Alexithymia in Adolescents with Autism Spectrum Disorder: Its Relationship to Internalising Difficulties, Sensory Modulation and Social Cognition / Bosiljka MILOSAVLJEVIC in Journal of Autism and Developmental Disorders, 46-4 (April 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1354-1367 Titre : Alexithymia in Adolescents with Autism Spectrum Disorder: Its Relationship to Internalising Difficulties, Sensory Modulation and Social Cognition Type de document : texte imprimé Auteurs : Bosiljka MILOSAVLJEVIC, Auteur ; Virginia CARTER LENO, Auteur ; Emily SIMONOFF, Auteur ; Gillian BAIRD, Auteur ; Andrew PICKLES, Auteur ; Catherine R.G. JONES, Auteur ; Catherine ERSKINE, Auteur ; Tony CHARMAN, Auteur ; Francesca HAPPE, Auteur Article en page(s) : p.1354-1367 Langues : Anglais (eng) Mots-clés : Alexithymia  Autism spectrum disorder  Emotion recognition  Theory of mind  Anxiety  Sensory processing Index. décimale : PER Périodiques Résumé : Alexithymia is a personality trait frequently found in adults with autism spectrum disorder (ASD), and has been linked to impairments in emotion recognition and empathy. The presentation of alexithymia within ASD at younger ages remains unexplored, and was examined in the present study. Alexithymia rates were significantly elevated in ASD (55 %; 31/56 scoring above cut-off) versus non-ASD adolescents (16 %; 5/32 scoring above cut-off). Within individuals with ASD, alexithymia was associated with increased self-reported anxiety, parent-reported emotional difficulties, self-reported sensory processing atypicalities, and poorer emotion recognition, but was not associated with theory of mind ability. Overall, our results suggest that alexithymia is highly prevalent, and has selective cognitive correlates in young people with ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2670-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284 [article] Alexithymia in Adolescents with Autism Spectrum Disorder: Its Relationship to Internalising Difficulties, Sensory Modulation and Social Cognition [texte imprimé] / Bosiljka MILOSAVLJEVIC, Auteur ; Virginia CARTER LENO, Auteur ; Emily SIMONOFF, Auteur ; Gillian BAIRD, Auteur ; Andrew PICKLES, Auteur ; Catherine R.G. JONES, Auteur ; Catherine ERSKINE, Auteur ; Tony CHARMAN, Auteur ; Francesca HAPPE, Auteur . - p.1354-1367. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-4 (April 2016) . - p.1354-1367 Mots-clés : Alexithymia  Autism spectrum disorder  Emotion recognition  Theory of mind  Anxiety  Sensory processing Index. décimale : PER Périodiques Résumé : Alexithymia is a personality trait frequently found in adults with autism spectrum disorder (ASD), and has been linked to impairments in emotion recognition and empathy. The presentation of alexithymia within ASD at younger ages remains unexplored, and was examined in the present study. Alexithymia rates were significantly elevated in ASD (55 %; 31/56 scoring above cut-off) versus non-ASD adolescents (16 %; 5/32 scoring above cut-off). Within individuals with ASD, alexithymia was associated with increased self-reported anxiety, parent-reported emotional difficulties, self-reported sensory processing atypicalities, and poorer emotion recognition, but was not associated with theory of mind ability. Overall, our results suggest that alexithymia is highly prevalent, and has selective cognitive correlates in young people with ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2670-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=284

Alterations in electrophysiological indices of perceptual processing and discrimination are associated with co-occurring emotional and behavioural problems in adolescents with autism spectrum disorder / Virginia CARTER LENO in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 50p. Titre : Alterations in electrophysiological indices of perceptual processing and discrimination are associated with co-occurring emotional and behavioural problems in adolescents with autism spectrum disorder Type de document : texte imprimé Auteurs : Virginia CARTER LENO, Auteur ; Susie CHANDLER, Auteur ; Pippa WHITE, Auteur ; Isabel YORKE, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Emily SIMONOFF, Auteur Article en page(s) : 50p. Langues : Anglais (eng) Mots-clés : asd  Comorbidity  eeg  erp  IAMHealth  Perceptual processing  Psychopathology  Sensory  approved by Camden and King's Cross Ethics Sub-Committee (14/LO/2098).Not  applicable.AP receives royalties from the Social Communication Questionnaire. The  other authors declare that they have no competing interests.Springer Nature  remains neutral with regard to jurisdictional claims in published maps and  institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Many young people with autism spectrum disorder (ASD) experience emotional and behavioural problems. However, the causes of these co-occurring difficulties are not well understood. Perceptual processing atypicalities are also often reported in individuals with ASD, but how these relate to co-occurring emotional and behavioural problems remains unclear, and few studies have used objective measurement of perceptual processing. Methods: Event-related potentials (ERPs) were recorded in response to both standard and deviant stimuli (which varied in pitch) in an auditory oddball paradigm in adolescents (mean age of 13.56 years, SD = 1.12, range = 11.40-15.70) with ASD (n = 43) with a wide range of IQ (mean IQ of 84.14, SD = 24.24, range 27-129). Response to deviant as compared to standard stimuli (as indexed by the mismatch negativity (MMN)) and response to repeated presentations of standard stimuli (habituation) were measured. Multivariate regression tested the association between neural indices of perceptual processing and co-occurring emotional and behavioural problems. Results: Greater sensitivity to changes in pitch in incoming auditory information (discrimination), as indexed by increased MMN amplitude, was associated with higher levels of parent-rated behaviour problems. MMN amplitude also showed a trend positive correlation with parent-rated sensory hyper-sensitivity. Conversely, greater habituation at the later N2 component was associated with higher levels of emotional problems. Upon more detailed analyses, this appeared to be driven by a selectively greater ERP response to the first (but not the second or third) standard stimuli that followed deviant stimuli. A similar pattern of association was found with other measures of anxiety. All results remained in covariation analyses controlling for age, sex and IQ, although the association between MMN amplitude and behaviour problems became non-significant when controlling for ASD severity. Conclusions: Findings suggest that alterations in mechanisms of perceptual processing and discrimination may be important for understanding co-occurring emotional and behavioural problems in young people with ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0236-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Alterations in electrophysiological indices of perceptual processing and discrimination are associated with co-occurring emotional and behavioural problems in adolescents with autism spectrum disorder [texte imprimé] / Virginia CARTER LENO, Auteur ; Susie CHANDLER, Auteur ; Pippa WHITE, Auteur ; Isabel YORKE, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Emily SIMONOFF, Auteur . - 50p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 50p. Mots-clés : asd  Comorbidity  eeg  erp  IAMHealth  Perceptual processing  Psychopathology  Sensory  approved by Camden and King's Cross Ethics Sub-Committee (14/LO/2098).Not  applicable.AP receives royalties from the Social Communication Questionnaire. The  other authors declare that they have no competing interests.Springer Nature  remains neutral with regard to jurisdictional claims in published maps and  institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: Many young people with autism spectrum disorder (ASD) experience emotional and behavioural problems. However, the causes of these co-occurring difficulties are not well understood. Perceptual processing atypicalities are also often reported in individuals with ASD, but how these relate to co-occurring emotional and behavioural problems remains unclear, and few studies have used objective measurement of perceptual processing. Methods: Event-related potentials (ERPs) were recorded in response to both standard and deviant stimuli (which varied in pitch) in an auditory oddball paradigm in adolescents (mean age of 13.56 years, SD = 1.12, range = 11.40-15.70) with ASD (n = 43) with a wide range of IQ (mean IQ of 84.14, SD = 24.24, range 27-129). Response to deviant as compared to standard stimuli (as indexed by the mismatch negativity (MMN)) and response to repeated presentations of standard stimuli (habituation) were measured. Multivariate regression tested the association between neural indices of perceptual processing and co-occurring emotional and behavioural problems. Results: Greater sensitivity to changes in pitch in incoming auditory information (discrimination), as indexed by increased MMN amplitude, was associated with higher levels of parent-rated behaviour problems. MMN amplitude also showed a trend positive correlation with parent-rated sensory hyper-sensitivity. Conversely, greater habituation at the later N2 component was associated with higher levels of emotional problems. Upon more detailed analyses, this appeared to be driven by a selectively greater ERP response to the first (but not the second or third) standard stimuli that followed deviant stimuli. A similar pattern of association was found with other measures of anxiety. All results remained in covariation analyses controlling for age, sex and IQ, although the association between MMN amplitude and behaviour problems became non-significant when controlling for ASD severity. Conclusions: Findings suggest that alterations in mechanisms of perceptual processing and discrimination may be important for understanding co-occurring emotional and behavioural problems in young people with ASD. En ligne : https://dx.doi.org/10.1186/s13229-018-0236-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

An emerging income differential for adolescent emotional problems / Emma GORE LANGTON in Journal of Child Psychology and Psychiatry, 52-10 (October 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1081-1088 Titre : An emerging income differential for adolescent emotional problems Type de document : texte imprimé Auteurs : Emma GORE LANGTON, Auteur ; Stephan COLLISHAW, Auteur ; Robert GOODMAN, Auteur ; Andrew PICKLES, Auteur ; Barbara MAUGHAN, Auteur Année de publication : 2011 Article en page(s) : p.1081-1088 Langues : Anglais (eng) Mots-clés : Income gradient;adolescence;emotional problems;sociodemographic risk factors  family factors  National Child Development Study  British Cohort Study  British Child and Adolescent Mental Health Surveys Index. décimale : PER Périodiques Résumé : Background:  While there is considerable evidence of income gradients in child and adolescent behaviour problems, evidence relating to children and young people’s emotional difficulties is more mixed. Older studies reported no income differentials, while recent reports suggest that adolescents from low-income families are more likely to experience emotional difficulties than their more affluent peers. Methods:  We compared the association between low- versus medium-/high-family income and parent-reported emotional difficulties in 15- and 16-year-olds in three large nationally representative cohorts studied in 1974, 1986 and 1999/2004. We then examined whether increases in the income differential could be accounted for by changes in the association of a range of sociodemographic factors (family type or size, maternal education or housing tenure) with either family income or emotional difficulties. Finally, in the most recent cohorts, we considered whether the effects of these sociodemographic variables were mediated by more proximal family factors (maternal distress, stressful life events or family dysfunction). Results:  An increasing income differential in adolescent emotional problems emerged over the period, with standardized coefficients for associations with low income increasing from .07 in 1974 and 1986 to .30 in 1999/2004. This was due partially (∼10%) to sociodemographic risk factors for emotional difficulties becoming more strongly associated with low-income families over time, and partially (∼40%) to the increasing impact of these risk factors. In the most recent cohorts, about 40% of the effects of sociodemographic risks appear to have been mediated by more proximal family factors. Conclusions:  These findings have implications for our understanding of the health burden of emotional problems, recognition of the health burden associated with inequality and public concern about the consequences of social change. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02447.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142 [article] An emerging income differential for adolescent emotional problems [texte imprimé] / Emma GORE LANGTON, Auteur ; Stephan COLLISHAW, Auteur ; Robert GOODMAN, Auteur ; Andrew PICKLES, Auteur ; Barbara MAUGHAN, Auteur . - 2011 . - p.1081-1088. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-10 (October 2011) . - p.1081-1088 Mots-clés : Income gradient;adolescence;emotional problems;sociodemographic risk factors  family factors  National Child Development Study  British Cohort Study  British Child and Adolescent Mental Health Surveys Index. décimale : PER Périodiques Résumé : Background:  While there is considerable evidence of income gradients in child and adolescent behaviour problems, evidence relating to children and young people’s emotional difficulties is more mixed. Older studies reported no income differentials, while recent reports suggest that adolescents from low-income families are more likely to experience emotional difficulties than their more affluent peers. Methods:  We compared the association between low- versus medium-/high-family income and parent-reported emotional difficulties in 15- and 16-year-olds in three large nationally representative cohorts studied in 1974, 1986 and 1999/2004. We then examined whether increases in the income differential could be accounted for by changes in the association of a range of sociodemographic factors (family type or size, maternal education or housing tenure) with either family income or emotional difficulties. Finally, in the most recent cohorts, we considered whether the effects of these sociodemographic variables were mediated by more proximal family factors (maternal distress, stressful life events or family dysfunction). Results:  An increasing income differential in adolescent emotional problems emerged over the period, with standardized coefficients for associations with low income increasing from .07 in 1974 and 1986 to .30 in 1999/2004. This was due partially (∼10%) to sociodemographic risk factors for emotional difficulties becoming more strongly associated with low-income families over time, and partially (∼40%) to the increasing impact of these risk factors. In the most recent cohorts, about 40% of the effects of sociodemographic risks appear to have been mediated by more proximal family factors. Conclusions:  These findings have implications for our understanding of the health burden of emotional problems, recognition of the health burden associated with inequality and public concern about the consequences of social change. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02447.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=142

Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders / Mark H. JOHNSON in Journal of Child Psychology and Psychiatry, 62-5 (May 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.610-630 Titre : Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders Type de document : texte imprimé Auteurs : Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Emily J.H. JONES, Auteur Article en page(s) : p.610-630 Langues : Anglais (eng) Mots-clés : Neurodevelopmental disorders  autism spectrum disorders  brain development Index. décimale : PER Périodiques Résumé : We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood. En ligne : http://dx.doi.org/10.1111/jcpp.13372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)-a systems neuroscience approach to common developmental disorders [texte imprimé] / Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Andrew PICKLES, Auteur ; Emily J.H. JONES, Auteur . - p.610-630. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-5 (May 2021) . - p.610-630 Mots-clés : Neurodevelopmental disorders  autism spectrum disorders  brain development Index. décimale : PER Périodiques Résumé : We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early-stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood. En ligne : http://dx.doi.org/10.1111/jcpp.13372 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

Annual Research Review: Threats to the validity of child psychiatry and psychology / Michael RUTTER in Journal of Child Psychology and Psychiatry, 57-3 (March 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.398-416 Titre : Annual Research Review: Threats to the validity of child psychiatry and psychology Type de document : texte imprimé Auteurs : Michael RUTTER, Auteur ; Andrew PICKLES, Auteur Article en page(s) : p.398-416 Langues : Anglais (eng) Mots-clés : Classification  diagnosis  genetics  epigenetics  bioinformatics  brain imaging  biomarkers  neural networks Index. décimale : PER Périodiques Résumé : Background Suggestions have been made that many claims concern false-positive findings in the field of child psychology and psychiatry. Findings The literature was searched for concepts and findings on the validity of child psychiatry and psychology. Substantial progress has been made in some, but not all, areas and considerable challenges remain in all. Conclusions The two major threats to validity concern the inability to examine brain tissues in life and the evidence that there is a high overlap among disorders. We emphasize the need to follow published guidelines on preplanned analyses and we note the dangers associated with unregulated flexibility in data analysis. We note the very important clinical and developmental findings that have been ignored, perhaps partly because of an excessive focus on technologies. Nevertheless, we are positive about both the accomplishments and the ways in which challenges are being met. En ligne : http://dx.doi.org/10.1111/jcpp.12461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Annual Research Review: Threats to the validity of child psychiatry and psychology [texte imprimé] / Michael RUTTER, Auteur ; Andrew PICKLES, Auteur . - p.398-416. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-3 (March 2016) . - p.398-416 Mots-clés : Classification  diagnosis  genetics  epigenetics  bioinformatics  brain imaging  biomarkers  neural networks Index. décimale : PER Périodiques Résumé : Background Suggestions have been made that many claims concern false-positive findings in the field of child psychology and psychiatry. Findings The literature was searched for concepts and findings on the validity of child psychiatry and psychology. Substantial progress has been made in some, but not all, areas and considerable challenges remain in all. Conclusions The two major threats to validity concern the inability to examine brain tissues in life and the evidence that there is a high overlap among disorders. We emphasize the need to follow published guidelines on preplanned analyses and we note the dangers associated with unregulated flexibility in data analysis. We note the very important clinical and developmental findings that have been ignored, perhaps partly because of an excessive focus on technologies. Nevertheless, we are positive about both the accomplishments and the ways in which challenges are being met. En ligne : http://dx.doi.org/10.1111/jcpp.12461 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Association between spectral electroencephalography power and autism risk and diagnosis in early development / Scott HUBERTY in Autism Research, 14-7 (July 2021)  

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Associations between emotion recognition and autistic and callous-unemotional traits: differential effects of cueing to the eyes / Virginia CARTER LENO in Journal of Child Psychology and Psychiatry, 64-5 (May 2023)  

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Associations between theory of mind and conduct problems in autistic and nonautistic youth / Virginia CARTER LENO in Autism Research, 14-2 (February 2021)  

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Autistic symptomatology and language ability in autism spectrum disorder and specific language impairment / Tom LOUCAS in Journal of Child Psychology and Psychiatry, 49-11 (November 2008)  

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Behavioural and physiological response to frustration in autistic youth: associations with irritability / Virginia CARTER LENO in Journal of Neurodevelopmental Disorders, 13 (2021)  

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Between a ROC and a hard place: decision making and making decisions about using the SCQ / Christina M. CORSELLO in Journal of Child Psychology and Psychiatry, 48-9 (September 2007)  

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Beyond intervention into daily life: A systematic review of generalisation following social communication interventions for young children with autism / Sophie CARRUTHERS in Autism Research, 13-4 (April 2020)  

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Callous-unemotional traits in youth with autism spectrum disorder (ASD): replication of prevalence estimates and associations with gaze patterns when viewing fearful faces / Virginia CARTER LENO in Development and Psychopathology, 33-4 (October 2021)  

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Caregiver behavioral changes mediate the effects of naturalistic developmental behavioral interventions: Combining evidence from three randomized controlled trials / Ji Eun HAN ; Hallie BROWN ; Catherine LORD ; Sally J. ROGERS ; Annette ESTES ; Connie KASARI ; Andrew PICKLES ; So Hyun KIM in Autism, 29-7 (July 2025)  

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Co-occurring Psychiatric Disorders in Preschool and Elementary School-Aged Children with Autism Spectrum Disorder / Fernando SALAZAR in Journal of Autism and Developmental Disorders, 45-8 (August 2015)  

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