Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories / Elysia Poggi DAVIS in Journal of Child Psychology and Psychiatry, 65-4 (April 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-4 (April 2024) . - p.508-534 Titre : Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories Type de document : Texte imprimé et/ou numérique Auteurs : Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.508-534 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The global burden of early life adversity (ELA) is profound. The World Health Organization has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to identify which individuals exposed to ELA will develop mental illness remains poor and there is a critical need to identify underlying pathways and mechanisms. This review proposes unpredictability as an understudied aspect of ELA that is tractable and presents a conceptual model that includes biologically plausible mechanistic pathways by which unpredictability impacts the developing brain. The model is supported by a synthesis of published and new data illustrating the significant impacts of patterns of signals on child development. We begin with an overview of the existing unpredictability literature, which has focused primarily on longer patterns of unpredictability (e.g. years, months, and days). We then describe our work testing the impact of patterns of parental signals on a moment-to-moment timescale, providing evidence that patterns of these signals during sensitive windows of development influence neurocircuit formation across species and thus may be an evolutionarily conserved process that shapes the developing brain. Next, attention is drawn to emerging themes which provide a framework for future directions of research including the evaluation of functions, such as effortful control, that may be particularly vulnerable to unpredictability, sensitive periods, sex differences, cross-cultural investigations, addressing causality, and unpredictability as a pathway by which other forms of ELA impact development. Finally, we provide suggestions for prevention and intervention, including the introduction of a screening instrument for the identification of children exposed to unpredictable experiences. En ligne : https://doi.org/10.1111/jcpp.13958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 [article] Annual Research Review: The power of predictability - patterns of signals in early life shape neurodevelopment and mental health trajectories [Texte imprimé et/ou numérique] / Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur . - p.508-534. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-4 (April 2024) . - p.508-534 Index. décimale : PER Périodiques Résumé : The global burden of early life adversity (ELA) is profound. The World Health Organization has estimated that ELA accounts for almost 30% of all psychiatric cases. Yet, our ability to identify which individuals exposed to ELA will develop mental illness remains poor and there is a critical need to identify underlying pathways and mechanisms. This review proposes unpredictability as an understudied aspect of ELA that is tractable and presents a conceptual model that includes biologically plausible mechanistic pathways by which unpredictability impacts the developing brain. The model is supported by a synthesis of published and new data illustrating the significant impacts of patterns of signals on child development. We begin with an overview of the existing unpredictability literature, which has focused primarily on longer patterns of unpredictability (e.g. years, months, and days). We then describe our work testing the impact of patterns of parental signals on a moment-to-moment timescale, providing evidence that patterns of these signals during sensitive windows of development influence neurocircuit formation across species and thus may be an evolutionarily conserved process that shapes the developing brain. Next, attention is drawn to emerging themes which provide a framework for future directions of research including the evaluation of functions, such as effortful control, that may be particularly vulnerable to unpredictability, sensitive periods, sex differences, cross-cultural investigations, addressing causality, and unpredictability as a pathway by which other forms of ELA impact development. Finally, we provide suggestions for prevention and intervention, including the introduction of a screening instrument for the identification of children exposed to unpredictable experiences. En ligne : https://doi.org/10.1111/jcpp.13958 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523

Development of the infant gut microbiome predicts temperament across the first year of life / Molly FOX in Development and Psychopathology, 34-5 (December 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-5 (December 2022) . - p.1914-1925 Titre : Development of the infant gut microbiome predicts temperament across the first year of life Type de document : Texte imprimé et/ou numérique Auteurs : Molly FOX, Auteur ; S. Melanie LEE, Auteur ; Kyle S. WILEY, Auteur ; Venu LAGISHETTY, Auteur ; Curt A. SANDMAN, Auteur ; Jonathan P. JACOBS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.1914-1925 Langues : Anglais (eng) Mots-clés : emotion regulation  gut–brain axis  infant development  microbiome  temperament Index. décimale : PER Périodiques Résumé : Perturbations to the gut microbiome are implicated in altered neurodevelopmental trajectories that may shape life span risk for emotion dysregulation and affective disorders. However, the sensitive periods during which the microbiome may influence neurodevelopment remain understudied. We investigated relationships between gut microbiome composition across infancy and temperament at 12 months of age. In 67 infants, we examined if gut microbiome composition assessed at 1 “3 weeks, 2, 6, and 12 months of age was associated with temperament at age 12 months. Stool samples were sequenced using the 16S Illumina MiSeq platform. Temperament was assessed using the Infant Behavior Questionnaire-Revised (IBQ-R). Beta diversity at age 1 “3 weeks was associated with surgency/extraversion at age 12 months. Bifidobacterium and Lachnospiraceae abundance at 1 “3 weeks of age was positively associated with surgency/extraversion at age 12 months. Klebsiella abundance at 1 “3 weeks was negatively associated with surgency/extraversion at 12 months. Concurrent composition was associated with negative affectivity at 12 months, including a positive association with Ruminococcus-1 and a negative association with Lactobacillus. Our findings support a relationship between gut microbiome composition and infant temperament. While exploratory due to the small sample size, these results point to early and late infancy as sensitive periods during which the gut microbiome may exert effects on neurodevelopment. En ligne : http://dx.doi.org/10.1017/S0954579421000456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Development of the infant gut microbiome predicts temperament across the first year of life [Texte imprimé et/ou numérique] / Molly FOX, Auteur ; S. Melanie LEE, Auteur ; Kyle S. WILEY, Auteur ; Venu LAGISHETTY, Auteur ; Curt A. SANDMAN, Auteur ; Jonathan P. JACOBS, Auteur ; Laura M. GLYNN, Auteur . - p.1914-1925. Langues : Anglais (eng) in Development and Psychopathology > 34-5 (December 2022) . - p.1914-1925 Mots-clés : emotion regulation  gut–brain axis  infant development  microbiome  temperament Index. décimale : PER Périodiques Résumé : Perturbations to the gut microbiome are implicated in altered neurodevelopmental trajectories that may shape life span risk for emotion dysregulation and affective disorders. However, the sensitive periods during which the microbiome may influence neurodevelopment remain understudied. We investigated relationships between gut microbiome composition across infancy and temperament at 12 months of age. In 67 infants, we examined if gut microbiome composition assessed at 1 “3 weeks, 2, 6, and 12 months of age was associated with temperament at age 12 months. Stool samples were sequenced using the 16S Illumina MiSeq platform. Temperament was assessed using the Infant Behavior Questionnaire-Revised (IBQ-R). Beta diversity at age 1 “3 weeks was associated with surgency/extraversion at age 12 months. Bifidobacterium and Lachnospiraceae abundance at 1 “3 weeks of age was positively associated with surgency/extraversion at age 12 months. Klebsiella abundance at 1 “3 weeks was negatively associated with surgency/extraversion at 12 months. Concurrent composition was associated with negative affectivity at 12 months, including a positive association with Ruminococcus-1 and a negative association with Lactobacillus. Our findings support a relationship between gut microbiome composition and infant temperament. While exploratory due to the small sample size, these results point to early and late infancy as sensitive periods during which the gut microbiome may exert effects on neurodevelopment. En ligne : http://dx.doi.org/10.1017/S0954579421000456 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

DHEA: a neglected biological signal that may affect fetal and child development / Elysia Poggi DAVIS ; Curt A. SANDMAN ; Laura M. GLYNN in Journal of Child Psychology and Psychiatry, 65-9 (September 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1145-1155 Titre : DHEA: a neglected biological signal that may affect fetal and child development Type de document : Texte imprimé et/ou numérique Auteurs : Elysia Poggi DAVIS, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.1145-1155 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background The stress-sensitive maternal hypothalamic-pituitary-adrenal (HPA) axis through the end-product cortisol, represents a primary pathway through which maternal experience shapes fetal development with long-term consequences for child neurodevelopment. However, there is another HPA axis end-product that has been widely ignored in the study of human pregnancy. The synthesis and release of dehydroepiandosterone (DHEA) is similar to cortisol, so it is a plausible, but neglected, biological signal that may influence fetal neurodevelopment. DHEA also may interact with cortisol to determine developmental outcomes. Surprisingly, there is virtually nothing known about human fetal exposure to prenatal maternal DHEA and offspring neurodevelopment. The current study examined, for the first time, the joint impact of fetal exposure to prenatal maternal DHEA and cortisol on infant emotional reactivity. Methods Participants were 124 mother-infant dyads. DHEA and cortisol were measured from maternal hair at 15?weeks (early gestation) and 35?weeks (late gestation). Observational assessments of positive and negative emotional reactivity were obtained in the laboratory when the infants were 6?months old. Pearson correlations were used to examine the associations between prenatal maternal cortisol, prenatal maternal DHEA, and infant positive and negative emotional reactivity. Moderation analyses were conducted to investigate whether DHEA might modify the association between cortisol and emotional reactivity. Results Higher levels of both early and late gestation maternal DHEA were linked to greater infant positive emotional reactivity. Elevated late gestation maternal cortisol was associated with greater negative emotional reactivity. Finally, the association between fetal cortisol exposure and infant emotional reactivity was only observed when DHEA was low. Conclusions These new observations indicate that DHEA is a potential maternal biological signal involved in prenatal programming. It appears to act both independently and jointly with cortisol to determine a child's emotional reactivity. Its role as a primary end-product of the HPA axis, coupled with the newly documented associations with prenatal development shown here, strongly calls for the inclusion of DHEA in future investigations of fetal programming. En ligne : https://doi.org/10.1111/jcpp.13952 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534 [article] DHEA: a neglected biological signal that may affect fetal and child development [Texte imprimé et/ou numérique] / Elysia Poggi DAVIS, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur . - p.1145-1155. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-9 (September 2024) . - p.1145-1155 Index. décimale : PER Périodiques Résumé : Background The stress-sensitive maternal hypothalamic-pituitary-adrenal (HPA) axis through the end-product cortisol, represents a primary pathway through which maternal experience shapes fetal development with long-term consequences for child neurodevelopment. However, there is another HPA axis end-product that has been widely ignored in the study of human pregnancy. The synthesis and release of dehydroepiandosterone (DHEA) is similar to cortisol, so it is a plausible, but neglected, biological signal that may influence fetal neurodevelopment. DHEA also may interact with cortisol to determine developmental outcomes. Surprisingly, there is virtually nothing known about human fetal exposure to prenatal maternal DHEA and offspring neurodevelopment. The current study examined, for the first time, the joint impact of fetal exposure to prenatal maternal DHEA and cortisol on infant emotional reactivity. Methods Participants were 124 mother-infant dyads. DHEA and cortisol were measured from maternal hair at 15?weeks (early gestation) and 35?weeks (late gestation). Observational assessments of positive and negative emotional reactivity were obtained in the laboratory when the infants were 6?months old. Pearson correlations were used to examine the associations between prenatal maternal cortisol, prenatal maternal DHEA, and infant positive and negative emotional reactivity. Moderation analyses were conducted to investigate whether DHEA might modify the association between cortisol and emotional reactivity. Results Higher levels of both early and late gestation maternal DHEA were linked to greater infant positive emotional reactivity. Elevated late gestation maternal cortisol was associated with greater negative emotional reactivity. Finally, the association between fetal cortisol exposure and infant emotional reactivity was only observed when DHEA was low. Conclusions These new observations indicate that DHEA is a potential maternal biological signal involved in prenatal programming. It appears to act both independently and jointly with cortisol to determine a child's emotional reactivity. Its role as a primary end-product of the HPA axis, coupled with the newly documented associations with prenatal development shown here, strongly calls for the inclusion of DHEA in future investigations of fetal programming. En ligne : https://doi.org/10.1111/jcpp.13952 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=534

Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health / Sabrina R. LIU in Development and Psychopathology, 35-2 (May 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-2 (May 2023) . - p.899-911 Titre : Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health Type de document : Texte imprimé et/ou numérique Auteurs : Sabrina R. LIU, Auteur ; Curt A. SANDMAN, Auteur ; Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur Article en page(s) : p.899-911 Langues : Anglais (eng) Mots-clés : acculturative stress  discrimination  infant emotion  parenting  prenatal Index. décimale : PER Périodiques Résumé : Preconception and prenatal stress impact fetal and infant development, and women of color are disproportionately exposed to sociocultural stressors like discrimination and acculturative stress. However, few studies examine links between mothers' exposure to these stressors and offspring mental health, or possible mitigating factors. Using linear regression, we tested associations between prenatally assessed maternal acculturative stress and discrimination on infant negative emotionality among 113 Latinx/Hispanic, Asian American, Black, and Multiethnic mothers and their children. Additionally, we tested interactions between stressors and potential pre- and postnatal resilience-promoting factors: community cohesion, social support, communalism, and parenting self-efficacy. Discrimination and acculturative stress were related to more infant negative emotionality at approximately 12 months old (M = 12.6, SD = .75). In contrast, maternal report of parenting self-efficacy when infants were 6 months old was related to lower levels of infant negative emotionality. Further, higher levels of parenting self-efficacy mitigated the relation between acculturative stress and negative emotionality. Preconception and prenatal exposure to sociocultural stress may be a risk factor for poor offspring mental health. Maternal and child health researchers, policymakers, and practitioners should prioritize further understanding these relations, reducing exposure to sociocultural stressors, and promoting resilience. En ligne : http://dx.doi.org/10.1017/S0954579422000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Intergenerational risk and resilience pathways from discrimination and acculturative stress to infant mental health [Texte imprimé et/ou numérique] / Sabrina R. LIU, Auteur ; Curt A. SANDMAN, Auteur ; Elysia Poggi DAVIS, Auteur ; Laura M. GLYNN, Auteur . - p.899-911. Langues : Anglais (eng) in Development and Psychopathology > 35-2 (May 2023) . - p.899-911 Mots-clés : acculturative stress  discrimination  infant emotion  parenting  prenatal Index. décimale : PER Périodiques Résumé : Preconception and prenatal stress impact fetal and infant development, and women of color are disproportionately exposed to sociocultural stressors like discrimination and acculturative stress. However, few studies examine links between mothers' exposure to these stressors and offspring mental health, or possible mitigating factors. Using linear regression, we tested associations between prenatally assessed maternal acculturative stress and discrimination on infant negative emotionality among 113 Latinx/Hispanic, Asian American, Black, and Multiethnic mothers and their children. Additionally, we tested interactions between stressors and potential pre- and postnatal resilience-promoting factors: community cohesion, social support, communalism, and parenting self-efficacy. Discrimination and acculturative stress were related to more infant negative emotionality at approximately 12 months old (M = 12.6, SD = .75). In contrast, maternal report of parenting self-efficacy when infants were 6 months old was related to lower levels of infant negative emotionality. Further, higher levels of parenting self-efficacy mitigated the relation between acculturative stress and negative emotionality. Preconception and prenatal exposure to sociocultural stress may be a risk factor for poor offspring mental health. Maternal and child health researchers, policymakers, and practitioners should prioritize further understanding these relations, reducing exposure to sociocultural stressors, and promoting resilience. En ligne : http://dx.doi.org/10.1017/S0954579422000141 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development / Leah A. GRANDE in Development and Psychopathology, 34-4 (October 2022)  

Public ISBD [article]  inDevelopment and Psychopathology > 34-4 (October 2022) . - p.1376-1385 Titre : Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development Type de document : Texte imprimé et/ou numérique Auteurs : Leah A. GRANDE, Auteur ; Danielle A. SWALES, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur ; Elysia Poggi DAVIS, Auteur Article en page(s) : p.1376-1385 Langues : Anglais (eng) Mots-clés : Child Development  Child, Preschool  Depression/psychology  Female  Humans  Mothers/psychology  Pregnancy  Prenatal Exposure Delayed Effects/psychology  Psychological Distress  Stress, Psychological/psychology  cognitive function  depression  fetal programming  maternal care  parenting  prenatal stress  resilience Index. décimale : PER Périodiques Résumé : Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Quality of maternal care (sensitivity to nondistress, positive regard, and intrusiveness reverse-scored) were assessed during a mother-child play interaction at 6 and 12 months. Child cognitive function and negative emotionality were assessed at 2 years, using The Bayley Scales and the Early Childhood Behavior Questionnaire. Elevated prenatal distress was associated with poorer child cognitive function and elevated negative emotionality. Children exposed to elevated prenatal maternal distress did not, however, display these outcomes if they received high-quality caregiving. Specifically, maternal care moderated the relation between prenatal psychological distress and child cognitive function and negative emotionality. This association remained after consideration of postnatal maternal psychological distress and relevant covariates. Sensitive maternal care was associated with altered offspring developmental trajectories, supporting child resilience following prenatal distress exposure. En ligne : http://dx.doi.org/10.1017/s0954579421000286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 [article] Maternal caregiving ameliorates the consequences of prenatal maternal psychological distress on child development [Texte imprimé et/ou numérique] / Leah A. GRANDE, Auteur ; Danielle A. SWALES, Auteur ; Curt A. SANDMAN, Auteur ; Laura M. GLYNN, Auteur ; Elysia Poggi DAVIS, Auteur . - p.1376-1385. Langues : Anglais (eng) in Development and Psychopathology > 34-4 (October 2022) . - p.1376-1385 Mots-clés : Child Development  Child, Preschool  Depression/psychology  Female  Humans  Mothers/psychology  Pregnancy  Prenatal Exposure Delayed Effects/psychology  Psychological Distress  Stress, Psychological/psychology  cognitive function  depression  fetal programming  maternal care  parenting  prenatal stress  resilience Index. décimale : PER Périodiques Résumé : Children exposed to prenatal maternal psychological distress are at elevated risk for a range of adverse outcomes; however, it remains poorly understood whether postnatal influences can ameliorate impairments related to prenatal distress. The current study evaluated if sensitivematernal care during the first postnatal year could mitigate child cognitive and emotional impairments associated with prenatal psychological distress. Prenatal maternal psychological distress was assessed via self-reports of anxiety, depression, and perceived stress for 136 mothers at five prenatal and four postpartum time points. Quality of maternal care (sensitivity to nondistress, positive regard, and intrusiveness reverse-scored) were assessed during a mother-child play interaction at 6 and 12 months. Child cognitive function and negative emotionality were assessed at 2 years, using The Bayley Scales and the Early Childhood Behavior Questionnaire. Elevated prenatal distress was associated with poorer child cognitive function and elevated negative emotionality. Children exposed to elevated prenatal maternal distress did not, however, display these outcomes if they received high-quality caregiving. Specifically, maternal care moderated the relation between prenatal psychological distress and child cognitive function and negative emotionality. This association remained after consideration of postnatal maternal psychological distress and relevant covariates. Sensitive maternal care was associated with altered offspring developmental trajectories, supporting child resilience following prenatal distress exposure. En ligne : http://dx.doi.org/10.1017/s0954579421000286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488

Prenatal maternal stress programs infant stress regulation / Elysia POGGI DAVIS in Journal of Child Psychology and Psychiatry, 52-2 (February 2011)  

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The future of intergenerational transmission research: A prospective, three-generation approach / Mariann A. HOWLAND ; Laura M. GLYNN in Development and Psychopathology, 36-5 (December 2024)  

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