Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation / Brittany G. TRAVERS in Molecular Autism, (March 2015)  

Public ISBD [article]  inMolecular Autism > (March 2015) . - p.1-15 Titre : Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Nicholas LANGE, Auteur ; Dan DESTICHE, Auteur ; Chad ENNIS, Auteur ; Jared A. NIELSEN, Auteur ; Alyson L. FROEHLICH, Auteur ; Molly B. D. PRIGGE, Auteur ; P. Thomas FLETCHER, Auteur ; Jeffrey S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Andrew L. ALEXANDER, Auteur Article en page(s) : p.1-15 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. En ligne : http://dx.doi.org/10.1186/s13229-015-0001-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] Atypical development of white matter microstructure of the corpus callosum in males with autism: a longitudinal investigation [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Nicholas LANGE, Auteur ; Dan DESTICHE, Auteur ; Chad ENNIS, Auteur ; Jared A. NIELSEN, Auteur ; Alyson L. FROEHLICH, Auteur ; Molly B. D. PRIGGE, Auteur ; P. Thomas FLETCHER, Auteur ; Jeffrey S. ANDERSON, Auteur ; Brandon A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; Janet E. LAINHART, Auteur ; Andrew L. ALEXANDER, Auteur . - p.1-15. Langues : Anglais (eng) in Molecular Autism > (March 2015) . - p.1-15 Index. décimale : PER Périodiques Résumé : The corpus callosum is the largest white matter structure in the brain, and it is the most consistently reported to be atypical in diffusion tensor imaging studies of autism spectrum disorder. In individuals with typical development, the corpus callosum is known to undergo a protracted development from childhood through young adulthood. However, no study has longitudinally examined the developmental trajectory of corpus callosum in autism past early childhood. En ligne : http://dx.doi.org/10.1186/s13229-015-0001-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Atypical diffusion tensor hemispheric asymmetry in autism / Nicholas LANGE in Autism Research, 3-6 (December 2010)  

Public ISBD [article]  inAutism Research > 3-6 (December 2010) . - p.350-358 Titre : Atypical diffusion tensor hemispheric asymmetry in autism Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jee Eun LEE, Auteur ; Michael P. FROIMOWITZ, Auteur ; Alyson L. FROEHLICH, Auteur ; Nagesh ADLURU, Auteur ; Brad WRIGHT, Auteur ; Caitlin RAVICHANDRAN, Auteur ; P. Thomas FLETCHER, Auteur ; Erin D. BIGLER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Année de publication : 2010 Article en page(s) : p.350-358 Langues : Anglais (eng) Mots-clés : adaptive functioning  classification  diffusion tensor imaging  hemispheric asymmetry  language functioning Index. décimale : PER Périodiques Résumé : Background: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter microstructure (WMM) in the superior temporal gyrus (STG) and temporal stem (TS), two brain regions in the temporal lobe containing circuitry central to language, emotion, and social cognition, would identify a useful combination of classification features and further understand autism neuropathology. Methods: WMM measurements from the STG and TS were examined from 30 high-functioning males satisfying full criteria for idiopathic autism aged 7–28 years and 30 matched controls and a replication sample of 12 males with idiopathic autism and 7 matched controls who participated in a previous case–control diffusion tensor imaging (DTI) study. Language functioning, adaptive functioning, and psychotropic medication usage were also examined. Results: In the STG, we find reversed hemispheric asymmetry of two separable measures of directional diffusion coherence, tensor skewness, and fractional anisotropy. In autism, tensor skewness is greater on the right and fractional anisotropy is decreased on the left. We also find increased diffusion parallel to white matter fibers bilaterally. In the right not left TS, we find increased omnidirectional, parallel, and perpendicular diffusion. These six multivariate measurements possess very high ability to discriminate individuals with autism from individuals without autism with 94% sensitivity, 90% specificity, and 92% accuracy in our original and replication samples. We also report a near-significant association between the classifier and a quantitative trait index of autism and significant correlations between two classifier components and measures of language, IQ, and adaptive functioning in autism. En ligne : http://dx.doi.org/10.1002/aur.162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] Atypical diffusion tensor hemispheric asymmetry in autism [Texte imprimé et/ou numérique] / Nicholas LANGE, Auteur ; Molly B. DUBRAY, Auteur ; Jee Eun LEE, Auteur ; Michael P. FROIMOWITZ, Auteur ; Alyson L. FROEHLICH, Auteur ; Nagesh ADLURU, Auteur ; Brad WRIGHT, Auteur ; Caitlin RAVICHANDRAN, Auteur ; P. Thomas FLETCHER, Auteur ; Erin D. BIGLER, Auteur ; Andrew A. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - 2010 . - p.350-358. Langues : Anglais (eng) in Autism Research > 3-6 (December 2010) . - p.350-358 Mots-clés : adaptive functioning  classification  diffusion tensor imaging  hemispheric asymmetry  language functioning Index. décimale : PER Périodiques Résumé : Background: Biological measurements that distinguish individuals with autism from typically developing individuals and those with other developmental and neuropsychiatric disorders must demonstrate very high performance to have clinical value as potential imaging biomarkers. We hypothesized that further study of white matter microstructure (WMM) in the superior temporal gyrus (STG) and temporal stem (TS), two brain regions in the temporal lobe containing circuitry central to language, emotion, and social cognition, would identify a useful combination of classification features and further understand autism neuropathology. Methods: WMM measurements from the STG and TS were examined from 30 high-functioning males satisfying full criteria for idiopathic autism aged 7–28 years and 30 matched controls and a replication sample of 12 males with idiopathic autism and 7 matched controls who participated in a previous case–control diffusion tensor imaging (DTI) study. Language functioning, adaptive functioning, and psychotropic medication usage were also examined. Results: In the STG, we find reversed hemispheric asymmetry of two separable measures of directional diffusion coherence, tensor skewness, and fractional anisotropy. In autism, tensor skewness is greater on the right and fractional anisotropy is decreased on the left. We also find increased diffusion parallel to white matter fibers bilaterally. In the right not left TS, we find increased omnidirectional, parallel, and perpendicular diffusion. These six multivariate measurements possess very high ability to discriminate individuals with autism from individuals without autism with 94% sensitivity, 90% specificity, and 92% accuracy in our original and replication samples. We also report a near-significant association between the classifier and a quantitative trait index of autism and significant correlations between two classifier components and measures of language, IQ, and adaptive functioning in autism. En ligne : http://dx.doi.org/10.1002/aur.162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children / Olivia SURGENT in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 48 p. Titre : Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur Article en page(s) : 48 p. Langues : Anglais (eng) Mots-clés : Humans  Child  White Matter  Brain  Quality of Life  Autistic Disorder  Brain Stem  Autism  Brainstem  Dti  Sensory features  Voxel-based analysis  White matter  TherVoyant). While both companies are involved in developing MRI-based surgery  techniques, neither are associated with any current areas of his research,  including the present publication. All other authors report no biomedical  financial interests of potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11 years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. En ligne : http://dx.doi.org/10.1186/s13229-022-00524-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Brainstem white matter microstructure is associated with hyporesponsiveness and overall sensory features in autistic children [Texte imprimé et/ou numérique] / Olivia SURGENT, Auteur ; Ali RIAZ, Auteur ; Karla K. AUSDERAU, Auteur ; Nagesh ADLURU, Auteur ; Gregory R. KIRK, Auteur ; Jose GUERRERO-GONZALEZ, Auteur ; Emily C. SKALETSKI, Auteur ; Steven R. KECSKEMETI, Auteur ; Douglas C. DEAN III, Auteur ; Susan ELLIS WEISMER, Auteur ; Andrew L. ALEXANDER, Auteur ; Brittany G. TRAVERS, Auteur . - 48 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 48 p. Mots-clés : Humans  Child  White Matter  Brain  Quality of Life  Autistic Disorder  Brain Stem  Autism  Brainstem  Dti  Sensory features  Voxel-based analysis  White matter  TherVoyant). While both companies are involved in developing MRI-based surgery  techniques, neither are associated with any current areas of his research,  including the present publication. All other authors report no biomedical  financial interests of potential conflicts of interest. Index. décimale : PER Périodiques Résumé : BACKGROUND: Elevated or reduced responses to sensory stimuli, known as sensory features, are common in autistic individuals and often impact quality of life. Little is known about the neurobiological basis of sensory features in autistic children. However, the brainstem may offer critical insights as it has been associated with both basic sensory processing and core features of autism. METHODS: Diffusion-weighted imaging (DWI) and parent-report of sensory features were acquired from 133 children (61 autistic children with and 72 non-autistic children, 6-11 years-old). Leveraging novel DWI processing techniques, we investigated the relationship between sensory features and white matter microstructure properties (free-water-elimination-corrected fractional anisotropy [FA] and mean diffusivity [MD]) in precisely delineated brainstem white matter tracts. Follow-up analyses assessed relationships between microstructure and sensory response patterns/modalities and analyzed whole brain white matter using voxel-based analysis. RESULTS: Results revealed distinct relationships between brainstem microstructure and sensory features in autistic children compared to non-autistic children. In autistic children, more prominent sensory features were generally associated with lower MD. Further, in autistic children, sensory hyporesponsiveness and tactile responsivity were strongly associated with white matter microstructure in nearly all brainstem tracts. Follow-up voxel-based analyses confirmed that these relationships were more prominent in the brainstem/cerebellum, with additional sensory-brain findings in the autistic group in the white matter of the primary motor and somatosensory cortices, the occipital lobe, the inferior parietal lobe, and the thalamic projections. LIMITATIONS: All participants communicated via spoken language and acclimated to the sensory environment of an MRI session, which should be considered when assessing the generalizability of this work to the whole of the autism spectrum. CONCLUSIONS: These findings suggest unique brainstem white matter contributions to sensory features in autistic children compared to non-autistic children. The brainstem correlates of sensory features underscore the potential reflex-like nature of behavioral responses to sensory stimuli in autism and have implications for how we conceptualize and address sensory features in autistic populations. En ligne : http://dx.doi.org/10.1186/s13229-022-00524-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism / Brittany G. TRAVERS in Journal of Autism and Developmental Disorders, 45-9 (September 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3030-3040 Titre : Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Erin D. BIGLER, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; Danica SAMSIN, Auteur ; Alyson FROEHLICH, Auteur ; Molly D. B. PRIGGE, Auteur ; Tyler C. DUFFIELD, Auteur ; Nicholas LANGE, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur Article en page(s) : p.3030-3040 Langues : Anglais (eng) Mots-clés : Autism  Motor  Diffusion tensor imaging  Brainstem  Grip strength  Finger tapping Index. décimale : PER Périodiques Résumé : Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5–33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem’s corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2467-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267 [article] Brainstem White Matter Predicts Individual Differences in Manual Motor Difficulties and Symptom Severity in Autism [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Erin D. BIGLER, Auteur ; Do P. M. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; Danica SAMSIN, Auteur ; Alyson FROEHLICH, Auteur ; Molly D. B. PRIGGE, Auteur ; Tyler C. DUFFIELD, Auteur ; Nicholas LANGE, Auteur ; Andrew L. ALEXANDER, Auteur ; Janet E. LAINHART, Auteur . - p.3030-3040. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-9 (September 2015) . - p.3030-3040 Mots-clés : Autism  Motor  Diffusion tensor imaging  Brainstem  Grip strength  Finger tapping Index. décimale : PER Périodiques Résumé : Mounting evidence suggests that poorer motor skills may be related to more severe autism symptoms. This study investigated if atypical white matter microstructure in the brain mediated the relationship between motor skills and ASD symptom severity. Sixty-seven males with ASD and 42 males with typical development (5–33 years old) completed a diffusion tensor imaging scan and measures of grip strength, finger tapping, and autism symptom severity. Within the ASD group, weaker grip strength predicted more severe autism symptoms. Fractional anisotropy of the brainstem’s corticospinal tract predicted both grip strength and autism symptom severity and mediated the relationship between the two. These findings suggest that brainstem white matter may contribute to autism symptoms and grip strength in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2467-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=267

Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review / Brittany G. TRAVERS in Autism Research, 5-5 (October 2012)  

Public ISBD [article]  inAutism Research > 5-5 (October 2012) . - p.289-313 Titre : Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review Type de document : Texte imprimé et/ou numérique Auteurs : Brittany G. TRAVERS, Auteur ; Nagesh ADLURU, Auteur ; Chad ENNIS, Auteur ; Do P. M. TROMP, Auteur ; Dan DESTICHE, Auteur ; Sam DORAN, Auteur ; Erin D. BIGLER, Auteur ; Nicholas LANGE, Auteur ; Janet E. LAINHART, Auteur ; Andrew A. ALEXANDER, Auteur Article en page(s) : p.289-313 Langues : Anglais (eng) Mots-clés : diffusion tensor imaging  neuroimaging  autism  white matter Index. décimale : PER Périodiques Résumé : White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder (ASD). From the 48 studies we reviewed, persons with ASD tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with ASD. Clinical implications and future research directions are discussed. Autism Res 2012, 5: 289–313. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1243 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183 [article] Diffusion Tensor Imaging in Autism Spectrum Disorder: A Review [Texte imprimé et/ou numérique] / Brittany G. TRAVERS, Auteur ; Nagesh ADLURU, Auteur ; Chad ENNIS, Auteur ; Do P. M. TROMP, Auteur ; Dan DESTICHE, Auteur ; Sam DORAN, Auteur ; Erin D. BIGLER, Auteur ; Nicholas LANGE, Auteur ; Janet E. LAINHART, Auteur ; Andrew A. ALEXANDER, Auteur . - p.289-313. Langues : Anglais (eng) in Autism Research > 5-5 (October 2012) . - p.289-313 Mots-clés : diffusion tensor imaging  neuroimaging  autism  white matter Index. décimale : PER Périodiques Résumé : White matter tracts of the brain allow neurons and neuronal networks to communicate and function with high efficiency. The aim of this review is to briefly introduce diffusion tensor imaging methods that examine white matter tracts and then to give an overview of the studies that have investigated white matter integrity in the brains of individuals with autism spectrum disorder (ASD). From the 48 studies we reviewed, persons with ASD tended to have decreased fractional anisotropy and increased mean diffusivity in white matter tracts spanning many regions of the brain but most consistently in regions such as the corpus callosum, cingulum, and aspects of the temporal lobe. This decrease in fractional anisotropy was often accompanied by increased radial diffusivity. Additionally, the review suggests possible atypical lateralization in some white matter tracts of the brain and a possible atypical developmental trajectory of white matter microstructure in persons with ASD. Clinical implications and future research directions are discussed. Autism Res 2012, 5: 289–313. © 2012 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.1243 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=183

Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder / K. MCLAUGHLIN in Autism Research, 11-3 (March 2018)  

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Role of autonomic, nociceptive, and limbic brainstem nuclei in core autism features / Brittany G. TRAVERS in Autism Research, 17-2 (February 2024)  

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