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Auteur Karen PIERCE |
Documents disponibles écrits par cet auteur (10)
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Atypical functional connectivity of temporal cortex with precuneus and visual regions may be an early-age signature of ASD / Teresa H. WEN ; Lauren KUPIS ; Lisa T. EYLER ; Vani TALUJA ; Jaden TROXEL ; Disha GOEL ; Michael V. LOMBARDO ; Karen PIERCE ; Eric COURCHESNE in Molecular Autism, 14 (2023)
[article]
Titre : Atypical functional connectivity of temporal cortex with precuneus and visual regions may be an early-age signature of ASD Type de document : Texte imprimé et/ou numérique Auteurs : Teresa H. WEN, Auteur ; Lauren KUPIS, Auteur ; Lisa T. EYLER, Auteur ; Vani TALUJA, Auteur ; Jaden TROXEL, Auteur ; Disha GOEL, Auteur ; Michael V. LOMBARDO, Auteur ; Karen PIERCE, Auteur ; Eric COURCHESNE, Auteur Article en page(s) : 11 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Social and language abilities are closely intertwined during early typical development. In autism spectrum disorder (ASD), however, deficits in social and language development are early-age core symptoms. We previously reported that superior temporal cortex, a well-established social and language region, shows reduced activation to social affective speech in ASD toddlers; however, the atypical cortical connectivity that accompanies this deviance remains unknown. METHODS: We collected clinical, eye tracking, and resting-state fMRI data from 86 ASD and non-ASD subjects (mean age 2.3?+?0.7 years). Functional connectivity of left and right superior temporal regions with other cortical regions and correlations between this connectivity and each child's social and language abilities were examined. RESULTS: While there was no group difference in functional connectivity, the connectivity between superior temporal cortex and frontal and parietal regions was significantly correlated with language, communication, and social abilities in non-ASD subjects, but these effects were absent in ASD subjects. Instead, ASD subjects, regardless of different social or nonsocial visual preferences, showed atypical correlations between temporal-visual region connectivity and communication ability (r(49)=0.55, p<0.001) and between temporal-precuneus connectivity and expressive language ability (r(49)=0.58, p<0.001). LIMITATIONS: The distinct connectivity-behavior correlation patterns may be related to different developmental stages in ASD and non-ASD subjects. The use of a prior 2-year-old template for spatial normalization may not be optimal for a few subjects beyond this age range. CONCLUSIONS: Superior temporal cortex is known to have reduced activation to social affective speech in ASD at early ages, and here we find in ASD toddlers that it also has atypical connectivity with visual and precuneus cortices that is correlated with communication and language ability, a pattern not seen in non-ASD toddlers. This atypicality may be an early-age signature of ASD that also explains why the disorder has deviant early language and social development. Given that these atypical connectivity patterns are also present in older individuals with ASD, we conclude these atypical connectivity patterns persist across age and may explain why successful interventions targeting language and social skills at all ages in ASD are so difficult to achieve. En ligne : http://dx.doi.org/10.1186/s13229-023-00543-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Molecular Autism > 14 (2023) . - 11 p.[article] Atypical functional connectivity of temporal cortex with precuneus and visual regions may be an early-age signature of ASD [Texte imprimé et/ou numérique] / Teresa H. WEN, Auteur ; Lauren KUPIS, Auteur ; Lisa T. EYLER, Auteur ; Vani TALUJA, Auteur ; Jaden TROXEL, Auteur ; Disha GOEL, Auteur ; Michael V. LOMBARDO, Auteur ; Karen PIERCE, Auteur ; Eric COURCHESNE, Auteur . - 11 p.
Langues : Anglais (eng)
in Molecular Autism > 14 (2023) . - 11 p.
Index. décimale : PER Périodiques Résumé : BACKGROUND: Social and language abilities are closely intertwined during early typical development. In autism spectrum disorder (ASD), however, deficits in social and language development are early-age core symptoms. We previously reported that superior temporal cortex, a well-established social and language region, shows reduced activation to social affective speech in ASD toddlers; however, the atypical cortical connectivity that accompanies this deviance remains unknown. METHODS: We collected clinical, eye tracking, and resting-state fMRI data from 86 ASD and non-ASD subjects (mean age 2.3?+?0.7 years). Functional connectivity of left and right superior temporal regions with other cortical regions and correlations between this connectivity and each child's social and language abilities were examined. RESULTS: While there was no group difference in functional connectivity, the connectivity between superior temporal cortex and frontal and parietal regions was significantly correlated with language, communication, and social abilities in non-ASD subjects, but these effects were absent in ASD subjects. Instead, ASD subjects, regardless of different social or nonsocial visual preferences, showed atypical correlations between temporal-visual region connectivity and communication ability (r(49)=0.55, p<0.001) and between temporal-precuneus connectivity and expressive language ability (r(49)=0.58, p<0.001). LIMITATIONS: The distinct connectivity-behavior correlation patterns may be related to different developmental stages in ASD and non-ASD subjects. The use of a prior 2-year-old template for spatial normalization may not be optimal for a few subjects beyond this age range. CONCLUSIONS: Superior temporal cortex is known to have reduced activation to social affective speech in ASD at early ages, and here we find in ASD toddlers that it also has atypical connectivity with visual and precuneus cortices that is correlated with communication and language ability, a pattern not seen in non-ASD toddlers. This atypicality may be an early-age signature of ASD that also explains why the disorder has deviant early language and social development. Given that these atypical connectivity patterns are also present in older individuals with ASD, we conclude these atypical connectivity patterns persist across age and may explain why successful interventions targeting language and social skills at all ages in ASD are so difficult to achieve. En ligne : http://dx.doi.org/10.1186/s13229-023-00543-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 Consistency between parent report and direct assessment of development in toddlers with autism spectrum disorder and other delays: Does sex assigned at birth matter? / Stephen James in Autism Research, 16-6 (June 2023)
[article]
Titre : Consistency between parent report and direct assessment of development in toddlers with autism spectrum disorder and other delays: Does sex assigned at birth matter? Type de document : Texte imprimé et/ou numérique Auteurs : Stephen James, Auteur ; Shreyas Hallur, Auteur ; Joshua Anbar, Auteur ; Nicole Matthews, Auteur ; Karen PIERCE, Auteur ; Christopher J. SMITH, Auteur Article en page(s) : p.1174-1184 Langues : Anglais (eng) Mots-clés : autism direct assessment parent report sex toddlers Index. décimale : PER Périodiques Résumé : Abstract The current study examined differences between parent report and diagnostician direct assessment of receptive language, expressive language, and fine motor abilities in toddlers with autism spectrum disorder (ASD) and other delays. Additionally, this study examined whether parent-diagnostician consistency varied by child diagnosis and sex assigned at birth (SAB). Initial mixed analysis of variances (ANOVAs) were conducted using data from a sample of 646 toddlers to examine whether parent-diagnostician consistency differed by child diagnosis. Matched samples (using child age, SAB, and nonverbal IQ) were then created within each diagnostic group and mixed ANOVAs were conducted to examine if consistency was similar in matched diagnostic subsamples and whether it differed by SAB. Findings from the full sample mostly replicated previous research that has documented consistency between parent report and direct observation regardless of child diagnosis. However, when examined in matched diagnostic subgroups, more nuanced patterns were observed. Parent report of receptive language was lower in ASD and ASD features subgroups and parent report of fine motor skills was lower than direct observation in the ASD, ASD features, and developmental delay groups. When examining the moderating effect of SAB, only expressive language was impacted for children in the ASD group. Results indicate the importance of considering child demographic characteristics and that child SAB may impact parent report and/or diagnostician perception of expressive language. En ligne : https://doi.org/10.1002/aur.2927 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507
in Autism Research > 16-6 (June 2023) . - p.1174-1184[article] Consistency between parent report and direct assessment of development in toddlers with autism spectrum disorder and other delays: Does sex assigned at birth matter? [Texte imprimé et/ou numérique] / Stephen James, Auteur ; Shreyas Hallur, Auteur ; Joshua Anbar, Auteur ; Nicole Matthews, Auteur ; Karen PIERCE, Auteur ; Christopher J. SMITH, Auteur . - p.1174-1184.
Langues : Anglais (eng)
in Autism Research > 16-6 (June 2023) . - p.1174-1184
Mots-clés : autism direct assessment parent report sex toddlers Index. décimale : PER Périodiques Résumé : Abstract The current study examined differences between parent report and diagnostician direct assessment of receptive language, expressive language, and fine motor abilities in toddlers with autism spectrum disorder (ASD) and other delays. Additionally, this study examined whether parent-diagnostician consistency varied by child diagnosis and sex assigned at birth (SAB). Initial mixed analysis of variances (ANOVAs) were conducted using data from a sample of 646 toddlers to examine whether parent-diagnostician consistency differed by child diagnosis. Matched samples (using child age, SAB, and nonverbal IQ) were then created within each diagnostic group and mixed ANOVAs were conducted to examine if consistency was similar in matched diagnostic subsamples and whether it differed by SAB. Findings from the full sample mostly replicated previous research that has documented consistency between parent report and direct observation regardless of child diagnosis. However, when examined in matched diagnostic subgroups, more nuanced patterns were observed. Parent report of receptive language was lower in ASD and ASD features subgroups and parent report of fine motor skills was lower than direct observation in the ASD, ASD features, and developmental delay groups. When examining the moderating effect of SAB, only expressive language was impacted for children in the ASD group. Results indicate the importance of considering child demographic characteristics and that child SAB may impact parent report and/or diagnostician perception of expressive language. En ligne : https://doi.org/10.1002/aur.2927 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=507 Examination of Clinical and Assessment Type Differences Between Toddlers with ASD from Multiplex and Simplex Families / Joshua Anbar in Journal of Autism and Developmental Disorders, 54-6 (June 2024)
[article]
Titre : Examination of Clinical and Assessment Type Differences Between Toddlers with ASD from Multiplex and Simplex Families Type de document : Texte imprimé et/ou numérique Auteurs : Joshua Anbar, Auteur ; Nicole Matthews, Auteur ; Stephen James, Auteur ; Afzal ARIFF, Auteur ; Karen PIERCE, Auteur ; Christopher J. SMITH, Auteur Article en page(s) : p.2170-2182 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Few studies have examined differences in autism spectrum disorder (ASD) phenotype between children from multiplex and simplex families at the time of diagnosis. The present study used an age- and gender-matched, community-based sample (n = 105) from the southwestern United States to examine differences in ASD symptom severity, cognitive development, and adaptive functioning. No significant differences between children from multiplex and simplex families were observed. Exploratory analysis revealed that parents underreported receptive and expressive language and fine motor skills compared to professional observation, especially among children from multiplex families. These findings suggest that diagnosticians may need to consider family structure when choosing and interpreting assessments of receptive language, expressive language, and fine motor skills. En ligne : https://doi.org/10.1007/s10803-022-05890-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530
in Journal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2170-2182[article] Examination of Clinical and Assessment Type Differences Between Toddlers with ASD from Multiplex and Simplex Families [Texte imprimé et/ou numérique] / Joshua Anbar, Auteur ; Nicole Matthews, Auteur ; Stephen James, Auteur ; Afzal ARIFF, Auteur ; Karen PIERCE, Auteur ; Christopher J. SMITH, Auteur . - p.2170-2182.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 54-6 (June 2024) . - p.2170-2182
Index. décimale : PER Périodiques Résumé : Few studies have examined differences in autism spectrum disorder (ASD) phenotype between children from multiplex and simplex families at the time of diagnosis. The present study used an age- and gender-matched, community-based sample (n = 105) from the southwestern United States to examine differences in ASD symptom severity, cognitive development, and adaptive functioning. No significant differences between children from multiplex and simplex families were observed. Exploratory analysis revealed that parents underreported receptive and expressive language and fine motor skills compared to professional observation, especially among children from multiplex families. These findings suggest that diagnosticians may need to consider family structure when choosing and interpreting assessments of receptive language, expressive language, and fine motor skills. En ligne : https://doi.org/10.1007/s10803-022-05890-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=530 Examination of the impact of the Get SET Early program on equitable access to care within the screen-evaluate-treat chain in toddlers with autism spectrum disorder / Christie PHAM in Autism, 27-6 (August 2023)
[article]
Titre : Examination of the impact of the Get SET Early program on equitable access to care within the screen-evaluate-treat chain in toddlers with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Christie PHAM, Auteur ; Elizabeth C BACON, Auteur ; Andrea GRZYBOWSKI, Auteur ; Cynthia CARTER-BARNES, Auteur ; Steven ARIAS, Auteur ; Ronghui XU, Auteur ; Linda LOPEZ, Auteur ; Eric COURCHESNE, Auteur ; Karen PIERCE, Auteur Article en page(s) : p.1790-1802 Langues : Anglais (eng) Mots-clés : autism spectrum disorders;development;family functioning and support;health services;race and ethnicity Index. décimale : PER Périodiques Résumé : Delays in autism spectrum disorder identification/services could impact developmental outcomes. Although trends are encouraging, children from historically underrepresented minority backgrounds are often identified later and have reduced engagement in care. It is unclear if disparities exist throughout the screen-evaluate-treat chain, or if early detection programs such as Get SET Early that standardize these steps are effective countermeasures. Pediatricians/primary care providers administered Communication and Symbolic Behavior Scales IT Checklist screens at 12-, 18-, and 24-month well-baby examinations, and parents designated race, ethnicity, and developmental concerns. Toddlers who scored in the range of concern, or whose pediatricians/primary care providers had concerns, were referred for evaluations. Rates of screening and evaluation engagement within ethnic/racial groups were compared to U.S. Census proportions. Age at screen, evaluation, and treatment and quantity was compared across groups. Regressions examined whether key factors were associated with ethnicity or race. No differences were found for mean age of screen, evaluation, initiation of behavioral therapy, or quantity received between racial and ethnic groups. Historically underrepresented minority children were more likely to fall into the range of concern, referred for evaluations, and have their parents express developmental concerns. Although there remain gaps within the pipeline, implementation of systemized programs can be effective in ensuring equitable access to resources across communities.Lay abstractDelays in autism spectrum disorder identification and access to care could impact developmental outcomes. Although trends are encouraging, children from historically underrepresented minority backgrounds are often identified at later ages and have reduced engagement in services. It is unclear if disparities exist all along the screen-evaluation-treatment chain, or if early detection programs such as Get SET Early that standardize, these steps are effective at ameliorating disparities. As part of the Get SET Early model, primary care providers administered a parent-report screen at well-baby examinations, and parents designated race, ethnicity, and developmental concerns. Toddlers who scored in the range of concern, or whose primary care provider had concerns, were referred for an evaluation. Rates of screening and evaluation engagement within ethnic/racial groups were compared to US Census data. Age at screen, evaluation, and treatment engagement and quantity was compared across groups. Statistical models examined whether key factors such as parent concern were associated with ethnicity or race. No differences were found in the mean age at the first screen, evaluation, or initiation or quantity of behavioral therapy between participants. However, children from historically underrepresented minority backgrounds were more likely to fall into the range of concern on the parent-report screen, their parents expressed developmental concerns more often, and pediatricians were more likely to refer for an evaluation than their White/Not Hispanic counterparts. Overall results suggest that models that support transparent tracking of steps in the screen-evaluation-treatment chain and service referral pipelines may be an effective strategy for ensuring equitable access to care for all children. En ligne : http://dx.doi.org/10.1177/13623613221147416 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509
in Autism > 27-6 (August 2023) . - p.1790-1802[article] Examination of the impact of the Get SET Early program on equitable access to care within the screen-evaluate-treat chain in toddlers with autism spectrum disorder [Texte imprimé et/ou numérique] / Christie PHAM, Auteur ; Elizabeth C BACON, Auteur ; Andrea GRZYBOWSKI, Auteur ; Cynthia CARTER-BARNES, Auteur ; Steven ARIAS, Auteur ; Ronghui XU, Auteur ; Linda LOPEZ, Auteur ; Eric COURCHESNE, Auteur ; Karen PIERCE, Auteur . - p.1790-1802.
Langues : Anglais (eng)
in Autism > 27-6 (August 2023) . - p.1790-1802
Mots-clés : autism spectrum disorders;development;family functioning and support;health services;race and ethnicity Index. décimale : PER Périodiques Résumé : Delays in autism spectrum disorder identification/services could impact developmental outcomes. Although trends are encouraging, children from historically underrepresented minority backgrounds are often identified later and have reduced engagement in care. It is unclear if disparities exist throughout the screen-evaluate-treat chain, or if early detection programs such as Get SET Early that standardize these steps are effective countermeasures. Pediatricians/primary care providers administered Communication and Symbolic Behavior Scales IT Checklist screens at 12-, 18-, and 24-month well-baby examinations, and parents designated race, ethnicity, and developmental concerns. Toddlers who scored in the range of concern, or whose pediatricians/primary care providers had concerns, were referred for evaluations. Rates of screening and evaluation engagement within ethnic/racial groups were compared to U.S. Census proportions. Age at screen, evaluation, and treatment and quantity was compared across groups. Regressions examined whether key factors were associated with ethnicity or race. No differences were found for mean age of screen, evaluation, initiation of behavioral therapy, or quantity received between racial and ethnic groups. Historically underrepresented minority children were more likely to fall into the range of concern, referred for evaluations, and have their parents express developmental concerns. Although there remain gaps within the pipeline, implementation of systemized programs can be effective in ensuring equitable access to resources across communities.Lay abstractDelays in autism spectrum disorder identification and access to care could impact developmental outcomes. Although trends are encouraging, children from historically underrepresented minority backgrounds are often identified at later ages and have reduced engagement in services. It is unclear if disparities exist all along the screen-evaluation-treatment chain, or if early detection programs such as Get SET Early that standardize, these steps are effective at ameliorating disparities. As part of the Get SET Early model, primary care providers administered a parent-report screen at well-baby examinations, and parents designated race, ethnicity, and developmental concerns. Toddlers who scored in the range of concern, or whose primary care provider had concerns, were referred for an evaluation. Rates of screening and evaluation engagement within ethnic/racial groups were compared to US Census data. Age at screen, evaluation, and treatment engagement and quantity was compared across groups. Statistical models examined whether key factors such as parent concern were associated with ethnicity or race. No differences were found in the mean age at the first screen, evaluation, or initiation or quantity of behavioral therapy between participants. However, children from historically underrepresented minority backgrounds were more likely to fall into the range of concern on the parent-report screen, their parents expressed developmental concerns more often, and pediatricians were more likely to refer for an evaluation than their White/Not Hispanic counterparts. Overall results suggest that models that support transparent tracking of steps in the screen-evaluation-treatment chain and service referral pipelines may be an effective strategy for ensuring equitable access to care for all children. En ligne : http://dx.doi.org/10.1177/13623613221147416 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=509 L'identification précoce de l'autisme : l'exploration du cerveau et du comportement / Karen PIERCE in Bulletin Scientifique de l'arapi (Le), 30 (décembre 2012)
[article]
Titre : L'identification précoce de l'autisme : l'exploration du cerveau et du comportement Type de document : Texte imprimé et/ou numérique Auteurs : Karen PIERCE, Auteur Année de publication : 2012 Article en page(s) : p.77-80 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187
in Bulletin Scientifique de l'arapi (Le) > 30 (décembre 2012) . - p.77-80[article] L'identification précoce de l'autisme : l'exploration du cerveau et du comportement [Texte imprimé et/ou numérique] / Karen PIERCE, Auteur . - 2012 . - p.77-80.
Langues : Français (fre)
in Bulletin Scientifique de l'arapi (Le) > 30 (décembre 2012) . - p.77-80
Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 Identifying prognostic markers in autism spectrum disorder using eye tracking / Elizabeth C. BACON in Autism, 24-3 (April 2020)
PermalinkRethinking the idea of late autism spectrum disorder onset / Elizabeth C. BACON in Development and Psychopathology, 30-2 (May 2018)
PermalinkStructural and Functional Brain Development in ASD: The Impact of Early Brain Overgrowth and Considerations for Treatment / Karen PIERCE
PermalinkThe Autism Diagnostic Observation Schedule—Toddler Module: A New Module of a Standardized Diagnostic Measure for Autism Spectrum Disorders / Rhiannon LUYSTER in Journal of Autism and Developmental Disorders, 39-9 (September 2009)
PermalinkThe Early Screening for Autism and Communication Disorders: Field-testing an autism-specific screening tool for children 12 to 36 months of age / Amy M. WETHERBY in Autism, 26-7 (October 2022)
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