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Détail de l'auteur
Auteur Elaine TIERNEY |
Documents disponibles écrits par cet auteur (8)
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Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials / Lawrence SCAHILL in Journal of Autism and Developmental Disorders, 43-3 (March 2013)
[article]
Titre : Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials Type de document : Texte imprimé et/ou numérique Auteurs : Lawrence SCAHILL, Auteur ; Victoria HALLETT, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Yanhong DENG, Auteur ; James DZIURA, Auteur ; Benedetto VITIELLO, Auteur Article en page(s) : p.739-746 Langues : Anglais (eng) Mots-clés : Social disability Autism Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Social withdrawal Risperidone Aberrant Behavior Checklist Index. décimale : PER Périodiques Résumé : There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials. En ligne : http://dx.doi.org/10.1007/s10803-012-1689-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192
in Journal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.739-746[article] Brief Report: Social Disability in Autism Spectrum Disorder: Results from Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Trials [Texte imprimé et/ou numérique] / Lawrence SCAHILL, Auteur ; Victoria HALLETT, Auteur ; Michael G. AMAN, Auteur ; Christopher J. MCDOUGLE, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur ; Elaine TIERNEY, Auteur ; Yanhong DENG, Auteur ; James DZIURA, Auteur ; Benedetto VITIELLO, Auteur . - p.739-746.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-3 (March 2013) . - p.739-746
Mots-clés : Social disability Autism Research Units on Pediatric Psychopharmacology (RUPP) Autism Network Social withdrawal Risperidone Aberrant Behavior Checklist Index. décimale : PER Périodiques Résumé : There is growing interest in measuring social disability as a core element of autism spectrum disorders in medication trials. We conducted a secondary analysis on the Aberrant Behavior Checklist Social Withdrawal subscale using data from two federally-funded, multi-site, randomized trials with risperidone. Study 1 included 52 subjects assigned to placebo and 49 subjects to risperidone under double-blind conditions. Study 2 included 49 subjects assigned to risperidone only and 75 subjects assigned to risperidone plus parent training. After 8 weeks of treatment, all active treatments were superior to placebo (effect sizes ranging from 0.42 to 0.65). The findings suggest that the Social Withdrawal subscale may be a useful measure of social disability in acute treatment trials. En ligne : http://dx.doi.org/10.1007/s10803-012-1689-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=192 Cholesterol Deficit in Autism: Insights from Smith–Lemli–Opitz Syndrome / Alka ANEJA
Titre : Cholesterol Deficit in Autism: Insights from Smith–Lemli–Opitz Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Alka ANEJA, Auteur ; Elaine TIERNEY, Auteur Année de publication : 2008 Importance : p.69-79 Langues : Anglais (eng) Mots-clés : Cholesterole Syndrome de Smith-Lemli-Opitz Neurostéroide Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=703 Cholesterol Deficit in Autism: Insights from Smith–Lemli–Opitz Syndrome [Texte imprimé et/ou numérique] / Alka ANEJA, Auteur ; Elaine TIERNEY, Auteur . - 2008 . - p.69-79.
Langues : Anglais (eng)
Mots-clés : Cholesterole Syndrome de Smith-Lemli-Opitz Neurostéroide Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=703 Exemplaires
Code-barres Cote Support Localisation Section Disponibilité aucun exemplaire Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders / Victoria HALLETT in Journal of Autism and Developmental Disorders, 43-10 (October 2013)
[article]
Titre : Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Victoria HALLETT, Auteur ; Luc LECAVALIER, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Noreen CIPRIANO, Auteur ; Michael G. AMAN, Auteur ; James T. MCCRACKEN, Auteur ; Christopher J. MCDOUGLE, Auteur ; Elaine TIERNEY, Auteur ; Bryan H. KING, Auteur ; Eric HOLLANDER, Auteur ; Linmarie SIKICH, Auteur ; Joel D. BREGMAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Lily KATSOVICH, Auteur ; Kimberly DUKES, Auteur ; Benedetto VITIELLO, Auteur ; Kenneth D. GADOW, Auteur ; Lawrence SCAHILL, Auteur Article en page(s) : p.2341-2352 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders Anxiety Measurement Clinical Trials Index. décimale : PER Périodiques Résumé : This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement. En ligne : http://dx.doi.org/10.1007/s10803-013-1775-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215
in Journal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2341-2352[article] Exploring the Manifestations of Anxiety in Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Victoria HALLETT, Auteur ; Luc LECAVALIER, Auteur ; Denis G. SUKHODOLSKY, Auteur ; Noreen CIPRIANO, Auteur ; Michael G. AMAN, Auteur ; James T. MCCRACKEN, Auteur ; Christopher J. MCDOUGLE, Auteur ; Elaine TIERNEY, Auteur ; Bryan H. KING, Auteur ; Eric HOLLANDER, Auteur ; Linmarie SIKICH, Auteur ; Joel D. BREGMAN, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Craig DONNELLY, Auteur ; Lily KATSOVICH, Auteur ; Kimberly DUKES, Auteur ; Benedetto VITIELLO, Auteur ; Kenneth D. GADOW, Auteur ; Lawrence SCAHILL, Auteur . - p.2341-2352.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 43-10 (October 2013) . - p.2341-2352
Mots-clés : Autism spectrum disorders Anxiety Measurement Clinical Trials Index. décimale : PER Périodiques Résumé : This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement. En ligne : http://dx.doi.org/10.1007/s10803-013-1775-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=215 Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders / Roumen N. NIKOLOV in Journal of Autism and Developmental Disorders, 39-3 (March 2009)
[article]
Titre : Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Roumen N. NIKOLOV, Auteur ; Lawrence SCAHILL, Auteur ; Bhavik SHAH, Auteur ; Maria RODOWSKI, Auteur ; Craig ERICKSON, Auteur ; Jelle LETTINGA, Auteur ; Karen E. BEARSS, Auteur ; David J. POSEY, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2009 Article en page(s) : p.405-413 Langues : Anglais (eng) Mots-clés : Autism Chronic-gastrointestinal-problems Pervasive-developmental-disorders Index. décimale : PER Périodiques Résumé : Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment. En ligne : http://dx.doi.org/10.1007/s10803-008-0637-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695
in Journal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.405-413[article] Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders [Texte imprimé et/ou numérique] / Roumen N. NIKOLOV, Auteur ; Lawrence SCAHILL, Auteur ; Bhavik SHAH, Auteur ; Maria RODOWSKI, Auteur ; Craig ERICKSON, Auteur ; Jelle LETTINGA, Auteur ; Karen E. BEARSS, Auteur ; David J. POSEY, Auteur ; Louise RITZ, Auteur ; Elaine TIERNEY, Auteur ; Christopher J. MCDOUGLE, Auteur ; Michael G. AMAN, Auteur ; Benedetto VITIELLO, Auteur ; L. Eugene ARNOLD, Auteur ; James T. MCCRACKEN, Auteur . - 2009 . - p.405-413.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 39-3 (March 2009) . - p.405-413
Mots-clés : Autism Chronic-gastrointestinal-problems Pervasive-developmental-disorders Index. décimale : PER Périodiques Résumé : Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment. En ligne : http://dx.doi.org/10.1007/s10803-008-0637-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695 Hypothesis: The Role of Sterols in Autism Spectrum Disorder / Ryan W. Y. LEE in Autism Research and Treatment, (February 2011)
[article]
Titre : Hypothesis: The Role of Sterols in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ryan W. Y. LEE, Auteur ; Elaine TIERNEY, Auteur Année de publication : 2011 Article en page(s) : 7 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A possible role for sterols in the development of autism spectrum disorder (ASD) has not been proven, but studies in disorders of sterol biosynthesis, chiefly Smith-Lemli-Opitz syndrome (SLOS), enable hypotheses on a causal relationship to be discussed. Advances in genetic technology coupled with discoveries in membrane physiology have led to renewed interest for lipids in the nervous system. This paper hypothesizes on the role of sterol dysfunction in ASD through the framework of SLOS. Impaired sonic hedgehog patterning, alterations in membrane lipid rafts leading to abnormal synaptic plasticity, and impaired neurosteroid synthesis are discussed. Potential therapeutic agents include the development of neuroactive steroid-based agents and enzyme-specific drugs. Future investigations should reveal the specific mechanisms underlying sterol dysfunction in neurodevelopmental disorders by utilizing advanced imaging and molecular techniques. En ligne : http://dx.doi.org/10.1155/2011/653570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=131
in Autism Research and Treatment > (February 2011) . - 7 p.[article] Hypothesis: The Role of Sterols in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Ryan W. Y. LEE, Auteur ; Elaine TIERNEY, Auteur . - 2011 . - 7 p.
Langues : Anglais (eng)
in Autism Research and Treatment > (February 2011) . - 7 p.
Index. décimale : PER Périodiques Résumé : A possible role for sterols in the development of autism spectrum disorder (ASD) has not been proven, but studies in disorders of sterol biosynthesis, chiefly Smith-Lemli-Opitz syndrome (SLOS), enable hypotheses on a causal relationship to be discussed. Advances in genetic technology coupled with discoveries in membrane physiology have led to renewed interest for lipids in the nervous system. This paper hypothesizes on the role of sterol dysfunction in ASD through the framework of SLOS. Impaired sonic hedgehog patterning, alterations in membrane lipid rafts leading to abnormal synaptic plasticity, and impaired neurosteroid synthesis are discussed. Potential therapeutic agents include the development of neuroactive steroid-based agents and enzyme-specific drugs. Future investigations should reveal the specific mechanisms underlying sterol dysfunction in neurodevelopmental disorders by utilizing advanced imaging and molecular techniques. En ligne : http://dx.doi.org/10.1155/2011/653570 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=131 Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity / Laudan B. JAHROMI in Journal of Autism and Developmental Disorders, 39-3 (March 2009)
PermalinkSensitivity of the modified Children’s Yale–Brown Obsessive Compulsive Scale to detect change: Results from two multi-site trials / Lawrence SCAHILL in Autism, 20-2 (February 2016)
PermalinkSmith-Lemli-Opitz Syndrome and Role of Cholesterol in Autism / Geeta SARPHARE
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