3 recherche sur le mot-clé '*Hypothalamo-Hypophyseal System'

Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation / Adrienne A. VANZOMEREN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1838-1853 Titre : Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation Type de document : Texte imprimé et/ou numérique Auteurs : Adrienne A. VANZOMEREN, Auteur ; Jingchen ZHANG, Auteur ; Sun-Kyung LEE, Auteur ; Meredith GUNLICKS-STOESSEL, Auteur ; Timothy PIEHLER, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.1838-1853 Langues : Anglais (eng) Mots-clés : Adolescent  African Americans  Child  *Depression  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  Saliva  *African American youth  *HPA axis  *maltreatment  *multigenic risk Index. décimale : PER Périodiques Résumé : Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Maltreatment timing, HPA axis functioning, multigenic risk, and depressive symptoms in African American youth: Differential associations without moderated mediation [Texte imprimé et/ou numérique] / Adrienne A. VANZOMEREN, Auteur ; Jingchen ZHANG, Auteur ; Sun-Kyung LEE, Auteur ; Meredith GUNLICKS-STOESSEL, Auteur ; Timothy PIEHLER, Auteur ; Dante CICCHETTI, Auteur . - p.1838-1853. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1838-1853 Mots-clés : Adolescent  African Americans  Child  *Depression  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  Saliva  *African American youth  *HPA axis  *maltreatment  *multigenic risk Index. décimale : PER Périodiques Résumé : Utilizing a large (N = 739), ancestrally homogenous sample, the current study aimed to better understand biological risk processes involved in the development of depressive symptoms in maltreated, African American children age 8-12 years. Maltreatment was independently coded from Child Protective Services records and maternal report. Self-reported depressive symptoms were attained in the context of a week-long, summer research camp. DNA was acquired from buccal cell or saliva samples and genotyped for nine polymorphisms in four hypothalamic-pituitary-adrenal (HPA)-axis-related genes: FKBP5, NR3C1, NR3C2, and CRHR1. Salivary cortisol samples were collected each morning (9 a.m.) and late afternoon (4 p.m.) throughout the week to assess HPA functioning. Results revealed that experiences of maltreatment beginning prior to age 5 were most predictive of depressive symptoms, whereas maltreatment onset after age 5 was most predictive of HPA axis dysregulation (blunted daytime cortisol patterns). Multigenic risk did not relate to HPA functioning, nor did it moderate the relationship between maltreatment and HPA activity. There was no mediation of the relationship between maltreatment and depressive symptoms by HPA dysfunction. Results are interpreted through a developmental psychopathology lens, emphasizing the principle of equifinality while carefully appraising racial differences. Implications for future research, particularly the need for longitudinal studies, and important methodological considerations are discussed. En ligne : http://dx.doi.org/10.1017/s0954579420000589 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Parental buffering in the context of poverty: positive parenting behaviors differentiate young children's stress reactivity profiles / Samantha M. BROWN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1778-1787 Titre : Parental buffering in the context of poverty: positive parenting behaviors differentiate young children's stress reactivity profiles Type de document : Texte imprimé et/ou numérique Auteurs : Samantha M. BROWN, Auteur ; Lisa J. SCHLUETER, Auteur ; Eliana HURWICH-REISS, Auteur ; Julia DMITRIEVA, Auteur ; Elly MILES, Auteur ; Sarah E. WATAMURA, Auteur Article en page(s) : p.1778-1787 Langues : Anglais (eng) Mots-clés : Child  Child, Preschool  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  *Parenting  Parents  Pituitary-Adrenal System  Poverty  Saliva  Stress, Psychological  *HPA axis  *early childhood  *poverty  *stress Index. décimale : PER Périodiques Résumé : Experiencing poverty increases vulnerability for dysregulated hypothalamic-pituitary-adrenal (HPA) axis functioning and compromises long-term health. Positive parenting buffers children from HPA axis reactivity, yet this has primarily been documented among families not experiencing poverty. We tested the theorized power of positive parenting in 124 parent-child dyads recruited from Early Head Start (Mage = 25.21 months) by examining child cortisol trajectories using five samples collected across a standardized stress paradigm. Piecewise latent growth models revealed that positive parenting buffered children's stress responses when controlling for time of day, last stress task completed, and demographics. Positive parenting also interacted with income such that positive parenting was especially protective for cortisol reactivity in families experiencing greater poverty. Findings suggest that positive parenting behaviors are important for protecting children in families experiencing low income from heightened or prolonged physiologic stress reactivity to an acute stressor. En ligne : http://dx.doi.org/10.1017/s0954579420001224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Parental buffering in the context of poverty: positive parenting behaviors differentiate young children's stress reactivity profiles [Texte imprimé et/ou numérique] / Samantha M. BROWN, Auteur ; Lisa J. SCHLUETER, Auteur ; Eliana HURWICH-REISS, Auteur ; Julia DMITRIEVA, Auteur ; Elly MILES, Auteur ; Sarah E. WATAMURA, Auteur . - p.1778-1787. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1778-1787 Mots-clés : Child  Child, Preschool  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  *Parenting  Parents  Pituitary-Adrenal System  Poverty  Saliva  Stress, Psychological  *HPA axis  *early childhood  *poverty  *stress Index. décimale : PER Périodiques Résumé : Experiencing poverty increases vulnerability for dysregulated hypothalamic-pituitary-adrenal (HPA) axis functioning and compromises long-term health. Positive parenting buffers children from HPA axis reactivity, yet this has primarily been documented among families not experiencing poverty. We tested the theorized power of positive parenting in 124 parent-child dyads recruited from Early Head Start (Mage = 25.21 months) by examining child cortisol trajectories using five samples collected across a standardized stress paradigm. Piecewise latent growth models revealed that positive parenting buffered children's stress responses when controlling for time of day, last stress task completed, and demographics. Positive parenting also interacted with income such that positive parenting was especially protective for cortisol reactivity in families experiencing greater poverty. Findings suggest that positive parenting behaviors are important for protecting children in families experiencing low income from heightened or prolonged physiologic stress reactivity to an acute stressor. En ligne : http://dx.doi.org/10.1017/s0954579420001224 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Racial discrimination and ethnic racial identity in adolescence as modulators of HPA axis activity / Emma K. ADAM in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1669-1684 Titre : Racial discrimination and ethnic racial identity in adolescence as modulators of HPA axis activity Type de document : Texte imprimé et/ou numérique Auteurs : Emma K. ADAM, Auteur ; Emily F. HITTNER, Auteur ; Sara E. THOMAS, Auteur ; Sarah Collier VILLAUME, Auteur ; Ednah E. NWAFOR, Auteur Article en page(s) : p.1669-1684 Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Child  Ethnic Groups  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  *Racism  Stress, Psychological  *HPA axis  *adolescence  *adversity  *cortisol  *early adulthood  *ethnic racial identity  *racial discrimination Index. décimale : PER Périodiques Résumé : We review evidence of racial discrimination as a critical and understudied form of adversity that has the potential to impact stress biology, particularly hypothalamic-pituitary-adrenal (HPA) axis activity. We highlight ethnic racial identity (ERI) as a positive regulatory influence on HPA axis activity, as indexed by levels of salivary cortisol. In past research by our group, Black individuals with high adolescent discrimination had low adult cortisol levels (hypocortisolism). Here, we present new analyses showing that ERI, measured prospectively from ages 12 through 32 in 112 Black and white individuals, is related to better-regulated cortisol levels in adulthood, particularly for Black participants. We also describe ongoing research that explores whether the promotion of ERI during adolescence can reduce ethnic-racial disparities in stress biology and in emotional health and academic outcomes. En ligne : http://dx.doi.org/10.1017/s095457942000111x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Racial discrimination and ethnic racial identity in adolescence as modulators of HPA axis activity [Texte imprimé et/ou numérique] / Emma K. ADAM, Auteur ; Emily F. HITTNER, Auteur ; Sara E. THOMAS, Auteur ; Sarah Collier VILLAUME, Auteur ; Ednah E. NWAFOR, Auteur . - p.1669-1684. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1669-1684 Mots-clés : Adolescent  Adult  Child  Ethnic Groups  Humans  Hydrocortisone  *Hypothalamo-Hypophyseal System  Pituitary-Adrenal System  *Racism  Stress, Psychological  *HPA axis  *adolescence  *adversity  *cortisol  *early adulthood  *ethnic racial identity  *racial discrimination Index. décimale : PER Périodiques Résumé : We review evidence of racial discrimination as a critical and understudied form of adversity that has the potential to impact stress biology, particularly hypothalamic-pituitary-adrenal (HPA) axis activity. We highlight ethnic racial identity (ERI) as a positive regulatory influence on HPA axis activity, as indexed by levels of salivary cortisol. In past research by our group, Black individuals with high adolescent discrimination had low adult cortisol levels (hypocortisolism). Here, we present new analyses showing that ERI, measured prospectively from ages 12 through 32 in 112 Black and white individuals, is related to better-regulated cortisol levels in adulthood, particularly for Black participants. We also describe ongoing research that explores whether the promotion of ERI during adolescence can reduce ethnic-racial disparities in stress biology and in emotional health and academic outcomes. En ligne : http://dx.doi.org/10.1017/s095457942000111x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437