An Observed Assessment of Sensory Responsivity in Autism Spectrum Disorders: Associations with Diagnosis, Age, and Parent Report / Sapna RAMAPPA in Journal of Autism and Developmental Disorders, 53-10 (October 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3860-3872 Titre : An Observed Assessment of Sensory Responsivity in Autism Spectrum Disorders: Associations with Diagnosis, Age, and Parent Report Type de document : texte imprimé Auteurs : Sapna RAMAPPA, Auteur ; Ariana ANDERSON, Auteur ; Jiwon JUNG, Auteur ; Robyn CHU, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Genevieve PATTERSON, Auteur ; Nana J. OKADA, Auteur ; Shulamite A. GREEN, Auteur Article en page(s) : p.3860-3872 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sensory features are common and impairing in autism spectrum disorder (ASD), but there are few observational sensory assessments that are valid across ages. We used the Sensory Processing 3-Dimensional (SP3-D) observed Assessment and parent-reported Inventory to examine sensory responsivity in 41 ASD and 33 typically-developing (TD) youth across 7-17 years. ASD youth had higher and more variable observed and reported sensory responsivity symptoms compared to TD, but the two measures were not correlated. Observed sensory over-responsivity (SOR) and sensory craving (SC) decreased with age in ASD, though SOR remained higher in ASD versus TD through adolescence. Results suggest that in ASD, the SP3-D Assessment can identify SOR through adolescence, and that there is value in integrating multiple sensory measures. En ligne : https://doi.org/10.1007/s10803-022-05653-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511 [article] An Observed Assessment of Sensory Responsivity in Autism Spectrum Disorders: Associations with Diagnosis, Age, and Parent Report [texte imprimé] / Sapna RAMAPPA, Auteur ; Ariana ANDERSON, Auteur ; Jiwon JUNG, Auteur ; Robyn CHU, Auteur ; Kaitlin K. CUMMINGS, Auteur ; Genevieve PATTERSON, Auteur ; Nana J. OKADA, Auteur ; Shulamite A. GREEN, Auteur . - p.3860-3872. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-10 (October 2023) . - p.3860-3872 Index. décimale : PER Périodiques Résumé : Sensory features are common and impairing in autism spectrum disorder (ASD), but there are few observational sensory assessments that are valid across ages. We used the Sensory Processing 3-Dimensional (SP3-D) observed Assessment and parent-reported Inventory to examine sensory responsivity in 41 ASD and 33 typically-developing (TD) youth across 7-17 years. ASD youth had higher and more variable observed and reported sensory responsivity symptoms compared to TD, but the two measures were not correlated. Observed sensory over-responsivity (SOR) and sensory craving (SC) decreased with age in ASD, though SOR remained higher in ASD versus TD through adolescence. Results suggest that in ASD, the SP3-D Assessment can identify SOR through adolescence, and that there is value in integrating multiple sensory measures. En ligne : https://doi.org/10.1007/s10803-022-05653-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=511

Brief Report: Characterization of Sensory Over-Responsivity in a Broad Neurodevelopmental Concern Cohort Using the Sensory Processing Three Dimensions (SP3D) Assessment / Mikaela A. ROWE ; Kaitlyn J. TRIMARCHI ; Rafael D. GARCIA ; Robyn CHU ; Mary C. STEELE ; Shalin PAREKH ; Jamie WREN-JARVIS ; Ioanna BOURLA ; Ian MARK ; Elysa J. MARCO ; Pratik MUKHERJEE in Journal of Autism and Developmental Disorders, 54-8 (August 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-8 (August 2024) . - p.3185-3192 Titre : Brief Report: Characterization of Sensory Over-Responsivity in a Broad Neurodevelopmental Concern Cohort Using the Sensory Processing Three Dimensions (SP3D) Assessment Type de document : texte imprimé Auteurs : Mikaela A. ROWE, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Robyn CHU, Auteur ; Mary C. STEELE, Auteur ; Shalin PAREKH, Auteur ; Jamie WREN-JARVIS, Auteur ; Ioanna BOURLA, Auteur ; Ian MARK, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur Article en page(s) : p.3185-3192 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Sensory Over-Responsivity (SOR) is an increasingly recognized challenge among children with neurodevelopmental concerns (NDC). To investigate, we characterized the incidence of auditory and tactile over-responsivity (AOR, TOR) among 82 children with NDC. We found that 70% of caregivers reported concern for their child?s sensory reactions. Direct assessment further revealed that 54% of the NDC population expressed AOR, TOR, or both - which persisted regardless of autism spectrum disorder (ASD) diagnosis. These findings support the high prevalence of SOR as well as its lack of specificity to ASD. Additionally, AOR is revealed to be over twice as prevalent as TOR. These conclusions present several avenues for further exploration, including deeper analysis of the neural mechanisms and genetic contributors to sensory processing challenges. En ligne : https://doi.org/10.1007/s10803-022-05747-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] Brief Report: Characterization of Sensory Over-Responsivity in a Broad Neurodevelopmental Concern Cohort Using the Sensory Processing Three Dimensions (SP3D) Assessment [texte imprimé] / Mikaela A. ROWE, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Robyn CHU, Auteur ; Mary C. STEELE, Auteur ; Shalin PAREKH, Auteur ; Jamie WREN-JARVIS, Auteur ; Ioanna BOURLA, Auteur ; Ian MARK, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur . - p.3185-3192. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-8 (August 2024) . - p.3185-3192 Index. décimale : PER Périodiques Résumé : Sensory Over-Responsivity (SOR) is an increasingly recognized challenge among children with neurodevelopmental concerns (NDC). To investigate, we characterized the incidence of auditory and tactile over-responsivity (AOR, TOR) among 82 children with NDC. We found that 70% of caregivers reported concern for their child?s sensory reactions. Direct assessment further revealed that 54% of the NDC population expressed AOR, TOR, or both - which persisted regardless of autism spectrum disorder (ASD) diagnosis. These findings support the high prevalence of SOR as well as its lack of specificity to ASD. Additionally, AOR is revealed to be over twice as prevalent as TOR. These conclusions present several avenues for further exploration, including deeper analysis of the neural mechanisms and genetic contributors to sensory processing challenges. En ligne : https://doi.org/10.1007/s10803-022-05747-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems / Hannah L. CHOI in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems Type de document : texte imprimé Auteurs : Hannah L. CHOI, Auteur ; Maia C. LAZERWITZ, Auteur ; Rachel POWERS, Auteur ; Mikaela ROWE, Auteur ; Jamie WREN-JARVIS, Auteur ; Amir SADIKOV, Auteur ; Lanya T. CAI, Auteur ; Robyn CHU, Auteur ; LaShelle RULLAN, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur Langues : Anglais (eng) Mots-clés : Emotional regulation  Functional MRI connectivity  Multimodal neuroimaging  Neurodevelopment  Resilience  Sensory over-responsivity  Sensory processing disorder  involving behavioral and neuroimaging data collection of human participants  between ages 8–12 years old was approved by the UCSF institutional review board.  Written informed consent from the parent or caregiver and assent from the  participant were collected. Consent for publication: All authors have provided  approval of the manuscript. This work was made publicly available as a preprint  uploaded to PsyArXiv at this link: https://osf.io/preprints/psyarxiv/ajs9w_v1  prior to publishing. It has not been published elsewhere. Competing interests:  The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Exogenous (outward-directed) and endogenous (inward-directed) neural systems are essential for cognition and behavior. However, how they are altered in neurodiverse (ND) children remains unanswered in part due to heterogeneity. Sensory over-responsivity (SOR), the most prevalent form of sensory processing disorder (SPD), serves as a quintessential paradigm for investigating the interaction between exogenous and endogenous brain networks given that both basic and higher-order sensory processing are substantially implicated in this condition. METHODS: Neurodiverse children ages 8–12 years old (n = 83; 30 females and 53 males) were directly assessed for SOR using a structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment (SP3D:A), and underwent 3 Tesla MRI. 39 ND children presented with SOR (ND/SOR) and 44 ND children presented without SOR (ND/NO-SOR). Exogenous and endogenous functional connectivity networks (FCNs) were generated through independent component analysis and investigated with two local functional connectivity (FC) measures, fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), as well as a long-range FC measure, dual regression (DR). Moreover, we examined FC in the context of behavioral regulation as assessed through the Behavioral Assessment System for Children, 3rd edition (BASC-3), categorizing children as "resilient" or "dysregulated" through latent profile analysis. RESULTS: In general, ND/SOR children exhibit reduced long-range exogenous FC. However, in terms of local FC, we find that ND/SOR children have reduced exogenous and elevated endogenous FC which is diametrically opposed to ND/NO-SOR children. Furthermore, this double dissociation is specific to ND children who are behaviorally resilient, while emotionally dysregulated ND children possess a distinct pattern. CONCLUSION: Achieving optimal brain system connectivity—a balanced contrast—is influenced by sensory over-responsivity and essential for resilience. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-025-09656-y. En ligne : https://dx.doi.org/10.1186/s11689-025-09656-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] A neural substrate for sensory over-responsivity defined by exogenous and endogenous brain systems [texte imprimé] / Hannah L. CHOI, Auteur ; Maia C. LAZERWITZ, Auteur ; Rachel POWERS, Auteur ; Mikaela ROWE, Auteur ; Jamie WREN-JARVIS, Auteur ; Amir SADIKOV, Auteur ; Lanya T. CAI, Auteur ; Robyn CHU, Auteur ; LaShelle RULLAN, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Emotional regulation  Functional MRI connectivity  Multimodal neuroimaging  Neurodevelopment  Resilience  Sensory over-responsivity  Sensory processing disorder  involving behavioral and neuroimaging data collection of human participants  between ages 8–12 years old was approved by the UCSF institutional review board.  Written informed consent from the parent or caregiver and assent from the  participant were collected. Consent for publication: All authors have provided  approval of the manuscript. This work was made publicly available as a preprint  uploaded to PsyArXiv at this link: https://osf.io/preprints/psyarxiv/ajs9w_v1  prior to publishing. It has not been published elsewhere. Competing interests:  The authors declare no competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Exogenous (outward-directed) and endogenous (inward-directed) neural systems are essential for cognition and behavior. However, how they are altered in neurodiverse (ND) children remains unanswered in part due to heterogeneity. Sensory over-responsivity (SOR), the most prevalent form of sensory processing disorder (SPD), serves as a quintessential paradigm for investigating the interaction between exogenous and endogenous brain networks given that both basic and higher-order sensory processing are substantially implicated in this condition. METHODS: Neurodiverse children ages 8–12 years old (n = 83; 30 females and 53 males) were directly assessed for SOR using a structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment (SP3D:A), and underwent 3 Tesla MRI. 39 ND children presented with SOR (ND/SOR) and 44 ND children presented without SOR (ND/NO-SOR). Exogenous and endogenous functional connectivity networks (FCNs) were generated through independent component analysis and investigated with two local functional connectivity (FC) measures, fractional amplitude of low-frequency fluctuations (fALFF) and regional homogeneity (ReHo), as well as a long-range FC measure, dual regression (DR). Moreover, we examined FC in the context of behavioral regulation as assessed through the Behavioral Assessment System for Children, 3rd edition (BASC-3), categorizing children as "resilient" or "dysregulated" through latent profile analysis. RESULTS: In general, ND/SOR children exhibit reduced long-range exogenous FC. However, in terms of local FC, we find that ND/SOR children have reduced exogenous and elevated endogenous FC which is diametrically opposed to ND/NO-SOR children. Furthermore, this double dissociation is specific to ND children who are behaviorally resilient, while emotionally dysregulated ND children possess a distinct pattern. CONCLUSION: Achieving optimal brain system connectivity—a balanced contrast—is influenced by sensory over-responsivity and essential for resilience. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s11689-025-09656-y. En ligne : https://dx.doi.org/10.1186/s11689-025-09656-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

Sensory over-responsivity: parent report, direct assessment measures, and neural architecture / Teresa TAVASSOLI in Molecular Autism, 10 (2019)  

Public ISBD [article]  inMolecular Autism > 10 (2019) . - 4 p. Titre : Sensory over-responsivity: parent report, direct assessment measures, and neural architecture Type de document : texte imprimé Auteurs : Teresa TAVASSOLI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Lisa PORTER, Auteur ; Sarah SCHOEN, Auteur ; Lucy Jane MILLER, Auteur ; Molly Rae GERDES, Auteur ; Julia OWEN, Auteur ; Pratik MUKHERJEE, Auteur ; Elysa J. MARCO, Auteur Article en page(s) : 4 p. Langues : Anglais (eng) Mots-clés : *Assessment  *Diffusion Tensor Imaging  *Neurodevelopmental disorder  *Sensory over-responsivity  *Sensory processing disorder  *autism  of California, San Francisco (10-01940). Written consent was collected from  parents of the participants.All recruited participants/parents have given consent  for publication during the recruitment process.The authors declare that they have  no competing interests.Springer Nature remains neutral with regard to  jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. Methods: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. Results: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. Conclusions: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. En ligne : https://dx.doi.org/10.1186/s13229-019-0255-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389 [article] Sensory over-responsivity: parent report, direct assessment measures, and neural architecture [texte imprimé] / Teresa TAVASSOLI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Lisa PORTER, Auteur ; Sarah SCHOEN, Auteur ; Lucy Jane MILLER, Auteur ; Molly Rae GERDES, Auteur ; Julia OWEN, Auteur ; Pratik MUKHERJEE, Auteur ; Elysa J. MARCO, Auteur . - 4 p. Langues : Anglais (eng) in Molecular Autism > 10 (2019) . - 4 p. Mots-clés : *Assessment  *Diffusion Tensor Imaging  *Neurodevelopmental disorder  *Sensory over-responsivity  *Sensory processing disorder  *autism  of California, San Francisco (10-01940). Written consent was collected from  parents of the participants.All recruited participants/parents have given consent  for publication during the recruitment process.The authors declare that they have  no competing interests.Springer Nature remains neutral with regard to  jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity. Methods: This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest. Results: Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR. Conclusions: This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR. En ligne : https://dx.doi.org/10.1186/s13229-019-0255-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=389

White matter microstructure of children with sensory over-responsivity is associated with affective behavior / Jamie WREN-JARVIS in Journal of Neurodevelopmental Disorders, 16 (2024)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 16 (2024) Titre : White matter microstructure of children with sensory over-responsivity is associated with affective behavior Type de document : texte imprimé Auteurs : Jamie WREN-JARVIS, Auteur ; Rachel POWERS, Auteur ; Maia C. LAZERWITZ, Auteur ; Jaclyn XIAO, Auteur ; Lanya T. CAI, Auteur ; Hannah L. CHOI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Mikaela A. ROWE, Auteur ; Mary C. STEELE, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur Langues : Anglais (eng) Mots-clés : Male  Child  Female  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging/methods  Diffusion Magnetic Resonance Imaging  Magnetic Resonance Imaging  Cerebellum  Dti  Depression  Mri  Sensory over-responsivity  Sensory processing disorder  Somatization  White matter  commercial or financial relationships that could be construed as a potential  conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. METHODS: Children ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. RESULTS: Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. CONCLUSION: White matter microstructure is related to affective behavior in children with SOR. En ligne : https://dx.doi.org/10.1186/s11689-023-09513-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] White matter microstructure of children with sensory over-responsivity is associated with affective behavior [texte imprimé] / Jamie WREN-JARVIS, Auteur ; Rachel POWERS, Auteur ; Maia C. LAZERWITZ, Auteur ; Jaclyn XIAO, Auteur ; Lanya T. CAI, Auteur ; Hannah L. CHOI, Auteur ; Annie BRANDES-AITKEN, Auteur ; Robyn CHU, Auteur ; Kaitlyn J. TRIMARCHI, Auteur ; Rafael D. GARCIA, Auteur ; Mikaela A. ROWE, Auteur ; Mary C. STEELE, Auteur ; Elysa J. MARCO, Auteur ; Pratik MUKHERJEE, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 16 (2024) Mots-clés : Male  Child  Female  Humans  White Matter/diagnostic imaging  Diffusion Tensor Imaging/methods  Diffusion Magnetic Resonance Imaging  Magnetic Resonance Imaging  Cerebellum  Dti  Depression  Mri  Sensory over-responsivity  Sensory processing disorder  Somatization  White matter  commercial or financial relationships that could be construed as a potential  conflict of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Sensory processing dysfunction (SPD) is linked to altered white matter (WM) microstructure in school-age children. Sensory over-responsivity (SOR), a form of SPD, affects at least 2.5% of all children and has substantial deleterious impact on learning and mental health. However, SOR has not been well studied using microstructural imaging such as diffusion MRI (dMRI). Since SOR involves hypersensitivity to external stimuli, we test the hypothesis that children with SOR require compensatory neuroplasticity in the form of superior WM microstructural integrity to protect against internalizing behavior, leaving those with impaired WM microstructure vulnerable to somatization and depression. METHODS: Children ages 8-12 years old with neurodevelopmental concerns were assessed for SOR using a comprehensive structured clinical evaluation, the Sensory Processing 3 Dimensions Assessment, and underwent 3 Tesla MRI with multishell multiband dMRI. Tract-based spatial statistics was used to measure diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) metrics from global WM and nineteen selected WM tracts. Correlations of DTI and NODDI measures with measures of somatization and emotional disturbance from the Behavioral Assessment System for Children, 3rd edition (BASC-3), were computed in the SOR group and in matched children with neurodevelopmental concerns but not SOR. RESULTS: Global WM fractional anisotropy (FA) is negatively correlated with somatization and with emotional disturbance in the SOR group but not the non-SOR group. Also observed in children with SOR are positive correlations of radial diffusivity (RD) and free water fraction (FISO) with somatization and, in most cases, emotional disturbance. These effects are significant in boys with SOR, whereas the study is underpowered for girls. The most affected white matter are medial lemniscus and internal capsule sensory tracts, although effects of SOR are observed in many cerebral, cerebellar, and brainstem tracts. CONCLUSION: White matter microstructure is related to affective behavior in children with SOR. En ligne : https://dx.doi.org/10.1186/s11689-023-09513-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

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