5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study / Robert KUMSTA in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.755-762 Titre : 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study Type de document : Texte imprimé et/ou numérique Auteurs : Robert KUMSTA, Auteur ; Michael RUTTER, Auteur ; Jana KREPPNER, Auteur ; Celia BECKETT, Auteur ; Jenny CASTLE, Auteur ; Suzanne E. STEVENS, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Keeley-Joanne BROOKES, Auteur ; Wolff SCHLOTZ, Auteur Année de publication : 2010 Article en page(s) : p.755-762 Langues : Anglais (eng) Mots-clés : Early-institutional-deprivation prospective-longitudinal-study gene–environment-interactions 5-HTTLPR depression Index. décimale : PER Périodiques Résumé : Background: A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to severe early institutional deprivation (ID), we tested whether the effect of ID on adolescent emotional problems is moderated by 5HTT genotype and stressful life events in adolescence. Methods: Emotional problems were assessed using questionnaire data (age 11), and on the basis of the CAPA diagnostic interview (age 15). Additionally, the number of stressful life events was measured. Results: There was a significant effect for genotype (p = .003) and a gene × environment interaction (p = .008) that was independent of age at testing. Carriers of the s/l and s/s genotype who experienced severe ID showed the highest emotional problem scores, while l/l homozygotes in the severe ID group showed the lowest overall levels. Furthermore, s/s carriers in the severe ID group who experienced a high number of stressful life events between 11 and 15 years had the largest increases in emotional problem scores, while a low number of stressful life events was associated with the largest decrease (4-way interaction: p = .05). Conclusions: The effects of severe early ID on emotional problems in adolescence are moderated by 5HTT genotype, and influenced by stressful life events in adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02249.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study [Texte imprimé et/ou numérique] / Robert KUMSTA, Auteur ; Michael RUTTER, Auteur ; Jana KREPPNER, Auteur ; Celia BECKETT, Auteur ; Jenny CASTLE, Auteur ; Suzanne E. STEVENS, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Keeley-Joanne BROOKES, Auteur ; Wolff SCHLOTZ, Auteur . - 2010 . - p.755-762. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.755-762 Mots-clés : Early-institutional-deprivation prospective-longitudinal-study gene–environment-interactions 5-HTTLPR depression Index. décimale : PER Périodiques Résumé : Background: A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to severe early institutional deprivation (ID), we tested whether the effect of ID on adolescent emotional problems is moderated by 5HTT genotype and stressful life events in adolescence. Methods: Emotional problems were assessed using questionnaire data (age 11), and on the basis of the CAPA diagnostic interview (age 15). Additionally, the number of stressful life events was measured. Results: There was a significant effect for genotype (p = .003) and a gene × environment interaction (p = .008) that was independent of age at testing. Carriers of the s/l and s/s genotype who experienced severe ID showed the highest emotional problem scores, while l/l homozygotes in the severe ID group showed the lowest overall levels. Furthermore, s/s carriers in the severe ID group who experienced a high number of stressful life events between 11 and 15 years had the largest increases in emotional problem scores, while a low number of stressful life events was associated with the largest decrease (4-way interaction: p = .05). Conclusions: The effects of severe early ID on emotional problems in adolescence are moderated by 5HTT genotype, and influenced by stressful life events in adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02249.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction / Marieke E. ALTINK in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1053-1060 Titre : The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction Type de document : Texte imprimé et/ou numérique Auteurs : Marieke E. ALTINK, Auteur ; Joseph A. SERGEANT, Auteur ; Wai CHEN, Auteur ; Keeley-Joanne BROOKES, Auteur ; Richard ANNEY, Auteur ; Ellen A. FLIERS, Auteur ; Dorine I.E. SLAATS–WILLEMSE, Auteur ; Barbara FRANKE, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Margaret J. THOMPSON, Auteur ; Michael GILL, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Aisling MULLIGAN, Auteur Année de publication : 2008 Article en page(s) : p.1053-1060 Langues : Anglais (eng) Mots-clés : Dopamine-receptor-D4-gene attention-deficit-hyperactivity-disorder-(ADHD) maternal-smoking-during-pregnancy gene-by-environment-interaction Index. décimale : PER Périodiques Résumé : Background: The dopamine receptor D4 (DRD4) 7-repeat allele and maternal smoking during pregnancy are both considered as risk factors in the aetiology of attention deficit hyperactivity disorder (ADHD), but few studies have been conducted on their interactive effects in causing ADHD. The purpose of this study is to examine the gene by environment (G×E) interaction of the DRD4 7-repeat allele and smoking during pregnancy on ADHD and oppositional behavior in families from the International Multicenter ADHD Genetics project; and further, to test the hypothesis that the direction of effect of the DRD4 7-repeat allele differs between ADHD affected and unaffected children. Methods: Linear mixed models were used to assess main and interactive effects of the DRD4 7-repeat allele and smoking during pregnancy in 539 ADHD-affected children and their 407 unaffected siblings, aged 6–17 years. Results: There was some evidence pointing to differential effects of the DRD4 7-repeat allele on ADHD and oppositional symptoms in the affected (fewer symptoms) and unaffected children (increasing ADHD symptoms of teacher ratings). Affected children were more often exposed to prenatal smoking than unaffected children. There were limited main effects of prenatal smoking on severity of symptoms. Given the number of tests performed, no indication was found for G×E interactions. Conclusion: Despite the large sample size, no G×E interactions were found. The impact of the DRD4 7-repeat allele might differ, depending on affected status and rater. This finding is discussed in terms of differences in the activity of the dopaminergic system and of different genes involved in rater-specific behaviors. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01998.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=606 [article] The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene–environment interaction [Texte imprimé et/ou numérique] / Marieke E. ALTINK, Auteur ; Joseph A. SERGEANT, Auteur ; Wai CHEN, Auteur ; Keeley-Joanne BROOKES, Auteur ; Richard ANNEY, Auteur ; Ellen A. FLIERS, Auteur ; Dorine I.E. SLAATS–WILLEMSE, Auteur ; Barbara FRANKE, Auteur ; Alejandro ARIAS-VASQUEZ, Auteur ; Margaret J. THOMPSON, Auteur ; Michael GILL, Auteur ; Cathelijne J.M. BUSCHGENS, Auteur ; Nanda N. ROMMELSE, Auteur ; Jan K. BUITELAAR, Auteur ; Philip ASHERSON, Auteur ; Stephen V. FARAONE, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Aisling MULLIGAN, Auteur . - 2008 . - p.1053-1060. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-10 (October 2008) . - p.1053-1060 Mots-clés : Dopamine-receptor-D4-gene attention-deficit-hyperactivity-disorder-(ADHD) maternal-smoking-during-pregnancy gene-by-environment-interaction Index. décimale : PER Périodiques Résumé : Background: The dopamine receptor D4 (DRD4) 7-repeat allele and maternal smoking during pregnancy are both considered as risk factors in the aetiology of attention deficit hyperactivity disorder (ADHD), but few studies have been conducted on their interactive effects in causing ADHD. The purpose of this study is to examine the gene by environment (G×E) interaction of the DRD4 7-repeat allele and smoking during pregnancy on ADHD and oppositional behavior in families from the International Multicenter ADHD Genetics project; and further, to test the hypothesis that the direction of effect of the DRD4 7-repeat allele differs between ADHD affected and unaffected children. Methods: Linear mixed models were used to assess main and interactive effects of the DRD4 7-repeat allele and smoking during pregnancy in 539 ADHD-affected children and their 407 unaffected siblings, aged 6–17 years. Results: There was some evidence pointing to differential effects of the DRD4 7-repeat allele on ADHD and oppositional symptoms in the affected (fewer symptoms) and unaffected children (increasing ADHD symptoms of teacher ratings). Affected children were more often exposed to prenatal smoking than unaffected children. There were limited main effects of prenatal smoking on severity of symptoms. Given the number of tests performed, no indication was found for G×E interactions. Conclusion: Despite the large sample size, no G×E interactions were found. The impact of the DRD4 7-repeat allele might differ, depending on affected status and rater. This finding is discussed in terms of differences in the activity of the dopaminergic system and of different genes involved in rater-specific behaviors. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01998.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=606

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