Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data / Tom A. MCADAMS in Journal of Child Psychology and Psychiatry, 64-4 (April 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.693-707 Titre : Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data Type de document : Texte imprimé et/ou numérique Auteurs : Tom A. MCADAMS, Auteur ; Rosa CHEESMAN, Auteur ; Yasmin I. AHMADZADEH, Auteur Article en page(s) : p.693-707 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Distinguishing between the effects of nature and nurture constitutes a major research goal for those interested in understanding human development. It is known, for example, that many parent traits predict mental health outcomes in children, but the causal processes underlying such associations are often unclear. Family-based quasi-experimental designs such as sibling comparison, adoption and extended family studies have been used for decades to distinguish the genetic transmission of risk from the environmental effects family members potentially have on one another. Recently, these designs have been combined with genomic data, and this combination is fuelling a range of exciting methodological advances. In this review we explore these advances - highlighting the ways in which they have been applied to date and considering what they are likely to teach us in the coming years about the aetiology and intergenerational transmission of psychopathology. En ligne : https://doi.org/10.1111/jcpp.13720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501 [article] Annual Research Review: Towards a deeper understanding of nature and nurture: combining family-based quasi-experimental methods with genomic data [Texte imprimé et/ou numérique] / Tom A. MCADAMS, Auteur ; Rosa CHEESMAN, Auteur ; Yasmin I. AHMADZADEH, Auteur . - p.693-707. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-4 (April 2023) . - p.693-707 Index. décimale : PER Périodiques Résumé : Distinguishing between the effects of nature and nurture constitutes a major research goal for those interested in understanding human development. It is known, for example, that many parent traits predict mental health outcomes in children, but the causal processes underlying such associations are often unclear. Family-based quasi-experimental designs such as sibling comparison, adoption and extended family studies have been used for decades to distinguish the genetic transmission of risk from the environmental effects family members potentially have on one another. Recently, these designs have been combined with genomic data, and this combination is fuelling a range of exciting methodological advances. In this review we explore these advances - highlighting the ways in which they have been applied to date and considering what they are likely to teach us in the coming years about the aetiology and intergenerational transmission of psychopathology. En ligne : https://doi.org/10.1111/jcpp.13720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=501

Anxiety in the family: a genetically informed analysis of transactional associations between mother, father and child anxiety symptoms / Yasmin I. AHMADZADEH in Journal of Child Psychology and Psychiatry, 60-12 (December 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1269-1277 Titre : Anxiety in the family: a genetically informed analysis of transactional associations between mother, father and child anxiety symptoms Type de document : Texte imprimé et/ou numérique Auteurs : Yasmin I. AHMADZADEH, Auteur ; T. C. ELEY, Auteur ; L. D. LEVE, Auteur ; D. S. SHAW, Auteur ; M. N. NATSUAKI, Auteur ; D. REISS, Auteur ; Jenae M. NEIDERHISER, Auteur ; T. A. MCADAMS, Auteur Article en page(s) : p.1269-1277 Langues : Anglais (eng) Mots-clés : Anxiety  genetics  longitudinal  parent-child relationships  structural equation modelling Index. décimale : PER Périodiques Résumé : BACKGROUND: Anxiety in parents is associated with anxiety in offspring, although little is known about the mechanisms underpinning these intergenerational associations. We conducted the first genetically sensitive study to simultaneously examine the effects of mother, father and child anxiety symptoms on each other over time. METHOD: Adoptive parent and child symptoms were measured at child ages 6, 7 and 8 years from 305 families involved in the Early Growth and Development Study, using a prospective adoption design. Children were adopted at birth to nonrelatives, and composite data on internalising problems within birth families were used as a proxy measure of offspring inherited risk for anxiety. Structural equation models were fitted to the data to examine prospective associations between adoptive mother, father and child symptoms, whilst accounting for individuals' symptom stability over time. RESULTS: Child anxiety symptoms at age 7 predicted adoptive mothers' anxiety symptoms at age 8. No mother-to-child or child-to-father effects were observed. These results were consistent in sensitivity analyses using only paternal offspring reports and using a second measure of child anxiety symptoms. Fathers' anxiety symptoms at child age 6 prospectively predicted child symptoms, but only when paternal offspring reports were included in the model. Composite data on birth family internalising problems were not associated with child anxiety symptoms. CONCLUSIONS: Results show environmentally mediated associations between parent and child anxiety symptoms. Results support developmental theories suggesting that child anxiety symptoms can exert influence on caregivers, and mothers and fathers may play unique roles during the development of child symptoms. Further research is needed on the role of genetic transmission associated with anxiety symptoms in biologically related families. In the meantime, researchers and clinicians should strive to include fathers in assessments and consider the effects of child symptoms on caregivers. En ligne : http://dx.doi.org/10.1111/jcpp.13068 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Anxiety in the family: a genetically informed analysis of transactional associations between mother, father and child anxiety symptoms [Texte imprimé et/ou numérique] / Yasmin I. AHMADZADEH, Auteur ; T. C. ELEY, Auteur ; L. D. LEVE, Auteur ; D. S. SHAW, Auteur ; M. N. NATSUAKI, Auteur ; D. REISS, Auteur ; Jenae M. NEIDERHISER, Auteur ; T. A. MCADAMS, Auteur . - p.1269-1277. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-12 (December 2019) . - p.1269-1277 Mots-clés : Anxiety  genetics  longitudinal  parent-child relationships  structural equation modelling Index. décimale : PER Périodiques Résumé : BACKGROUND: Anxiety in parents is associated with anxiety in offspring, although little is known about the mechanisms underpinning these intergenerational associations. We conducted the first genetically sensitive study to simultaneously examine the effects of mother, father and child anxiety symptoms on each other over time. METHOD: Adoptive parent and child symptoms were measured at child ages 6, 7 and 8 years from 305 families involved in the Early Growth and Development Study, using a prospective adoption design. Children were adopted at birth to nonrelatives, and composite data on internalising problems within birth families were used as a proxy measure of offspring inherited risk for anxiety. Structural equation models were fitted to the data to examine prospective associations between adoptive mother, father and child symptoms, whilst accounting for individuals' symptom stability over time. RESULTS: Child anxiety symptoms at age 7 predicted adoptive mothers' anxiety symptoms at age 8. No mother-to-child or child-to-father effects were observed. These results were consistent in sensitivity analyses using only paternal offspring reports and using a second measure of child anxiety symptoms. Fathers' anxiety symptoms at child age 6 prospectively predicted child symptoms, but only when paternal offspring reports were included in the model. Composite data on birth family internalising problems were not associated with child anxiety symptoms. CONCLUSIONS: Results show environmentally mediated associations between parent and child anxiety symptoms. Results support developmental theories suggesting that child anxiety symptoms can exert influence on caregivers, and mothers and fathers may play unique roles during the development of child symptoms. Further research is needed on the role of genetic transmission associated with anxiety symptoms in biologically related families. In the meantime, researchers and clinicians should strive to include fathers in assessments and consider the effects of child symptoms on caregivers. En ligne : http://dx.doi.org/10.1111/jcpp.13068 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Parental criticism and adolescent internalising symptoms: using a Children-of-Twins design with power calculations to account for genetic influence / Yasmin I. AHMADZADEH in Journal of Child Psychology and Psychiatry, 63-5 (May 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.599-607 Titre : Parental criticism and adolescent internalising symptoms: using a Children-of-Twins design with power calculations to account for genetic influence Type de document : Texte imprimé et/ou numérique Auteurs : Yasmin I. AHMADZADEH, Auteur ; Thalia C. ELEY, Auteur ; Laurie HANNIGAN, Auteur ; Cathy CRESWELL, Auteur ; Paul LICHTENSTEIN, Auteur ; Erica SPOTTS, Auteur ; Jody GANIBAN, Auteur ; Jenae M. NEIDERHISER, Auteur ; Frühling V. RIJSDIJK, Auteur ; Tom A. MCADAMS, Auteur Article en page(s) : p.599-607 Langues : Anglais (eng) Mots-clés : Adolescent  Humans  Parents  Phenotype  Sweden  Twins/genetics/psychology  Parenting  genetics  intergenerational  psychopathology Index. décimale : PER Périodiques Résumé : BACKGROUND: Parental criticism is correlated with internalising symptoms in adolescent offspring. This correlation could in part reflect their genetic relatedness, if the same genes influence behaviours in both parents and offspring. We use a Children-of-Twins design to assess whether parent-reported criticism and offspring internalising symptoms remain associated after controlling for shared genes. To aid interpretation of our results and those of previous Children-of-Twins studies, we examine statistical power for the detection of genetic effects and explore the direction of possible causal effects between generations. METHODS: Data were drawn from two Swedish twin samples, comprising 876 adult twin pairs with adolescent offspring and 1,030 adolescent twin pairs with parents. Parent reports of criticism towards their offspring were collected concurrently with parent and offspring reports of adolescent internalising symptoms. Children-of-Twins structural equation models were used to control for genetic influence on the intergenerational association between parental criticism and adolescent internalising. RESULTS: Parental criticism was associated with adolescent internalising symptoms after controlling for genetic influence. No significant role was found for shared genes influencing phenotypes in both generations, although power analyses suggested that some genetic effects may have gone undetected. Models could not distinguish directionality for nongenetic, causal effects between generations. CONCLUSIONS: Parental criticism may be involved in psychosocial family processes in the context of adolescent internalising. Future studies should seek to identify these processes and provide clarity on the direction of potential causal effects. En ligne : http://dx.doi.org/10.1111/jcpp.13498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Parental criticism and adolescent internalising symptoms: using a Children-of-Twins design with power calculations to account for genetic influence [Texte imprimé et/ou numérique] / Yasmin I. AHMADZADEH, Auteur ; Thalia C. ELEY, Auteur ; Laurie HANNIGAN, Auteur ; Cathy CRESWELL, Auteur ; Paul LICHTENSTEIN, Auteur ; Erica SPOTTS, Auteur ; Jody GANIBAN, Auteur ; Jenae M. NEIDERHISER, Auteur ; Frühling V. RIJSDIJK, Auteur ; Tom A. MCADAMS, Auteur . - p.599-607. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-5 (May 2022) . - p.599-607 Mots-clés : Adolescent  Humans  Parents  Phenotype  Sweden  Twins/genetics/psychology  Parenting  genetics  intergenerational  psychopathology Index. décimale : PER Périodiques Résumé : BACKGROUND: Parental criticism is correlated with internalising symptoms in adolescent offspring. This correlation could in part reflect their genetic relatedness, if the same genes influence behaviours in both parents and offspring. We use a Children-of-Twins design to assess whether parent-reported criticism and offspring internalising symptoms remain associated after controlling for shared genes. To aid interpretation of our results and those of previous Children-of-Twins studies, we examine statistical power for the detection of genetic effects and explore the direction of possible causal effects between generations. METHODS: Data were drawn from two Swedish twin samples, comprising 876 adult twin pairs with adolescent offspring and 1,030 adolescent twin pairs with parents. Parent reports of criticism towards their offspring were collected concurrently with parent and offspring reports of adolescent internalising symptoms. Children-of-Twins structural equation models were used to control for genetic influence on the intergenerational association between parental criticism and adolescent internalising. RESULTS: Parental criticism was associated with adolescent internalising symptoms after controlling for genetic influence. No significant role was found for shared genes influencing phenotypes in both generations, although power analyses suggested that some genetic effects may have gone undetected. Models could not distinguish directionality for nongenetic, causal effects between generations. CONCLUSIONS: Parental criticism may be involved in psychosocial family processes in the context of adolescent internalising. Future studies should seek to identify these processes and provide clarity on the direction of potential causal effects. En ligne : http://dx.doi.org/10.1111/jcpp.13498 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

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