADHD diagnoses from archival assessment data for 419 youth with ASD without ID. We examined diagnostic discriminability of the parent and teacher ADHD Rating Scale (ADHD R-S), and Attention and ADH Problems Scales of the Child Behavior Checklist and Teacher Report Form using receiver operating characteristic (ROC) curves. Hierarchical logistic regression was used to examine measures’ unique contribution to ADHD diagnosis. Results Sixty-one percent of the study sample met DSM-5 criteria for an attention disorder. ADHD, Combined (ADHD-C) represented the largest proportion of ADHD diagnoses (76.8%), followed by Inattentive (ADHD-I;19.7%), Hyperactive/Impulsive (.02%), and Un-/Other Specified (.02%). Measures provided greater diagnostic discriminability in identifying ADHD-C relative to ADHD-I. The ADHD R-S inattentive symptom count provided the greatest discriminability for both subtypes and was the only scale that provided clinically meaningful differentiation between those with ASD only and ASD + ADHD-I. Conclusions These results support using the ADHD R-S to capture comorbid ADHD symptoms in ASD. The findings underscore the need for more thorough examination of inattentive symptoms to rule out ADHD-I. En ligne : https://doi.org/10.1016/j.rasd.2019.101468 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Neural correlates of schema-dependent episodic memory and association with behavioral flexibility in autism spectrum disorders and typical development / Kevin M. COOK in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Neural correlates of schema-dependent episodic memory and association with behavioral flexibility in autism spectrum disorders and typical development Type de document : texte imprimé Auteurs : Kevin M. COOK, Auteur ; Xiaozhen YOU, Auteur ; Joseph Bradley CHERRY, Auteur ; Junaid S. MERCHANT, Auteur ; Mary SKAPEK, Auteur ; Meredith D. POWERS, Auteur ; Cara E. PUGLIESE, Auteur ; Lauren KENWORTHY, Auteur ; Chandan J. VAIDYA, Auteur Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder  Child  Humans  Memory, Episodic  Mental Recall  Prefrontal Cortex/diagnostic imaging  Recognition, Psychology  Associative memory  Behavioral flexibility  Medial temporal lobe  Executive function  Prefrontal cortex  fMRI  Executive Function. The other authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Conceptual knowledge frameworks termed schemas facilitate memory formation and are posited to support flexible behavior. In adults, the medial temporal lobe (MTL) and medial prefrontal cortex (mPFC) trade-off in supporting schema-based memory formation, such that encoding of subsequently remembered schema-congruent information relies on mPFC, whereas schema-incongruent information relies on MTL. Whether this is true in the immature brain and relates to behavioral flexibility is unknown. In this preliminary investigation, we aimed to replicate the adult findings in typically developing (TD) children and to investigate the relevance to behavioral flexibility by examining a disorder with pathognomonic behavioral rigidity, autism spectrum disorder (ASD). METHODS: Children completed an associative subsequent memory paradigm, encoding object-scene pairs in an MRI scanner and subsequently completing a recognition test outside the scanner after a delay. Recognition performance was back sorted to construct remembered vs forgotten contrasts. One-way ANOVAS were conducted in MTL and mPFC masks for schema-congruency, followed by congruency by flexibility scores. Exploratory analyses were then conducted within the whole brain. RESULTS: As reported in adults, episodic memory was strongest for schema-congruent object-scene pairs, followed by intermediate pairs, and lowest for schema-incongruent pairs in both TD and ASD groups. However, the trade-off between mPFC and MTL in TD children differed from adult reports such that mPFC supported memory for intermediate schema-congruency and left anterior MTL supported memory for schema-congruent pairs. In ASD, mPFC engagement interacted with flexibility such that activation supporting memory for intermediate schema-congruency varied with parent-reported flexibility and was higher in those with more flexible behavior. A similar interaction was also observed in both the left dorsolateral and rostrolateral PFC in whole-brain analysis. CONCLUSION: Our findings provide the first preliminary evidence for the association of schema-based episodic memory formation and behavioral flexibility, an executive function impaired in multiple developmental disorders. Upon replication, this line of research holds promise for memory-based interventions addressing executive problems of behavioral rigidity. En ligne : https://dx.doi.org/10.1186/s11689-021-09388-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Neural correlates of schema-dependent episodic memory and association with behavioral flexibility in autism spectrum disorders and typical development [texte imprimé] / Kevin M. COOK, Auteur ; Xiaozhen YOU, Auteur ; Joseph Bradley CHERRY, Auteur ; Junaid S. MERCHANT, Auteur ; Mary SKAPEK, Auteur ; Meredith D. POWERS, Auteur ; Cara E. PUGLIESE, Auteur ; Lauren KENWORTHY, Auteur ; Chandan J. VAIDYA, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Adult  Autism Spectrum Disorder  Child  Humans  Memory, Episodic  Mental Recall  Prefrontal Cortex/diagnostic imaging  Recognition, Psychology  Associative memory  Behavioral flexibility  Medial temporal lobe  Executive function  Prefrontal cortex  fMRI  Executive Function. The other authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Conceptual knowledge frameworks termed schemas facilitate memory formation and are posited to support flexible behavior. In adults, the medial temporal lobe (MTL) and medial prefrontal cortex (mPFC) trade-off in supporting schema-based memory formation, such that encoding of subsequently remembered schema-congruent information relies on mPFC, whereas schema-incongruent information relies on MTL. Whether this is true in the immature brain and relates to behavioral flexibility is unknown. In this preliminary investigation, we aimed to replicate the adult findings in typically developing (TD) children and to investigate the relevance to behavioral flexibility by examining a disorder with pathognomonic behavioral rigidity, autism spectrum disorder (ASD). METHODS: Children completed an associative subsequent memory paradigm, encoding object-scene pairs in an MRI scanner and subsequently completing a recognition test outside the scanner after a delay. Recognition performance was back sorted to construct remembered vs forgotten contrasts. One-way ANOVAS were conducted in MTL and mPFC masks for schema-congruency, followed by congruency by flexibility scores. Exploratory analyses were then conducted within the whole brain. RESULTS: As reported in adults, episodic memory was strongest for schema-congruent object-scene pairs, followed by intermediate pairs, and lowest for schema-incongruent pairs in both TD and ASD groups. However, the trade-off between mPFC and MTL in TD children differed from adult reports such that mPFC supported memory for intermediate schema-congruency and left anterior MTL supported memory for schema-congruent pairs. In ASD, mPFC engagement interacted with flexibility such that activation supporting memory for intermediate schema-congruency varied with parent-reported flexibility and was higher in those with more flexible behavior. A similar interaction was also observed in both the left dorsolateral and rostrolateral PFC in whole-brain analysis. CONCLUSION: Our findings provide the first preliminary evidence for the association of schema-based episodic memory formation and behavioral flexibility, an executive function impaired in multiple developmental disorders. Upon replication, this line of research holds promise for memory-based interventions addressing executive problems of behavioral rigidity. En ligne : https://dx.doi.org/10.1186/s11689-021-09388-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

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