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Auteur Kandice J. VARCIN |
Documents disponibles écrits par cet auteur (19)
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Symptom severity in autism spectrum disorder is related to the frequency and severity of nausea and vomiting during pregnancy: a retrospective case-control study / Andrew J. O. WHITEHOUSE in Molecular Autism, 9 (2018)
[article]
Titre : Symptom severity in autism spectrum disorder is related to the frequency and severity of nausea and vomiting during pregnancy: a retrospective case-control study Type de document : Texte imprimé et/ou numérique Auteurs : Andrew J. O. WHITEHOUSE, Auteur ; Gail A. ALVARES, Auteur ; D. CLEARY, Auteur ; A. HARUN, Auteur ; A. STOJANOSKA, Auteur ; L. J. TAYLOR, Auteur ; Kandice J. VARCIN, Auteur ; M. MAYBERY, Auteur Article en page(s) : 37p. Langues : Anglais (eng) Mots-clés : Adolescent Autism Spectrum Disorder/epidemiology Case-Control Studies Child Child, Preschool Female Humans Male Morning Sickness/epidemiology Nausea/epidemiology Pregnancy Index. décimale : PER Périodiques Résumé : Background: Nausea and vomiting during pregnancy (NVP) is thought to be caused by changes in maternal hormones during pregnancy. Differences in hormone exposure during prenatal life have been implicated in the causal pathways for some cases of autism spectrum disorder (ASD). However, no study has investigated whether the presence and severity of NVP may be related to symptom severity in offspring with ASD. Methods: A large sample of children with ASD (227 males and 60 females, aged 2 to 18 years) received a clinical assessment, during which parents completed questionnaires regarding their child's social (Social Responsiveness Scale, SRS) and communication (Children's Communication Checklist-2nd edition, CCC-2) symptoms. Parents also reported on a 5-point scale the frequency and severity of NVPs during the pregnancy of the child being assessed: (1) no NVP during the pregnancy, (2) occasional nausea, but no vomiting, (3) daily nausea, but no vomiting, (4) occasional vomiting, with or without nausea, and (5) daily nausea and vomiting. Results: Impairments in social responsiveness in offspring, as indexed by SRS total score, significantly increased as a function of the frequency and severity of their mothers' NVP, as did the level of language difficulties as indexed by the Global Communication Composite of the CCC-2. Conclusions: The strong, positive association between increasing frequency and severity of NVP and ASD severity in offspring provides further evidence that exposure to an atypical hormonal environment during prenatal life may affect neurodevelopment and contribute to the ASD phenotype. Given that the measure of NVP symptoms in the current study was based on retrospective recall, replication of this finding is required before strong conclusions can be drawn. En ligne : https://dx.doi.org/10.1186/s13229-018-0223-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371
in Molecular Autism > 9 (2018) . - 37p.[article] Symptom severity in autism spectrum disorder is related to the frequency and severity of nausea and vomiting during pregnancy: a retrospective case-control study [Texte imprimé et/ou numérique] / Andrew J. O. WHITEHOUSE, Auteur ; Gail A. ALVARES, Auteur ; D. CLEARY, Auteur ; A. HARUN, Auteur ; A. STOJANOSKA, Auteur ; L. J. TAYLOR, Auteur ; Kandice J. VARCIN, Auteur ; M. MAYBERY, Auteur . - 37p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 37p.
Mots-clés : Adolescent Autism Spectrum Disorder/epidemiology Case-Control Studies Child Child, Preschool Female Humans Male Morning Sickness/epidemiology Nausea/epidemiology Pregnancy Index. décimale : PER Périodiques Résumé : Background: Nausea and vomiting during pregnancy (NVP) is thought to be caused by changes in maternal hormones during pregnancy. Differences in hormone exposure during prenatal life have been implicated in the causal pathways for some cases of autism spectrum disorder (ASD). However, no study has investigated whether the presence and severity of NVP may be related to symptom severity in offspring with ASD. Methods: A large sample of children with ASD (227 males and 60 females, aged 2 to 18 years) received a clinical assessment, during which parents completed questionnaires regarding their child's social (Social Responsiveness Scale, SRS) and communication (Children's Communication Checklist-2nd edition, CCC-2) symptoms. Parents also reported on a 5-point scale the frequency and severity of NVPs during the pregnancy of the child being assessed: (1) no NVP during the pregnancy, (2) occasional nausea, but no vomiting, (3) daily nausea, but no vomiting, (4) occasional vomiting, with or without nausea, and (5) daily nausea and vomiting. Results: Impairments in social responsiveness in offspring, as indexed by SRS total score, significantly increased as a function of the frequency and severity of their mothers' NVP, as did the level of language difficulties as indexed by the Global Communication Composite of the CCC-2. Conclusions: The strong, positive association between increasing frequency and severity of NVP and ASD severity in offspring provides further evidence that exposure to an atypical hormonal environment during prenatal life may affect neurodevelopment and contribute to the ASD phenotype. Given that the measure of NVP symptoms in the current study was based on retrospective recall, replication of this finding is required before strong conclusions can be drawn. En ligne : https://dx.doi.org/10.1186/s13229-018-0223-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 The course and prognostic capability of motor difficulties in infants showing early signs of autism / M. K. LICARI in Autism Research, 14-8 (August 2021)
[article]
Titre : The course and prognostic capability of motor difficulties in infants showing early signs of autism Type de document : Texte imprimé et/ou numérique Auteurs : M. K. LICARI, Auteur ; Kandice J. VARCIN, Auteur ; K. HUDRY, Auteur ; H. C. LEONARD, Auteur ; Gail A. ALVARES, Auteur ; S. V. PILLAR, Auteur ; P. G. STEVENSON, Auteur ; Matthew N. COOPER, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.1759-1768 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder Autistic Disorder Humans Infant Motor Skills Prognosis Prospective Studies early identification infancy motor skills Index. décimale : PER Périodiques Résumé : Delays within the motor domain are often overlooked as an early surveillance marker for autism. The present study evaluated motor difficulties and its potential as an early predictive marker for later autism likelihood in a cohort of infants (N = 96) showing early behavioral signs of autism aged 9-14?months. The motor domain was evaluated using the motor subscales of the Mullen Scales of Early Learning at baseline, and at a 6-month follow-up. The Autism Diagnostic Observation Schedule - Toddler Module (ADOS-T) was completed at follow-up as a measure of autism likelihood. Motor difficulties were common at baseline, with 63/96 (65.6%) infants scoring very low or below average in the gross motor domain and 29/96 (30.2%) in the fine motor domain. At follow-up, gross motor difficulties had resolved for many, with 23/63 (36.5%) infants maintaining these difficulties. Fine motor difficulties resolved in fewer infants, with 20/29 (69.0%) continuing to present with fine motor delays at follow-up. Adjusted linear regression models suggested that fine motor scores at baseline (? = -0.12, SE = 0.04) and follow-up (? = -0.17, SE = 0.05) were associated with higher ADOS-T scores; with difficulties across both timepoints (? = 5.60, SE = 1.35) the strongest (largest in magnitude) association with ADOS-T scores of the predictors examined. Motor difficulties are prominent in children displaying emerging signs of autism, with persistent fine motor difficulties predictive of the developing autism phenotype. The findings indicate the potential clinical value of including evaluation of motor skills within early autism surveillance measures. LAY SUMMARY: This prospective study evaluated motor development over a 6-month period in infants showing early behavioral signs of autism. Atypical motor development was a common feature of infants showing early signs of autism and persistent fine motor difficulties were predictive of the emerging autism phenotype. En ligne : http://dx.doi.org/10.1002/aur.2545 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449
in Autism Research > 14-8 (August 2021) . - p.1759-1768[article] The course and prognostic capability of motor difficulties in infants showing early signs of autism [Texte imprimé et/ou numérique] / M. K. LICARI, Auteur ; Kandice J. VARCIN, Auteur ; K. HUDRY, Auteur ; H. C. LEONARD, Auteur ; Gail A. ALVARES, Auteur ; S. V. PILLAR, Auteur ; P. G. STEVENSON, Auteur ; Matthew N. COOPER, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.1759-1768.
Langues : Anglais (eng)
in Autism Research > 14-8 (August 2021) . - p.1759-1768
Mots-clés : Autism Spectrum Disorder Autistic Disorder Humans Infant Motor Skills Prognosis Prospective Studies early identification infancy motor skills Index. décimale : PER Périodiques Résumé : Delays within the motor domain are often overlooked as an early surveillance marker for autism. The present study evaluated motor difficulties and its potential as an early predictive marker for later autism likelihood in a cohort of infants (N = 96) showing early behavioral signs of autism aged 9-14?months. The motor domain was evaluated using the motor subscales of the Mullen Scales of Early Learning at baseline, and at a 6-month follow-up. The Autism Diagnostic Observation Schedule - Toddler Module (ADOS-T) was completed at follow-up as a measure of autism likelihood. Motor difficulties were common at baseline, with 63/96 (65.6%) infants scoring very low or below average in the gross motor domain and 29/96 (30.2%) in the fine motor domain. At follow-up, gross motor difficulties had resolved for many, with 23/63 (36.5%) infants maintaining these difficulties. Fine motor difficulties resolved in fewer infants, with 20/29 (69.0%) continuing to present with fine motor delays at follow-up. Adjusted linear regression models suggested that fine motor scores at baseline (? = -0.12, SE = 0.04) and follow-up (? = -0.17, SE = 0.05) were associated with higher ADOS-T scores; with difficulties across both timepoints (? = 5.60, SE = 1.35) the strongest (largest in magnitude) association with ADOS-T scores of the predictors examined. Motor difficulties are prominent in children displaying emerging signs of autism, with persistent fine motor difficulties predictive of the developing autism phenotype. The findings indicate the potential clinical value of including evaluation of motor skills within early autism surveillance measures. LAY SUMMARY: This prospective study evaluated motor development over a 6-month period in infants showing early behavioral signs of autism. Atypical motor development was a common feature of infants showing early signs of autism and persistent fine motor difficulties were predictive of the emerging autism phenotype. En ligne : http://dx.doi.org/10.1002/aur.2545 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=449 The misnomer of 'high functioning autism': Intelligence is an imprecise predictor of functional abilities at diagnosis / Gail A. ALVARES in Autism, 24-1 (January 2020)
[article]
Titre : The misnomer of 'high functioning autism': Intelligence is an imprecise predictor of functional abilities at diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : Gail A. ALVARES, Auteur ; Keely BEBBINGTON, Auteur ; D. CLEARY, Auteur ; K. EVANS, Auteur ; E. J. GLASSON, Auteur ; M. T. MAYBERY, Auteur ; S. PILLAR, Auteur ; M. ULJAREVIC, Auteur ; Kandice J. VARCIN, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.221-232 Langues : Anglais (eng) Mots-clés : adaptive behaviour autism spectrum disorders cognitive impairment intellectual disability Index. décimale : PER Périodiques Résumé : 'High functioning autism' is a term often used for individuals with autism spectrum disorder without an intellectual disability. Over time, this term has become synonymous with expectations of greater functional skills and better long-term outcomes, despite contradictory clinical observations. This study investigated the relationship between adaptive behaviour, cognitive estimates (intelligence quotient) and age at diagnosis in autism spectrum disorder. Participants (n = 2225, 1-18 years of age) were notified at diagnosis to a prospective register and grouped by presence (n = 1041) or absence (n = 1184) of intellectual disability. Functional abilities were reported using the Vineland Adaptive Behaviour Scales. Regression models suggested that intelligence quotient was a weak predictor of Vineland Adaptive Behaviour Scales after controlling for sex. Whereas the intellectual disability group's adaptive behaviour estimates were close to reported intelligence quotients, Vineland Adaptive Behaviour Scales scores fell significantly below intelligence quotients for children without intellectual disability. The gap between intelligence quotient and Vineland Adaptive Behaviour Scales scores remained large with increasing age at diagnosis for all children. These data indicate that estimates from intelligence quotient alone are an imprecise proxy for functional abilities when diagnosing autism spectrum disorder, particularly for those without intellectual disability. We argue that 'high functioning autism' is an inaccurate clinical descriptor when based solely on intelligence quotient demarcations and this term should be abandoned in research and clinical practice. En ligne : http://dx.doi.org/10.1177/1362361319852831 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414
in Autism > 24-1 (January 2020) . - p.221-232[article] The misnomer of 'high functioning autism': Intelligence is an imprecise predictor of functional abilities at diagnosis [Texte imprimé et/ou numérique] / Gail A. ALVARES, Auteur ; Keely BEBBINGTON, Auteur ; D. CLEARY, Auteur ; K. EVANS, Auteur ; E. J. GLASSON, Auteur ; M. T. MAYBERY, Auteur ; S. PILLAR, Auteur ; M. ULJAREVIC, Auteur ; Kandice J. VARCIN, Auteur ; J. WRAY, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.221-232.
Langues : Anglais (eng)
in Autism > 24-1 (January 2020) . - p.221-232
Mots-clés : adaptive behaviour autism spectrum disorders cognitive impairment intellectual disability Index. décimale : PER Périodiques Résumé : 'High functioning autism' is a term often used for individuals with autism spectrum disorder without an intellectual disability. Over time, this term has become synonymous with expectations of greater functional skills and better long-term outcomes, despite contradictory clinical observations. This study investigated the relationship between adaptive behaviour, cognitive estimates (intelligence quotient) and age at diagnosis in autism spectrum disorder. Participants (n = 2225, 1-18 years of age) were notified at diagnosis to a prospective register and grouped by presence (n = 1041) or absence (n = 1184) of intellectual disability. Functional abilities were reported using the Vineland Adaptive Behaviour Scales. Regression models suggested that intelligence quotient was a weak predictor of Vineland Adaptive Behaviour Scales after controlling for sex. Whereas the intellectual disability group's adaptive behaviour estimates were close to reported intelligence quotients, Vineland Adaptive Behaviour Scales scores fell significantly below intelligence quotients for children without intellectual disability. The gap between intelligence quotient and Vineland Adaptive Behaviour Scales scores remained large with increasing age at diagnosis for all children. These data indicate that estimates from intelligence quotient alone are an imprecise proxy for functional abilities when diagnosing autism spectrum disorder, particularly for those without intellectual disability. We argue that 'high functioning autism' is an inaccurate clinical descriptor when based solely on intelligence quotient demarcations and this term should be abandoned in research and clinical practice. En ligne : http://dx.doi.org/10.1177/1362361319852831 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=414 The Role of Negative Affectivity in Concurrent Relations Between Caregiver Psychological Distress and Social-Emotional Difficulties in Infants With Early Signs of Autism / Lacey CHETCUTI in Autism Research, 13-8 (August 2020)
[article]
Titre : The Role of Negative Affectivity in Concurrent Relations Between Caregiver Psychological Distress and Social-Emotional Difficulties in Infants With Early Signs of Autism Type de document : Texte imprimé et/ou numérique Auteurs : Lacey CHETCUTI, Auteur ; Mirko ULJAREVIC, Auteur ; Kandice J. VARCIN, Auteur ; Maryam BOUTRUS, Auteur ; Ming Wai WAN, Auteur ; Vicky SLONIMS, Auteur ; Jonathan GREEN, Auteur ; Leonie SEGAL, Auteur ; Teresa IACONO, Auteur ; Cheryl DISSANAYAKE, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur Article en page(s) : p.1349-1357 Langues : Anglais (eng) Mots-clés : autism spectrum disorder caregivers infant social-emotional difficulties temperament Index. décimale : PER Périodiques Résumé : Recent evidence suggests the link between caregiver psychological distress and offspring social-emotional difficulties may be accounted for by offspring temperament characteristics. However, existing studies have only focused on neurotypical children; thus, the current study sought to provide an initial examination of this process among children with varying levels of early autism features. Participants included 103 infants aged 9-16?months (M = 12.39, SD = 1.97; 68% male) and their primary caregiver (96% mothers) referred to a larger study by community healthcare professionals. We utilized caregiver-reported measures of psychological distress (Depression Anxiety Stress Scales), infant temperament (Infant Behavior Questionnaire-Revised) and internalizing and externalizing symptoms (Infant-Toddler Social and Emotional Assessment) and administered the Autism Observation Schedule for Infants (AOSI) at an assessment visit to quantify autism features. Infant negative affectivity was found to mediate positive concurrent relations between caregiver psychological distress and infant internalizing and externalizing symptoms, irrespective of the infants' AOSI score. While preliminary and cross-sectional, these results replicate and extend previous findings suggesting that the pathway from caregiver psychological distress to negative affectivity to social-emotional difficulties might also be apparent among infants with varying levels of autism features. More rigorous tests of causal effects await future longitudinal investigation. LAY SUMMARY: Offspring of caregivers experiencing psychological distress (i.e., symptoms of depression, anxiety, and/or stress) may themselves be at increased risk of poor mental health outcomes. Several previous studies conducted with neurotypical children suggest that this link from caregiver-to-child may be facilitated by children's temperament qualities. This study was a preliminary cross-sectional exploration of these relationships in infants with features of autism. We found that infants' elevated negative emotions were involved in the relation between caregiver heightened psychological distress and children's mental health difficulties, consistent with neurotypical development. Autism Res 2020, 13: 1349-1357. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430
in Autism Research > 13-8 (August 2020) . - p.1349-1357[article] The Role of Negative Affectivity in Concurrent Relations Between Caregiver Psychological Distress and Social-Emotional Difficulties in Infants With Early Signs of Autism [Texte imprimé et/ou numérique] / Lacey CHETCUTI, Auteur ; Mirko ULJAREVIC, Auteur ; Kandice J. VARCIN, Auteur ; Maryam BOUTRUS, Auteur ; Ming Wai WAN, Auteur ; Vicky SLONIMS, Auteur ; Jonathan GREEN, Auteur ; Leonie SEGAL, Auteur ; Teresa IACONO, Auteur ; Cheryl DISSANAYAKE, Auteur ; Andrew J. O. WHITEHOUSE, Auteur ; Kristelle HUDRY, Auteur . - p.1349-1357.
Langues : Anglais (eng)
in Autism Research > 13-8 (August 2020) . - p.1349-1357
Mots-clés : autism spectrum disorder caregivers infant social-emotional difficulties temperament Index. décimale : PER Périodiques Résumé : Recent evidence suggests the link between caregiver psychological distress and offspring social-emotional difficulties may be accounted for by offspring temperament characteristics. However, existing studies have only focused on neurotypical children; thus, the current study sought to provide an initial examination of this process among children with varying levels of early autism features. Participants included 103 infants aged 9-16?months (M = 12.39, SD = 1.97; 68% male) and their primary caregiver (96% mothers) referred to a larger study by community healthcare professionals. We utilized caregiver-reported measures of psychological distress (Depression Anxiety Stress Scales), infant temperament (Infant Behavior Questionnaire-Revised) and internalizing and externalizing symptoms (Infant-Toddler Social and Emotional Assessment) and administered the Autism Observation Schedule for Infants (AOSI) at an assessment visit to quantify autism features. Infant negative affectivity was found to mediate positive concurrent relations between caregiver psychological distress and infant internalizing and externalizing symptoms, irrespective of the infants' AOSI score. While preliminary and cross-sectional, these results replicate and extend previous findings suggesting that the pathway from caregiver psychological distress to negative affectivity to social-emotional difficulties might also be apparent among infants with varying levels of autism features. More rigorous tests of causal effects await future longitudinal investigation. LAY SUMMARY: Offspring of caregivers experiencing psychological distress (i.e., symptoms of depression, anxiety, and/or stress) may themselves be at increased risk of poor mental health outcomes. Several previous studies conducted with neurotypical children suggest that this link from caregiver-to-child may be facilitated by children's temperament qualities. This study was a preliminary cross-sectional exploration of these relationships in infants with features of autism. We found that infants' elevated negative emotions were involved in the relation between caregiver heightened psychological distress and children's mental health difficulties, consistent with neurotypical development. Autism Res 2020, 13: 1349-1357. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430