Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism / Charles LAIDI in Journal of Autism and Developmental Disorders, 49-4 (April 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409 Titre : Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism Type de document : texte imprimé Auteurs : Charles LAIDI, Auteur ; Jennifer BOISGONTIER, Auteur ; Amicie DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; Sevan HOTIER, Auteur ; Marc-Antoine D'ALBIS, Auteur ; Richard DELORME, Auteur ; Federico BOLOGNANI, Auteur ; Christian CZECH, Auteur ; Céline BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; Julie PETIT, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Alexandru GAMAN, Auteur ; Elie TOLEDANO, Auteur ; Myriam Ly LE-MOAL, Auteur ; Isabelle SCHEID, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur Article en page(s) : p.1402-1409 Langues : Anglais (eng) Mots-clés : Adults  Anterior cingulate cortex  Autism  Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388 [article] Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism [texte imprimé] / Charles LAIDI, Auteur ; Jennifer BOISGONTIER, Auteur ; Amicie DE PIERREFEU, Auteur ; Edouard DUCHESNAY, Auteur ; Sevan HOTIER, Auteur ; Marc-Antoine D'ALBIS, Auteur ; Richard DELORME, Auteur ; Federico BOLOGNANI, Auteur ; Christian CZECH, Auteur ; Céline BOUQUET, Auteur ; Anouck AMESTOY, Auteur ; Julie PETIT, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Alexandru GAMAN, Auteur ; Elie TOLEDANO, Auteur ; Myriam Ly LE-MOAL, Auteur ; Isabelle SCHEID, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur . - p.1402-1409. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-4 (April 2019) . - p.1402-1409 Mots-clés : Adults  Anterior cingulate cortex  Autism  Mri Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. En ligne : https://dx.doi.org/10.1007/s10803-018-3807-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=388

Preserved navigation abilities and spatio-temporal memory in individuals with autism spectrum disorder / Nathan NEU ; Aurélie WATILLIAUX ; Axelle MARTINEZ-TERUEL ; Mihoby RAZAFINIMANANA ; Jennifer BOISGONTIER ; Sevan HOTIER ; Marc-Antoine D'ALBIS ; Richard DELORME ; Anouck AMESTOY ; Stefan HOLIGA ; Myriam Ly LE-MOAL ; Pierrick COUPÃ ; Marion LEBOYER ; Josselin HOUENOU ; Laure RONDI-REIG ; Anne-Lise PARADIS in Autism Research, 16-2 (February 2023)  

Public ISBD [article]  inAutism Research > 16-2 (February 2023) . - p.280-293 Titre : Preserved navigation abilities and spatio-temporal memory in individuals with autism spectrum disorder Type de document : texte imprimé Auteurs : Nathan NEU, Auteur ; Aurélie WATILLIAUX, Auteur ; Axelle MARTINEZ-TERUEL, Auteur ; Mihoby RAZAFINIMANANA, Auteur ; Jennifer BOISGONTIER, Auteur ; Sevan HOTIER, Auteur ; Marc-Antoine D'ALBIS, Auteur ; Richard DELORME, Auteur ; Anouck AMESTOY, Auteur ; Stefan HOLIGA, Auteur ; Myriam Ly LE-MOAL, Auteur ; Pierrick COUPÃ, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Laure RONDI-REIG, Auteur ; Anne-Lise PARADIS, Auteur Article en page(s) : p.280-293 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Cerebellar abnormalities have been reported in autism spectrum disorder (ASD). Beyond its role in hallmark features of ASD, the cerebellum and its connectivity with forebrain structures also play a role in navigation. However, the current understanding of navigation abilities in ASD is equivocal, as is the impact of the disorder on the functional anatomy of the cerebellum. In the present study, we investigated the navigation behavior of a population of ASD and typically developing (TD) adults related to their brain anatomy as assessed by structural and functional MRI at rest. We used the Starmaze task, which permits assessing and distinguishing two complex navigation behaviors, one based on allocentric learning and the other on egocentric learning of a route with multiple decision points. Compared to TD controls, individuals with ASD showed similar exploration, learning, and strategy performance and preference. In addition, there was no difference in the structural or functional anatomy of the cerebellar circuits involved in navigation between the two groups. The findings of our work suggest that navigation abilities, spatio-temporal memory, and their underlying circuits are preserved in individuals with ASD. En ligne : https://doi.org/10.1002/aur.2865 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495 [article] Preserved navigation abilities and spatio-temporal memory in individuals with autism spectrum disorder [texte imprimé] / Nathan NEU, Auteur ; Aurélie WATILLIAUX, Auteur ; Axelle MARTINEZ-TERUEL, Auteur ; Mihoby RAZAFINIMANANA, Auteur ; Jennifer BOISGONTIER, Auteur ; Sevan HOTIER, Auteur ; Marc-Antoine D'ALBIS, Auteur ; Richard DELORME, Auteur ; Anouck AMESTOY, Auteur ; Stefan HOLIGA, Auteur ; Myriam Ly LE-MOAL, Auteur ; Pierrick COUPÃ, Auteur ; Marion LEBOYER, Auteur ; Josselin HOUENOU, Auteur ; Laure RONDI-REIG, Auteur ; Anne-Lise PARADIS, Auteur . - p.280-293. Langues : Anglais (eng) in Autism Research > 16-2 (February 2023) . - p.280-293 Index. décimale : PER Périodiques Résumé : Abstract Cerebellar abnormalities have been reported in autism spectrum disorder (ASD). Beyond its role in hallmark features of ASD, the cerebellum and its connectivity with forebrain structures also play a role in navigation. However, the current understanding of navigation abilities in ASD is equivocal, as is the impact of the disorder on the functional anatomy of the cerebellum. In the present study, we investigated the navigation behavior of a population of ASD and typically developing (TD) adults related to their brain anatomy as assessed by structural and functional MRI at rest. We used the Starmaze task, which permits assessing and distinguishing two complex navigation behaviors, one based on allocentric learning and the other on egocentric learning of a route with multiple decision points. Compared to TD controls, individuals with ASD showed similar exploration, learning, and strategy performance and preference. In addition, there was no difference in the structural or functional anatomy of the cerebellar circuits involved in navigation between the two groups. The findings of our work suggest that navigation abilities, spatio-temporal memory, and their underlying circuits are preserved in individuals with ASD. En ligne : https://doi.org/10.1002/aur.2865 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=495

Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis / Pilar GARCES in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 22 p. Titre : Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis Type de document : texte imprimé Auteurs : Pilar GARCES, Auteur ; Sarah BAUMEISTER, Auteur ; Luke MASON, Auteur ; Christopher H. CHATHAM, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Emily J.H. JONES, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; Sarah DURSTON, Auteur ; Bob ORANJE, Auteur ; Antonio M. PERSICO, Auteur ; Christian F. BECKMANN, Auteur ; Thomas BOURGERON, Auteur ; Flavio DELL'ACQUA, Auteur ; Christine ECKER, Auteur ; Carolin MOESSNANG, Auteur ; Tony CHARMAN, Auteur ; Julian TILLMANN, Auteur ; Declan G.M. MURPHY, Auteur ; Mark H. JOHNSON, Auteur ; Eva LOTH, Auteur ; Daniel BRANDEIS, Auteur ; Joerg F. HIPP, Auteur Article en page(s) : 22 p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Brain/diagnostic imaging  Brain Mapping/methods  Child  Cross-Sectional Studies  Electroencephalography/methods  Humans  Magnetic Resonance Imaging/methods  Reproducibility of Results  Autism spectrum disorder  Eeg  Functional connectivity  Power spectrum  Resting state Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed. METHODS: We quantified resting state EEG alpha peak metrics, power spectrum (PS, 2-32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n=212 ASD, n=199 neurotypicals [NT], all with IQ?> 75). We performed analyses in source-space using individual head models derived from the participants' MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%-30% split). RESULTS: In the training dataset, we found an interaction between age and group for the reactivity to eye opening (p=.042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52-0.62, specificity 0.59-0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset. LIMITATIONS: The statistical power to detect weak effects-of the magnitude of those found in the training dataset-in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset's effects. CONCLUSIONS: This suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects. En ligne : http://dx.doi.org/10.1186/s13229-022-00500-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Resting state EEG power spectrum and functional connectivity in autism: a cross-sectional analysis [texte imprimé] / Pilar GARCES, Auteur ; Sarah BAUMEISTER, Auteur ; Luke MASON, Auteur ; Christopher H. CHATHAM, Auteur ; Stefan HOLIGA, Auteur ; Juergen DUKART, Auteur ; Emily J.H. JONES, Auteur ; Tobias BANASCHEWSKI, Auteur ; Simon BARON-COHEN, Auteur ; Sven BÖLTE, Auteur ; Jan K. BUITELAAR, Auteur ; Sarah DURSTON, Auteur ; Bob ORANJE, Auteur ; Antonio M. PERSICO, Auteur ; Christian F. BECKMANN, Auteur ; Thomas BOURGERON, Auteur ; Flavio DELL'ACQUA, Auteur ; Christine ECKER, Auteur ; Carolin MOESSNANG, Auteur ; Tony CHARMAN, Auteur ; Julian TILLMANN, Auteur ; Declan G.M. MURPHY, Auteur ; Mark H. JOHNSON, Auteur ; Eva LOTH, Auteur ; Daniel BRANDEIS, Auteur ; Joerg F. HIPP, Auteur . - 22 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 22 p. Mots-clés : Adolescent  Adult  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Brain/diagnostic imaging  Brain Mapping/methods  Child  Cross-Sectional Studies  Electroencephalography/methods  Humans  Magnetic Resonance Imaging/methods  Reproducibility of Results  Autism spectrum disorder  Eeg  Functional connectivity  Power spectrum  Resting state Index. décimale : PER Périodiques Résumé : BACKGROUND: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but results are inconsistent. Unbiased investigation in large and comprehensive samples focusing on replicability is needed. METHODS: We quantified resting state EEG alpha peak metrics, power spectrum (PS, 2-32 Hz) and functional connectivity (FC) in 411 children, adolescents and adults (n=212 ASD, n=199 neurotypicals [NT], all with IQ?> 75). We performed analyses in source-space using individual head models derived from the participants' MRIs. We tested for differences in mean and variance between the ASD and NT groups for both PS and FC using linear mixed effects models accounting for age, sex, IQ and site effects. Then, we used machine learning to assess whether a multivariate combination of EEG features could better separate ASD and NT participants. All analyses were embedded within a train-validation approach (70%-30% split). RESULTS: In the training dataset, we found an interaction between age and group for the reactivity to eye opening (p=.042 uncorrected), and a significant but weak multivariate ASD vs. NT classification performance for PS and FC (sensitivity 0.52-0.62, specificity 0.59-0.73). None of these findings replicated significantly in the validation dataset, although the effect size in the validation dataset overlapped with the prediction interval from the training dataset. LIMITATIONS: The statistical power to detect weak effects-of the magnitude of those found in the training dataset-in the validation dataset is small, and we cannot fully conclude on the reproducibility of the training dataset's effects. CONCLUSIONS: This suggests that PS and FC values in ASD and NT have a strong overlap, and that differences between both groups (in both mean and variance) have, at best, a small effect size. Larger studies would be needed to investigate and replicate such potential effects. En ligne : http://dx.doi.org/10.1186/s13229-022-00500-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

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