Pubmed (TSA) du 20/09/26
1. DeZayas LB, Pendergrass JA, Marshall AR, Han JB, Kronfli FR, Vollmer TR. Assessing Social Consequences for Task Completion in Individuals with Autism Spectrum Disorder. Behav Sci (Basel). 2026; 16(9).
We used a concurrent operant assessment (COA) to evaluate social preferences for individuals with autism spectrum disorder across three comparison conditions: praise versus no interaction, preferred conversation topics versus no interaction, and preferred conversation topics versus praise. First, a multiple stimulus without replacement preference assessment was conducted to identify the preferred conversation topics and interests for all participants. Second, a COA was conducted where participants were able to choose which consequence they wanted to receive while working on an academic task during each comparison condition. We found that five out of six participants allocated more time to the praise side over no interaction, five out of six participants allocated more time to the preferred conversation topics over no interaction, and four out of six participants allocated more time to the preferred conversation topics over praise. The results indicate that social stimuli such as praise and preferred conversation topics may function as preferred stimuli indicating a need for future researchers and clinicians to individualize reinforcers. Thus, a proof-of-concept study is established to evaluate procedures for indicating preferences for types of social interaction.
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2. Hauck S, de Oliveira LT. A topological architecture of neurodivergence: Transdiagnostic reframing of autism, ADHD, dyslexia, DCD, and high-ability profiles within the high processing cost phenotypes (HPCPh) framework. Neurosci Biobehav Rev. 2026; 191: 106992.
BACKGROUND: Current neurodevelopmental classifications partition autism, ADHD, developmental coordination disorder (DCD), dyslexia, twice-exceptionality, and high-ability phenotypes into ostensibly separate clinical entities. AIMS: This narrative conceptual review aims to develop the phenotype-level clinical implications of an extracellular matrix (ECM)-based mechanobiological account of atypical neural topology, formulated in prior work, through the High Processing Cost Phenotypes (HPCPh) framework: these presentations are proposed to be phenotype-specific topological expressions of a shared developmental substrate. PROPOSALS: Within this model, a more permissive and insufficiently stabilized neural architecture is proposed to give rise to a recurrent geometry of Islands (high-gain domains of efficient local capture and integration), Deserts (weakly stabilized domains of serial implementation, gating, timing, and sensorimotor translation), and Bridges (energetically expensive compensatory pathways linking them). This Island-Desert-Bridge (IDB) topology is used to organize recurrent clinical paradoxes across neurodivergent presentations, including sensory talent with severe overload, preserved intention with dyspraxic execution, semantic richness with reading bottlenecks, salience-driven hyperfocus with routine failure, and high abstract capacity sustained by exhausting masking. The framework proposes a thermodynamic interpretation of some burnout- and depression-like states as load-related reductions in functional throughput when the allostatic cost of bridging exceeds metabolic and autonomic tolerance; this formulation does not exclude primary mood disorders and requires empirical differentiation. Functional Iron Blockade (FIB) is introduced as one candidate, hypothesis-level containment mechanism. CONCLUSIONS: By shifting emphasis from symptom-based deficits to topological cost, the HPCPh framework provides a falsifiable, transdiagnostic account that reconnects neurodevelopmental phenotypes with developmental biology, systems neuroscience, and allostatic physiology.
