Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ / Celeste H.M. CHEUNG in Journal of Child Psychology and Psychiatry, 53-8 (August 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.864-873 Titre : Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ Type de document : texte imprimé Auteurs : Celeste H.M. CHEUNG, Auteur ; Alexis C. FRAZIER-WOOD, Auteur ; Yannis PALOYELIS, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Jan K. BUITELAAR, Auteur ; Barbara FRANKE, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Nanda N. ROMMELSE, Auteur ; Joseph A. SERGEANT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur Année de publication : 2012 Article en page(s) : p.864-873 Langues : Anglais (eng) Mots-clés : ADHD  reading difficulties  IQ  familial  sibling-pair  comorbidity Index. décimale : PER Périodiques Résumé : Background:  Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalisability of the findings to a clinical population, and by measuring reading difficulties both with a rating scale and with an objective task. This study investigated the familial relationships between ADHD, reading difficulties and IQ in a sample of individuals diagnosed with ADHD combined type, their siblings and control sibling pairs. Methods:  Multivariate familial models were run on data from 1,789 individuals at ages 6–19. Reading difficulties were measured with both rating scale and an objective task. IQ was obtained using the Wechsler Intelligence Scales (WISC–III/WAIS–III). Results:  Significant phenotypic (.2–.4) and familial (.3–.5) correlations were observed among ADHD, reading difficulties and IQ. Yet, 53%–72% of the overlapping familial influences between ADHD and reading difficulties were not shared with IQ. Conclusions:  Our finding that familial influences shared with general cognitive ability, although present, do not account for the majority of the overlapping familial influences on ADHD and reading difficulties extends previous findings from a population-based study to a clinically ascertained sample with combined type ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02527.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177 [article] Aetiology for the covariation between combined type ADHD and reading difficulties in a family study: the role of IQ [texte imprimé] / Celeste H.M. CHEUNG, Auteur ; Alexis C. FRAZIER-WOOD, Auteur ; Yannis PALOYELIS, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Jan K. BUITELAAR, Auteur ; Barbara FRANKE, Auteur ; Ana MIRANDA, Auteur ; Fernando MULAS, Auteur ; Nanda N. ROMMELSE, Auteur ; Joseph A. SERGEANT, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Stephen V. FARAONE, Auteur ; Philip ASHERSON, Auteur ; Jonna KUNTSI, Auteur . - 2012 . - p.864-873. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-8 (August 2012) . - p.864-873 Mots-clés : ADHD  reading difficulties  IQ  familial  sibling-pair  comorbidity Index. décimale : PER Périodiques Résumé : Background:  Twin studies using both clinical and population-based samples suggest that the frequent co-occurrence of attention deficit hyperactivity disorder (ADHD) and reading ability/disability (RD) is largely driven by shared genetic influences. While both disorders are associated with lower IQ, recent twin data suggest that the shared genetic variability between reading difficulties and ADHD inattention symptoms is largely independent from genetic influences contributing to general cognitive ability. The current study aimed to extend the previous findings that were based on rating scale measures in a population sample by examining the generalisability of the findings to a clinical population, and by measuring reading difficulties both with a rating scale and with an objective task. This study investigated the familial relationships between ADHD, reading difficulties and IQ in a sample of individuals diagnosed with ADHD combined type, their siblings and control sibling pairs. Methods:  Multivariate familial models were run on data from 1,789 individuals at ages 6–19. Reading difficulties were measured with both rating scale and an objective task. IQ was obtained using the Wechsler Intelligence Scales (WISC–III/WAIS–III). Results:  Significant phenotypic (.2–.4) and familial (.3–.5) correlations were observed among ADHD, reading difficulties and IQ. Yet, 53%–72% of the overlapping familial influences between ADHD and reading difficulties were not shared with IQ. Conclusions:  Our finding that familial influences shared with general cognitive ability, although present, do not account for the majority of the overlapping familial influences on ADHD and reading difficulties extends previous findings from a population-based study to a clinically ascertained sample with combined type ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02527.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=177

Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes / T. LI in Journal of Child Psychology and Psychiatry, 62-9 (September 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1140-1149 Titre : Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes Type de document : texte imprimé Auteurs : T. LI, Auteur ; D. VAN ROOIJ, Auteur ; N. ROTH MOTA, Auteur ; Jan K. BUITELAAR, Auteur ; M. HOOGMAN, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; B. FRANKE, Auteur Article en page(s) : p.1140-1149 Langues : Anglais (eng) Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnostic imaging/epidemiology  Brain/diagnostic imaging  Case-Control Studies  Female  Humans  Magnetic Resonance Imaging  Male  Thalamus/diagnostic imaging  Adhd  community detection  effect sizes  neuroanatomic heterogeneity  subcortical volume Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. METHODS: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. RESULTS: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. CONCLUSIONS: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups. En ligne : http://dx.doi.org/10.1111/jcpp.13384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes [texte imprimé] / T. LI, Auteur ; D. VAN ROOIJ, Auteur ; N. ROTH MOTA, Auteur ; Jan K. BUITELAAR, Auteur ; M. HOOGMAN, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; B. FRANKE, Auteur . - p.1140-1149. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-9 (September 2021) . - p.1140-1149 Mots-clés : Adult  Attention Deficit Disorder with Hyperactivity/diagnostic imaging/epidemiology  Brain/diagnostic imaging  Case-Control Studies  Female  Humans  Magnetic Resonance Imaging  Male  Thalamus/diagnostic imaging  Adhd  community detection  effect sizes  neuroanatomic heterogeneity  subcortical volume Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes. METHODS: Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD) algorithm clustered participants into subgroups based on the networks. RESULTS: Exploratory factor analysis revealed three factors (basal ganglia, limbic system, and thalamus) in boys and men with and without ADHD. Factor structures for girls and women differed from those in males. Given sample size considerations, we concentrated subsequent analyses on males. Male participants could be separated into four communities, of which one was absent in healthy men. Significant case-control differences of subcortical volumes were observed within communities in boys, often with stronger effect sizes compared to the entire sample. As in the entire sample, none were observed in men. Affected men in two of the communities presented comorbidities more frequently than those in other communities. There were no significant differences in ADHD symptom severity, IQ, and medication use between communities in either boys or men. CONCLUSIONS: Our results indicate that neuroanatomic heterogeneity in subcortical volumes exists, irrespective of ADHD diagnosis. Effect sizes of case-control differences appear more pronounced at least in some of the subgroups. En ligne : http://dx.doi.org/10.1111/jcpp.13384 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

A longitudinal study of the gut microbiota during the first three years of life: Links with problem behavior and executive functions at preschool age / Yvonne WILLEMSEN in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.2032-2048 Titre : A longitudinal study of the gut microbiota during the first three years of life: Links with problem behavior and executive functions at preschool age Type de document : texte imprimé Auteurs : Yvonne WILLEMSEN, Auteur ; Yangwenshan OU, Auteur ; Clara BELZER, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Hauke SMIDT, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur Article en page(s) : p.2032-2048 Langues : Anglais (eng) Mots-clés : cognition  early life  executive functions  gut microbiota  problem behavior Index. décimale : PER Périodiques Résumé : Early life is a sensitive period when microbiota-gut-brain interactions may have important impact on development. This study investigated the associations of the gut microbiota in the first three years of life (two, six, and 12 weeks, and one and three years) with problem behavior and executive functions in N = 64 three-year-old children. Higher relative abundance of Streptococcus at the age of two weeks, as well as its trajectory over time (including ages two, six and 12 weeks, and one and three years), was related to worse executive functions. Higher relative abundance of [Ruminococcus] torques group at the age of three years, as well as its trajectory from one to three years, was associated with less internalizing behavior. Besides, several robust age-specific associations were identified: higher Bifidobacterium relative abundance (age three years) was associated with more internalizing and externalizing issues; higher Blautia relative abundance (age three years) was linked to less internalizing behavior; and increased relative abundance of an unidentified Enterobacteriaceae genus (age two weeks) was related to more externalizing behavior. Our findings provide important longitudinal evidence that early-life gut microbiota may be linked to behavioral and cognitive development in low-risk children. En ligne : https://dx.doi.org/10.1017/S0954579423001402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] A longitudinal study of the gut microbiota during the first three years of life: Links with problem behavior and executive functions at preschool age [texte imprimé] / Yvonne WILLEMSEN, Auteur ; Yangwenshan OU, Auteur ; Clara BELZER, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Hauke SMIDT, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur . - p.2032-2048. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.2032-2048 Mots-clés : cognition  early life  executive functions  gut microbiota  problem behavior Index. décimale : PER Périodiques Résumé : Early life is a sensitive period when microbiota-gut-brain interactions may have important impact on development. This study investigated the associations of the gut microbiota in the first three years of life (two, six, and 12 weeks, and one and three years) with problem behavior and executive functions in N = 64 three-year-old children. Higher relative abundance of Streptococcus at the age of two weeks, as well as its trajectory over time (including ages two, six and 12 weeks, and one and three years), was related to worse executive functions. Higher relative abundance of [Ruminococcus] torques group at the age of three years, as well as its trajectory from one to three years, was associated with less internalizing behavior. Besides, several robust age-specific associations were identified: higher Bifidobacterium relative abundance (age three years) was associated with more internalizing and externalizing issues; higher Blautia relative abundance (age three years) was linked to less internalizing behavior; and increased relative abundance of an unidentified Enterobacteriaceae genus (age two weeks) was related to more externalizing behavior. Our findings provide important longitudinal evidence that early-life gut microbiota may be linked to behavioral and cognitive development in low-risk children. En ligne : https://dx.doi.org/10.1017/S0954579423001402 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

A longitudinal study of the gut microbiota during the first three years of life: links with problem behavior and executive functions at preschool age - CORRIGENDUM / Yvonne WILLEMSEN in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.2049-2049 Titre : A longitudinal study of the gut microbiota during the first three years of life: links with problem behavior and executive functions at preschool age - CORRIGENDUM Type de document : texte imprimé Auteurs : Yvonne WILLEMSEN, Auteur ; Yangwenshan OU, Auteur ; Clara BELZER, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Hauke SMIDT, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur Article en page(s) : p.2049-2049 Langues : Anglais (eng) Mots-clés : addendum  cognition  early life  executive functions  gut microbiota  problem behavior Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1017/S0954579424000129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] A longitudinal study of the gut microbiota during the first three years of life: links with problem behavior and executive functions at preschool age - CORRIGENDUM [texte imprimé] / Yvonne WILLEMSEN, Auteur ; Yangwenshan OU, Auteur ; Clara BELZER, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Hauke SMIDT, Auteur ; Roseriet BEIJERS, Auteur ; Carolina DE WEERTH, Auteur . - p.2049-2049. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.2049-2049 Mots-clés : addendum  cognition  early life  executive functions  gut microbiota  problem behavior Index. décimale : PER Périodiques En ligne : https://dx.doi.org/10.1017/S0954579424000129 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11 / Judith S. NIJMEIJER in Journal of Autism and Developmental Disorders, 44-7 (July 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1671-1680 Titre : Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11 Type de document : texte imprimé Auteurs : Judith S. NIJMEIJER, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Nanda N. ROMMELSE, Auteur ; Marieke E. ALTINK, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Ellen A. FLIERS, Auteur ; Barbara FRANKE, Auteur ; Ruud B. MINDERAA, Auteur ; Joseph A. SERGEANT, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur Article en page(s) : p.1671-1680 Langues : Anglais (eng) Mots-clés : ASD  ADHD  Comorbidity  Genetics Index. décimale : PER Périodiques Résumé : We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children’s Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing. En ligne : http://dx.doi.org/10.1007/s10803-014-2039-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236 [article] Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11 [texte imprimé] / Judith S. NIJMEIJER, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Nanda N. ROMMELSE, Auteur ; Marieke E. ALTINK, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Ellen A. FLIERS, Auteur ; Barbara FRANKE, Auteur ; Ruud B. MINDERAA, Auteur ; Joseph A. SERGEANT, Auteur ; Jan K. BUITELAAR, Auteur ; Pieter J. HOEKSTRA, Auteur ; Catharina A. HARTMAN, Auteur . - p.1671-1680. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-7 (July 2014) . - p.1671-1680 Mots-clés : ASD  ADHD  Comorbidity  Genetics Index. décimale : PER Périodiques Résumé : We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children’s Social Behavior Questionnaire (CSBQ)) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing. En ligne : http://dx.doi.org/10.1007/s10803-014-2039-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=236

SLC2A3 single-nucleotide polymorphism and duplication influence cognitive processing and population-specific risk for attention-deficit/hyperactivity disorder / Sören MERKER in Journal of Child Psychology and Psychiatry, 58-7 (July 2017)  

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The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction / Marieke E. ALTINK in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)  

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