Neuronal and glial cell number is altered in a cortical layer-specific manner in autism / C. FALCONE in Autism, 25-8 (November 2021)  

Public ISBD [article]  inAutism > 25-8 (November 2021) . - p.2238-2253 Titre : Neuronal and glial cell number is altered in a cortical layer-specific manner in autism Type de document : Texte imprimé et/ou numérique Auteurs : C. FALCONE, Auteur ; N. Y. MEVISES, Auteur ; T. HONG, Auteur ; B. DUFOUR, Auteur ; X. CHEN, Auteur ; S. C. NOCTOR, Auteur ; V. MARTÍNEZ CERDEÑO, Auteur Article en page(s) : p.2238-2253 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Cell Count  Cerebral Cortex  Humans  Neuroglia  Neurons  anatomy  autism  cerebral cortex  postmortem Index. décimale : PER Périodiques Résumé : The cerebral cortex affected with autism spectrum disorder presents changes in the number of neurons and glia cells, possibly leading to a dysregulation of brain circuits and affecting behavior. However, little is known about cell number alteration in specific layers of the cortex in autism spectrum disorder. We found an increase in the number of neurons and a decrease in the number of astrocytes in specific layers of the prefrontal cortex in postmortem human brains from autism spectrum disorder cases. We hypothesize that this may be due to a failure in neural stem cells to shift differentiation from neurons to glial cells during prenatal brain development. These data provide key anatomical findings that contribute to the bases of autism spectrum disorder pathogenesis. En ligne : http://dx.doi.org/10.1177/13623613211014408 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Neuronal and glial cell number is altered in a cortical layer-specific manner in autism [Texte imprimé et/ou numérique] / C. FALCONE, Auteur ; N. Y. MEVISES, Auteur ; T. HONG, Auteur ; B. DUFOUR, Auteur ; X. CHEN, Auteur ; S. C. NOCTOR, Auteur ; V. MARTÍNEZ CERDEÑO, Auteur . - p.2238-2253. Langues : Anglais (eng) in Autism > 25-8 (November 2021) . - p.2238-2253 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Cell Count  Cerebral Cortex  Humans  Neuroglia  Neurons  anatomy  autism  cerebral cortex  postmortem Index. décimale : PER Périodiques Résumé : The cerebral cortex affected with autism spectrum disorder presents changes in the number of neurons and glia cells, possibly leading to a dysregulation of brain circuits and affecting behavior. However, little is known about cell number alteration in specific layers of the cortex in autism spectrum disorder. We found an increase in the number of neurons and a decrease in the number of astrocytes in specific layers of the prefrontal cortex in postmortem human brains from autism spectrum disorder cases. We hypothesize that this may be due to a failure in neural stem cells to shift differentiation from neurons to glial cells during prenatal brain development. These data provide key anatomical findings that contribute to the bases of autism spectrum disorder pathogenesis. En ligne : http://dx.doi.org/10.1177/13623613211014408 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis / W. YAN in Autism, 25-7 (October 2021)  

Public ISBD [article]  inAutism > 25-7 (October 2021) . - p.1872-1884 Titre : Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis Type de document : Texte imprimé et/ou numérique Auteurs : W. YAN, Auteur ; R. J. SIEGERT, Auteur ; H. ZHOU, Auteur ; X. ZOU, Auteur ; L. WU, Auteur ; X. LUO, Auteur ; T. LI, Auteur ; Y. HUANG, Auteur ; H. GUAN, Auteur ; X. CHEN, Auteur ; M. MAO, Auteur ; K. XIA, Auteur ; L. ZHANG, Auteur ; E. LI, Auteur ; C. LI, Auteur ; X. ZHANG, Auteur ; Y. ZHOU, Auteur ; A. SHIH, Auteur ; E. FOMBONNE, Auteur ; Y. ZHENG, Auteur ; J. HAN, Auteur ; Z. SUN, Auteur ; Y. H. JIANG, Auteur ; Y. WANG, Auteur Article en page(s) : p.1872-1884 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  China  Humans  Parents  Psychometrics  Reproducibility of Results  Autism Spectrum Rating Scale  Rasch analysis  autism spectrum disorders  parent version  psychometrics  school-age children Index. décimale : PER Périodiques Résumé : The Autism Spectrum Rating Scale is a behavioural rating scale completed by parents and teachers that is useful for identifying children with an autism spectrum disorder. The development of a modified Autism Spectrum Rating Scale suitable for use in China is important for the identification of children in China with an autism spectrum disorder. In this study, we examined the Modified Chinese Autism Spectrum Rating Scale using a statistical technique known as Rasch analysis. Rasch analysis tests whether the questionnaire meets the standards for modern scientific measurement. We used Rasch analysis to examine data from 2013 children in China including 420 diagnosed with an autism spectrum disorder who had been rated by a parent or grandparent. After removing a small number of items (questions), the Modified Chinese Autism Spectrum Rating Scale met the stringent criteria for Rasch measurement. The availability of a reliable and precise tool for assessing behaviours characteristic of an autism spectrum disorder in Chinese children will improve the identification and diagnosis of autism spectrum disorder in China, thus enabling better provision of support services. En ligne : http://dx.doi.org/10.1177/13623613211004054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451 [article] Psychometric properties of the Chinese Parent Version of the Autism Spectrum Rating Scale: Rasch analysis [Texte imprimé et/ou numérique] / W. YAN, Auteur ; R. J. SIEGERT, Auteur ; H. ZHOU, Auteur ; X. ZOU, Auteur ; L. WU, Auteur ; X. LUO, Auteur ; T. LI, Auteur ; Y. HUANG, Auteur ; H. GUAN, Auteur ; X. CHEN, Auteur ; M. MAO, Auteur ; K. XIA, Auteur ; L. ZHANG, Auteur ; E. LI, Auteur ; C. LI, Auteur ; X. ZHANG, Auteur ; Y. ZHOU, Auteur ; A. SHIH, Auteur ; E. FOMBONNE, Auteur ; Y. ZHENG, Auteur ; J. HAN, Auteur ; Z. SUN, Auteur ; Y. H. JIANG, Auteur ; Y. WANG, Auteur . - p.1872-1884. Langues : Anglais (eng) in Autism > 25-7 (October 2021) . - p.1872-1884 Mots-clés : Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  China  Humans  Parents  Psychometrics  Reproducibility of Results  Autism Spectrum Rating Scale  Rasch analysis  autism spectrum disorders  parent version  psychometrics  school-age children Index. décimale : PER Périodiques Résumé : The Autism Spectrum Rating Scale is a behavioural rating scale completed by parents and teachers that is useful for identifying children with an autism spectrum disorder. The development of a modified Autism Spectrum Rating Scale suitable for use in China is important for the identification of children in China with an autism spectrum disorder. In this study, we examined the Modified Chinese Autism Spectrum Rating Scale using a statistical technique known as Rasch analysis. Rasch analysis tests whether the questionnaire meets the standards for modern scientific measurement. We used Rasch analysis to examine data from 2013 children in China including 420 diagnosed with an autism spectrum disorder who had been rated by a parent or grandparent. After removing a small number of items (questions), the Modified Chinese Autism Spectrum Rating Scale met the stringent criteria for Rasch measurement. The availability of a reliable and precise tool for assessing behaviours characteristic of an autism spectrum disorder in Chinese children will improve the identification and diagnosis of autism spectrum disorder in China, thus enabling better provision of support services. En ligne : http://dx.doi.org/10.1177/13623613211004054 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=451

Puppets facilitate attention to social cues in children with ASD / S. MACARI in Autism Research, 14-9 (September 2021)  

Public ISBD [article]  inAutism Research > 14-9 (September 2021) . - p.1975-1985 Titre : Puppets facilitate attention to social cues in children with ASD Type de document : Texte imprimé et/ou numérique Auteurs : S. MACARI, Auteur ; X. CHEN, Auteur ; Ludivine BRUNISSEN, Auteur ; E. YHANG, Auteur ; E. BRENNAN-WYDRA, Auteur ; A. VERNETTI, Auteur ; Fred R. VOLKMAR, Auteur ; J. CHANG, Auteur ; Katarzyna CHAWARSKA, Auteur Article en page(s) : p.1975-1985 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child, Preschool  Communication  Cues  Humans  attention  eye tracking  puppets Index. décimale : PER Périodiques Résumé : Diminished visual attention to faces of social partners represents one of the early characteristics of autism spectrum disorder (ASD). Here we examine if the introduction of puppets as social partners alters attention to speakers' faces in young children with ASD and typically developing (TD) controls. Children with ASD (N = 37; M(age)  = 49.44?months) and TD (N = 27; M(age)  = 40.66?months) viewed a video depicting a puppet and a human engaged in a conversation. Dwell time on these faces was analyzed as a function of group and speaker's identity. Unlike TD controls, the ASD group exhibited limited visual attention to and chance-level visual preference for the human speaker. However, attention to and preference for the puppet speaker's face was greater than chance and comparable across the two groups. While there was a strong association between low human speaker preference and high autism severity, no association with autism severity was found for puppet speaker preference. Unlike humans, expressive and verbal puppets attracted the attention of children with ASD at levels comparable to that of TD controls. Considering that puppets can engage in reciprocal interactions and deliver simplified, salient social-communicative cues, they may facilitate therapeutic efforts in children with ASD. LAY SUMMARY: While studies have shown support for therapeutic uses of robots with children with autism, other similar agents such as puppets remain to be explored. When shown a video of a conversation between a puppet and a person, young children with ASD paid as much attention to the puppet's face as typically-developing (TD) children. Since puppets can engage in back-and-forth interactions and model social interactions and communication, they may play a promising role in therapeutic efforts for young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Puppets facilitate attention to social cues in children with ASD [Texte imprimé et/ou numérique] / S. MACARI, Auteur ; X. CHEN, Auteur ; Ludivine BRUNISSEN, Auteur ; E. YHANG, Auteur ; E. BRENNAN-WYDRA, Auteur ; A. VERNETTI, Auteur ; Fred R. VOLKMAR, Auteur ; J. CHANG, Auteur ; Katarzyna CHAWARSKA, Auteur . - p.1975-1985. Langues : Anglais (eng) in Autism Research > 14-9 (September 2021) . - p.1975-1985 Mots-clés : Autism Spectrum Disorder  Autistic Disorder  Child  Child, Preschool  Communication  Cues  Humans  attention  eye tracking  puppets Index. décimale : PER Périodiques Résumé : Diminished visual attention to faces of social partners represents one of the early characteristics of autism spectrum disorder (ASD). Here we examine if the introduction of puppets as social partners alters attention to speakers' faces in young children with ASD and typically developing (TD) controls. Children with ASD (N = 37; M(age)  = 49.44?months) and TD (N = 27; M(age)  = 40.66?months) viewed a video depicting a puppet and a human engaged in a conversation. Dwell time on these faces was analyzed as a function of group and speaker's identity. Unlike TD controls, the ASD group exhibited limited visual attention to and chance-level visual preference for the human speaker. However, attention to and preference for the puppet speaker's face was greater than chance and comparable across the two groups. While there was a strong association between low human speaker preference and high autism severity, no association with autism severity was found for puppet speaker preference. Unlike humans, expressive and verbal puppets attracted the attention of children with ASD at levels comparable to that of TD controls. Considering that puppets can engage in reciprocal interactions and deliver simplified, salient social-communicative cues, they may facilitate therapeutic efforts in children with ASD. LAY SUMMARY: While studies have shown support for therapeutic uses of robots with children with autism, other similar agents such as puppets remain to be explored. When shown a video of a conversation between a puppet and a person, young children with ASD paid as much attention to the puppet's face as typically-developing (TD) children. Since puppets can engage in back-and-forth interactions and model social interactions and communication, they may play a promising role in therapeutic efforts for young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2552 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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